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Harvard GazetteOfficial news from Harvard University covering innovation in teaching, learning, and researchYou like Ike. But AI may help campaigns figure how to ensure you actually voteStrategists predict powerful new technology will bring seismic shifts in U.S. political life
You like Ike. But AI may help campaigns figure how to ensure you actually vote
Strategists predict powerful new technology will bring seismic shifts in U.S. political life
Christina Pazzanese
Harvard Staff Writer
4 min read
At a Harvard Kennedy School event Monday, strategists from both parties forecast that the 2028 presidential election will mark the start of a seismic and generational shift in U.S. politics as campaigns fully embrace the rapidly escalating power of AI.
“It’ll be the first AI campaign, so the stakes are going to be unbelievably high,” said Doug Sosnik, a former White House political director and veteran political adviser to dozens of Democratic candidates, including President Bill Clinton.
The strategists discussed how they expect AI to impact everything from how candidates reach and persuade potential voters to how organizations figure out where their supporters are and what will get them to actually vote on Election Day.
Sara Fagen, a strategic data and technology consultant, said that because of its speed and power, AI soon will allow political campaigns to customize their messaging to reach specific voters using data collected about a voter’s activities and motivations in a much more sophisticated way than currently.
“Eventually, probably not in ’28, but perhaps in the next presidential [election], you’ll hit a button and your target audience of 20 million people will get 20 million different campaigns,” said Fagen, who served as White House director of political affairs under President George W. Bush.
“Eventually, probably not in ’28, but perhaps in the next presidential [election], you’ll hit a button and your target audience of 20 million people will get 20 million different campaigns.”
Sara Fagen
Like the historic 1960 presidential election between John F. Kennedy Jr. and Richard Nixon, the first in which television played a decisive role, reshaped political campaigns for decades, 2028 will usher in a new political era, said Sosnik, now a fall 2026 Hauser Leader, Center for Public Leadership at HKS.
It’s been more than two decades since political campaigns began to harness data and technology in a serious way, analysts said.
Before 2004, campaigns had been organized and analyzed around precincts. But as Republicans found it increasingly difficult to accurately map Democratic voters, they turned to a very early form of data analytics during the 2004 presidential election between George W. Bush and John Kerry.
“We were able to figure out a different way to do this and sort of pinpoint who would be a supporter, who would need to be persuaded. It didn’t matter where they lived; it just mattered based on our algorithm and how to make those predictions,” said Fagen, who worked on the Bush campaign. “And we did that, and we did it very successfully.”
In 2008, the Obama campaign famously took microtargeting and data analytics to the next level and made it a significant component of the campaign’s structure, not just a helpful add-on. Since then, there’s been very little change in how campaigns use data and digital technology until now, they said.
Two big costly features of campaigns, advertising and polling, will also change thanks to AI, Sosnik and Fagen said.
Campaigns will be able to crank out new content much faster and cheaper and AI will affect advertising buying decisions, not only where and when to place ads, but how to best approach voters, said Sosnik.
Pollsters continue to face difficulties connecting with younger and non-college-educated adults by phone, a trend that’s likely to grow and leads to a skewed sense of the electorate.
With AI’s ability to analyze vast data sets, polling firms and even news organizations will be able to build “synthetic” cohorts to test messaging, particularly on voters who shun politics or are harder to reach by phone and better predict what people will or won’t support rather than relying solely on traditional polling methods, which are very expensive to do properly, said Fagen.
Certainly, they warned, AI’s entry into the body politic poses risks that have already emerged. Some campaigns have begun using AI-created images and deep fakes, as well as near-perfect voice manipulations that put words into a person’s mouth that were never said.
There are some “very positive” aspects of AI becoming a fixture of campaigns, Fagen said.
Fact-checking will become much faster and draw from a wider array of sources, providing voters with more information that’s less easily manipulated to assess the accuracy of candidates and political claims.
Even with political will, efforts by Congress or the courts to regulate AI will not catch up to how campaigns are currently using it in time to affect the 2026 midterms or 2028 presidential election, said Fagen.
Sosnick agreed.
By the time Congress finally takes action on AI, “It’s not going to matter functionally,” he said.
What it’s really like to be youngHarvard faculty recommend books that capture youth in all its joy and agony
Harvard faculty recommend books that capture youth in all its joy and agony
Clea Simon
Harvard Correspondent
8 min read
As the fall semester kicks in and students once again crowd the Square, Harvard faculty look back on favorite reads about youth — with a few choices from their own earlier days.
“Quarterlife: The Search for Self in Early Adulthood”
By Satya Doyle Byock
The book asks young people to figure out their path through careful attention to their experiences and responses to opportunities and disappointments to see what really matters. The author, a Jungian psychologist, provides guidance for discovering a way, building skill, and making persistent effort to a create a joyful life beyond the bounds of what society says is best. She asks of readers that rather than comparing themselves to others, they find what makes them come alive and where they can contribute to a better world to find meaning.
I have shared it with one of my daughters and my niece (both aged 25), who are navigating their lives in these chaotic times. They have found it helpful.
Climate Action Accelerator Professor of Organismic and Evolutionary Biology; Director of the Harvard University Herbaria
“A Portrait of the Artist as a Young Man”
By James Joyce
“Portrait” recounts the youthful confusion of Stephen Dedalus, soon to reappear as the nomadic aesthete of “Ulysses.”It wrenchingly captures the shock and trepidation of being dropped into a new school environment, one rife with menacing teachers and mischievous peers. One of my favorite scenes is where the other boys taunt Stephen, demanding to know whether he still kisses his mother goodnight. “What was the right answer to the question?” he agonizes. “Was it right to kiss his mother or wrong to kiss his mother?”
Professor of English and Interim Director of Undergraduate Studies
“The Song of the Lark”
By Willa Cather
A big, long novel about how a girl with almost no advantages growing up in the Great Plains in the late 1800s gets help, avoids entanglements, and finds the life she wants as a singer.
“The Stars and the Blackness Between Them”
By Junauda Petrus
A girl from the West Indies and a girl from Minneapolis find their way to each other, fall in love, and figure out how to be Black in an anti-Black world, with help and hindrances from adults. There’s magic, by the end.
“Synclair”
By Rachel Gold
A group of queer young people in the 2010s figure out how to help one another, who should be dating whom (it’s complicated), how to get help (and not hindrance) from religion, and why there’s a literal skeleton (a symbol for adult life?) in someone’s backyard.
I’d say that youth is a topic only in retrospect, because the young aren’t conscious of the ways in which they’re young. So for me, the great novel of youth is Flaubert’s “Sentimental Education,”which ends with a protagonist in jaded late middle age, looking back on a scene of disappointment from his youth and realizing what he couldn’t have known at the time, that he’d never be so happy again.
Dean of Undergraduate Education and Samuel Zemurray Jr. and Doris Zemurray Stone Professor of English of English
“The Bell Jar”
By Sylvia Plath
First published under a pseudonym in 1963, the book remains a compelling exploration of the pressures and perils of young womanhood. Based on Plath’s summer working as an intern at the magazine Mademoiselle, the novel follows Esther Greenwood, a bright, ambitious college student searching for creative and romantic fulfillment. It contains so many memorable passages, from its opening sentence — “It was a queer, sultry summer, the summer they executed the Rosenbergs, and I didn’t know what I was doing in New York” — to an extended metaphor of a fig tree, which represents the many decisions Esther must make. One wishes Plath, who died one month after the novel’s publication, had lived to write more about precocious young women and their dreams.
Visiting Lecturer on English and Director of Junior Tutorials
“Stop-Time”
By Frank Conroy
Publishedin 1967, there’s nothing dated about this memoir of Conroy’s difficult, itinerant boyhood in Florida and New York. What it tells us about the pain, pleasure, and estrangement of childhood feels bracingly fresh almost 60 years later. By re-entering his memories with the narrative precision of a novelist, Conroy helped make possible much of the autobiography that followed. It’s hard to imagine Tobias Wolff writing “This Boy’s Life”or Mary Karr writing “The Liars’ Club”without Conroy having gone first. Psychologically astute and resistant to sentimentality, “Stop-Time”is one of those books I return to every few years with the keenest pleasure.
Youth is a time of becoming, we say, and of growth — but those terms sound so very orderly and peaceful when held up against the turbulence and violence of “My Brilliant Friend.” Has any other novel ever depicted with quite as much brutal honesty as this one the fierce intensities of both identification and dis-identification that shape this stage of life? Or examined with quite so much analytic prowess the volatile compound of love and hate and envy and admiration that define girls’ friendships?
A dark, angry play about teenagers discovering their sexuality in a censorious and stifling society. Its psychological acuity, inventive structure, and anguished critique have lost none of their power since the play was written in 1891. Now well-known through its modern adaptation as a musical, Wedekind’s original play continues to surprise and shock. There are many strong English translations, including versions by Ted Hughes, Jonathan Franzen, and Anya Reiss.
My favorite book on youth. I remember reading it when I was 10 years old. What it really drove home for me was how, if we’re not careful, the considerable talents and imagination of children can be contaminated and swayed into forces that are more harmful than good; that there is something vitally important about childhood and that, sadly, many of the ills of the world don’t wait for adulthood. They begin early on, by both twisting and squandering the talents, imagination, gifts, and hopes of children.
“Island”
By Aldous Huxley
The importance of childhood education is something Huxley (author of “Brave New World”) emphasized in this lesser-known book. There’s quite a bit in that book about taking childhood education very seriously. In particular, Huxley urges us to teach critical thinking skills to children and the notion of the interconnectedness of living things early on.
I would recommend this award-winning historical novel about a young girl coming of age in the tumultuous intertribal warfare of seventh-century C.E. England. Based on the life of St. Hilda of Whitby, it’s a beautifully written novel about a young girl with a brilliant political mind who finds ways to manipulate others through the language of religion and prophesy to rise to the position of king’s adviser in a violent, male-dominated court, while also navigating childhood and adolescence. At the same time, it’s an incredibly well-researched and immersive picture of life in early medieval England in the ruins of the Roman empire and during the rise of Christianity.
In many ways, this story touched upon the second-generation immigrant experience. As a second-generation immigrant, I really resonated with characters who wrestled with the cider house rules (literally, those found posted within the cider house). Second-generation immigrants like me often dwell, sometimes literally, in two worlds and spend much of our lives trying to rectify the values and expectations of two societies that can have disparate ideas about raising children and more. The idea presented in the novel that each one of us “should be of use” in this life was deeply familiar, though as a teenager I wrestled with knowing what that meant for me. Finally, the protagonist’s return to his childhood home reminds me that we cannot easily abandon our heritage but must, on our own terms and in our own time, come to a fuller understanding of how we put our experiences to use in building the life we want to live.
Linda Bilmes is doing the mathKennedy School budget analyst has made it her life’s mission to elucidate the heavy toll of war: ‘If we don’t account for something, we don’t value it.’
Kennedy School budget analyst has made it her life’s mission to elucidate the heavy toll of war: ‘If we don’t account for something, we don’t value it.’
At a session of the Senate Appropriations Committee in July, U.S. Defense Secretary Pete Hegseth told lawmakers that the first six months of the fitful war with Iran had cost taxpayers an estimated $37.5 billion.
Or not exactly — a little less, he clarified. The estimate included “MILPAY, O&M and other anticipated costs through September 30.”
In a rancorous hearing marked by charges of recklessness and countercharges of “cowardice,” it was a bureaucratic aside.
And yet, of course, it was that moment that drew the particular attention of Linda Bilmes, the Daniel Patrick Moynihan Senior Lecturer in Public Policy at the Harvard Kennedy School.
“Thirty-seven and a half billion dollars, that’s not a serious number,” said Bilmes. “There’s no way it’s less than $100 billion — but then that’s only the tip of the iceberg.”
It can be difficult, Bilmes admits, to sum up her varied career in the private sector, public service, and academia.
But there have been a few throughlines, she says, notably the ideathat “accounting really matters. If we don’t account for something, we don’t value it.”
Bilmes is no firebrand. But quietly, laboriously, she has pushed thousands of students, fellow citizens, and public officials to a wholesale reappraisal of the assets Americans take for granted and the terrible liabilities we shudder to contemplate.
Bilmes has become one of the nation’s leading experts on the cost of the wars that have followed the Sept. 11 attacks, which she reckons in the trillions. Her next book, “The Ghost Budget,” forthcoming this fall, will build on that work, arguing that the scale, complexity, and opacity of American military operations have led to fraud, disillusionment, and strategic errors.
Bilmes graduated from Harvard College in 1980 and from Harvard Business School in 1984. She worked as a consultant before rising to the No. 2 job in Bill Clinton’s Department of Commerce.
As the administration wound down, she had the inside track at a number of high-profile jobs in the private sector. But she had just survived a major medical episode, with three young children — so an offer to teach at the Kennedy School seemed like an appealing shift.
“I was shocked at what the numbers were telling me. I became sort of obsessed.”
So in 2002, it was as a first-semester teacher that Bilmes watched the successor administration on its march to war with Iraq.
That November, Defense Secretary Donald Rumsfeld projected that the conflict would cost under $50 billion — and dismissed higher estimates as “baloney.”
Bilmes’ students wanted to know: How much would the war cost, really? She found strikingly little by way of a “serious number,” except for a 2002 article by Yale economist William Nordhaus.
In the best case, Nordhaus calculated, the war could cost as little as $100 billion. But things could also deteriorate. If,he wrote, “the war drags on, occupation is lengthy, nation building is costly, [and] there is lingering military and political resistance in the Islamic world to U.S. occupation,” the Iraq invasion could cost as much as $1.9 trillion.
Thereafter Nordhaus returned to the work that led to his Nobel, in 2018.But he encouraged Bilmes to keep up the tally — and she did.“I was shocked at what the numbers were telling me,” Bilmes said. “I became sort of obsessed.”
One could imagine war costs as an upscaled household budget, simply balancing — as Hegseth did in July — appropriations with expenses: recruiting, training, transporting and equipping soldiers and sailors; building and repairing bases; buying, maintaining and replacing jets, ships and missile batteries.
But that would be a mistake, Bilmes has argued. It imagines a simple budgetary stream — but any modern war represents a spreading, untraceable Amazon of costs and liabilities.
A stockpiled missile, once it explodes, must be replaced at a new — and often higher — price. When soldiers are injured, sickened, or killed, it creates not just a moral debt but a fiscal obligation that will stay with their country for decades. And when a war is funded by borrowing, every dollar spent also opens a long horizon of repayment.
Whatever their failings, many wartime presidents have been candid about those costs, Bilmes argues, citing tax hikes and budget cuts imposed by Woodrow Wilson and Harry Truman.
The result, she argues, was a reliable fiscal pattern: “During those wars, one, people who were upper-class, even upper-middle-class, paid higher taxes than they do now. And two, they paid higher taxes at the end of the war than they did at the beginning.”
Starting in 2001, that pattern substantially ended.
As presidents of both parties continued military operations or started new ones, calls for collective national sacrifice were dropped, as were marginal tax rates. That left military expenses of every stripe to be financed by borrowing.
The new approach troubles Bilmes not just as a self-styled “fiscal conservative” but also as a parent: “Speaking as an old person, the cost of the Iraq war is not going to be paid by me, but by your generation, by my three sons, by their children.”
Her concerns don’t end there. The daughter of a WWII veteran, Bilmes is aware of the way a war weighs on the people who fight it — and that the nature of their sacrifice weighs differently today.
“The good news is that there’s a much higher survival rate” for service members involved in an exchange of fire, she said, and much more social acceptance of conditions like post-traumatic stress.
More veterans of all ages are classified — and compensated — as suffering from higher rates of disability. “That is the right thing to do,” Bilmes noted. But the culture change has created a “much broader eligibility pool,” and higher costs associated with the average veteran’s care.
Finally, there’s Bilmes’ practice as a Quaker. While she doesn’t often make the categorical antiwar claims associated with that tradition, it was in a Quaker meeting that this part of her career was — as it were — ratified.
“I did sit in silent prayer and asked the higher power if there was anything that I personally could do about all this,” she recalled. “And it came to me that I could help put a price tag on it. I have felt called to do that ever since.”
Bilmes’ peak media exposure came by doing that very plainly.
“The Three Trillion Dollar War,” a book co-authored with the economist Joseph Stiglitz, argued that, five years in, the Iraq war’s cost had exceeded Rumsfeld’s initial estimate by a factor of 60,000, and that even Nordhaus’ worst-case scenario was too optimistic.
The book, published in 2008, was a sober reckoning of missed opportunities and overlooked risks — and turned out to be a New York Times bestseller, not that Bilmes has trumpeted that about.
In fact, Philip Tizzani didn’t immediately make the connection between his professor in public finance in 2013 and her arguments, which he’d first come upon as an undergrad.
“When I graduated in 2008, there was a lot of disillusionment about the political moment — but it was only then sort of taking form, what precisely about that war was so perplexing and so bad,” said Tizzani, today a Democratic staff member on the House Appropriations Committee.
Together, Bilmes and Stiglitz had shown that it wasn’t just a “gut feeling,” Tizzani added — that “we could actually quantify all the off-the-book costs that this thing has incurred.”
“I tell my students that ‘a million seconds ago’ was about 11 days ago. A billion seconds ago is more like 30 years — like roughly, when the movie ‘The Lion King’ came out. A trillion seconds ago, wooly mammoths existed.”
Even as she dug deeper into the cost of combat, Bilmes discovered a second vocation at Harvard, as a teacher of a very practical kind. The spark came more than 20 years ago from the late Thomas Menino, then mayor of Boston. He served as matchmaker between her and Joe Curtatone, then the newly elected mayor of Somerville.
Curtatone hoped to implement good-government policies from City Hall, but without enlisting an army of high-price consultants. “Menino told him, ‘Get Linda to do it. Get her students to do it,’” Bilmes recalled with a smile.
Curtatone presented Bilmes’ class with an offer. Come work long hours, helping his fledgling office with budget design, operations, finance. The position is unpaid, but you don’t have to complete the course’s final paper.
“And the Kennedy School students, being the tire-biters that they are, said yes — 67 of them,” Bilmes laughed. “And they swarmed Somerville that semester.”
That city-government field lab endures to this day, and — along with her scrutiny of the Iran war — occupies much of Bilmes’ time.
“The Ghost Budget” will highlight the fact that military expenditures once debated in Congress and in the press are increasingly hidden from view: in supplemental and contingency budgets, in borrowing that circumvented congressional approval, and payments to private contractors, among other things.
As a budget expert and a citizen, Bilmes sets a high value on transparency. If disclosures must sometimes be limited in the interest of national security, she said, that doesn’t explain why “the Pentagon flunks its audit year after year … If that was a company in the private sector, it couldn’t carry on.”
It can be thankless, serving as the unofficial financial watchdog of the most sophisticated military in the history of the world, one that is capable of serious mistakes. And Bilmes has sometimes struggled to convey the awesome amounts of spending that wars can so quickly involve.
“One of the problems in the English language is the fact that the words ‘million,’ ‘billion’ and ‘trillion’ rhyme,” said Bilmes. Each number can seem to suggest, simply, “a large amount,” especially within a torrent of daily news and information.
But she has learned ways to emphasize their radical differences in meaning. Early in the semester, Bilmes tackles the problem this way: “I tell my students that ‘a million seconds ago’ was about 11 days ago. A billion seconds ago is more like 30 years — like roughly, when the movie ‘The Lion King’ came out.”
She wraps up by pointing out that “a trillion seconds ago, wooly mammoths existed.”
Whatever the increments, Bilmes remains passionately committed to tracking the value, too often uncounted, of what is preserved, pursued — or frittered away.
That kind of practicality, and perseverance, makes students like Tizzani very grateful for the role Bilmes has played in their lives.
“There’s just such deep virtue, I think, in giving future public servants the tools that will make them useful,” he said. “It may not get appreciated alongside other things happening there, but she is a bedrock institution, to me.”
Epidemiologist I-Min Lee has published hundreds of papers on exercise and heart health in her time with the Harvard Alumni Health Study and the Women’s Health Study
Tech insiders call for humanist-scientist discourse amid ‘Copernican moment’ of AI age
Sy Boles
Harvard Staff Writer
5 min read
Artificial intelligence advances daily. Right now, humans, with our values and beliefs, are the decision-makers who set the agenda, form relationships, create culture. There is a growing sense of profound discomfort over the fact that AI soon may take over some of that. What is our place when we are no longer solely at the center of things?
“I think we’re going to start seeing a lot of exciting applications [for AI] coming out … but it’s important to talk about this in a way that respects what it is to be human,” said panelist Ken Archer, product lead in responsible AI at Microsoft.
The panel was the first in a yearlong series exploring what makes us distinctly human and why that is important in the “Copernican moment” of the AI age. Future panels will bring together scientists and humanists to probe what artificial intelligence means for death and grieving, faith and religion, and empathy and meaning-making, among other topics.
“These kinds of questions are the kinds of questions that humanists have asked, at least some of them, for a very long time — poets, philosophers, historians, novelists. This is the domain of the human, and we really have to bring our judgment to bear,” said Sean Kelly, dean of Arts and Humanities and the Teresa G. and Ferdinand F. Martignetti Professor of Philosophy, who introduced the panel.
Archer and fellow panelist Jackson Kernion ’12, who leads the human feedback program at Anthropic, began by offering contrasting visions of a different kind of intelligence: the human one.
“The human mind is not different in kind from a reptile mind or a monkey mind,” Kernion said. “I was always attracted to the idea that the mind is like a computer, which is maybe convenient for the work I went into.”
Archer, on the other hand, saw the human mind, with its capacity for reason and for updating its background knowledge or assumptions, as distinct from other kinds of intelligence.
“We’re in the world, making distinctions within the world. This is basically thinking, and it’s our best definition we have so far,” Archer said. “What it lacks is the precision of mathematical physics, but I think it can get us started to have a good conversation about whether AI can surpass us.”
“I’m present for every moment of my life, and I bring with me all my experiences that accrue. LLMs are born anew in every context window.”
Jackson Kernion
How would those two perspectives, then, inform what it would mean for AI to outmatch us, asked Moira Weigel, the host of the discussion and an assistant professor of comparative literature in the Faculty of Arts and Sciences.
AI would first require a longer memory, Kernion said.
“I’m present for every moment of my life, and I bring with me all my experiences that accrue,” he said. “LLMs are born anew in every context window. They have all this background knowledge in their weights, but they pop into existence from the first token of the context window until they’re done generating, and that really is very much unlike us.”
Or, he joked, maybe a human life is just one long context window, referring to the amount of text an AI can process at one time when asked to generate a response.
Archer pointed to Martin Heidegger’s concept of thrownness, or Geworfenheit — the uniquely human experience of finding oneself thrown into the pre-existing world — and the uniquely human act of expressing that experience in language.
It’s humanity’s “thrownness” that gives us our ability to adapt to a frustrating, imperfect world, Archer said, a trait that still confounds the most advanced large language models.
AI may excel at chess, he explained, which is a closed world with fixed rules. “But when presented with an impossible task, does it step back from the world and say, ‘Well, what is the significance of this task I have been given?’ … No.”
The conversation took place days after news of an Anthropic researcher quitting over the risk of self-improving AI snowballing out of human control and amid the ongoing conversation about how a swarm of OpenAI agents recently went rogue and hacked the AI code repository Hugging Face.
Archer and Kernion, who both work in AI safety, are not immune from concerns about the products they help build — including the uncanny ways the models can seem, in Kernion’s words, like developing organisms.
“Every RL [reinforcement learning] training run is starting from this infant you’re growing in a weird way. The public only sees the final product; there are all sorts of weird, messed-up models you don’t see. I want to spend the time making sure the reward signals are specified the way we want,” Kernion said.
The researchers acknowledged that aligning AI with human values is no easy task, especially since humans are rarely aligned with one another. For those messy contingencies, Archer said, scientists ought to enlist the help of the humanities.
“We need the academy, and we need philosophy in particular, at this moment. Unfortunately, it’s less common today than it used to be, for when society faces a crisis, to call the philosophers.”
Can you tell an amorphophallus from an aspergillus? Word nerds, classicists, and botanists, it’s your time to shine in etymology quiz inspired by Div School book
Can you tell an amorphophallus from an aspergillus?
Sy Boles
Harvard Staff Writer
1 min read
Word nerds, classicists, and botanists, it’s your time to shine in etymology quiz inspired by Div School book
Can plants see? Can they pray? If trees could make music, what would it sound like?
Those questions and others are explored in “Thinking with Plants and Fungi,” a collection of essays from botanists, anthropologists, artists, and theologians inspired by a conference of the same name, hosted at the Harvard Divinity School’s Center for the Study of World Religions.
At the core of the book is an inquiry into how we should think about organisms that are wildly different from us. It’s an open question, but one way might be through the names we give them, whether in International Scientific Vocabulary or otherwise.
Joan Brugge’s decadeslong professional fight against cancer began when she tried to make sense of a tragedy
Anna Lamb
Harvard Staff Writer
6 min read
A series focused on the personal side of Harvard research and teaching.
Joan Brugge was on track to graduate from Northwestern University in a few years and launch into a career teaching math when a single phone call changed the direction of her life.
“I was a sophomore and I got this call from my parents, sobbing, asking could I please come home because my sister was going to be operated on,” Brugge said.
It turned out that her sister, who was 21, had a malignant brain tumor and was set to undergo treatment in their hometown of Cincinnati. Repeated radiation treatments ultimately damaged her sister’s brain to the point where she could not function independently, forcing her into a nursing home. In 1970, a little more than a year after the treatments began, Brugge’s sister died.
In an attempt to make sense of how her sister had gone from healthy and vibrant to so sick in a matter of months, Brugge said on that first trip back to Ohio she had started asking her sister’s doctors questions. She wanted to understand if they knew what caused the tumor, because then they might be able to fix what was wrong. Or at least, prevent it from happening to others.
“The doctor said we don’t know, but they were beginning to look at viruses. So I went back to Northwestern and asked my adviser if I could do an independent literature study on viruses and cancer,” Brugge said. “That was my first exposure to scientific literature, and it really was fascinating, just to see how a hypothesis was generated or question was raised in the introduction and then experiments were done to address it. I was hooked after I started doing that.”
Instead of being the math teacher she once imagined, Brugge is now the Louise Foote Pfeiffer Professor of Cell Biology in the Blavatnik Institute at Harvard Medical School and director of HMS’s Ludwig Center, where she helps bring together interdisciplinary cancer research.
As for the career path she abandoned, she said she probably wouldn’t have lasted all four years studying numbers.
“I really liked math because I liked to solve problems,” Brugge said. “But I think when we got into some of the really heavy math, I might have faded out in terms of the really esoteric math.”
“But,” she added, “I’m still really addicted to solving problems.”
“After seeing what my family went through and what my sister went through, that was the motivation. Just to be part of research that could potentially make a difference.”
Brugge studied biology as an undergraduate, going on to earn a Ph.D. in virology from Baylor College of Medicine. As a postdoc in 1975, she was on the foreground of one of the most significant cancer discoveries, one that still shapes researchers’ understanding of the disease today.
At that time Harold Varmus and Michael Bishop, scientists at the University of California, San Francisco, identified the SRC gene as an important protein controlling cell growth — both in healthy cells and, when dysregulated, in cancer cells. In the lab Brugge was working in at the University of Colorado, scientists were able to detect and isolate the SRC gene to further break down its role in creating cancer cells.
“It became clear that a gene in one cell could control proliferation, and in another cell, aggregation of cells, and so it all depends on what other genes are expressed — what genes are turned on or off in each individual cell, and that provides a pipeline for these oncogenes to have influence,” Brugge said. “That made it clear that I wasn’t going to be discovering a eureka cure for cancer, and that put me in the mindset of just trying to understand as much as we could about the pathways that are disrupted in cancer.”
Brugge went on to have professorships at SUNY-Stony Brook and the University of Pennsylvania, before branching out to become the scientific director and senior vice president at ARIAD Pharmaceuticals. She returned to academia as a professor of cell biology at HMS in 1997 and chaired the department from 2004-2014, when she became co-director of the Ludwig Center.
Through it all, Brugge said her thoughts have always come back to her sister.
“After seeing what my family went through and what my sister went through, that was the motivation,” she said. “Just to be part of research that could potentially make a difference.”
In addition to her sister, Brugge lost her mother to cancer — ovarian in 2008 — spurring her involvement in Havard research analyzing human tumors before and after chemotherapy, to figure out how to kill cells that survive treatment.
“It was just after my mom had passed away, so I definitely leapt on that,” Brugge said.
Brugge was brought on with enthusiasm, as her lab had experience using cutting-edge tools including 3D/organoid cell cultures, genetically engineered and transplantation-based animal models, single-cell analysis, metabolomics, and high-throughput microscopy.
“I was brought in not because I had ovarian cancer research experience, but because I had been working with these 3D models where cells are able to grow in a context that more closely mimics the tumor context in vivo, because tumors don’t grow on a really hard plastic petri dish,” Brugge said.
The single-cell approach has been especially important in studying the highly volatile BRCA 1 and 2 mutations in breast cancer. The hope is to one day identify the precursors of cancer in order to eliminate the cells before they accumulate and become almost untreatable.
“We think we have a handle on the cells that could be the precursors of cancer, and now we’re trying to figure out what alterations they’re causing, and what are the vulnerabilities of the cells that carry those, so we could try to eliminate them or prevent them from progressing into cancer,” Brugge said.
Despite all the progress, Brugge said one of her biggest worries is continuing to find funding.
“What gets me down, and in those states where I’m like, ‘What am I doing? How much longer can I do this?’ is the funding,” she said. “When we went through the terminations, that was really tough.”
Last year, Brugge’s lab lost significant federal money, forcing her and her team to seek out private funding to finish their work. While they were able to cover costs for projects in their later stages, Brugge said it’s especially disheartening to see research defunded when important cancer breakthroughs are on the horizon.
“There’s great promise in checkpoint inhibitors, which wake up the immune cells and can work really great in some tumors. And there hasn’t been super rapid progress in figuring out how to manipulate the immune system in those tumors where the first therapies aren’t working. But it’s going to come,” she said.
And when she runs up against a roadblock, Brugge said memories of her sister remind her of the importance of her work.
“She definitely comes to mind,” Brugge said. “Definitely.”
One encounter changed everything for researcher who hopes to help mothers and families detect and treat the effects of dangerous drinking
When everything is politics on campusSociologist Neil Gross argues polarization undermining education opportunities, lays out how students might change things
Sociologist Neil Gross argues polarization undermining education opportunities, lays out how students might change things
Jacob Sweet
Harvard Staff Writer
6 min read
Colby College sociologist Neil Gross says he thought he had a sense of the level of polarization on American college campuses based on his prior research.
But Gross, author of the new book “What Happened to College,” said in an interview that he was surprised by how much things had changed in recent decades.
“I didn’t realize how far it had gone,” said Gross, who is currently conducting research at the Radcliffe Institute with Harvard sociologist Michéle Lamont on intellectual pluralism and changing scholarly habits . “I think that was the biggest surprise — just the extent of it.”
Gross’ book breaks the divisiveness into two types: ideological and affective.
Ideological polarization is what happens when people’s beliefs drift further apart. Democrats become more liberal, and Republicans become more conservative.
Affective polarization, the core concept of Gross’s book, is arguably more insidious and counter-productive.
It’s when certain beliefs and affiliations become an increasingly large aspect of one’s identity and a basis for how to judge others. People begin to feel more positively about people who share their set of views and more negatively about those who differ.
Gross, the Charles A. Dana Professor of Sociology at Colby, taught at Harvard in the mid-2000s. He argues in his book that since the 1990s affective polarization has outpaced ideological.
“[T]he negative feelings some Americans have toward the other side increasingly involve disdain or hatred tied to the sense that people with opposing political beliefs are immoral,” he writes.
The trend isn’t limited to college campuses, but it’s there they have become a major talking point. Many students find themselves contending with sharp and caustic divides.
Drawing on hundreds of interviews and a trove of survey data, Gross argues that affective polarization shapes students’ experience before they even arrive.
“There’s a lot of writing off of whole colleges, whole states, whole populations, because of stereotypes about what people on the other side might believe, think, hold dear,” he said.
In one of many case studies in the book, he tells the story of an anonymous student, “Maddy,” who decided which colleges to apply to based largely on political reputation — spurning schools like Emory in Atlanta out of discomfort with the prospect of living in the South.
When she arrived on campus on a bucolic liberal arts campus known for its relative conservatism, she made friends with people who agreed with her politically and ended up with none who didn’t.
“Maddy knows of conservative students,” Gross writes, “but she hasn’t had much occasion to talk to them.”
To Gross, this is a missed opportunity.
“Some studies show that students gain more critical thinking skills when they’re around people who think differently, politically and otherwise,” he notes in the book. “If prospective students focus too much on political comfort, they may be hampering their own growth.”
“If prospective students focus too much on political comfort, they may be hampering their own growth.”
Neil Gross
This impulse isn’t universal. Only 34 percent of students surveyed by Gross said that their school’s political reputation was a somewhat important, important, or very important factor in their decision.
But there are plenty of reasons students like Maddy end up separated from the ideologically opposed. Gross describes how a student’s political views can weigh on their chances of getting into nonpolitical clubs or even securing a date with someone with a different political affiliation.
Pervasive political sorting can divide even students who don’t consider themselves particularly interested in politics.
Another student, “Albert,” arrived at college a moderate liberal but found himself turned off by an especially progressive instructor who, he was told, gave better grades to students who expressed liberal politics.
He became closer with students in his fraternity who leaned more conservative, drifting apart from his more liberal friends in the process.
Gross describes how certain flashpoints, like the war in Gaza, politicized clubs that had no overt political link. One student described the drama that unfolded when her a cappella group considered removing a traditional Hanukkah song from its concert program.
“[W]hen everything is politics,” writes Gross, “some of the greatest pleasures of the human experience — singing songs together, learning and growing alongside others, even when we don’t all agree — are lost.”
To disrupt political polarization on campus, Gross suggests six points for improvement.
Before students are admitted, he suggests, they should prove their openness toward reasoned debate. (Harvard has incorporated this practice since 2024, asking applicants to recount a time they strongly disagreed with someone.)
Further, Gross writes, colleges should train students in constructive dialogue skills — helping them speak more comfortably about controversial topics. He also believes faculty should be trained in how to encourage healthy debates around controversial subjects in class.
He believes schools should increase political diversity both of students and faculty. For admissions, it could mean colleges more aggressively recruiting high schoolers from rural areas whose ideological viewpoints are underrepresented on campus.
When students arrive, he thinks colleges should consider random roommate assignments, which could boost connections between students who might not otherwise interact.
On the faculty side, universities could recruit professors who specialize in subjects like classics, military history, and the sociology of religion, which tend to attract more conservative voices.
Gross, who has partnered at Radcliffe with Lamont, the Robert I Goldman Professor of European Studies and a professor of sociology and African and African American studies, believes campus political environments can change.
Recently, he said, he’s heard from many students who said that it’s important to listen to people they disagree with and who want a different kind of college experience. “There seems to be a moderation,” he said.
“I think students ultimately recognize that a highly affectively polarized country is not a functional country,” Gross said. “It’s not a pleasant place to live.”
He senses a growing sentiment from students who want to change the status quo: “Maybe we can learn something different in college that will help us fix this.”
Where U.S. has lost ground since 9/11FDNY chief, admiral who survived Pentagon attack, Time journalist say decline in national unity since then is perhaps most damaging problem
Moderator Meghan O’Sullivan (from left), Joseph Pfeifer, Nancy Gibbs, and Michael Mullen.
Niles Singer/Harvard Staff Photographer
Clea Simon
Harvard Correspondent
5 min read
FDNY chief, admiral who survived Pentagon attack, Time journalist say decline in national unity since then is perhaps most damaging problem
After the terrorist attacks on Sept. 11, 2001, the nation rallied under the cry “Never forget.”
But 25 years later, several lessons that emerged from that day of death and destruction have been forgotten, according to a panel of experts at a John F. Kennedy Jr. Forum at the Institute of Politics on Tuesday night.
Three panelists — the first New York Fire Department chief to respond to the attack, a Navy admiral who was in the Pentagon that day, and a journalist who covered it for Time magazine — were all personally impacted by the attack.
Chief of Counterterrorism and Emergency Preparedness for the Fire Department of New York, Joseph Pfeifer, now a Kennedy School senior fellow and author of “Ordinary Heroes: A Memoir of 9/11,” was inspecting a suspected gas leak nearby in lower Manhattan at 8:46 that morning when the first plane hit the North Tower of the World Trade Center.
“Every first responder looked at the burning building and knew they were going to the most dangerous fire of their lives,” he recalled.
Recognizing immediately that the crash was deliberate, he also explained how, nearly an hour later, when the South Tower was collapsing, he had to make a fateful decision. Trusting his “gut feeling” and years of training, he called for all firefighters to evacuate.
“It was probably the first time in history a fire chief pulled firefighters out when there were thousands of people in the building,” he said.
Adm. Michael Glenn “Mike” Mullen, who would go on to serve as President George W. Bush’s chairman of the Joint Chiefs of Staff (2007–2011), was in the Pentagon when it was hit by a third plane that day.
On realizing what had happened, the Pentagon immediately went “into crisis mode” and called on everyone in the complex to evacuate. But, he told the audience, many of whom had not been born in 2001, confusion ruled the day.
“What sometimes gets lost is how little we knew,” he said. “We didn’t know how many planes it would be or where they were coming from.”
“Everyone understood we were living in an illusion that had been shattered, but no one knew what that was going to mean in a day, a week, a month, or 25 years.”
Nancy Gibbs
Nancy Gibbs, Lombard Director of the Shorenstein Center and Edward R. Murrow Professor of the Practice of Press, Politics and Public Policy, was working for Time magazine when she got the assignment to write about that day.
Although she was in Westchester with a sick child at the time of the attacks, her immersive cover story, “If You Want to Humble an Empire,” brought her into close contact with survivors, first responders, and officials, among others.
That day’s legacy, she said, included an end to the “certainty of safety that we [Americans] took for granted.”
“Everyone understood we were living in an illusion that had been shattered, but no one knew what that was going to mean in a day, a week, a month, or 25 years,” said Gibbs, who would go on to become the magazine’s first female editor-in-chief.
One result, she continued, was “the unbelievable heroism” of ordinary people, recalling “lines looping around hospitals of people wanting to give blood, and people opening their homes to dust-covered, traumatized” survivors.
Twenty-five years later, said Pfeifer, “we are in a better position” in terms of national security.
In large part that is due, Mullen said, to tighter cooperation resulting from the establishment of the Department of Homeland Security, which was made up of all or parts of 22 departments and agencies. Before Sept. 11, he pointed out, “We had all the information we needed to put it together ahead of time, and yet we couldn’t do that.”
In the past 25 years, we haven’t had another such attack.
Citing the “thousands and thousands [of people] working to make sure it didn’t happen again,” he said that the effort is ongoing. “We have to stay vigilant.”
Like the intelligence services, all three panelists agreed, the nation at large learned how much stronger we are together.
Pfeifer, for example, turned his three watchwords — connect, collaborate, and coordinate — into a challenge coin, which he presented to Mullen.
But all three stressed that hard-won unity is now under threat.
“When we’re put under stress, our stress response is to turn into our own groups. What we need to do is have a sense of crisis empathy, working with our partners and exchanging ideas, and, as we move ahead, to coordinate our efforts,” said Pfeifer.
On Sept. 11, said Mullen, “We had a moment of unity. That coming together was really important.”
The highly divisive responses to the pandemic, said Gibbs, revealed how that sense of national unity has fractured.
After the Sept. 11 attacks, she noted, the nation engaged in a hard conversation over what measures might be required to ensure our security. One potential sticking point was the question of which was more important: privacy or security.
But that debate was possible because of a shared understanding of what had happened.
“We were having an intensive debate over values, but we could have that kind of argument because it was taking place on top of a baseline of shared assumptions,” Gibbs said. “A large majority of people in this country believe that no longer exists.”
In large part, she concluded, this fragmentation is due to social media. While in 2001, there was no TikTok or Facebook, the current climate has created a situation where “all of us are living in different information environments.”
Who needs opioids?HSDM team explores how artificial intelligence could help clinicians tailor pain treatment to individual patients
As concerns about misuse persist, paper suggests role for AI in making pain treatment more precise
For a patient having their wisdom teeth removed, the days after surgery can bring an important question: How much pain medication will I actually need?
Over-the-counter medications such as acetaminophen and ibuprofen provide adequate pain relief for most, but some patients experience breakthrough pain that does not respond to these medications and may benefit from an opioid. For clinicians, the challenge is knowing before surgery which patients will need additional pain relief.
Harvard School of Dental Medicine faculty, residents, and students are exploring whether artificial intelligence could help make those decisions more precise. In a new paper published in Current Surgery Reports, the authors examine how AI and machine learning could help clinicians predict postoperative opioid needs and identify patients who may be at greater risk for misuse, prolonged use, or inadequate pain control.
“The fundamental problem is that opioid prescribing is still largely standardized, while patients’ actual pain medication needs are highly individualized. Two patients can undergo essentially the same operation, performed by the same surgeon, and have very different experiences with pain and swelling afterward due to biology and pain tolerance,” said Tim Wang, senior author and chief resident of the Oral and Maxillofacial Surgery (OMFS) program at the Dental School and Massachusetts General Hospital.
Rethinking ‘just-in-case’ prescribing
Oral and maxillofacial surgery procedures lead to the most dental opioid prescriptions, accounting for more than 60 percent of opioids prescribed by dentists in the U.S. Procedures such as third-molar extraction can also represent a patient’s first exposure to prescription opioids.
But the amount prescribed does not always reflect how much a patient ultimately needs. The authors highlight a prospective study of patients undergoing third-molar surgery in which only 7 percent required opioids when recovery followed an uneventful course. Other research has found that more than half of opioids prescribed after dental surgery remain unused, creating opportunities for misuse or diversion.
“The challenge for the surgeon is that we have to make the prescribing decision before we know how that individual patient will respond in terms of postoperative pain,” said Wang.
The authors describe this practice as “just-in-case” prescribing, providing medication in anticipation of potential pain rather than basing the prescription on a patient’s individual risk and expected needs. At the same time, efforts to reduce unnecessary prescribing must not leave patients who do need additional pain relief without adequate treatment.
For Samat Borbiev, D.M.D. ’28, and Clark Morgan, D.M.D. ’28, student authors who contributed to the paper, the challenge is finding that balance.
“With more breakthroughs in clinical biomarkers and AI, we can help merge the two to create more tools for physicians to help them make informed decisions on pain control, management, and also nudge physicians when a patient may need more counseling and time to help manage their pain,” said Borbiev.
That balance can be particularly difficult because the factors that influence pain and opioid response extend beyond the procedure itself.
“Ultimately, the amount of clinical, genetic, and social data that may influence an ideal pain-control regimen is greater than what one provider can fully collect and consider, opening the door for AI to aid in clinical decision-making,” Morgan noted.
Using AI to account for individual differences
The authors point to machine learning as one way clinicians could account for these differences. AI models can analyze large amounts of clinical, behavioral, and biological data to identify patterns associated with opioid use, misuse, and prolonged use.
They highlight research involving more than 560,000 Medicare beneficiaries in which machine learning methods outperformed traditional statistical approaches in predicting opioid overdose risk. Other models have demonstrated the ability to predict opioid use disorder and prolonged postoperative opioid use with varying degrees of accuracy.
For clinicians, the potential value of these tools lies in translating those predictions into more individualized care. AI could potentially be incorporated into electronic health records to help determine the appropriate type, quantity, or duration of an opioid prescription, flag patients who may benefit from additional monitoring, and enhance existing prescription drug monitoring programs.
The promise of artificial intelligence is that it may allow us to move away from a one-size-fits-all approach toward more individualized prescribing.”
Tim Wang
“The promise of artificial intelligence is that it may allow us to move away from a one-size-fits-all approach toward more individualized prescribing,” said Wang. AI could also help clinicians quickly review prescription drug monitoring data and identify relevant patterns in a patient’s history, he added.
The technology could also continue to support care after a patient leaves the clinic. The authors describe systems that could incorporate patient-reported pain, medication use, and adherence to refine recommendations over time, while also helping clinicians provide targeted education about pain management and medication use.
“It’s true that an inpatient setting provides relative ease for pain monitoring and management per the physician perspective, but the moment a patient is discharged we lose the benefit of direct supervision,” said Matthew Watt, D.M.D. ’26, OMFS resident and a contributor to the paper. “AI can be leveraged with greater return in the at-home setting, where we can utilize these models for more tailored pain regimens.”
Over 60%
of dental opioids are prescribed for oral surgery.
Only 7%
of patients required opioids after routine wisdom tooth surgery.
Over 50%
of opioids prescribed after dental surgery go unused.
The authors emphasize that AI is not a replacement for clinical judgment. Much of the existing research is retrospective, and many models have undergone limited external validation. Their performance can also vary depending on the populations and data used to train them.
Despite these challenges, Wang said the goal is not simply to reduce opioid prescribing, but to make it more precise without compromising patient outcomes.
“For patients, that could mean a pain-management plan shaped not only by the procedure they underwent, but also by the individual recovering from it,” he said.
Does having a bad dream make you a bad person?Psychologist breaks down what those negative night narratives might be trying to tell you
A series of random questions answered by Harvard experts.
Deirdre Leigh Barrett is a dream researcher and a Harvard Medical School lecturer on psychology in the department of psychiatry at Cambridge Health Alliance. She is also the author of “The Committee of Sleep: How Artists, Scientists, and Athletes Use Their Dreams for Creative Problem Solving — And How You Can Too.”
Dream interpretation is tricky. Let’s say there’s a dog in your dream. I find it helpful to ask: What is a dog to you? You might say they are cute, childlike creatures that need someone to care for them; or that they’re big animals with sharp teeth and one bit you when you were a child; or that a dog is the most loyal creature on the planet, more trustworthy than any human. For each of those three definitions, the presence of a dream dog could mean wildly different things.
Dreams are an opportunity to process what’s happening in our waking lives. During REM sleep — when we dream — the emotional centers of the brain are highly active (sometimes even more than when we are awake). The same is true for our secondary visual cortex, one part of the brain responsible for forming images. Given this, it makes sense that the emotions and visuals are so powerful and stick with us even when we wake up. The emotions can linger even when your waking mind knows it wasn’t real, like when you feel the intense jealousy of a partner cheating on you in your dream and you’re still mad about it. This can become a cycle where the emotions of a dream impact the way we feel or act the next day, which in turn might continue to impact our dreams moving forward. Your dreams are most often made up of things from the last 24 hours — and very often related to what you were thinking about before falling asleep.
“Dreams are an opportunity to process what’s happening in our waking lives.”
In negative dreams, it can be helpful to parse out the key elements and ask what those things mean to you. Anxiety dreams are quite common. If you ask people if they’ve ever dreamed of being inappropriately clothed in public or having their teeth fall out, more than half of people will say yes. It’s also quite common to have dreams where you are the violent one; many people dream that they commit murder. What’s interesting in these cases is that the dream often focuses on one of two things: how to hide the body or how to evade capture from the police. Like anxiety dreams, these dreams tend to be about shame or guilt. Often, it doesn’t even matter if you committed the dream murder; the concern is centered on being discovered or blamed. Sometimes the emotions are heightened in the dream but dissipate upon waking; other times the guilt sets in after the dream is over. You might think: Would I really do that?
If you are having a recurring dream — either a specific dream or similar thematic elements — pay attention. Negative dreams can reveal things that aren’t resolved or that you might want to change or understand differently. Think back on the day and reflect on whether you had a run-in with an authority figure, a social situation that didn’t sit well, or an experience where you felt helpless. These are examples of things we tend to suppress in our daily lives, which means they may come out in our dreams. The dream could be a metaphor, a call to action for a situation in your life (ideally in a less hostile way). Start asking yourself: Is there some way I could deal with this differently in my waking life? You’re not a bad person; just because you dreamed you murdered someone doesn’t mean you would in real life. But it may mean you need to pay more attention to how you show up in your waking hours.
Frontline researcher sees newly approved medication as ‘critical first step’ toward transformation of care
Alvin Powell
Harvard Staff Writer
7 min read
Brian Wolpin.
Last month, the Food and Drug Administration approved a new drug for one of the deadliest cancers, lending new hope to patients whose treatment options had been severely limited.
The drug, daraxonrasib, doubled survival time for patients with previously treated metastatic pancreatic cancer to a median of 13.2 months from 6.7 months for those who received the chemotherapy standard of care.
According to the National Cancer Institute, more than 67,000 people will be diagnosed with pancreatic cancer in the U.S. in 2026 and almost 57,000 will die from it. The five-year survival rate is 13.7 percent.
Brian Wolpin, Robert T. and Judith B. Hale Chair in Pancreatic Cancer and Harvard Medical School professor of medicine at Dana-Farber Cancer Institute, led the global Phase 3 daraxonrasib trial, called RASolute 302, and presented the results in May at the annual meeting of the American Society of Clinical Oncology.
The drug, created by California-based Revolution Medicines, binds to and inhibits an enzyme, KRAS, that energizes pancreatic cancer cell growth and whose molecular structure had previously made that binding difficult.
In a conversation with the Gazette, Wolpin said that the advance has the potential to transform pancreatic cancer care within a decade, shifting the narrative around a disease that till now has proven extremely difficult to treat.
This interview has been edited for clarity and length.
Gazette: At what point did you understand that daraxonrasib was something special?
Brian Wolpin: The preclinical data were very impressive, with evidence of substantial anti-tumor activity of the drug in the laboratory. However, efficacy in the laboratory does not guarantee success when a medication is given to patients.
Clinically, the first time it was clear that this was going to be different than other approaches we had tested was in an initial group of patients treated within the Phase 1 clinical trial, which was mainly designed to evaluate the safety of daraxonrasib and identify the appropriate dose to move forward into larger studies. We started to see patients who — at a relatively low dose — had resolution of their abdominal pain within a few weeks of starting on treatment. Pancreatic cancer causes substantial abdominal pain and if a patient’s pain goes away, it’s very often indicative that the tumor is shrinking. When we saw these symptomatic improvements with daraxonrasib, we thought, “Something is happening here.” Follow-up CT scans showed reduction in the tumor burden in these patients.
When we saw patients do well during the Phase 1 study and then into Phase 2, we had a clinical sense that this was really different from what we had seen in prior clinical trials. Unfortunately, we have had many trials that have been unsuccessful in pancreatic cancer, so we have comparators for when a drug is not working in patients.
“It felt like a validation that rigorous and diligent science can bring advancements to patients even for the toughest of cancer types.”
This study provided the combination of results that we were hoping for, with longer length of life and better quality of life for daraxonrasib compared to chemotherapy. Daraxonrasib is a pill that patients take once per day, so they don’t have to sit in the infusion room for five hours to get infusions. They don’t need a chemotherapy pump or central access with a port-a-cath, and the side effects are generally less than what we see with chemotherapy. It’s important to help people live longer, but you would also like them to live well with a better quality of life.
How did you feel when you heard about the FDA approval?
First, I was thrilled for patients that a new treatment option would become widely available soon. This has been a very long time in coming. Second, it felt like a validation that rigorous and diligent science can bring advancements to patients even for the toughest of cancer types. The approval was the culmination of many years of work by the field at large, our team at Dana-Farber, and Revolution Medicines. It was also a relief to see this happen, as there has been substantial pessimism that new drugs could break through and show benefit in this disease. To see that happen was extremely gratifying, and I hope will change the narrative that pancreatic cancer is too difficult for new drugs to treat.
Why did you choose to specialize in pancreatic cancer?
A little over 20 years ago, as I was starting my oncology training at Dana-Farber, I saw several patients who presented with metastatic pancreatic cancer and who died within three months or so. I initially thought that must be an anomaly. However, rapid cancer progression and short survival time were more the norm than the anomaly for patients with pancreatic cancer. That was surprising to me. It was also motivating. It seemed that patients really needed us to step up, better understand the biology of the disease, and define more effective therapeutic approaches.
When were you first aware of the key advance that led to daraxonrasib’s ability to inhibit KRAS, which had resisted earlier attempts to alter it?
Targeting mutant RAS has been something that the scientific and medical communities have wanted to do for decades. KRAS is mutated in up to 95 percent of pancreatic cancer, and KRAS along with two other RAS family members, NRAS and HRAS, are mutated at lower frequencies in many other cancer types, including lung cancer, colorectal cancer, melanoma, and others. Thus, there has been intense interest in trying to target these mutant proteins as a therapeutic approach for multiple cancers.
Some of the first evidence that this targeting might be possible occurred when fragments and then drugs were identified and designed to bind to and inhibit signaling from a specific mutation in KRAS, known as KRAS G12C. This led to a reinvigoration of the idea that RAS, which had become known as an “undruggable” target, could in fact be effectively inhibited. However, the KRAS G12C mutation is present predominantly in lung and colorectal cancers, so was not directly relevant to the vast majority of patients with pancreatic cancer. Additional work was required to identify drugs that could inhibit the KRAS mutations seen in most pancreatic cancers. One of the important aspects of daraxonrasib was that it was designed as a multi-selective RAS inhibitor, such that it binds to and inhibits signaling of most RAS mutations, including those most commonly present in pancreatic cancer.
This trial was in patients in which the disease is advanced and who had received prior chemotherapy. Is there the potential for more dramatic results in patients who are getting their first diagnosis of pancreatic cancer?
Yes. There are initial data to suggest that using daraxonrasib earlier in a patient’s treatment course may be more effective than after the patient has received prior chemotherapy. There are now ongoing Phase 3 clinical trials to formally evaluate this question.
Is there a new sense of hope in the patient community?
I definitely think so. There’s more hope today because this drug works better than anything we’ve had before and targets the driving mutation present in nearly all pancreatic cancers. This is a critical first step that’s going to open up a large number of new approaches to treating the disease. I very much think that five years — and certainly 10 years — from now we won’t recognize what we were doing before to treat pancreatic cancer. Treatment will be substantially different because of the advances that are going to come. This has opened the door.
What it takes to solve math’s toughest problemsLogic skills, yes, but also two seemingly incompatible traits: Confidence and humility
Logic skills, yes, but also two seemingly incompatible traits: Confidence and humility
This is a story about keeping the faith in a discipline not exactly known for its religiosity: mathematics.
The field of arithmetic statistics — the study of statistical patterns in arithmetic objects such as number fields, class groups, and elliptic curves — rests on sets of conjectures whose predictions have been only partially proven.
In 2001, mathematician Jordan Ellenberg ’93, Ph.D. ’98, and some colleagues set out on a humbling yearslong odyssey to disprove one of the field’s most famous sets of predictions, the Cohen-Lenstra conjectures.
“We were like, there’s no evidence these conjectures are true,” Ellenberg said. “People conjecture them because we can’t think of any reason to think otherwise, but there’s no real evidence that they’re true.”
The conjectures — formulated by Henri Cohen and Hendrik Lenstra in the 1980s at the dawn of computational number theory — predict that the structures of certainarithmetic objects display statistical regularities.
In a simple example, non-prime number can be broken down into a unique set of prime factors, like the number 6 factors as 2 x 3. But if you allow numbers that can be more complicated, factorization is not necessarily unique — for example, 6 can also be factored as (1+ √-5) x (1 – √-5). The Cohen-Lenstra conjectures predict, then, the chance that numbers factor uniquely when we allow the use of a random square root.
Ellenberg, who is now a professor of mathematics at the University of Wisconsin-Madison, is a prominent scholar best known in his field for his work on number theory. Outside of his field, he’s best known for breaking down math concepts for lay audiences, as well as for his 2014 book, “How Not to be Wrong: The Power of Mathematical Thinking.”
Book title notwithstanding, Ellenberg has been wrong, at least a couple of times.
He was wrong in 2001 when he set out to disprove the Cohen-Lenstra conjectures: After enough time spent trying and failing to find evidence against them, he was forced to admit defeat and started trying to prove them instead.
Jordan Ellenberg. Photo by Mats Rudels
His first major step toward that goal was a celebrated paper, co-written in 2009 along with his frequent collaborators Akshay Venkatesh and Craig Westerland. That paper proved a weaker form of the conjectures by showing that geometric spaces eventually stabilize in predictable ways as the spaces grow.
Later, the trio realized they could take their conclusions a step further if they could figure out the number to which those spaces stabilize. They posted a follow-up paper in 2012.
That too was well-received. The authors had given seminars about it. But in 2013, a colleague alerted Ellenberg to a problem with the paper’s conclusion.
It’s the kind of problem that scholars have nightmares about. Ellenberg could have been forgiven for indulging in one or several of humankind’s unhealthy coping mechanisms. But instead he called his co-authors, and they spent weeks going over their work.
Finally, they concluded there was no easy workaround.
“What we hoped was a minor technical issue was not going to be easy to fix,” Ellenberg said.
The mathematicians retracted their paper. Ellenberg published a blog post owning up to the error — and calling on others in the field to be more honest about theirs.
Thirteen years later, the retraction is a minor plot point in a flourishing career, but one Ellenberg doesn’t mind revisiting.
“Honestly,” he said, “I don’t mind being identified as a guy who made a mistake. I think it’s important that people have models for what to do in this situation, because we’re human beings carrying out a human endeavor; there are going to be mistakes.”
Math, Ellenberg has discovered, is a profession that requires two seemingly incompatible traits: a wild belief in one’s own ideas, and the humility to abandon them graciously.
“A project might take years, and there might be 100 things that have to go your way,” he said. If just one of them doesn’t, proof could be doomed.
“You have to have the faith, possibly misplaced, that the thing is going to work out.”
Jordan Ellenberg
“You have to have the faith, possibly misplaced, that the thing is going to work out,” he said. “You need that to drive you through, but you also need resilience when it doesn’t work out. And maybe you have to have incorrigibility in your faith, even after it’s failed to be justified in the past, to be like, ‘Well, I blew it this time, but next time I feel just as confident.’”
But blowing it, mathematically speaking, is not a binary. Much of the math in the retracted paper remains useful. And further work, including by Harvard’s William Caspar Graustein Professor of Mathematics Melanie Wood, has uncovered related predictions in other settings. More recently, Aaron Landesman ’16 has proved new cases of Cohen-Lenstra’s predictions over function fields, staking a much stronger claim in the conjectures’ favor.
Landesman talks about Ellenberg with the enthusiasm of a devotee. He’s gone out of his way to attend Ellenberg’s lectures; he’s read his books. “He gives the most inspiring talks, and it’s a lot of fun talking to him,” Landesman said.
As a graduate student, Landesman’s favorite paper was the piece Ellenberg co-authored in 2009 on the Cohen-Lenstra conjectures. Was Landesman intimidated, then, when he set out to prove what they had failed to in the retracted 2012 paper? Not in the least.
“What’s important is to be aware of the past work and make sure you understand the error, because you don’t want to do the same thing,” he said.
In other words, whatever combination of faith and humility propelled Ellenberg through more than a decade of wrestling with Cohen-Lenstra, Landesman has it too. In a series of papers co-written with his friend and collaborator Ishan Levy, Landesman — now a researcher at Harvard — made progress on Cohen-Lenstra and on what he describes as the other two major conjectures in arithmetic statistics, the Poonen-Rains conjectures and Malle’s conjecture.
“There’s still a long way to go to actually prove the full Cohen-Lenstra conjecture,” Landesman said, “but we’re getting closer.”
“My hat is off to them,” Ellenberg said of Landesman and Levy. “To put together a very long argument like what they did — maybe stamina is the wrong word. Maybe faith is a better word.”
For his part, Ellenberg is getting ready to publish another book, this one to be titled “Don’t be Too Sure.”
Has Homeland Security kept up with its mission?Former DHS secretary says U.S. safer now than before 9/11, agency has largely successfully evolved with emerging threats
Former DHS secretary says U.S. safer now than before 9/11, agency has largely successfully evolved with emerging threats
Christina Pazzanese
Harvard Staff Writer
7 min read
AP Photo/Alex Brandon
The attacks against the U.S. on Sept. 11, 2001, exposed critical gaps in information-sharing among key security agencies. In response, the government brought together 22 federal entities to form the Department of Homeland Security (DHS) to better anticipate and address the threat of terrorism from overseas and to strengthen coordination among various emergency-response agencies.
Now the third-largest Cabinet-level department, DHS has been in the spotlight recently primarily for the activities of two components: Customs and Border Protection (CBP) and Immigration and Customs Enforcement (ICE). But the department, which employs more than 250,000, oversees a very broad portfolio that also includes the Federal Emergency Management Agency (FEMA), the Coast Guard, Transportation Security Administration (TSA), Secret Service, Cybersecurity and Infrastructure Security Agency, and other units.
In this edited conversation, the Gazette asked former DHS Secretary Alejandro Mayorkas, who served during the Biden administration and is currently a fall fellow at the Institute of Politics at Harvard Kennedy School, about how the Department has changed since 9/11 and how well it appears to be meeting the evolving threats facing the U.S. today.
Gazette: Would you say the U.S. is safer today than it was in 2001?
Alejandro Mayorkas: Yes, I would. The federal government has matured tremendously in its counterterrorism mission and how it performs it in terms of the tools it has at its disposal, the coordination among different agencies and departments, as well as between the federal government and state and local authorities, as well as foreign governments.
Terrorism from overseas was the main focus early on. How have the threats to the U.S. changed since 9/11?
The threats have remained and changed — it’s been additive. It’s not as though one threat has emerged and another has receded. Unfortunately, in this domain, the threats of 2001 and early on have remained, and new threats have emerged as well.
Back in 2001 and the years immediately following the tragedy of 9/11, the main threat was the threat of individuals with foreign terrorist ideologies entering the United States to do us harm. That threat has persisted.
What we saw, however, in 2010, 2012, and in the ensuing years, was the emergence of homegrown violent extremists — the individual, already resident in the United States, radicalized to violence by a foreign terrorist ideology. That threat, similarly, has persisted.
Yet another threat vector has emerged: the individual resident in the United States radicalized not necessarily by a foreign terrorist ideology, but by an ideology of hate, politically motivated violence, by false narratives, conspiracy theories, and other forces.
We also have had, of course, the advent of the cyber threat from criminals and adverse nation-states. We’ve had the tool of disinformation seeking to sow discord within the domestic population.
So, the threat landscape has become increasingly complex, and the government’s tools to address it have matured as well.
“The cybersecurity of our nation’s critical infrastructure is something that is in dire need of strengthening.”
Has DHS kept pace with the changing nature of these threats?
I cannot overstate the dedication and talent of the people within the Department of Homeland Security who dedicate their careers to the fight against terrorism and the fight against violence, the mission of keeping the American public safe and secure.
It is an extraordinary challenge, given the pace at which technological advances equip people with bad intentions. It is very, very difficult.
The mission of Homeland Security is a mission of partnerships. The federal government cannot do it alone. We need to partner with our foreign allies, with other federal partners, with state and local law enforcement, and quite frankly, with the American public itself. In Secretary Janet Napolitano’s tenure, she created the “If you see something, say something” campaign that speaks of each citizen’s opportunity to contribute to the mission of security.
Is DHS still maintaining those partnerships with U.S. allies and states?
We are. I think that the security cooperation persists. We have our close allies in what we call “the five eyes” in addition to the U.S., including the U.K., Canada, New Zealand, and Australia. We continue to collaborate despite perhaps tensions in other areas of our relationships.
What are some areas in which DHS could do better?
I think the cybersecurity of our nation’s critical infrastructure is something that is in dire need of strengthening. Our ability to share information on a reciprocal basis with other countries needs to be broadened. These are challenges that we faced in the prior administration and before.
And, of course, technology. AI presents an opportunity. We began operational use of artificial intelligence to advance our security architecture, but in the wrong hands, it presents a tremendous threat. And so, our ability to keep pace with technological change, both from an operational perspective, advantaging ourselves, as well as defending ourselves. That’s one area that needs to be, and I’m sure is, an area of constant focus.
Looking back, what were the most important lessons learned at DHS since 9/11?
One of the most important lessons is the need to coordinate amongst the different federal departments and agencies, both within DHS and among DHS and others. Because each of us has different capabilities and tools and authorities, and that coordination is key.
I take great pride in the fact that the coordination within DHS advanced considerably over the four years of the prior administration, and I am confident the current secretary, Markwayne Mullin, is focused on that, as well.
Critics say DHS has grown too large, and its portfolio too broad to be as effective or as nimble as the U.S. needs. With the array of threats and malign actors expanding, and the asymmetry of many of those threats, is the organization’s current structure still the best approach?
It is a very large department. It’s the third-largest in the federal government behind the Department of Defense and Veteran Affairs, which has considerable administrative responsibilities spread across the country to take care of the men and women who have served our country in uniform.
I felt very strongly as the secretary that the department was more fit for purpose during my tenure than ever before. We had matured in our coordination between and amongst the different capabilities resident in the department.
The structure is, and continues to be, effective in fighting the threat of terrorism and different brands of violence targeted at the American public. I do think certain changes need to be made within the department, but a wholesale restructuring of the department is not something I think is needed.
What kind of changes would you like to see?
I think that would get into the weeds of operations, but I certainly have some ideas with respect to, for example, equipping the Cybersecurity and Infrastructure Security Agency (CISA) with new authorities to drive the strengthening of critical infrastructure.
I think some of the department’s grant-making authorities need to be placed elsewhere; they’re all resident in FEMA right now. I think some of the counterterrorism grant programs would best belong elsewhere. There are a number of changes along those lines, and others that should at least be considered and studied.
Border security and immigration enforcement appear to be high priorities at DHS. In your view, are those elements receiving outsized attention at the department?
I think the secretary and the department continue to hold the counterterrorism mission, the reason why the department was created in the first place, as the top priority. It is not the subject of as considerable public discourse as some of the other issues grabbing the headlines, but I am confident that that remains the top priority of the department.
We yearn for more resources for the border security mission and other missions. The question is not whether the funding is called for, but perhaps more so, the question should be: How is that being spent? Now, I won’t engage in those discussions, but I am confident that the counterterrorism mission remains the highest priority of the department.
When the sea steals homes and jobsAlong West Africa’s Gulf of Guinea, Salata Institute research is helping communities weigh excruciating choices
Makoko, a fishing community and informal settlement on a lagoon in Lagos, Nigeria, is built on stilts, allowing residents to live with the rising and falling water.
Photos and video by David Trilling
David Trilling
Salata Institute Communications
9 min read
Along West Africa’s Gulf of Guinea, Salata Institute research is helping communities and governments weigh excruciating choices about what to protect, how to adapt, and when to retreat
One night about two years ago, the sea came and swallowed Josephine Domevenu’s shop, a kiosk where she sold clothing and packaged snacks: “It happened so fast, I didn’t have time to get anything out.”
Her house, set a few blocks from the water in Keta, a narrow strip of land in eastern Ghana, was still safe. But within a year, the Atlantic lapped at her door. Then came another storm. The sea tore through several rooms and overturned her grandparents’ graves in the garden, filling the cinderblock tombs with sand — a baleful omen for Domevenu and her three children.
“The sea is angry with us,” she said.
Keta is perched uneasily between the Atlantic and a flood-prone lagoon. The beaches have always shifted here; an eastward-racing current both erodes and replenishes the sand. But in recent decades, across West Africa’s Gulf of Guinea, ports, dams, and coastal construction have disrupted that balance.
Now climate change is making storms more violent and rains harder, deadlier, and less predictable. The sea is taking more land. Some stretches of the West African coast are losing more than 30 feet a year.
How these communities can adapt was the focus of a three-year project led by Harvard’s Salata Institute that examined what interventions remain possible as growing coastal populations in resource-constrained countries face a rapidly advancing sea.
Josephine Domevenu, 25, with one of her three children. Her Keta, Ghana, home, seen here in the background, has been repeatedly damaged by the sea over the last two years. Previously she lost her shop, where she sold food and clothing, and all her merchandise. Her grandparents’ graves, outside her home, were also washed away. “It’s really painful.”
David Trilling
Working with universities in Ghana, Côte d’Ivoire, and Nigeria, the research team modeled future sea-level rise, flood exposure, and erosion; assessed the costs and benefits of managed retreat; and looked beyond the shoreline, suggesting financing options and ways to adapt to the collapse of fisheries that have long provided West African nations with a stable source of protein. The goal was not just to produce research, but to strengthen local capacity and put solutions on the table.
“We did not arrive with science and tell people, in many elaborate ways, that they are in trouble,” said Emmanuel Akyeampong, the principal investigator and the Ellen Gurney Professor of History and Professor of African and African American Studies. “Our project instead asked what can be done with the resources actually available. Communities are eager to feel that they are not helpless.”
‘Shifting the problem’
There is one room left at Domevenu’s home and, for now, a reprieve. This year, Ghana’s government has built several dozen groynes — stone barriers set at right angles to the coast — about 700 feet apart to hold the beach in place.
They are working, but at a cost. By interrupting the natural flow of sand, typically both carried away and redeposited by the currents, the groynes starve beaches downdrift.
Not far, beyond the last groyne, Kwashiwor Dansa is watching the sea close in. For more than 30 years, she has made her living smoking anchovies, mackerel, and sardines over sugarcane husks, buying fresh from fishermen who land their catch outside her home in flat-bottomed canoes painted with names like “Hope in God” and “Who Knows Tomorrow.”
“The sea is getting closer now,” Dansa said, explaining that erosion on her stretch of beach started this spring with the arrival of the groynes. “I’m afraid. If the builders are not in a hurry to put one here, the sea will take our house in weeks. They’d better hurry.”
Because of new groynes nearby, Kwashiwor Dansa, 62, of Keta sees erosion outside her home bringing the sea closer and closer.
David Trilling
Though the groynes may provide a fix, they require constant, costly upkeep.
“They are a temporary fix,” said Kwasi Appeaning Addo, a coastal morphologist at the University of Ghana. “People are upset, so they shout at politicians and politicians dump boulders. But it just shifts the problem downdrift. We are not managing erosion; we are fighting erosion, and it’s a fight we cannot win.”
Addo points to nearby Benin as a model for nature-based protection. There, crews rebuilt beaches with sand dredged from the ocean and planted mangroves to hold it in place.
Equipping governments with useful findings
In June, Akyeampong and his co-investigators led a series of policy dialogues in Ghana, Côte d’Ivoire, and Nigeria, bringing researchers, planners, and government agencies together to confront the difficult choices facing coastal communities. The meetings put the project’s data, models, and planning tools in the hands of officials who could act on them.
Political scientist Robert Paarlberg, an associate at the Weatherhead Center, described how climate and demographic pressures are converging. “Not only are climate risks increasing, but population growth on these coasts is surging and putting more people at risk,” he said. “There is a demographic challenge as well as an atmospheric challenge, and the collision between these two is what’s creating the difficult policy choices these governments face today.”
The fishing community of Makoko is emblematic of the collision between swelling populations on the Gulf of Guinea coast and two impacts of climate change — extreme rainfall and declining fish stocks.
A fisherman casts a net for sardines, knee-deep in the riptide in Okun Alfa, Lagos, Nigeria. His net used to bring a bounty. At sunset on a recent Saturday, he empties it onto the sand. It is mostly trash.
Okun Alfa was losing almost 12 meters of beach per year to erosion. Groynes placed in the mid-2010s have slowed the rate, but it continues.
A Keta cemetary that had been destroyed by coastal erosion is now protected by a groyne, seen in the background.
One place emblematic of that collision is Makoko, a fishing community in Lagos, Nigeria, built by its residents on stilts above a lagoon. Encircled by the megacity, thousands of people live in makeshift shelters, some with tarps for walls. They punt to their homes in canoes, the lack of sanitation masked by the smell and haze of smoking fish.
Residents describe their lives there as far from ideal. But Makoko, having adapted to the water’s rise and fall, offers lessons for governments that cannot engineer their way out of sea-level rise, said Mokolade Johnson, a landscape architect at the University of Lagos. “We must borrow ideas from the people of Makoko. We are not going to relocate to the Sahara Desert.”
The policy dialogues also tackled bread-and-butter concerns as traditional economic systems crumble. One approach is to seek adaptation in the blue economy: restoring marine ecosystems, sustaining ports and tourism, and vocational training to help fishing communities find new work as overfishing exhausts stocks and ocean warming drives fish farther from shore. That does not mean seawalls and other engineered defenses should be dismissed, Paarlberg said. But governments should weigh them against nature-based solutions, managed physical retreat from the shore, and “economic retreat” to alternative livelihoods.
The foundation of a home destroyed by coastal flooding in Okun Alfa.
A woman smoking fish at the shore in Accra, Ghana.
Planning with hope
In Lagos, a shortage of land makes relocation especially difficult for the poorest and most vulnerable.
At least once a week, high tide carries the Atlantic over the beach, past a mound of sand and cinderblocks that residents have piled at the top of Baale Street, and over the sandbags protecting Kudirat Abdulateef’s shop and home.
Abdulateef, who sells red pepper, cheese balls, and plastic bags, expects to be displaced — again.
“The sea is destroying my shop, my home. It is punishing my efforts to stop the water. But I have nowhere else to go,” she said. “I dream about the water. Things were not like this before.”
At high tide, at least once a week, the water washes up over the beach past the pile of sand residents have shoveled at the top of Baale Street and covers the sandbags Kudirat Abdulateef has filled outside her shop in Okun Alfa.
Her home sits between two groynes in Okun Alfa, a Lagos district where the sea has advanced about half a mile inland since the 1990s. Researchers say a luxury development built on an artificial island several miles to the west has worsened the erosion.
At the last groyne, the current curls back toward the land, scouring away a neighborhood in less than a decade.
As the sun set on a recent Saturday, Joseph, who has fished these waters for 54 years, stood thigh-deep in the riptide casting a net for sardines. His net once came back heaving. This time, when he emptied it onto the beach, it held mostly trash.
Okun Alfa is one of six communities featured in a portable “booxhibition” created by the research team for people experiencing coastal loss. Unfolding from a book-like box, the exhibition can be strung up quickly, showing maps, historical data, and illustrations of how the coastlines have changed and what they could look like in the decades ahead.
Staging the “booxhibition” in Azuretti, Ivory Coast.
Akyeampong calls it a “visual rendering of the science” — a way to make sea-level projections, erosion models, and adaptation choices legible to the people most affected.
For Supriya Ambwani, a research associate at the Critical Landscapes Design Lab, the goal is not to prescribe a single solution, but to help communities imagine alternatives.
“It feels like a hopeless situation,” she said. “But once you start thinking of solutions, it creates something to work toward. Even if you don’t agree with all the ideas, it prompts people to engage differently.”
“If we don’t imagine what the future could look like,” Ambwani said, “we’re going to struggle to get there.”
More evidence that mass shootings are suicidal actsNew research finds national peaks for suicides, gun rampages take place within days of each other in summer
More evidence that mass shootings are suicidal acts
New research finds national peaks for suicides, gun rampages take place within days of each other in summer
Alvin Powell
Harvard Staff Writer
4 min read
Research suggests that most mass shootings are at their core suicidal acts, and new findings linking gun violence, suicide, and seasonality add support to that theory.
The new study led by a Harvard Medical School clinical fellow in medicine at Brigham and Women’s Hospital shows that annual peaks for mass shootings and suicide occur within days of each other in late June and July. Annual low points for both occur in the winter months, between December and February.
Mark Czeisler, lead author of the paper and also a resident physician at the hospital, said the link described by the study can inform medical and public health efforts. For instance, screening for suicide and gun violence can be enhanced as summer approaches, along with preparations to ensure health systems are ready to respond to violent events.
The findings, published in the Journal of Biological Rhythms, also raise questions about the nature of the connection between suicide, mass shootings, and seasons, especially as they mirror seasonal variation in depression, which has long been shown to peak in winter months.
What the work does not do, Czeisler said, is establish causation. Just because two variables peak at the same time is no guarantee that they are linked, he pointed out.
“We want to be very clear that the temporal alignment does not prove that there is causation between the two variables,” Czeisler said. “There are a lot of things that vary with the seasons: temperature, daylight/photo period, and social routines and the social exposure that people experience. In the case of school shootings, there’s the additional element that a lot of schools are closed over the summer.”
Czeisler said he became interested in the topic during the pandemic, as mass shootings rose along with concerns about mental health and suicide.
When he looked into the subject, he saw that studies of mass shootings were often focused on the individual characteristics and life histories of shooters, he said.
One such study, published in 2021, focused on mass shootings since 1966 and suggested that in addition to the desire to hurt others, many mass shooters were also suicidal, with a plan to kill themselves or be killed during the event.
Another study, published in 2024, indicated that the percentage of shooters who died during shootings had doubled over the prior 20 years.
Czeisler, whose Ph.D. research investigated circadian rhythms and their disruption during the pandemic, wondered whether another biological rhythm — seasonality — might be important in exploring the question, allowing a broader view than prior studies more tightly focused on the shooters themselves.
“Further research is really needed to look at each of these elements and additional potential elements that could account for why the seasonal patterns are so closely aligned.”
Mark Czeisler
In conducting the research, Czeisler used publicly available data from the Gun Violence Archive, the National Center for Health Statistics, and the Centers for Disease Control and Prevention, and analyzed 3,305 mass shootings and 360,827 suicide deaths between January 2014 and October 2021.
Mass shootings are significantly rarer than suicides in the U.S. and have a 613 percent difference between their summertime peak and winter valley. Suicides rose 12 percent between their valley and peak.
“Further research is really needed to look at each of these elements and additional potential elements that could account for why the seasonal patterns are so closely aligned,” Czeisler said. “But in the interim, we wanted raise awareness that these are temporally aligned and to advocate for both enhanced screening in the summer for suicidality and potential for gun violence and to ensure there are resources available from a healthcare perspective to respond to these extreme violence events.”
One potential follow-up study that might be illuminating can’t be done, Czeisler said. It would be instructive to look for similar patterns elsewhere, including nations in the Southern Hemisphere, to see whether annual patterns observed here are reversed, as would be expected if they are driven by seasonal variation.
The problem — though a good one to have — is that the large number of mass shootings seen in the U.S. is not replicated in other countries.
“It would be beneficial to have comparisons in other parts of the world where seasons are inverted, but fortunately, those data are not available because there aren’t enough mass shootings to study them,” Czeisler said.
If you are having thoughts of suicide, call or text 988 to reach the 988 Suicide and Crisis Lifeline.
Survey of young researchers raises concerns over future of science in U.S.Fewer planning careers in academy, nation, and more doubt value of Ph.D. amid policy shifts in funding, international students
Survey of young researchers raises concerns over future of science in U.S.
Fewer planning careers in academy, nation, and more doubt value of Ph.D. amid policy shifts in funding, international students
Alvin Powell
Harvard Staff Writer
5 min read
One-third of young scientists who were planning careers in academic research changed their minds in the spring of 2025, according to a new survey, with fewer expecting to remain in higher education and in the U.S. to work or feeling that pursuing a Ph.D. was the right decision.
The survey, recently published as a working paper by the National Bureau of Economic Research, was taken at a time of tightening government policy on science funding and the presence of international students in the country. The government’s efforts in those areas have been stymied by the courts, at least initially.
But the new study suggests the high-profile campaign and lack of a final legal resolution have fueled uncertainty among younger scientists about the prospects for careers here. It also adds to researchers’ concerns about the disruption of the partnership between the U.S. government and universities that has driven the nation’s leadership in scientific discovery, innovation, and economic growth.
The survey, conducted in March 2025, showed that a third of the respondents who had previously said they were likely or very likely to pursue a career in academia no longer felt that way. Similarly, almost a fourth of those who had previously expected to stay and work in the U.S. no longer felt that was likely or very likely. And finally, when asked whether they were satisfied with having pursued a Ph.D., 17 percent fewer said they were either satisfied or neutral about the decision compared with six months earlier.
The survey occurred somewhat serendipitously.
A team including Raffaella Sadun, the Charles Edward Wilson Professor of Business Administration at Harvard Business School, and colleagues from the Massachusetts Institute of Technology and Monash University in Australia were in the midst of a large study of biomedical lab management practices when the Trump administration began its crackdown on government-funded science and higher education.
“We were running interviews with senior postdocs in the labs, and we started to realize we were in the middle of a pretty big policy change,” said Sadun. “The change was seeping into the interviews and, as we were talking to the postdocs, the anxiety was palpable. They started telling us how the uncertainty of the research funding environment, the policy changes, was affecting their own decisions.”
“The change was seeping into the interviews and, as we were talking to the postdocs, the anxiety was palpable. They started telling us how the uncertainty of the research funding environment, the policy changes, was affecting their own decisions.”
Raffaella Sadun
Sadun and colleagues had already compiled a sample of 2,466 biomedical research labs across the U.S. and, as strife between the administration and universities mounted, they understood they were in a position to analyze the extent of the disruption in real time.
So they reached out to more than 13,000 doctoral students and postdoctoral fellows who had taken part in the larger management study with a simple, six-question survey: “How likely are you to stay in academia?” “How likely are you to stay in the United States?” And “How satisfied are you with having pursued a Ph.D. in science?” They asked each question twice, once “for now” and again for, “six months ago.”
“We are running these interviews. We have this unusual access to a large number of labs and people. We had to run with this,” Sadun said. “It’s not perfect, but let’s try to measure as much as we can whether the current uncertain environment is having an impact on how they perceive or how they’re thinking about their future career moves.”
The authors acknowledged that the survey design — asking respondents how they would have answered a question six months earlier — may make it vulnerable to “recall bias,” in which respondents remember the past more favorably than they then viewed it.
The original management study, however, provided a check against that, since about a quarter of respondents had previously answered the Ph.D. satisfaction question before the end of 2024 — and the January 2025 start of the new administration. A comparison of those past responses with the recalled ones showed no sign of recall bias, according to the study.
The management researchers received responses from 916 scientists from 770 labs at 134 institutions.
The responses indicated that six months prior to the survey, 66 percent said they were likely to stay in academia, a figure that fell 22 percentage points, to 44 percent, by March 2025. Similarly, 93 percent of respondents said that six months earlier they had been likely or very likely to remain in the U.S. That number fell to 72 percent in March 2025. And while 92 percent of those who six months prior had been neutral or satisfied with their decision to pursue a Ph.D., that fell to 76 percent by March 2025.
The implications of the young scientists’ changed intentions are potentially important for U.S. science and more broadly, the nation’s economy, Sadun said.
She also acknowledged, however, that though she knows several scientists who have already relocated, broadly speaking, people don’t always follow through on their stated intentions. That’s something that can be studied in future research.
“This is not great for research and it’s problematic from the perspective that R&D activities that are conducted in universities are an engine of growth,” Sadun said. “What you’re looking at is a significant shrinking of a population of scientists that you’ve created. They’ve spent time here, they’ve learned here. You’ve shaped this talent and this talent is telling you, ‘I want out.’”
This research was funded by the Alfred P. Sloan Foundation.
A new diplomacy for 21st century as economic, political, tech power shiftsNew Harvard Kennedy School program to focus on emerging issues, building bench of professionals, scholarship on negotiation, building and managing ties
A new diplomacy for 21st century as economic, political, tech power shifts
Christina Pazzanese
Harvard Staff Writer
5 min read
New Harvard Kennedy School program to focus on emerging issues, building bench of professionals, scholarship on negotiation, building and managing ties
American foreign policy is currently being tested by bloody conflicts in the Middle East and Ukraine and escalating political and trade tensions with powerful rivals like China, historic allies such as Canada and Mexico, and dozens of other nations.
At the same time, the U.S. diplomatic bench is rapidly dwindling, warns Ambassador Nicholas Burns, the Roy and Barbara Goodman Family Professor of the Practice of Diplomacy and International Relations at Harvard Kennedy School.
There have been staff cuts of 20 percent at the State Department and about one-third of U.S. ambassadorships remain vacant. In addition, the share of trained career ambassadors in the U.S. diplomatic corps, rather than political appointees, has shrunk since 2025, from 70 percent to just 17 percent as of Aug. 2026.
“This is a catastrophically low level and a complete change from any prior president over 60 years, and if you couple that with the destruction of USAID back in the winter of 2025, you’re looking at a dramatically weakened Foreign Service,” said Burns, the U.S. ambassador to China during the Biden administration. He will lead a new Harvard Kennedy School initiative to advance the practice and study of diplomacy.
The Program on Diplomacy and Statecraft is a nonpartisan, multipronged effort at the Belfer Center focused on the key issues diplomats around the world confront. Its members will contribute scholarship to the fields of negotiation and diplomacy, and help build up a new diplomatic bench to prepare for national security challenges.
Hit Netflix dramas like “The Diplomat” notwithstanding, being an ambassador or a member of the Foreign Service is “an all-encompassing job,” said Burns. “Yes, we have American diplomats assigned to the embassy in Paris in gilded halls negotiating with French diplomats, but we also have people on the front lines of the worst disasters in the world.”
Informed by Burns’ experience in China (“by far, the major foreign policy challenge for the American people in the next 20 years”), the program will emphasize managing the U.S.-China relationship and competition across the Indo-Pacific region, as well as diplomacy across the globe.
In 2025, they interviewed former Secretary of State Mike Pompeo about his work during the first Trump administration and have invited former Secretary of State Anthony Blinken to visit next year.
Also featured in the program are modules on cultural diplomacy and preparing a new generation of leaders to serve in diplomatic roles.
Despite its centrality to American power overseas, few schools of government have a platform dedicated to teaching diplomacy in the same way they do for the military and intelligence, said Director Julian Simcock, M.P.A. ’13, who served in national security and diplomatic roles at the White House and State Department, respectively.
“At its core, diplomacy is often about addressing disputes without the use of force. It’s not a refuge from conflict; it’s a way of managing conflict.”
Julian Simcock
“At its core, diplomacy is often about addressing disputes without the use of force. It’s not a refuge from conflict; it’s a way of managing conflict,” he said.
“It’s my view, and I believe Nick shares it, that the vast majority of conflicts and current geopolitical complexities are going to be addressed by diplomats, not by the use of force, and so we want to create a place which is really dedicated to those issues,” Simcock said.
Without first-hand experience, understanding what really happens in diplomacy and what it takes to do well can be difficult, which makes learning from practitioners vital, he said.
“So often, it’s practiced beyond the view of the public, and I think one part of the appeal for students seems to be to learn more about what this craft looks like inside those negotiations,” said Simcock. “What does it sound like when you’re in one of these rooms negotiating with a foreign counterpart?”
While the abrupt dissolution of USAID and dramatic Foreign Service and State Department staff cutbacks have drawn widespread criticism, Burns says there is room for improvement.
“I certainly would not say the Foreign Service or the State Department is perfect,” he said. “The State Department, like many government agencies, is often reactive, slow to reform and slow to accept change.”
To that end, one early ambition of the program will be to reassess how U.S. diplomacy is organized and administered. A comprehensive nonpartisan report of recommendations will be published by early 2028.
“We can’t go back to the blueprint of the State Department in 1924 or even 2014, or USAID. We’ve got to imagine, reimagine, reinvent the Foreign Service and State Department of the future,” said Burns.
Diplomacy in the 21st century, for example, will require some knowledge of evolving tech.
“You can’t be a modern diplomat right now without at least a fundamental elementary understanding of AI and other frontline technology fields because so many future global challenges revolve around those issues,” Burns noted.
Replenishing and revitalizing American diplomacy is demanding work that students, not faculty or practitioners, must helm if real change is to take place, he said.
“This younger generation at Harvard and around the country is going to have to lead us forward.”
Dustin Tingley named vice provost for advances in learningHe will lead University efforts in pedagogical innovation, digital education, and ways tech can support teaching, lifelong learning, research
Dustin Tingley named vice provost for advances in learning
He will lead University efforts in pedagogical innovation, digital education, and ways tech can support teaching, lifelong learning, research
3 min read
Dustin Tingley, a distinguished political scientist and leader in education innovation, has been named Harvard’s next vice provost for advances in learning, the University announced today.
“I am delighted that Dustin has agreed to serve as the next vice provost for advances in learning,” said University Provost John F. Manning. “He brings to this important role a wealth of experience in residential and online education, a deep understanding of technology’s potential to support academic excellence, and a strong commitment to innovation.”
As vice provost for advances in learning, Tingley will lead the University’s efforts in pedagogical innovation, digital education, and exploring the role of technology in supporting teaching, lifelong learning, and research on campus and around the world.
Tingley became interim vice provost in August 2025 and was deputy vice provost prior to that. He has long worked to develop, launch, and oversee initiatives to support teaching and learning at Harvard and beyond. Over the past decade, he also served as faculty director for the office’s Data Science and Technology Group, as well as for the Harvard Initiative for Learning and Teaching.
“It is an honor to continue to work alongside staff, faculty, and students in our collective pursuit of rigorous and engaging learning opportunities,” Tingley said. “The positive benefit we can bring to society through learning is a core mission of higher education institutions, and one where Harvard continues to have tremendous impact and opportunity.”
As a political scientist and public policy scholar with an interest in research methodology, Tingley’s research interests are broad, spanning international relations; the political economy of energy; data science and machine learning; and digital education. His recent work has included understanding how communities view changes in energy technologies, predicting students’ likelihood for online course completion, and applying machine learning to the social sciences.
Tingley has a joint appointment in the Government Department and the Harvard Kennedy School and teaches on the politics of climate and energy and international relations. In addition, he has taught on the business of the energy sector at Harvard Business School.
In 2012, he co-founded ABLConnect, an online database of active learning resources. He also previously served as director of graduate studies for the Government Department and faculty director of the Institute for Quantitative Social Science’s Undergraduate Research Scholar program.
Tingley holds a Ph.D. in politics from Princeton University and a Bachelor of Arts in political science with a minor in mathematics from the University of Rochester.
‘Our University is, at its heart, an affirmation of humanity’Garber reminds faculty, students at Morning Prayers that AI is powerful technology but human intelligence, values remain in charge
‘Our University is, at its heart, an affirmation of humanity’
Alan Garber.
Photos by Veasey Conway/Harvard Staff Photographer
Liz Mineo
Harvard Staff Writer
5 min read
Garber reminds faculty, students at Morning Prayers that AI is powerful technology but human intelligence, values remain in charge
Amid the mushrooming use of AI, Harvard President Alan Garber reminded students and faculty during the first Morning Prayers ceremony of the new academic year that technology is a tool and that human intelligence and values remain in charge — and at the heart of the University’s work.
“This is a week of beginnings, as new students arrive on campus, continuing students return, and we work together to advance Harvard’s mission,” said Garber at Memorial Church’s Appleton Chapel on Wednesday morning. “This moment of renewal is an opportune time to pause and consider the meaning of all that we undertake here, powered, as ever, by human intelligence.”
The meaning, said Garber, lies in the myriad ways in which the work done at the University, across fields and disciplines, aims to “push the boundaries of knowledge” to address the world’s most significant challenges.
“What does that mean?” he asked. “It means that we seek to solve the biggest problems: approaching climate change from a wide range of vantage points; battling cancer with ever-more-powerful tools of our own design; and racing the clock to untangle the origins of degenerative neurological disease. It means we preserve life as we lengthen and improve it while marveling at the majesty and mysteries of the plants and animals that share our planet. It means that we go to extremes — from parsecs to Planck lengths — to explore the measurable, eagerly plunging into the unknown, seeking to understand the meaning of time and space. And, through the many forms of beauty and meaning held in the arts and humanities, we contend, too, with the immensurables and the immutables — grief, joy, and love among them.”
Garber spoke about the impact of artificial intelligence in transforming scientific research as its tools help scientists do their work at a much faster speed. A faculty member who used AI tools for his research told Garber recently how he was able to accomplish in six months what it would have taken him 10 years, Garber said.
“I’m convinced that advances in knowledge — essential to human progress, and at the core of our excellence as a research university — will soon be made more rapidly than at any other time in human existence.”
Alan Garber
“I’m convinced that advances in knowledge — essential to human progress, and at the core of our excellence as a research university — will soon be made more rapidly than at any other time in human existence,” said Garber. “When I think about the new age now unfolding, I tend to focus on the costs, risks, and benefits of the changes to come, and what they mean for our mission and our community. I rarely think about dreams. But perhaps, as we continue to ponder challenges and possibilities, we should give ourselves greater license to imagine the future that we hope to inhabit.”
While the pursuit of discoveries, breakthroughs, glory, and success is exciting and uplifting, that should be accompanied by “compassion, selflessness, humility, and wonder,” Garber said, as well as a love for the work itself, and the “good inherent in our work and the good that comes from it.”
Garber also spoke about how the Jewish tradition exalts human capacities for creativity and curiosity, judgment, and reason, and considers human intelligence precious and unique.
Edward Jones, the Gund University Organist and Choirmaster, leads a choir group.
“As we are told in the book of Genesis — known in Hebrew as Bereshit, or ‘In the beginning …’ — humanity was not simply made but created ‘in His image,’” said Garber. “That verse tells us human life is sacred, each human is unique, and humans have distinct capabilities. Among them is the ability to choose freely, not by an algorithm.
“For Rabbi Akiva, the possession of self-knowledge was especially important: He commented that ‘it was made known to him that he was created in the image (as it is said “for in the image of God did He make the human.)’ [Mishna Avot 3:14] Thus human intelligence is not only precious. It is distinct from any intelligence that humans have created, as astounding as the unfolding technical advances are.”
In closing, Garber reminded the audience that Harvard is a community devoted to learning.
“Learning is at the heart of what makes us human,” said Garber. “It begins at our beginnings and persists as long as each of us does, an unceasing process of discovery and insight. Learning is not only lifelong. Learning is life. And the preservation of learning, the work to which Harvard has set itself for centuries, is more than just a path to greatness or even to goodness. The preservation of learning — the elevation and celebration of learning — is the preservation of human life itself.
“Our University is, at its heart, an affirmation of humanity, an affirmation of our unique and wondrous capacities and the care and skill they beget.”
Why is yogurt good for us? Genghis Khan supposedly fed it to his troops for strength and bravery. He might have been onto something.
A series of random questions answered by Harvard experts.
Kerry L. Ivey is a nutritional epidemiologist, clinical dietitian, and bioinformatician. She is a Harvard Medical School assistant professor of medicine at Brigham and Women’s Hospital and the corresponding author of a review of yogurt and human health in the Journal of Nutrition, Health and Aging.
People have been making health claims about yogurt for hundreds of years. The Mongol emperor Genghis Khan, in the late 12th and early 13th centuries, reportedly believed yogurt would give his army strength and bravery; it’s only recently that the science is catching up. Bravery: probably not. But a lot of my research looks at how we can stay vital and healthy as we age, and if we can increase our protein intake while reducing chronic disease risk, which yogurt can help us do, then maybe Genghis Khan was onto something.
Now, there’s an interesting paradox here. Yogurt, particularly full-fat yogurt, can contain saturated fat, which has traditionally raised concerns it increases LDL cholesterol and cardiovascular disease risk. Meta-analysis of randomized controlled trials has found that probiotic yogurt can actually reduce total LDL cholesterol in people with mild to moderate elevated cholesterol, while large observational studies suggest that people who regularly eat yogurt tend to have better heart health.
In large U.S. studies, eating yogurt at least five times per week was associated with a 16 percent lower risk of high blood pressure, and among people with high blood pressure, eating yogurt at least twice a week was associated with a 17 percent lower risk of cardiovascular disease in women and 21 percent lower risk in men. And particularly interesting given concerns about saturated fat, a large Danish study found that replacing low-fat and high-fat milk with whole-fat yogurt was associated with an 11-13 percent lower risk of heart disease. These findings illustrate what we call the “food-matrix effect,” where the health effects of a whole food cannot necessarily be predicted from one nutrient, such as saturated fat, considered in isolation.
The problem with these observational studies is that they can’t show causality. Results are susceptible to confounding by other variables like overall diet, lifestyle, and socioeconomic factors. Exactly how and why yogurt is beneficial, and for whom, at what stage of life, is not clear.
All of this paints a complicated picture for the consumer standing in the grocery store, looking at so many different products. Some have high protein, some have more sugar, some have more fat. There’s no straightforward answer, no magic number of servings of yogurt that everyone should eat. I think of it more like a nutrient-dense component of an overall healthy dietary pattern. That might be having yogurt with fruit and whole grains at breakfast or having some yogurt as a snack instead of something more highly processed or higher calorie, or even using plain yogurt in savory dips or dressings.
But we still have a lot to learn — both about the mechanisms by which yogurt is beneficial, and about the strains of bacteria, which are actually very, very different from one another all the way up to their taxonomic class. My hope is that by continuing to study this food, we can get closer to personalized nutrition — the right type of yogurt with the right type of bacteria, for the right person, at the right time.
— As told to Sy Boles, Harvard Staff Writer
Strange encounters with familyFor photography scholar, albums are a poignant reminder of the details a picture leaves out
A detail from the family photo archive of Robin Kelsey.
Photos by Stephanie Mitchell/Harvard Staff Photographer
Stephanie Mitchell
Harvard Staff Photographer
2 min read
For photography scholar, albums are a poignant reminder of the details a picture leaves out
Robin Kelsey is no less interested in what a picture hides than what it reveals. Turns out the mystery runs just as deep — more so, perhaps — when the person looking back at him is blood.
“Did they have a temper? Were they friendly? Did they laugh a lot? You can’t tell from these images.”
Kelsey, the Shirley Carter Burden Professor of Photography and the author of “Photography and the Art of Chance,” was reacting to pictures of his mother’s family, from Mason City, Iowa, sent to him by a cousin.
He paused to recall a line from an essay by the German cultural critic Siegfried Kracauer — “Beneath a person’s photograph, their history is buried as if under a blanket of snow” — before paging deeper into the past.
Robin Kelsey examines photographs from his family archive.
“One of the things I love about my mother’s side of the family is they were a bit eccentric, a bit zany in certain respects,” Kelsey said. “They were creative and pretty intrepid.”
Many of the black-and-white images capture playful summer moments spent at the family cabin in northern Minnesota. They document days of swimming, canoeing, camping, and throwing horseshoes.
Some names and faces are familiar — Kelsey’s great-grandparents William and Hattie Egloff; his great-uncles Max and Bill — but the context is lost, leaving the photographs as a kind of sediment, to use another of Kracauer’s metaphors. Even so, said Kelsey, “I like the feeling of spending time with the ancestors. We’re a culture that tends not to value ancestors … snapshots are one way that we can bring them to mind.”
For a scholar who’s spent decades devoted to photography, the images introduce an intimate tension between viewer and subject. His relatives, he said, “were people of action and activity. They wouldn’t sit around looking at old photographs. There’s a paradox there with what I love doing.” Laughing, he added, “They would tell me to go out and chop some wood and make myself useful.”
Otherwise, he’s left to wonder.
“The magic of these old photographs is that they are simply moments in a story that you have to write with your imagination.”
Pioneering cancer fighter sees promise beyond melanoma breakthrough‘This is not a time that we should be pulling back,’ says Catherine Wu. ‘It’s a very, very exciting time in the field.’
Pioneering cancer fighter sees promise beyond melanoma breakthrough
File photo by Stephanie Mitchell/Harvard Staff Photographer
Alvin Powell
Harvard Staff Photographer
6 min read
‘This is not a time that we should be pulling back,’ says Catherine Wu. ‘It’s a very, very exciting time in the field.’
In mid-August, the drugmakers Moderna and Merck announced that a cancer vaccine trial had successfully lowered risk of both death and metastases of melanoma, a deadly skin cancer. The vaccine, designed to be given to melanoma patients after initial treatment, primes the immune system to recognize and attack tumor cells should they recur.
Moderna and Merck announced only that the Phase 3 trial was successful. The companies plan to release full results at a European conference later this year.
The trial’s approach, which tunes immune cells to recognize tumor-specific proteins called neoantigens, was pioneered in part at Harvard-affiliated labs, including that of Catherine Wu, a Harvard Medical School professor of medicine at the Dana-Farber Cancer Institute, and Nir Hacohen, HMS professor of medicine at Massachusetts General Hospital and core member at the Broad Institute of MIT and Harvard.
In a conversation with the Gazette, Wu said that she’s optimistic that the technique will be effective against cancers beyond melanoma.
This interview has been edited for clarity and length.
Gazette: A couple of years ago, you said that in two years you expected large, industry-run trials to confirm positive results of the many smaller trials you have conducted using neoantigens to create a cancer vaccine. Were you specifically thinking of this Merck-Moderna trial?
Catherine Wu: Yes — in our smaller prior studies, we found activities from neoantigen-targeting vaccines across many different tumor settings and had hoped that such results would be borne out in larger studies. The promising results from Moderna-Merck are specific to melanoma, but hopefully this is the first of many that are to come. Moderna and Merck have several other large studies that are underway, with participant numbers that are in the hundreds to over a thousand per study. They are all of similar design, with the targeting of multiple personal neoantigens per vaccine using mRNA as a delivery format. One study is in kidney cancer, and the others are in squamous cell carcinoma, bladder cancer, and lung cancer.
When we talk about your pioneering work in this field, are the important keys leading to this trial the identification and work with neoantigens and the genetic-sequencing advances that allow for speedy analysis of the tumor genome?
That’s right. We had a terrific local team that helped bring these pieces together, not only Nir Hacohen at the Broad Institute, but also doctors Edward Fritsch and Patrick Ott, who were instrumental in the clinical translation of our work that we first reported in 2017. What made our 2017 study the first of its kind was that these are personalized vaccines, not one-size-fits-all. We used real-time genomic-sequencing data and a computational approach to identify the tumor targets to put into a vaccine. That was a conceptual advance that necessitated generating a different type of manufacturing strategy. We had to go to the FDA for early guidance because we weren’t creating the same one vaccine that we were going to distribute to many people. Instead, we were creating a new, personalized product unique to each patient tumor for each patient treated — a fundamentally different process than what had been done before for vaccines. To make that cost-effective, we had to disrupt the usual manufacturing process for vaccines, namely so we could make frequent yet small quantities of vaccine for any individual patient.
How important was the FDA approval that allowed that 2017 study to move forward? If the agency had told you that each unique vaccine for each patient had to be approved separately, would that have been a deal-breaker?
For sure. Ours was the first trial to approach the FDA like that. We were crammed in a tiny conference room packed with interested members of various departments, curious to see how genomics, immunology, and personalized medicine were all going to come together. It was exciting. I am really appreciative of what the FDA does. These are really dedicated, hardworking people who just want to make sure that the safety guardrails are there for patients.
Is Merck and Moderna’s next step to try to get the vaccine approved for patients?
I imagine that is so. I expect that the first approval will be for melanoma, but depending on future results, hopefully for other solid tumor malignancies as well. I am optimistic that this type of customized immune therapy will be available for cancer patients more broadly.
The companies have said that they’ve met their clinical trial endpoints and that they plan to release full results this fall. What will you be looking for? Is there a scenario in which something in the full results tempers enthusiasm around this work?
It’s hard to know. As you say, the company has only given us broad strokes of positive results right now. As in any study, when fuller results of the study come out, I expect we will collectively scrutinize the composition of the patients enrolled in the study. Was there any skewing in the characteristics of the patients enrolled in the different arms of the study? Was there uneven balance one way or the other that could impact the interpretation of the results? Were there any differences in the number of vaccine administrations? We will see.
Are there cancers for which this technology might not be appropriate?
There are settings where I think that we’re not yet finding the best vaccine targets. Particular areas of need include pediatric tumors and blood malignancies, whose mutational burden is quite low, and hence have a low neoantigen burden.
People have talked about the end of cancer for a long time, but it feels like today’s therapies, including this vaccine, are closing in. Are we seeing the end of cancer in real time?
The end of the beginning, maybe? I do think we’re seeing vast improvements in front of our eyes for the cancer therapeutic landscape. Part of the challenge now is: How do we get our therapies out there fast enough? That requires resources. This is not a time that we should be pulling back. It’s a very, very exciting time in the field.
Reliving 2020 through fictionInstructor’s debut novel joins growing subgenre of books confronting pandemic’s surreal early days
Instructor’s debut novel joins growing subgenre of books confronting pandemic’s surreal early days
Sy Boles
Harvard Staff Writer
7 min read
Early in Leah De Forest’s debut novel, New Yorkers pause to appreciate fat raindrops viewed from the comfortable side of a window. It’s miserable to be caught in the rain without an umbrella, but through the glass, it’s beautiful.
“And aren’t so many things?” De Forest writes in “Any Kind of Known Tomorrow,” out Sept. 15. “Beautiful not just from a distance, but from the right distance.”
The novel takes place in the surreal early days of the COVID-19 pandemic, a time of makeshift facemasks, bleach-wiping groceries, and wondering just how bad things would get. It follows four women — a daughter, a mother, and a grandmother, along with an unexpected guest — sardined in a New York City apartment during the pressure-cooker weeks of the lockdown. The book joins a growing catalog of novels that tackle that bizarre period, including Ben Lerner’s “Transcription,” Ann Patchett’s “Tom Lake,” and Gary Shteyngart’s “Our Country Friends.”
De Forest, an instructor and academic adviser at Harvard Extension School, talks about the challenges and possibilities of revisiting the pandemic in fiction. The interview was edited for clarity and length.
Gazette: What made you want to engage with the very particular moment of the early pandemic?
Leah De Forest: I actually started writing this book in 2018. The draft I finished in 2019 was set in New York City, generally concerned with displacement and belonging, and it featured a character struggling with a novel disease.
In 2020, I started working on the next draft — and changed course to account for what was going on in the world. Everything felt unstable at that time, and I was interested in how people were dealing with that. Denial, anxiety, retreat: I’m sure we all saw lots of different responses. I took my characters and explored how each of them was metabolizing those early weeks.
Did you worry that readers wouldn’t be ready to, or wouldn’t want to, revisit such an intense and difficult time?
When you’re writing a book, you’re writing the story that’s in front of you. This is what was in front of me. Later on, you might start thinking about whether there are readers for a book and what the marketplace is like.
Fiction has always been an important part of how I process the world. Literature has an ongoing role in representing a range of experiences — including, I think, the pandemic, which affected so many people. Any book can only get at a slice of any event or experience, right? My hope is that as people start to feel ready to read about the pandemic, they’ll find the right books for them.
What do you make of the subgenre of COVID-19 literature that’s come out in the last few years?
Looking back, the pandemic can seem like a sort of bubble. We entered this strange time together, and then at some point — and exactly when was different for everybody, and for some people it’s of course still ongoing — we came out of it. In just beginning to talk to people about this book, I’ve noted that people often have a story to offer. It might be, “I went back home to be with my family for the first time in a decade and we fought all the time,” or “I had to quarantine in my childhood bedroom.” And of course, there was so much loss. There’s a lot to process.
“We entered this strange time together, and then at some point — and exactly when was different for everybody, and for some people it’s of course still ongoing — we came out of it.”
In terms of books out there, I admired how Ann Patchett’s “Tom Lake,” for example, captured the sense of isolation people felt during the pandemic — and the way the family in that book has to retreat. The need for isolation folded the family back in on itself, in a way.
Your book follows three generations of women in the Parris family who each engage with the pandemic in different ways, so tell me a little bit about those women.
Hadley Parris, the mother, is convinced at first that everything is going to be fine. Understandably, she thinks, “Well, surely this can’t be happening.”
Hadley’s mother, Aileen, gets kind of obsessed with the news. She tracks everything blow by blow — in some ways, she’s as fascinated by the performance as by the reality. As time goes on, though, she’s afraid. And Isabelle, one of the younger characters, is anxious about the future generally, so for her, it’s a confirmation of what she already knew: Things are bad. There’s tension between the characters, because you have one person saying, “Everything is going to be fine,” and somebody else saying, “Wait, I really don’t think this is going to be OK.”
The fourth primary character, Anna, is a teen girl whom the Parris family takes in in a moment of need. But Anna needs to keep working outside of the home to make ends meet, which Aileen perceives as a selfish exposure risk. Talk to me about that tension.
I’m always interested in how structural factors, such as class, affect the way people interact. In Aileen’s case, she just doesn’t get other people’s perspectives, though she does sometimes try. That made her interesting to work with, because she’s often misunderstanding what’s going on and struggles to understand other people’s emotions. In this situation, although she might eventually come to understand that it’s not possible for someone to just quit their job, she’ll struggle to really feel why.
Through your omniscient narrator, you also dip into the heads of other people in this world, the man at the bus stop, a nurse at the hospital. Why did you choose to visit these other worldviews?
The pandemic reminded us how connected we all are. People bonded with neighborhood groups and pods; it was, in many cases, a shared experience. But in other ways we were really isolated. The experience was not the same for everyone. In terms of the book, there was an interesting tension: These characters are in this very confined space, but the whole big world is always right out there, affecting them all very directly, in ways they can’t always see.
With every beat of the heart, every moment we’re alive, there’s so much going on. In our own bodies, of course, and also in our families, our communities, and beyond. Writing in this way allowed me to at least have the fantasy that I could access some of that complexity. An omniscient narrator can capture a sense of scope that isn’t always possible when you’re living in the moment. And I really enjoyed working in this mode. It’s the ideal fantasy, right? Like going to a dinner party and being able to read everybody’s minds at the table, what everybody’s thinking and not saying to the other person — as well as pop into the passing Toyota Corolla, see what’s going on in there, and maybe zoom into a distant warehouse, where someone’s packing broccoli or socks or bicycle parts.
The book and its characters are all wrestling with uncertainty in their own way. What do you hope readers take away about how we can relate to the discomfort of not knowing?
So many things in this world are uncertain, and I think we all have to find our way to live with that. I don’t have a simple answer for how, which is probably why I wrote a book around it. But I’ll say this: The books I love the most show me something that I recognize in the world and maybe haven’t fully articulated for myself yet. I hope that readers who are interested in examining uncertainty, and the complicated relationships between mothers and daughters, and the strange and sometimes amazing ways we’re all connected, might find some of that in this book.
Will Meta settlement reduce physical, mental health risks for young users?Experts say many of its terms may help limit use, negative social comparisons, but regulation may still be necessary
Will Meta settlement reduce physical, mental health risks for young users?
Christina Pazzanese
Harvard Staff Writer
long read
Experts say many of its terms may help limit use, negative social comparisons, but regulation may still be necessary
Now we’ll see whether it works, specialists on technology law say.
Meta decided on Aug. 26 to settle a lawsuit brought by dozens of state attorneys general for nearly $18 billion over claims that it endangered the physical and mental health of children and teens with its addictive social media platforms, including Facebook and Instagram.
In addition to the payout, Meta agreed to modify a number of design features that critics and researchers say encourage excessive use as well as those that psychologists say lead users to making unhealthy negative social comparisons between themselves and peers or influencers.
The recent Meta case was being closely watched by legal experts and is considered a bellwether. But legal scholars note that it is just one of thousands still pending against social media companies.
In this edited discussion, the Gazette asked Leah Plunkett ’01, J.D. ’06, Meyer Research Lecturer on Law at Harvard Law School and a faculty associate at the Berkman Klein Center (BKC), and Christian Sandvig, a BKC fellow who studies the ethics of information technology and is part of the Center’s new AI & Youth Safety Initiative, about their take on the agreement.
Gazette: How big of a deal is this settlement?
Leah Plunkett: This is a huge deal. This is a paradigm-shifting deal when it comes to social media and the way it interacts with kid and teen users, as well as the family, schools, and communities around them. It is also paradigm-shifting in terms of what those kids, teens, families, schools, and communities can expect in their interactions.
I think it sends a huge warning shot across the bow for any AI or other emerging tech company. If they choose to take the same push-the-boundaries, see-if-you-can-get-away-with-it approach that the social media companies have by and large taken, it’s going to be trillions with a T instead of billions with a B when the tab is called for them because of the size and scale they’re operating in.
The other thing about this is we see the states decisively establish themselves as the trusted leaders for the public interest when it comes to kids, teens, schools, families, communities, and digital life. The federal government has not succeeded in providing the type of comprehensive statutory or regulatory reform, or even the sustained and creative types of enforcement actions that are needed in such a complicated tech landscape.
Christian Sandvig: It’s great news and it’s terrible news at the same time. I was happy about it, but there are some serious problems with it.
I would say there’s a consensus that the platforms are causing harm, and it’s always nice to see a settlement or some sort of judicial process where people who have been wronged are made good. So, generally speaking, it seems like steps in the right direction.
I was pleased that there are interface changes that have to be done by the platforms. Some are straightforward and obvious, things that, in the trial, the whistleblower was identifying as necessary. That’s great that they’re doing those things as opposed to just the money.
“The period of lockout — 12 a.m. to 6 a.m. — is really well-supported by evidence. Researchers have found that sleep disruption is a big consequence of using these apps.”
Christian Sandvig
The period of lockout — 12 a.m. to 6 a.m. — is really well-supported by evidence. Researchers have found that sleep disruption is a big consequence of using these apps. So, if you had children who are bound to the account, and there’s a way to enforce that it’s really a child’s account, then that seems like a positive move.
But the negative side of it is — just to take one example — Facebook introduced the “like” button in 2009. Academic researchers were writing about how this could be harmful to adolescents as early as 2013. I wrote a paper about it in 2013, and it’s 2026.
And so, if this is our template for regulating technology, it failed. We didn’t do anything about it for such a huge number of years.
Leah Plunkett. Photo courtesy of Leah Plunkett
Christian Sandvig. Photo by Jeffrey Smith
The other negative is it only affects Meta; the other apps don’t have to do anything. Even if it just affects Meta and it’s good, we still have some questions about whether the specific features that have been proposed are going to work.
For an example there’s an exception for direct messaging. But we know that direct messaging is a source of all kinds of horrible things that youth and teens have to experience on social media, like bullying and sexual imagery that is unwanted.
By settling, is Meta essentially conceding that some of these features are potentially harmful to children and teens?
Plunkett: What I see Meta doing here is while preserving, as a legal matter, their position that they’re not admitting wrongdoing, as a practical matter, and certainly as an optics matter, for the public this is Meta behaving as if they know that major features and operations of their platforms have been risky and harmful to kids and teens, and by extension, their families, schools, and communities.
Or at minimum, they are unable to establish convincingly, both in court and in the court of public opinion, that these major design and operations features of their platforms were safe or neutral.
Are any of the feature modifications Meta has agreed to make, such as limiting the amount of time and time of day younger users can be on the platforms, likely to make a difference?
Plunkett: I’ve been reading through the 122-page settlement document. What I am seeing so far is we have age assurance, which is a necessary, but not in and of itself sufficient, condition to provide protections. Age assurance is a bit like coming up with a way to ID at the front door of a restaurant and see if somebody gets the drink bracelet or not. It does not act as a safety protection; it’s identification.
I’m seeing what the settlement agreement is calling “time management,” meaning overall duration of time allowed per day, night access mode 10 p.m. to 7 a.m. based on the device’s local time zone.
Push notifications will be disabled, which is a big deal. “Meta must implement productive pauses and notices to reduce or prevent excessive mindless or unintended teen usage.” I think that may almost matter more than the hours, because core to Meta’s business model is directing and capturing focus and attention. I do think that matters.
The settlement agreement also has Meta agreeing to “identification of suspected secondary accounts.” It looks to me that this is designed to help try to cut back on teens having multiple accounts. But, whether it’s Meta or any other social media platform, a teen with a real commitment to do an end run could figure it out. There are any number of ways that teens could still try to get around this.
A lot of people are talking about this settlement as being a Big Tobacco moment. That is true in a descriptive way. My understanding from the state AGs’ press releases is that this is the largest state consumer protection settlement in history outside of the big tobacco settlements of the ’90s just in terms of money.
What still isn’t being done that you think would make a difference?
Plunkett: I think it is really significant that Meta is taking these steps around what they’re calling the social comparison tools. These types of tools have documented impacts on young people’s health and sense of self and emerging identity.
“I think it is really significant that Meta is taking these steps around what they’re calling the social comparison tools. These types of tools have documented impacts on young people’s health and sense of self and emerging identity.”
Leah Plunkett
The reason it’s so important is that these kinds of social comparison filters are in a somewhat odd or even sensitive place from a legal perspective in terms of whether they are speech or activities by the platform or by companies authorized to be on the platform that might enjoy some type of free speech or even Section 230 protection such that it would be difficult, if not impossible, for a federal or state legislature or a federal or state regulator to ban them or limit them.
So, to have the platform itself say, “we’re dialing these back” is really the best way for this to be addressed, because it gets us out of some of these complicated and still very much emerging and unsettled questions.
There’s a lot in the injunctive relief part of the settlement that is designed to limit or prohibit teens from being contacted by inappropriate other users or seeing inappropriate content. There’s better parental safety and supervision; there’s better content reporting. If that all happens, that’s really big.
What I would like to see Meta and the other platforms do as well is put ethical, practical limitations in place on the marketplaces that exist for child and teen influencer content that draw adult audiences, particularly adult audiences who have — to use the language of the settlement — inappropriate intentions or, in some instances, illegal or criminal intentions.
I do think that there still are a lot of marketplaces on Meta and other social media platforms where we are seeing parents or other adults monetize and, in too many instances, exploit the private experiences of or performances by their kids or kids in their lives for the viewing pleasure, advertising dollars, brand sponsorships, of other adults and institutions.
This settlement does not look to me like it is going to meaningfully disrupt and regulate those entertainment marketplaces. That remains a pretty big area of my concern. But that was not the focus of the AGs’ litigation.
Sandvig: The issue that researchers have pointed out is it’s fundamental to the technology, and so it’s not clear how to solve them with features. Researchers have complained that many of the safety features already in all social media platforms are ineffective. They are usually settings, and they’re hard to find.
In this settlement, there are instances of changing things that used to be opt-in to things that affect everybody or all children on the platform. So, it’s clear that someone was listening to that criticism.
But then there are still other features that were implemented as options, like the algorithmic feed versus chronological feed. That’s an option that no one would use, I think.
This isn’t probably something that we should solve with repeated lawsuits, but rather some structure of regulation. Political commentators say this is a bipartisan issue where we have consensus, which is very rare. That there’s a lot of people in both parties who are excited about doing something about this. I guess the downside of the settlement is perhaps it makes that harder because people might think the problem has been solved.
Note to stressed parents: Instead of trying to be perfect, do this.Experts offer tips for raising children while overwhelmed
Note to stressed parents: Instead of trying to be perfect, do this.
Experts offer tips for raising children while overwhelmed
Anna Lamb
Harvard Staff Writer
6 min read
Parental stress is an urgent public health crisis, according to a 2024 U.S. Surgeon General report that found nearly half of parents and caregivers face daily pressures that they feel are “completely overwhelming.”
A panel of experts convened recently at Harvard’s T.H. Chan School of Public Health to discuss how parents can care for themselves while raising healthy children and what communities and governments can do to help.
Karestan Koenen, a professor of psychiatric epidemiology at the Chan School, kicked off the discussion by acknowledging the unique strains on parents today.
“The first thing I want to say is that there isn’t anything wrong with the parents themselves,” she said. “I think when we’re stressed as parents, we often blame ourselves, but parents are facing so many systemic challenges. Challenges coming out of the COVID-19 pandemic, challenges with lower incomes, higher childcare costs, community supports being eroded, the barrage of information from social media and global events.”
“I think when we’re stressed as parents, we often blame ourselves, but parents are facing so many systemic challenges.”
Karestan Koenen
When a parent gets overwhelmed, the panelists agreed, the first step is to acknowledge it.
“The key here is recognizing early on when there’s distress, difficulties moving day to day, when it’s starting to show up in how we’re engaging with our family, with children, maybe how we are showing up at work,” said Archana Basu, a Chan School epidemiologist and Harvard Medical School assistant professor of psychology at Massachusetts General Hospital.
The next step, according to Basu, is to address the behavior changes with children.
“We know that honest communication that is direct and describes what is happening — the impact on the family or the immediate environment — is key,” she said. “Younger children need more concrete information about things like difficulty getting out of bed or how a parent might be feeling because it’s harder for a younger child to understand a parent’s emotional state if they’re not described in more concrete terms. Older children, on the other hand, often have heard about it. They have access to a lot of information online.”
Parents can ask what their kids have read online, and any questions they might have, said Basu. “And throughout it all, noting that, ‘You know me as your parent. I’m the best source of information for you about my health.’”
Richard Weissbourd, a senior lecturer at the Harvard Graduate School of Education and director of the Making Caring Common Project, agrees that communication is essential.
“Even at a pretty young age, you can tell kids, ‘I’m experiencing something that’s upsetting, and it’s not about you.’ And the data show it’s healthy and a huge relief for kids,” he said.
Plus, open communication can be a learning opportunity for children.
“Even at a pretty young age, you can tell kids, ‘I’m experiencing something that’s upsetting, and it’s not about you.’ And the data show it’s healthy and a huge relief for kids.”
Richard Weissbourd
“Kids really want to understand how you cope with something, and depression anxiety can have damaging effects on kids. But it’s also true that parents who are depressed and anxious often have a lot of wisdom about suffering and have wisdom to share. And I would encourage parents to think about what wisdom they have to share.”
For Jayne Singer, a psychologist and HMS assistant professor of pediatrics at Boston Children’s Hospital, teaching moments can also come when our stress manifests in temper flare-ups — when a child gets on mom’s last nerve and she snaps.
“After there’s been a disconnect, after there’s been a mismatch, there is the opportunity to come back into relationship and model the key things that we’re helping children to develop as emotionally competent people,” she said. “The ability to express the emotion, be able to understand that the emotion was tied to a circumstance, and then it led to an impulse and behavior. So, if after losing it, coming back in and saying, ‘You know what? I was feeling really angry. I was feeling really frustrated. I love you.’”
Moreover, she said, parents need to acknowledge that they are not going to be perfect when trying to raise the next generation.
“We’re not holding ourselves up as paragons, but we are saying we too are going to lose our temper sometimes,” she said. “Young children test our limits, they test the limits of our patience. And that’s a crucial thing for them to understand in order to develop empathy. Like, ‘Oh, right, my behavior does have an effect on other people. I need to learn how to manage my own impulses that come from my own upset.’”
For Weissbourd, the focus for parents should be on this long-term emotional development, rather than parents policing their kids’ achievements or day-to-day emotional well-being.
“Hyper-focus on achievement and on well-being moment-to-moment often overwhelms our focus on kids tuning into other people, empathizing with other people, caring for other people,” he said. “And when they’re able to do those things, they’re going to have better relationships their whole life. They’re going to be better parents. They’re going to be better romantic partners, better friends, and that’s the most robust and durable source of happiness that we have.”
On a macro level, the panelists pointed to the need for better food and housing security for parents, more parks and recreation programs and places for kids and for parents to informally gather in community. But on the micro level, parents can take control of day-to-day habits for stress management like exercise or talking with a friend.
Singer suggests taking a few seconds to oneself when the day gets overwhelming.
“Can you give yourself permission to pick yourself up out of the fray, go to the bathroom and do a body scan, even if it’s for 30 seconds? Where am I feeling the tension? Is it my head? Is it my stomach? Is it my chest? Are my shoulders up at my ears? Take 30 seconds to take care of yourself and breathe,” she said. “Or do progressive muscle relaxation, just little micro practices to punctuate the day. Often, with that message of being nurturing and responsive, we forget to take care of ourselves.”
And when parents aren’t perfect, the panel all agreed that it’s better to apologize after the fact and continue trying to improve.
“What I’ve learned is the parenting journey and the opportunity to repair is never over,” Koenen said. “I’ve had conversations with my son as a teenager and emerging adult about things in the past related to my parenting stress and honest conversations where he said to me, ‘It was hard when I was young. You were really stressed.’ And I just said, ‘I’m sorry, I’m sorry I showed up like this.’ It’s great if you can repair in the short term, but life will also present you with deep opportunities in the long term.”
‘Very excited to start this new chapter of my life’Scenes from the Yard on move-in day
‘Very excited to start this new chapter of my life’
1 min read
Scenes from the Yard on move-in day
As Harvard’s Class of 2030 arrived in Harvard Yard for move-in day, students shared what they’re looking forward to, from meeting new people to starting classes to exploring campus, while their parents talked about their own mixed emotions. They shared feeling both pride and sadness that comes with the day, and the start of a new chapter — for everyone.
Hope, joy, heavy liftingBittersweet goodbyes and jitters make way for excitement as Class of 2030 settles in on move-in day
Members of the Crimson Key Society welcome first-year students to Harvard. Photo by Grace DuVal
Bittersweet goodbyes and jitters make way for excitement as Class of 2030 settles in on move-in day
Harvard Yard awoke from its summer slumber on Wednesday as members of the Class of 2030 were greeted by campus regulars eager to welcome the first-year students to their new home.
Among the fresh faces was Nathaniel Shugarman, who arrived from the Florida Keys.
“This is incredible, to be here,” said Shugarman. “I’m definitely nervous about the classes and adjusting from high school, but I’m excited for all the people. It’s incredible. It feels so historic and electric.”
His mother, Megan Shugarman, described her emotions.
“I’m feeling super blessed and grateful. It’s the end of a childhood era, so that part makes me sad. But I’m so excited, and everything’s been so friendly and open.”
First-year students line up in the Yard. Stephanie Mitchell/Harvard Staff Photographer
Also moving a plane ride away from her family was Bethany King, a water polo player from Santa Barbara, California.
“I’m pumped. I’ve been greeted with lots of vibes, high energy. It’s getting me excited for my four years,” she said, grinning alongside her parents, Sheryl and Brian. “If this is my first day at Harvard, shoot, what’s going to be in the next four years?”
“I’m pumped. I’ve been greeted with lots of vibes, high energy. It’s getting me excited for my four years.”
Bethany King
King said already, she’s making tons of friends.
“It’s just like Instagram requests,” she said. “Follow, follow, follow, follow.”
Moving closer to home was Ilaria Luna, whose father, Franceso, and sister Esther patiently waited with her belongings outside Wigglesworth Hall. Harvard is closer to their hometown of Washington, D.C., than Shanghai, where Luna just finished a gap year.
“We were empty-nesters last year,” Francesco said. “So we’ve been through this.”
Kyla Skinner (center) arrives with her parents. Stephanie Mitchell/Harvard Staff Photographer
Farhan Khan (from left) speaks with Harvard President Alan Garber and his wife, Anne Yahanda. Stephanie Mitchell/Harvard Staff Photographer
Hannah Wurzburger and mother Leah Wurzburger.
Stephanie Mitchell/Harvard Staff Photographer
Harvard College Dean David Deming helps a family move into Hollis Hall. Photo by Carlos Sanchez
Cosmo He (right) poses for a photo with his dad in front of Johnston Gate. Photo by Grace DuVal
Likewise Thomas Grieser’s parents, who live in Newton, Massachusetts. Thomas spent the past five years attending Eton College in the United Kingdom.
“I’m excited to have him closer to home,” his mother, Kathleen, said as the pair took a break from moving boxes into Straus Hall. “And my husband and I both went to Harvard, so it really feels like a homecoming.”
Outside Matthews Hall, Leah Wurzburger guarded her daughter Hannah’s pile of belongings while helpers lugged her first load up several flights. Watching the third of her three kids move into College was bittersweet, she said.
“She’s my baby,” she said. “It’s very emotional, but I’m very excited for her. I’m very excited for all the opportunities.”
Dean of the Faculty of Arts and Sciences Hopi Hoekstra greets new students. Photo by Carlos Sanchez
And while this wasn’t her first college move-in rodeo, it was her first with a daughter, Wurzburger said. To sum up her feelings becoming an empty-nester, she quoted Stephen Sondheim lyrics.
“I’m excited and scared,” she said. “Hannah’s a little bit nervous, mainly excited, and I’m all those things plus very sad.”
President Alan Garber was out in the Yard, greeting students and parents.
“I get a huge burst of energy meeting each incoming student, and from all I’ve heard and what I’ve seen today, this will be an incredible group of Harvard students,” Garber said.
Which diet is right for you? Wrong question.Quiz based on Daniel Lieberman’s new book looks at food fads through evolutionary lens
Quiz based on Daniel Lieberman’s new book looks at food fads through evolutionary lens
Humans didn’t evolve to shop for food that has been collected, packaged with nutritional information, and arranged by category in brightly lit supermarkets. In fact, we didn’t evolve to choose our food at all.
In his new book, “Fed Up: What Evolution Reveals about Food, Diet, Health, and Eating Well,” Daniel Lieberman, Edwin M. Lerner II Professor of Biological Sciences in the Department of Human Evolutionary Biology, explores how our ancestors evolved to eat almost anything they could hunt, gather, or grow in whatever habitat they happened to find themselves. Which makes the modern American diet’s embarrassment of riches a real conundrum. Should we eat low-carb or low-fat, vegan or strictly animal products?
In “Fed Up,” Lieberman argues that most diets cling too firmly to one “big idea” and that they can, and should be, much more flexible. Lieberman helped us develop this quiz based on the book to help us make sense of it all.
Crackers are past date on box. Should I toss them?Policy expert says new California law highlights need for national standards on safety labels to cut high levels of U.S. food waste
Crackers are past date on box. Should I toss them?
Policy expert says new California law highlights need for national standards on safety labels to cut high levels of U.S. food waste
Alvin Powell
Harvard Staff Writer
9 min read
In July, a new labeling law took effect in California to make clear the dates when foods have merely passed their prime and when they would actually be risky to eat. The rule standardizes label language (such as “Best if used by” versus “Use by”) with an aim to increase safety and clarity for consumers and reduce food waste.
The Gazette spoke with Emily Broad Leib, clinical professor of law and director of Harvard Law School’s Food Law and Policy Clinic, about the potential impact of the law, the movement to pass similar legislation at state and federal levels, and its potential to address a national problem of consumers throwing out about a third of the food they buy. The interview has been edited for clarity and length.
Gazette: California recently passed legislation regulating date labels because of their role in food waste. What was the source of the confusion?
Emily Broad Leib: We know that in the U.S. and in other places they’ve been tied to both household-level food waste and waste throughout the supply chain. I’ve heard from partners in the supply chain that sometimes food will be thrown away three months before the date because they know that’s not enough time to get it to the distributor, onto the shelf, and into someone’s home.
Another thing we see is uncertainty around whether food can safely be donated past the date. For some of these foods, the date is really just an estimate and means there’s likely nothing wrong with it. A lot of food pantries and food banks have their own guidelines, but there are fringe foods where they’re not sure: Would the company think this is still safe? This should clarify that for them.
On the consumer side, we did a national survey in 2025 and asked 2,000 Americans, “What do you think these date labels mean?”
Forty-three percent say they always or usually throw food away because of the date, not because they looked at the food, smelled it, or tasted it. That is higher than we saw in a similar survey nine years ago. Eighty-eight percent say they at least occasionally throw food away purely because of the date, and most of them say they do it for certain foods.
But the foods those people are choosing are not necessarily foods where there’s a safety-based reason to do it.
Before these labels came around, how did people tell if food was spoiling? Was food poisoning a bigger problem?
It’s really important, especially in this moment when people are hearing about food poisoning — cyclospora, or salmonella, or E. coli — to say that date labels aren’t tied to that, with one small exception, which I’ll explain. But the FDA has said repeatedly they don’t regulate date labels because they’re not tied to food safety.
In the 1950s, we started having refrigerators and freezers and full-service grocery stores. People became removed from where their food came from.
The generation before, people either grew their own food or were very close to it. If food looked good, they would eat it. If it was starting to spoil, but they could cut off the moldy part, they would do that.
By the 1970s, people were far removed from their food production and asking, “How do I know if this food is still fresh?” So companies responded with these freshness labels and, over time, states began requiring them.
Consumers understood then that it was purely about freshness, but today the majority of people think it’s about safety, and if they eat something after that date, they’re going to end up in the hospital with salmonella. That is just not true.
“About a year ago, the EPA put out a report that says a household of four is throwing away $3,000 worth of food each year.”
Then what do these labels do?
The primary use of date labels is around stock rotation, supply-chain management, and to indicate to consumers when the company believes it’s going to taste its best. There’s good reason for food companies, which are fighting for our attention and dollars, to want you to eat their product when it’s at its absolute peak.
That hasn’t been communicated well because the majority of consumers interpret them as safety dates.
Ideally, a majority of foods would have one standard label they use to indicate freshness and peak quality.
There are a small handful of foods, however, that do become riskier after the “Use by” date. These are foods that have become contaminated with listeria, that you store in the refrigerator, and that you’re not going to cook.
The prime example is deli meat. That doesn’t mean all deli meat is unsafe — dried, cured meats like salami have low risk. But sliced turkey, chicken, roast beef, and others should be eaten within the time period on the label. If you go longer and it happens to be contaminated, it could increase your risk.
That’s the same for some prepared salads, like chicken salad or egg salad. These foods are fine to eat, but if contaminated, they can get worse over time, even if it’s in your refrigerator — because unlike other pathogens, listeria can reproduce under refrigeration.
California has said that companies need to use different label language for foods labeled for safety versus those labeled for freshness. The primary concern is people throwing food away that is actually safe to eat.
Standardizing the labels lets people know that if it smells and tastes fine, even if it is past-date, those foods with the quality label are not going to get you sick.
And California is requiring two labels, “Best if used by” and “Use by”?
It would be one or the other.
For the food with the “Best if used by” peak-quality label, it’s actually impossible to tell when it’s going to become unsafe. And if it were unsafe, it would be moldy or spoiled or no longer palatable.
Humans are pretty good at determining when something’s no longer palatable. It would smell or look gross. This standard quality label is saying, “If it still smells and tastes good, don’t throw it away. Don’t waste your money.”
The “Use by” date would be only on a small number of foods where the company is communicating, “This food is riskier. Clear this out of your refrigerator and don’t keep it past this date.”
How big a factor is consumer handling? If you leave a steak out overnight versus sticking it right in the fridge and grilling it in a day or two?
That’s a piece of it, but there are other complications, too. One is that some people don’t keep their refrigerator at 40 degrees, which is advised. If your refrigerator’s at 45, food is going to spoil faster. So there are other factors that happen at home that make it difficult to say how long food will stay at peak freshness and quality.
If you freeze meats and fish and other things, can you ignore the “Use by” date?
Definitely. In California, their required language is “Best if used by” or “Best if used or frozen by,” and same thing on the “Use by” label: “Use by or freeze by.” Again, for both types of food, the freezing stops the process that leads to spoilage or illness. Listeria cannot grow when your food is in the freezer.
We want to educate people because it’s not just food that’s wasted, people are throwing away money. About a year ago, the EPA put out a report that says a household of four is throwing away $3,000 worth of food each year. No one wants to be doing that.
How big a piece of the food waste pie is this food labeling problem?
It’s hard to say, and in my dream world we would have much better data. We do know that we waste about a third — 30 to 33 percent — of the food supply in the U.S. every year, and 35 percent of that waste happens in households. A big reason for that is incorrect understanding of date labels.
Research in the U.K. found that 20 percent of household food waste was due to date-label confusion, and I imagine it is worse in the U.S.
How many states have laws like California’s?
California’s the first one, and New York has passed a law to do the same kind of thing. The latest I checked, the New York bill is still waiting for the governor’s signature, but it’s passed both houses of the legislature. Massachusetts and other states have introduced bills to do the same thing.
When we started working on this issue, we found that 41 states required different date labels and required them on different foods. Clearly, they can’t be science-based if every state is doing it differently. But these newer laws, like California’s, are really focused on following the science and standardizing these labels.
We are now working on whether we can fix this at the federal level since there’s no science-based reason Massachusetts and Mississippi shouldn’t have the same rules.
At the end of the Biden administration, there was a Federal Register request for information by the FDA and USDA on this topic. They have not taken action, but my understanding is they’re reviewing the comments and information they’ve gotten.
There’s also a bill, the Food Date Labeling Act, that has gotten bipartisan co-sponsors in the last two Congresses. I’m delighted that states are taking action, but in the long term it makes more sense to handle this federally because it will help everyone and standardize what consumers see.
Mystery statue unearthed at Sardis archaeological dig2,500-year-old marble sculpture of young man hid face-down for centuries, broken and recycled as paving stones
2,500-year-old marble sculpture of young man hid face-down for centuries, broken and recycled as paving stones
Researchers with the long-running Harvard-Cornell Archaeological Exploration of Sardis have unearthed a larger-than-life statue, estimated to be nearly 2,500 years old.
The discovery is remarkable for several reasons, said Nicholas Cahill, the field director of the AES team and a professor of Greek and Roman art and archaeology at the University of Wisconsin-Madison.
“It is very rare to find such monumental sculptures of this period anywhere in the Mediterranean, and this exceptionally well-preserved, unique monument casts important new light on the major arts of Lydia, and on the Lydians’ ties to their own past,” he said.
The excavation is sponsored by the Ministry of Culture and Tourism of the Republic of Türkiye and by Harvard Art Museums. The Turkish site was named a UNESCO World Heritage Site last year, cementing its position as a critical site for understanding the ancient world.
Researchers made the discovery in late May while examining a major Roman colonnaded avenue. The statue had been broken in two main pieces and reused, face down, as paving stones in the ancient thoroughfare.
“You sort of see these whole worlds opening up in front of you,” Cahill said of the moment he realized the team had found something extraordinary.
A team of conservators carefully excavated around the statue to gradually reveal its full shape and size in the ground.
“Then the guesswork started,” said Susanne Ebbinghaus, the George M.A. Hanfmann Curator of Ancient Art at the Harvard Art Museums, who was in Sardis for part of the excavation. “‘Is this archaic? Maybe not, it looks a little later. Is it a guy? Is it a girl?’ When they started cleaning the soil around the head, we saw he had sideburns, so that question was settled.”
Upon arrival at the expedition compound, the statue gets an initial cleaning.
Archaeologists estimate the figure would have stood taller than 7 feet.
The team lifts the sculpture from the road.
The people of the Lydian empire, which controlled what is now western Türkiye from about the middle of the 7th century to the middle of the 6th century B.C., left little written record of their civilization. Much of what was known came from what Greeks and Romans wrote about it — and from their point of view, the Lydians were eastern barbarians. But archaeological evidence has revealed that Sardis, the capital of the Lydian empire, was a center for luxury and culture, particularly perfumes and fine clothing.
James McCurley ’27, a Classics and Physics concentrator who worked on the dig over the summer, said the excavation of the mammoth statue proved the highlight of his experience. “After all the anticipation, I was worried the statue might be underwhelming, that we’d dig it up and find its front weathered beyond recognition. Discovering that the statue was not only well-preserved, but almost intact and 2,500 years old was a wonderful surprise.”
Conservators lifted the pieces from the ground on July 13 and transported them to an AES conservation lab to begin a thorough, and still ongoing, analysis.
Many details have been revealed since that early, excited guesswork.
At well over 7 feet tall, the figure would have towered over onlookers. He wears a tunic of thinner material (called a chiton in Greek), a diagonally wrapped mantle, and a distinctive, perhaps local garment with fine horizontal folds. The design has few parallels in ancient sculpture, said Harvard Art Museums’ Bahadir Yildirim, who is the Sardis expedition administrative director and who participated in the cleaning and analysis.
“The surprising thing about this piece is that it has some features that haven’t been seen on sculpture like that … the drapery underneath, the distinctive horizontal patterning,” he said.
Bahadir Yildirim, Sardis expedition administrator and assistant director of fieldwork, takes a closer look at the statue’s unusual design.
The statue’s bolt-upright stance, long coiffed hair, and manner of dress resemble archaic Greek sculptures from the 6th century B.C. But the prominent veins and other anatomical details betray a much later date, likely in the 470s to 450s B.C., the early Classical period in Greece. During this era, Sardis was no longer an independent capital but had been conquered by the Achaemenid Persians and had become a major provincial center.
But the figure shows no Persian influence. The statue, therefore, comes across at first as a very traditional sculpture, adhering to age-old hairstyles and dress codes, while also hinting at familiarity with the current styles in Greece where such a sculpture might have been depicted as a nude youth. But the Lydians and other Anatolian peoples did not exercise naked and did not depict their young men without clothes.
The references to multiple cultural traditions and time periods reflect an artist with a complex understanding of his or her place in the world, Cahill said.
“This sculptor knows about contemporary styles in Mediterranean and Anatolian sculpture, the interest in hands and the structure of the face and so forth, and yet [the statue is] wearing clothes from 100 years earlier,” Cahill said. “I think they’re very clearly looking back to their own past.”
The original placement and purpose of the monumental statue is unknown. But one possibility is that it stood at the sanctuary of Cybele, the native mother goddess, which has never been found but has been described in literary sources as one of the most important sanctuaries in Sardis. It was common for wealthy citizens or political leaders to ensconce their likeness in the presence of a deity so they could effectively worship in perpetuity, explained Ebbinghaus.
“You put yourself in a prominent place where your fellow citizens or subjects can see you, but also you are indeed worshiping the god — and if you’re a ruler, drawing legitimization from the relationship to that deity. So it might well have been an important person being represented,” she said.
Most ancient marble statues were painted, and this one was likely no exception. The Sardis conservation team is now working to clean the statue while preserving any remaining flecks of paint for color analysis.
When conservation is complete, the fragments will be joined and the statue will be displayed in a Turkish archaeological museum, along with other finds from Sardis. The first Harvard excavation of Sardis, a joint project with Cornell University, began in 1958 and was led by George M.A. Hanfmann (1911-1986), a professor of fine arts at Harvard and curator of ancient art at the Fogg Art Museum.
Making the case for independent scienceMed School lecturer nods to wider implications in blueprint for Hungary
Med School lecturer offers blueprint for Hungary, with an eye on the U.S.
Hungarian Prime Minister Viktor Orbán’s 16-year rule ended in the spring, when voters replaced him with Péter Magyar, who has pledged to undo Orbán-led initiatives that in the eyes of critics isolated and politicized science.
Albert-László Barabási, a Harvard Medical School lecturer on medicine, part-time, at Brigham and Women’s Hospital and a distinguished university professor at Northeastern University, is a graduate of Eötvös Loránd University in Budapest and a visiting professor at the Central European University in Vienna. He recently penned an op-ed in the journal Science laying out a blueprint for how Magyar might proceed.
We spoke to Barabási about his proposals for Hungary and how politics can undermine research. The interview has been edited for clarity and length.
Gazette: What happened to Hungarian science during the Orbán administration?
Albert-László Barabási: Hungary has a particular pride in science and in how many intellectuals the country produces, particularly how many Nobel Prize winners, which is close to a dozen. That includes two in 2023, one in physics and one in medicine, and last year’s literature winner.
The Orbán regime politicized science. Research institutions and national labs had traditionally been under the direction of the Hungarian Academy of Sciences. About seven years ago, the government removed these institutions from the academy, saying they wanted to reorganize them to be more competitive. Virtually all scientists, including all members of the academy, were against the change, but it did not matter.
To their credit, the government attracted a well-respected academic back from Singapore to run the new institutions, and increased funding. They increased both salaries and the resources going to research projects, but they never managed to address the psychological break that resulted from stripping away academic control.
It did not end there. The Orbán government started a system that, on one hand, you could view as a positive. But on the other, the execution was politicized. They wanted to bring the Hungarian universities up to an international level and concluded, rightly, that the universities needed new funding and independence. So, they created foundations that effectively made them into organizations that are independent of the government and then donated state properties — shares of major companies, land — into those foundations to secure the resources to expand and function.
In principle, this makes lots of sense. In practice, the boards were stacked with political appointees, so they were not independent. As a result, the EU protested and locked out these universities from the Erasmus program, which supports education, as well as from the European funding system. The few universities that did not undergo this transformation remained within the EU system, but, deprived of new funds, became deeply impoverished.
What was the impact on the quality of the country’s science?
Science is a collaborative enterprise, so no matter where you are in your career, undergraduate, Ph.D. student, postdoc, even faculty, you need to be able to collaborate and learn from international colleagues. The EU has created a framework for that, and Hungary had been successful at taking advantage of it. That framework was artificially cut — students couldn’t travel, faculty couldn’t collaborate — and the consequences will probably be seen decades from now, in lost collaborations, diminished impact and productivity.
You outlined several steps that Hungary’s new leaders should take. First is re-establishing trust. What do you mean by that?
The Orbán regime lost trust by packing the university boards in a way that wasn’t transparent, and by removing the control of the research institutions from the academy. There is a need for a reset — and it is already happening. While the outcomes are uncertain, the direction is good. In my mind, the question is, will the universities retain independence and get the funds they need to thrive? That we can probably only assess later.
Another recommendation is to make reforms durable.
The independence of the research network is technically already in place and guaranteed by law. The question is whether the new government agrees with that setup or whether they’ll seek an alternative. It doesn’t really matter in my mind whether it’s controlled by the academy or by the government or whether it’s set up as an independent body. What matters is the independence of the researchers and the decision makers who fund the research.
“What matters is the independence of the researchers and the decision makers who fund the research.”
Have the decision-making structures in the U.S. been damaged in a similar way, in your view?
We have seen evidence of the decisions of the scientific body being overturned by political appointees, both in the U.S. and in Hungary before the elections. Who gets funded or who does not get funded is no longer a decision left to the research community alone. When I talk about independence in the U.S., I mean restoring a system that for decades had no political interference. All that matters is if my research is of sufficient quality, not whether it is politically acceptable.
Hungary seems to be on the road to de-politicizing its science. How long is this road?
You could say six months: Put the laws in place, secure the necessary funding, and let it go. But the government has many other issues to deal with. There are issues with the healthcare system, the educational system, and outdated transportation. So how do you assign priorities? I was in Budapest in May at the National Academy meeting, and the new prime minister came and addressed the membership. He said that he intends to increase funding to the European norm, which requires allotting another 1 percent of GDP to innovation and science. If he lives up to those words, Hungary could open another golden era in science.
The why behind sexResearch details answer to a question that’s more complex than it seems
Michael M. Desai. Niles Singer/Harvard Staff Photographer
Alvin Powell
Harvard Staff Writer
5 min read
Research details answer to a question that’s more complex than it seems
Why is there sex — or, more precisely, sexual reproduction? If you’re an evolutionary biologist, the answer isn’t obvious.
Sexual reproduction is biologically costly, requiring not only competition for mates, but also the creation of entire populations in which only half the individuals can give birth. That reality has led scientists to wonder why it arose in the first place. After all, in asexual reproduction — as occurs when bacteria divide — not only can you skip the wooing and its costs, but every individual is a potential mother.
New research from a group of Harvard biologists dives into the benefits that come with sexual reproduction, particularly in changing environments.
The work was conducted in the lab of Fisher Professor of the Natural Sciences Michael Desai and led by Ph.D. student Shreyas Pai and Parris Humphrey, then a postdoctoral fellow. The team used a strain of yeast as a model organism. The yeast, commonly used in bread baking and beer brewing, has the scientific advantage of being able to reproduce either asexually or sexually.
Another advantage is that yeast produce new generations in only 90 minutes, taking the guesswork out of experiments on evolution, which is generally understood to promote slow change over long stretches of time. With a new generation every hour and half, Desai’s team was able to observe changes after 960 generations in just four months, something that would take hundreds to thousands of years in large mammals.
The research, published in the journal Science in April and supported by the National Science Foundation, the National Institutes of Health, and the National Institute of General Medical Sciences, began with a dozen identical populations of yeast growing in ideal conditions. All initially reproduced asexually, but every 100 generations, designated lines were induced to reproduce sexually for a single generation.
The scientists first confirmed earlier work showing that in a constant, favorable environment, sexually reproducing populations gain more fitness than asexually reproducing populations. Over those nearly 1,000 generations, the fitness of sexually reproducing populations increased 8 percent over the ancestral population, compared with a 5.7 percent increase for asexual populations.
Next, the researchers tested evolution in different environments — one saltier, one hotter, another with decreased acidity, and one with lower phosphate. In these altered conditions, researchers found that sexually reproducing populations had fitness advantages of between 2 percent and 5.6 percent over asexual populations.
While those numbers may not seem large enough to matter, Desai said that over long periods of time, an advantage of even a fraction of a percentage point can allow a particular population to dominate.
“Selective differences of fractions of a percent in large populations can drive total shifts in population composition.”
Michael M. Desai
“Selective differences of fractions of a percent in large populations can drive total shifts in population composition,” said Desai, the paper’s senior author. “A several percent effect in a microbe is large. It might take 50 to 100 generations to take over.”
Desai said that the work also probed the mechanism by which sexual reproduction is advantageous in a shifting environment. Some genes are “pleiotropic,” meaning that they affect the expression of several traits, some of which can be adaptive, some harmful. Harmful traits that affect an individual’s ability to survive or reproduce are reduced or removed from the population naturally. But traits that are neutral or only mildly harmful can survive as what scientists call “hitchhiking load,” particularly if other traits of the same gene provide an adaptive advantage.
When the environment changes for the worse, as it did for the experimental yeast, some of those previously neutral or mildly disadvantageous mutations may threaten survival. That is where sexual reproduction gets its edge.
Asexual populations have no way to eliminate the threat because their offspring are clones and genetically identical. Sexually reproducing populations, on the other hand, produce offspring with a mix of their parents’ genes, some of which may not carry the harmful “hitchhikers.” Over time, that reduces or eliminates the harmful effects of those genes.
“We showed that, without sex, it’s not just that the populations are accumulating deleterious baggage, they’re accumulating baggage that maybe is not so bad in the environment they’re evolving in, but would hurt you elsewhere,” Desai said. “In contrast, when you have sex, you purge that hitchhiking pleiotropic cost and prevent yourself from specializing quite as much just to the environment that you’re in. That can be a big advantage when the environment shifts or fluctuates.”
While Desai and colleagues worked with microbes, he said that the effects extend into more complex organisms where asexual reproduction, while rarer, is still represented. In the plant kingdom, for example, cuttings can grow into fully mature plants that are genetically identical to the parent. Among animals, certain species of lizard can undergo parthenogenesis, in which their eggs are self-fertilized, producing offspring that are clones of their parents.
“We believe that this general mechanism by which sex speeds adaptation and purges hitchhiking deleterious load should be a general advantage of sex across all sorts of organisms,” Desai said. “I think it’s great that we can learn so much about how evolution acts and how the ways in which we reproduce, copy, and re-sort our genomes makes sense all the way across these enormous differences in organisms’ complexity and scale.”
Home is at the heart of Parton’s music, author saysMartha Ackmann tells Radcliffe audience the origin story of a songwriting legend
Home is at the heart of Parton’s music, author says
Martha Ackmann tells Radcliffe audience the origin story of a songwriting legend
Anna Lamb
Harvard Staff Writer
3 min read
Editor’s note: Dolly Parton died at 80 years old on August 25.
Would Dolly Parton be Dolly Parton if she grew up outside Appalachia? Unlikely, says Martha Ackmann.
Ackmann, the author of “Ain’t Nobody’s Fool: The Life and Times of Dolly Parton,” spoke with Joanna Weiss, the editor of Harvard Magazine, about Parton’s upbringing, career, and legacy in a Radcliffe book talk this month.
“There are many, many books about Dolly Parton, but I wanted to locate her in her historical and cultural setting,” Ackmann said. “When I was writing, I would say to myself, ‘Would Dolly Parton be Dolly Parton if she had grown up in Wyoming?’ And I think the answer is no.”
“There are many, many books about Dolly Parton, but I wanted to locate her in her historical and cultural setting.”
Martha Ackmann
Parton made a name for herself not only as a singer, but as a songwriter adept at drawing inspiration from her surroundings. This year, the Academy of Country Music named her a recipient of its Poet’s Award for her “honesty, heart and unmatched storytelling power.” Parton, the group said, has written songs that “have shaped the culture of country music and continue to resonate far beyond genre lines.”
Parton, who grew up in Locust Ridge, Tennessee, honed her skills as a musician and a songwriter in empty chapels and around the house. She picked up various instruments, or really anything that made a sound, and became a prolific writer.
In 1967, Parton was introduced to the public on the popular “Porter Wagoner Show,” where she performed original music and duets with Wagoner. Her biggest early success came in 1974 with the release of “I Will Always Love You,” which Elvis Presley’s manager, Colonel Tom Parker, sought the rights for only to have Parton turn him down.
“The thought of Elvis recording her song was like something she never dreamed,” Ackmann said. “But Colonel Parker calls and says, ‘Elvis always retains the publishing rights.’ She knew her worth, and she knew she had a right to that, and that she better protect it.”
In addition to her 58-year marriage to Carl Dean, who died last year, Parton’s ties to her home and her extended family have provided a deep well of support and inspiration, Ackmann noted. In turn, she’s made her home region the focus of much of her philanthropic work.
Ackmann described Parton’s affection and devotion toward home with a phrase borrowed from the country legend’s grandmother, who would tell her grandchildren to return to their cabin “once the sun is beginning to leave the pinnacle.”
“I love that,” Ackmann said. “And I also thought of that metaphorically. When things begin to get dark, it’s time to come home. Not just geographically, but to one’s values, to one’s truths, to one’s family, to what keeps our feet on the ground, and I think that that guiding light very much traveled down to Dolly as well.”
How to fix U.S. healthcare? ‘Radical action,’ says John McDonough.Chan School expert links soaring costs to broader policy shifts in ‘America’s Wrong Turn’
How to fix U.S. healthcare? ‘Radical action,’ says John McDonough.
Chan School expert links soaring costs to broader policy shifts in ‘America’s Wrong Turn’
Alvin Powell
Harvard Staff Writer
5 min read
John McDonough. Veasey Conway/Harvard Staff Photographer
“What happened in 1980?” John McDonough wondered every time he looked at the numbers.
After 1980, U.S. healthcare became far more expensive than care in peer nations such as France and Germany. In 1980, the U.S. was at the top of a tight pack of industrialized democracies. After that, the cost of American healthcare soared. By 2024, U.S. spending as a percentage of GDP was about 50 percent higher than that of peer nations.
“In the early 1980s, we can see a significant upsurge,” McDonough, professor of the practice of public health at the Harvard T.H. Chan School of Public Health, said in an interview. “All of a sudden, we jumped from the rest of the crowd and were now in a category by ourselves. Over the following 40, 45 years, the distance kept growing.”
McDonough knew what he could rule out: Any suggestion that Americans get more for their money. On the contrary, millions of U.S. citizens are uninsured; out-of-pocket costs and medical debt are high; and even people with insurance have trouble getting appointments. Meanwhile, physician satisfaction is low, leading to early retirements and migration to nontraditional models like concierge care.
When the pandemic hit, McDonough had time for a deep dive into the issue. This month, after a five-year “labor of love,” he’s presenting his answer in a new book, “America’s Wrong Turn: US Health Care in the Neoliberal Era.” In it, McDonough links increases in healthcare costs to a new political and economic era dominated by a belief in an unfettered free market, tax cuts, deregulation, privatization, smaller government, increased immigration, and free trade.
This trend in U.S. policy — “Reaganomics” before it became “neoliberalism” — included tax, spending, and regulatory overhauls instituted during President Ronald Reagan’s eight years in the White House. But McDonough, a Democrat who served 13 years in the Massachusetts House of Representatives, isn’t just interested in Reagan. Over the next 40 years, some presidents adhered to neoliberalism’s tenets but even those who didn’t were influenced by its deep penetration into the nation’s political and economic ecosystem, he says.
McDonough found a guide in the writings of Yale University political scientist Stephen Skowronek, who suggests that presidents should be measured by the durability and influence of their ideas and values well beyond their terms in office. Skowronek identified only five singular and decades-long eras in U.S. history, those of Thomas Jefferson, Andrew Jackson, Abraham Lincoln, Franklin Delano Roosevelt, and Ronald Reagan.
While Reagan was the first president to espouse neoliberal political and economic philosophy, the core ideas date back decades, fostered by Nobel Prize-winning economist Milton Friedman, who became a key economic adviser to Reagan.
“There was a New Deal-FDR era between 1933 and 1980,” McDonough said. “The neoliberal era that Reagan kicked off saw itself as the corrective to the pro-government prior era. Important dynamic consistencies persisted among Ronald Reagan and Bill Clinton, George W. Bush, and even Barack Obama. There were sets of beliefs with a Republican conservative flavor and with a Democratic flavor that were surprisingly consistent.”
When describing the U.S. healthcare system under neoliberalism, McDonough, who worked with U.S. senators on the Affordable Care Act, cites several major effects, chief among them a permissiveness toward corporate mergers and consolidations that reduces competition, and an unleashing of private equity.
Since the 1980s, U.S. healthcare has become increasingly consolidated, dominated by fewer and larger organizations. The two largest dialysis centers have 92 percent of the U.S. market, for example, while the two largest providers of intravenous solutions control 75 percent of the market. The two largest syringe manufacturers have a 69 percent market share.
Consolidation extends to physician and hospital markets, with 90 percent of hospital markets, 65 percent of physician specialist markets, and 74 percent of health insurance markets considered highly concentrated, McDonough writes.
“It will take radical action to reinvigorate the values and principles of our health system that have been lost and eroded. An essential way to do this is to understand how we got to this position in the first place.”
John McDonough
One argument for larger organizations is the potential for cost saving through both efficiencies and a greater ability to negotiate savings, but the cost-saving record of larger organizations in healthcare is poor, McDonough says. He cites a 2022 RAND study that indicates that price increases of between 3 percent and 65 percent accompany hospital mergers.
Private equity’s focus on generating profits to maximize shareholder value conflicts with improving patient care, McDonough argues. When private equity firms target businesses, enhance their operations, and quickly resell them at a profit, critics say the value extraction from the deals creates harmful operating cuts and dismantling rather than business improvement.
McDonough reviews other key forces in the evolution of U.S. healthcare in recent decades, including fragmentation leading to high administrative costs, low spending on public health and preventive care, unequal access and uneven quality of care, and cost shifts onto consumers via copays, coinsurance and other cost-sharing mechanisms, which result in high levels of medical debt.
McDonough offers prescriptions, but recognizes that change will require political buy-in for things such as strengthened antitrust action to break up megacompanies and stronger regulation of prescription drug pricing, both difficult in an era of sharply divided politics. Government, along with industry, needs to reaffirm a commitment to patient care as the center of its efforts, he says, while also foregrounding equity, access, affordability, and population health.
“The damage to U.S. health and medical care from the 40-year neoliberal era has left considerable harm for patients and consumers, for medical workers at all levels, and for public/population health,” McDonough said. “It will take radical action to reinvigorate the values and principles of our health system that have been lost and eroded. An essential way to do this is to understand how we got to this position in the first place.”
‘Pop Culture Jeopardy!’ champs knew they had film covered. TV? Not so much.How former Harvard classmates binge-watched and buzzed their way to victory
Jack Goldfisher (left) and Henry Johnson. Photo courtesy of Jack Goldfisher
‘Pop Culture Jeopardy!’ champs knew they had film covered. TV? Not so much.
Jacob Sweet
Harvard Staff Writer
7 min read
How former Harvard classmates binge-watched and buzzed their way to victory
On their first day of preparation for “Pop Culture Jeopardy!,” contestants Jack Goldfisher and Henry Johnson realized they had a problem. Neither of them had watched much television.
The 2018 College graduates had met in the course “Men to Boys: Masculinity in Postwar Hollywood Film,” where many of their classmates had encyclopedic knowledge of both forms. Now the pair were living in Los Angeles, and Goldfisher was sure Johnson — who had co-written a kids’ show for Apple TV — would have the category handled. It turned out they both knew much more about film.
“We thought that each other knew a lot of information because we know a lot of the same information,” Goldfisher said, “which is probably not the way to optimize the team.”
Goldfisher and Johnson hadn’t planned to compete as a duo. When they were selected for the show, they didn’t even know each other very well. Their mutual friend Jack Stovitz, who took the same course under Professor of the Practice in Media and Activism Michael Bronski, had recruited them to a three-person team before the first season of the “Jeopardy!” spinoff. When the show cut team sizes by one for its second season, Stovitz, who had just sold a script to Netflix, bowed out for convenience and left the acquaintances to fend for themselves.
On a large screen in Goldfisher’s apartment, the “AMC B-Listers,” as Goldfisher and Johnson would be known, began to prepare. They took online quizzes on their weak subjects, like anime and country music, while reviewing the results of decades of major award shows.
The goal was not mastery but modest familiarity. They skipped detailed synopses on shows like “The Wire” and practiced identifying the two main characters, the setting, and the theme song. They created several dozen flashcards, many of which just included names of bands and all of their members. Season 2 of “Pop Culture Jeopardy!” was set to stream on Netflix, so they spent extra time reviewing content on that platform, just in case.
On the first day of filming, the two showed up early in the morning at Sony’s Culver City lot not knowing when they might compete in the five episodes recorded that day. When they weren’t called for game one, they waited in the green room with teams who all seemed to know the answer to every question asked by host and 2004 Harvard College graduate Colin Jost.
“Well, everyone here seems to know everything, so we were like, whatever happens, happens.”
Jack Goldfisher
“Well, everyone here seems to know everything,” Goldfisher said, “so we were like, whatever happens, happens.” Their goal was to win one game before losing — “because you inevitably lose,” he added, “which is the worst part about ‘Jeopardy!’”
They felt lucky that their jitters had subsided by the time they were selected for the day’s final taping. When their educated guesses led to a near-sweep of a category about the pop culture podcast “The Breakfast Club,” they realized that aggression would play a big part in their success.
Not knowing everything about television was fine; in “Final Jeopardy!,” each knew half the background knowledge required to identify which ’80s song became a top-selling digital hit decades after its release, thanks to its use in two series finales. (“Don’t Stop Believin’” from “The Sopranos” and “Glee.”)
After the relatively narrow win in the first game, Goldfisher and Johnson dominated the second and third, clinching a spot in the season’s final tournament. They attributed part of their success simply to enjoying the game and not burdening themselves with expectations. “I think Henry and I both love games so much that we’re able to separate the stakes from the game,” Goldfisher said. “We were having fun. I think that’s a big element of it.”
A large part of the fun was becoming closer friends. On their day off before the playoffs, they had to keep their success a secret. “It’s not like a sporting event where the game is airing that night and everyone can see how you do,” Johnson said. “The fact that we had to go through this really condensed boot-camp period where we’re obsessively excited about this thing that no one else knows about is a really fun bonding experience.”
In the semifinals, the pair found themselves in a distant second place after the first round. “I think, looking back, we probably could have prepared better,” Johnson told Jost between rounds. “I was really convinced there’d be a category about Borscht Belt comedians.”
They were kept in the game partly through their dominance of the “Real Housewives Wit and Wisdom” category, about a show they didn’t watch. Entering Final Jeopardy!, they were in second place. The last prompt: “The last to garner nominations in all four major acting categories at the Oscars were both directed by him.” For 30 seconds, the other groups struggled, but Johnson knew the answer cold. Naming “David O. Russell” earned them a spot in the finals. As the camera flashed to them, Goldfisher gave Johnson a kiss on the cheek.
The championship didn’t start so well. After part one of the two-episode final, they fell nearly 30,000 points behind the dominant “One Baddie After Another” team. Before game two, they agreed they’d have to dial up the aggression. Every guess deserved a buzz. Botching a couple of early questions only encouraged them; they’d have to risk making mistakes if they wanted a chance to win.
Tides started to turn when they doubled up their earnings on a Daily Double! question about the actress Awkwafina. Then, right before their second Daily Double, they nailed a question about Balatro, a game their friends had frequently played until 3 a.m. “It felt like an enchanted moment,” Goldfisher said — like a scene from “Slumdog Millionaire.”
Still nearly 20,000 points behind their competitors, they risked everything to double their 21,200 total on the category “Headlining the Festival.”
In 2022 J. Cole had a good time headlining this Tennessee musical festival whose name is Creole slang for “a real good time.”
Goldfisher, focusing on the rapper J. Cole, thought back to the music festival the rapper’s label put on in North Carolina. But that didn’t seem correct.
“It can’t just be Bonnaroo, right?” Johnson whispered to his partner. It felt too obvious. The major festival takes place in Tennessee but didn’t hold an exceptionally close tie to the rapper.
“If we’d had a semi-reasonable alternative to Bonnaroo, we probably would have guessed it,” Johnson said, “but we came up so empty that it was like, ‘We have to say a word.’”
Bonnaroo was right. The two pushed into the lead as the crowd, and even one opposing team, broke into applause.
“I told you anything could happen!” Jost exclaimed.
The duo couldn’t have been disappointed when the category of Final Jeopardy! popped up: 21st-century movies.
Edith Macefield’s refusal to sell her house to developers, who built around it, was said to inspire the makers of this Oscar-winning film.
The two baseball fans plan to use some of the money to attend a Cubs vs. Mariners game together. Goldfisher has already put some of the money toward completing a low-budget feature he co-wrote and directed this February, and Johnson plans to put money toward the scholarship fund of a high-school classmate who died.
Screening newborns for cancer riskBlood samples routinely collected at birth could be used for genetic testing, potentially helping 1,000 children a year, study suggests
Blood samples routinely collected at birth could be used for genetic testing, potentially helping 1,000 children a year, study suggests
Mass General Brigham Communications
5 min read
Genetic testing added to routine newborn screening could identify some babies at increased risk of developing cancer before symptoms appear, new research suggests.
The large population-based study led by researchers at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and Mass General Brigham was published in Nature Communications.
Newborns in the U.S. routinely undergo screening for a group of rare, treatable disorders by applying biochemical tests to a few drops of blood collected from a baby’s heel at about 24 hours after birth. Currently, cancer risk is not included because it would require DNA sequencing. But researchers say it may be possible to use the same blood samples to detect new or inherited mutations that predispose some children to cancer, much as genetic testing can identify adults at high risk for cancers such as breast or colon cancer.
“Genomic newborn screening, the sequencing of DNA extracted from heel-stick samples, provides a platform for identifying children at high risk for early cancer in order to institute vetted surveillance protocols,” said co-senior author Richard B. Parad, Harvard Medical School professor of pediatrics at Brigham and Women’s Hospital and director of the Neonatal Genomic Medicine Program in the Mass General Brigham Department of Pediatrics. “Through the collaboration of newborn screening programs, geneticists, and oncologists, preventive care can be provided to children who would otherwise remain undiagnosed until symptoms of their cancer developed.”
“Genomic newborn screening, the sequencing of DNA extracted from heel-stick samples, provides a platform for identifying children at high risk for early cancer in order to institute vetted surveillance protocols.”
Richard B. Parad
“I take care of families who carry genes associated with increased risks of childhood cancer —they have a predisposition syndrome that ‘runs’ in the family,” said Lisa Diller, HMS professor of pediatrics at Dana-Farber Cancer Institute and Dana-Farber Vice Chair of Pediatric Oncology. “When a new baby is born in that family, we test the child. If that child has the familial mutation, my job is to make sure that if that child develops a tumor, or even a pre-tumor, we catch it early, which may allow for less toxic therapies and better outcomes.”
In the study, Diller — in collaboration with Parad and Arindam Bhattacharjee, HMS assistant professor of pediatrics at Brigham and Women’s and expert in newborn screening at Mass General Brigham — analyzed archived newborn dried blood spots from 1,948 children born in Michigan who later developed a solid tumor or brain tumor by age 8. Using a panel of 11 genes linked to pediatric cancer predisposition syndromes, they found pathogenic or likely pathogenic variants in 132 children, nearly 7 percent of the group. The work is among the first and largest population-based studies to assess the feasibility of detecting cancer risk at birth through DNA sequencing based newborn screening. As a public health intervention, implementing such a program could help identify 1,000 children annually in the U.S. who would benefit from early detection and treatment.
The findings suggest that some children with cancer could be identified at birth with a potentially harmful DNA sequence change in a cancer risk gene. If followed with syndrome-specific surveillance protocols aimed at catching cancers earlier, developing tumors may be easier to treat and treatment is less likely to cause lasting harm. Overall, the researchers estimate that about 1 in 27,000 newborns would develop an early onset cancer that could have been predicted through genomic newborn screening, a frequency in the range of some conditions already included in newborn screening programs.
The strongest signals were seen in cancers already known to have clear inherited risk links. All six children in the study who developed medullary thyroid carcinoma had a germline RET mutation. Forty percent of children with retinoblastoma, the most common eye tumor of childhood, had a germline RB1 mutation. Across several other cancers, including choroid plexus carcinoma, adrenocortical carcinoma, pineoblastoma, and medulloblastoma, 11 to 30 percent of cases had a detectable mutation in one of the genes studied. In 130 of the 132 children with a mutation, the gene was known to be associated with the type of tumor they later developed.
Children with these cancer-predisposing mutations tended to develop cancer much earlier than other children in the study. The median age at diagnosis was 14 months for children with a detected mutation, compared with 32 months for children without one, underscoring how quickly these cancers can appear and how valuable advance warning could be.
Retinoblastoma offers a particularly clear example of how this information might change care. The researchers identified RB1 mutations in 69 children, 68 of whom later developed retinoblastoma. Among children with retinoblastoma, those with an RB1 mutation were diagnosed at a median age of 9 months, compared with 23 months for those without a detected germline RB1 mutation. If these children had been identified at birth, they could have undergone regular eye exams to detect tumors earlier, potentially improving vision outcomes and reducing the need for intensive treatments such as eye removal, chemotherapy, or radiation.
“I have seen this happen,” Diller added. “Finding an early tumor or pre-tumor saves that child from a more difficult-to-treat and sometimes fatal diagnosis.”
These findings provide strong evidence that selected pediatric cancer-risk genes could be valuable additions to expanded newborn screening, particularly when early detection can lead to closer surveillance, earlier diagnosis, and less toxic treatment. The Mass General Brigham team continues to work toward how to implement cancer risk gene DNA sequencing workflow in public health newborn screening in order to channel identified newborns into clinical surveillance protocols at Dana-Farber.
Funding for this study was provided by a “Traditional Bridge Grant” from the Bridge Project, a partnership between the Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology and the Dana-Farber/Harvard Cancer Center. Initial support also came from Harvard Radcliffe Institute programs.
Holding onto your humanity, against the herdA.R.T. kicks off season with ‘Rhinoceros,’ starring Paul Giamatti, Tatiana Maslany, and John Turturro
John Turturro (from left), Diane Paulus, Tatiana Maslany, and Paul Giamatti. Niles Singer/Harvard Staff Photographer
A.R.T. kicks off season with ‘Rhinoceros,’ starring Paul Giamatti, Tatiana Maslany, and John Turturro
It’s Sunday morning, and everything seems normal in the small town — until a peculiar transformation happens: One by one, the townspeople turn into rhinoceroses.
So begins the first production of the American Repertory Theater’s 2026-2027 season, an adaptation based on Derek Prouse’s English translation of the Eugène Ionesco absurdist play “Rhinoceros,” which premiered in 1959. Directed by the Terrie and Bradley Bloom Artistic Director Diane Paulus ’88, “Rhinoceros” features three Emmy Award-winning actors: Paul Giamatti, Tatiana Maslany, and John Turturro. The show opens Friday and runs through Sept. 27.
“It’s a serious play, but there’s something very childlike about it,” said Giamatti, known for his Golden Globe-winning role in “The Holdovers” and HBO’s SAG-winning “Too Big to Fail.” He plays the pompous, bourgeois character Jean, one of the first residents to transform. “The more bizarre and funnier it is, almost the more serious it becomes in a strange way,” he said.
The premise of the play is slightly ridiculous. Yet it allows the audience to explore what it means to be human in a world that values conformity. That theme attracted Turturro, the award-winning actor, writer, and director, because of how applicable it is today, he said. He plays the lead role of Berenger, who must decide whether to follow the crowd or remain true to his values.
“There are certain essential themes in literature or in the world that just recycle,” he noted. In “Rhinoceros,” Turturro sees how the characters become afraid of their differences — so much so they are willing to accept the flawed logic that eventually leads to “barbaric” behaviors. “[What starts as] a small discrepancy between people becomes this big, giant chasm,” he said.
Tony Award-winner Paulus said that when Ionesco wrote the play, he used metaphor to speak to his experience growing up in Romania and witnessing the Iron Guard, seeing the rise of Nazism in France, and then watching the French intellectual left embrace Joseph Stalin. Paulus believes the story will resonate with modern audiences.
“This play allows us space to look at things that are going to feel like they’re ripped out of the headlines, and yet we’re talking about rhinoceroses taking over a little, small town.”
Diane Paulus
“This play allows us space to look at things that are going to feel like they’re ripped out of the headlines, and yet we’re talking about rhinoceroses taking over a little, small town,” she said. “It allows us to hear the play in a timeless way and also allows us to relate to it very personally.”
When Maslany — known for her roles in the television shows “Orphan Black,” “She-Hulk,” and “Maximum Pleasure Guaranteed” — read the play for the first time, she was floored.
“I read it in one sitting and just kind of felt bowled over by it. It really hit me in this incredibly emotional way,” she said. She plays the “confusing and complicated” character Daisy, an office receptionist and Berenger’s romantic interest. “It was really funny and felt like it couldn’t have been more prescient.”
Giamatti said the play raises fundamental questions about humanity amid the rise of social media and artificial intelligence.
“What makes you a human being, what makes you an individual?” Giamatti said. “[Berenger is] the one guy who’s fighting to be an individual, and he’s a wreck. And what makes him human is the fact that he’s a wreck.”
The cast also includes Harriett D. Foy, Peter Francis James, Kristine Nielsen, Alex Ross, and Clay Singer, with Britt Faulkner, David Mason, Amelia Sipkin,and Scott Stangland as understudies. Everyone has worked together to give the historic play new life.
“The way that [Turturro] leads is [by] facilitating what’s beautiful about every performer that’s in the space,” Maslany said. “He sees something, and he’s like, ‘Oh yes! Let’s invite that more into the show. Let’s, in fact, highlight it and make it a thing.’ It’s so infinitely generous.”
“Rhinoceros” is Paulus’s last directing project at the Loeb Drama Center before the A.R.T. moves to its new home in Allston, the Goel Center for Creativity & Performance.
“It’s your dream as a director to be working with actors like this cast, who bring the combination of craft and attention and rigor with utter playfulness and creativity and spontaneity,” she said. “It’s been an incredible collaboration in discovering what this is [and what] will be unique to our production.”
As for the actual mechanics of transforming into a rhinoceros on stage? Well, the cast says you’ll have to see it for yourself.
“You have to buy a ticket,” said Giamatti, who added he has always loved stories about people “unlacing and letting their animal out.” He’s excited to give it a try himself.
“It’s fun, it’s interesting,” he said. “Just as an acting thing, it’s a challenge.”
One answer but with more than one way to get thereJon Star, professor of teaching and learning, finds flexibility is key to helping students master math
One answer but with more than one way to get there
Liz Mineo
Harvard Staff Writer
5 min read
Jon Star, professor of teaching and learning, finds flexibility is key to helping students master math
A series focused on the personal side of Harvard research and teaching.
Finding a calling wasn’t the hard part for Jon Star. That came when he started figuring out the complexities of his chosen profession.
Growing up in Columbus, Georgia, Star worked as a camp counselor and a math tutor, and the jobs sparked something in him. He liked helping kids learn.
His path became clearer years later during a stint as a math teacher at Albuquerque Academy in New Mexico.
Star was tutoring a smart, hardworking student who came from a family where everybody excelled at math, except her. Trying to help this student work through (and sometimes around) roadblocks sparked questions for Star about how math is taught and learned.
“The student ended up being successful in the course, but I’m not sure how much that had to do with me or her hard work,” recalled Star, now the Carl H. Pforzheimer, Jr. Professor of Teaching and Learning. “That experience made me realize that learning math is a complicated process in which the mind of the student and the actions of the teacher have to come together.”
Star, who has studied how children learn math in middle and high school over the past 20 years, says one of the most effective ways to teach math is by helping students figure out how to solve math problems using multiple strategies, rather than a single method.
In a research paper co-authored with researchers from Vanderbilt University on algebra instruction, Star found that math teaching and learning improve when students begin to develop flexibility in problem solving, a concept that involves the knowledge of several strategies and the ability to choose among them on a particular problem.
“There are many ways to solve a math problem,” Star said. “There is never one way.”
In fact, that observation highlights the problem with the way math was — and sometimes still is — taught. By rote.
“Learning to solve problems in multiple ways helps them understand the math, but also to be able to solve unfamiliar problems when they encounter them.”
Jon Star
“We often think that the best way to teach someone how to solve a math problem is to show them one way to do it, including the steps, and then have them practice that one way to do it,” said Star. “What I’m after is not just, ‘Did you get the right answer?’ or ‘Did you follow the steps?’ but it’s so much broader, richer and deeper than that. … Learning to solve problems in multiple ways helps them understand the math, but also to be able to solve unfamiliar problems when they encounter them.”
Math teaching in the U.S. has improved over the years, said Star, but it has yet to translate into students’ math scores, which lag behind pre-pandemic scores as well as those of many peer nations.
According to the latest Nation’s Report Card released in 2024, the average math score for fourth-graders was two points higher than in 2022, but three points lower than the 2019 pre-pandemic score. The 2023 results from the Trends in International Mathematics and Science Study (TIMSS) showed that U.S. fourth-graders’ math scores were better than the international average but worse than those of Singapore, Japan, England, Sweden, and Germany, and several other countries.
Among the factors that can complicate math teaching are emerging technologies — AI in particular — along with dwindling investment in teacher training and mounting shortages of practitioners, said Star. He worries that math teachers may be choosing to teach in ways that are easier for them but may not be the best for students.
“Teachers are facing a difficult choice,” said Star. “The questions are how do we create incentives in the teaching profession that lead teachers to teach in a more ambitious way, and how can we maintain high standards in teacher training so that teachers are trained to teach the way we know through 30 years of work that teachers should be teaching?”
Math teachers should see themselves as discussion guides, not merely lecturers explaining concepts, said Star.
“There’s certainly going to be times when they’re going to teach, but there are other times when they need to stimulate a discussion and mold it into the outcome that they seek and the points they want to make,” he added.
Star should know.
He has been teaching math in a Watertown middle school for seven years using a practice based on his research. And his work there more often informs his teaching at Harvard rather than the other way around, he said.
As a working teacher, Star knows what new teachers need to do to help students deepen their knowledge of mathematics and their appreciation for it.
“In mathematics, we’re not just interested in getting the right answer, but we’re interested in how you get the right answer,” said Star. “Creative, innovative mathematicians have a word for this, which is elegance.”
Star said he enjoys mathematics’ elegance and beauty, but what really keeps him going is teaching math and teaching in general.
He recalled that after graduating from Brown University with a degree in electrical engineering, he received two job offers, one from an engineering company and another from a private high school.
The decision was easy, he said.
“It was a sort of a fork in the road,” said Star. “I could have made three times more money as an engineer, but I ultimately decided to take the teaching job. I never looked back. … It’s not the mathematics that drives me so much, it’s the drive to help children make sense of and understand the mathematics that they are learning in school and to help them experience the very beginnings of the beauty of mathematics.”
Does vitriol make you feel special?Beyond the algorithm, online negativity takes on a life of its own. Here’s why.
Beyond the algorithm, online negativity takes on a life of its own. Here’s why.
Sy Boles
Harvard Staff Writer
6 min read
It doesn’t take a scientist to figure out that social media can trend toward the negative. But it might take one to figure out why.
In a new paper in PNAS, incoming professor of psychology Joshua Conrad Jackson and colleagues show that attention-seeking algorithms aren’t the only driver of online negativity. Another culprit is what psychologists call differentiation, the innate drive to stand out from one’s peers.
“Negative information is just much more diverse than positive information,” Jackson said. For example, he added, “If you’re talking about ‘The Odyssey,’ this new Christopher Nolan film, the top comment in a thread might be ‘I liked it’ — but then what else is there to say? If you want to stand out and say something new, you have to talk about something you disliked about the film.”
Jackson and his colleagues analyzed more than 2 billion comments from 2,150 Reddit communities and found that both threads and communities became more negative over time, and that semantic differentiation drove that trend — that is, negative comments were more semantically unique from what had already been said. They then replicated their observational findings with an experiment that showed that social media users who were primed to be unique posted more negative comments than users who were primed to conform.
We talked to Jackson about takeaways from the paper and potential implications for other forms of media. The interview has been edited for clarity and length.
Gazette: Why did you want to test the idea that differentiation might be contributing to negativity on social media?
Jackson: We started our paper with Godwin’s Law, which is the idea that the longer a conversation continues on social media, the probability of someone being compared to Hitler or Nazis approaches one. Harvard economists actually tested Godwin’s Law, and found that it’s not true.
But I don’t think it was meant to be literally true: I think it was meant to capture this intuition that dialogue on social media is more negative than it needs to be.
Of course, feed-ranking algorithms are a big part of the story: These are the algorithms that pick up on divisive content that gets people’s attention, keeps people engaged, and makes them angry so that they post their own divisive content, creating a vicious cycle and generating ad revenue in the process. This paper was kind of a side quest. We wanted to know if conversations would turn negative even in the absence of those algorithms.
What did you find in your analysis?
We found that the entire website of Reddit has become more negative over time. Moreover, the longer a given community exists, the more negative it becomes — and the longer a comment thread continues, the more negative the thread becomes. This is the first time someone has shown that, so that’s a finding in and of itself.
“Moreover, the longer a given community exists, the more negative it becomes — and the longer a comment thread continues, the more negative the thread becomes.”
But then we wanted to understand whether our hypothesis is correct — that this is happening because of differentiation. If so, you’d expect to see that the longer people comment, they’re more likely to make comments more distinct from the most modal comment. You’d find that the more positive a conversation starts, the more negative it will become — because if the thread starts really positive, the positive comments are all taken at the beginning and you have to go negative. And you’d also expect that the larger a community, the more negative it would get, because the information ecosystem is more crowded. And all that proved to be the case.
Are people consciously choosing to be negative to stand out, or is it more implicit than that?
Some research has shown that it can be a conscious choice, and people do it because that’s what they see get rewarded. We’re adding this idea that it’s not just a conscious choice: There’s a more indirect route that this can happen, and that’s what we get at in our experiment.
We find that when we incentivize people to stand out, people get more negative over time. We didn’t incentivize them to be negative; yet they become more negative as a side effect of trying to say something unique.
So are we doomed to live in a perpetually more negative social media landscape?
One thing we try to stress in the paper is that it’s not like these communities fall off a cliff of toxicity. In that way, I think the stereotype of social media is worse than the reality. In our paper, we limit our analysis to the first 50 comments in a thread. But we did run other analyses of these rare threads that go into the thousands of comments. You start to see this interesting oscillation where now you can stand out by being more positive again.
“You start to see this interesting oscillation where now you can stand out by being more positive again.”
This study pertains only to Reddit posts, but surely Reddit isn’t the only place where this trend is salient.
The shift toward negativity could theoretically creep into any conversation where you need to stay focused on a particular topic, but there is a risk of running out of things to say.
Cable news channels with a 24-hour news cycle are a good candidate, because anchors and correspondents are often covering stories for long periods of time with little new information. Under these conditions, there is a risk that discourse turns more negative because there are just more negative things to say.
In contrast, everyday conversations allow us to change topics frequently and avoid this negativity trap. Trying to differentiate oneself isn’t inherently bad. Decades of research suggest that it is a natural human motive. However, our study shows that this motive can promote negativity when conversation must stay on a single topic.
Finally, unrelatedly, you just joined the Faculty of Arts and Sciences in July. What’s on tap for you in your first semester this fall?
I’m very excited. I’ve been a professor at the business school at the University of Chicago for the past three years, but I’m a cultural psychologist by training, so it’s great to be back in a psychology department.
This fall I’ll be teaching a class called “From Bows to Bots: How Humans Invent Technology and How It Reinvents Us,” which deals with how the mind has kept up with new technological innovations over human history. We’ll ask how humans could create stone tools or bows and arrows that other animals couldn’t. We’ll go all the way through state formation to AI and social media algorithms, asking how the mind was able to generate these new inventions, and how these technologies have in turn reshaped the mind.
What the framers were really thinkingOrigin story of Declaration of Independence involves more than just embrace of Enlightenment ideas, scholars say
Origin story of Declaration of Independence involves more than just embrace of Enlightenment ideas, scholars say
Part of a series of occasional features marking the 250th anniversary of the Declaration of Independence
Celebrations of the 250th anniversary of the Declaration of Independence have called attention once again to the oft-repeated origin tale of how the revolutionary document sprang from Enlightenment ideas — natural rights, the social contract, and separation of powers.
But other parts of the story often get less attention. That is how the founders’ thinking was affected by existing social and political conditions on the ground, as well as their familiarity with the evolution of English constitutional history.
The independence movement really took hold when political leaders grew angry over the imposition of Parliament’s tax laws, such as the 1764 Sugar Act, the 1765 Stamp Act, and the 1767 Townshend Acts that imposed tariffs on British goods. And their efforts to oppose British rule were bolstered by early forms of self-government that had emerged in the American colonies.
“Town meetings and colonial assemblies made the Revolution happen,” said Robert Allison, Ph.D. ’92, a Suffolk University historian who studies early American colonial history. “Parliament declared that it had the power to govern the colonies ‘in all cases whatsoever,’ but each colony already had an elected assembly which made laws for it. And in New England each town had a meeting — at least once a year, but in many cases when any 10 tax-paying adult men signed a warrant for one — that made laws and elected all officials in the town.”
As the movement took shape, the framers of the Declaration were heavily influenced by 17th century political philosophy, specifically John Locke’s ideas of natural rights and government by consent and Montesquieu’s doctrine of separation of powers.
But they had to adapt some those ideas, many of which had never been tried in practice, according to Michael Klarman, Charles Warren Professor of American Legal History at Harvard Law School.
One example is the way they took Locke’s foundational formula of universal natural rights, “life, liberty, and property,” and substituted the right to property with “the pursuit of happiness” in the Declaration of Independence.
The antecedents to the phrase “the pursuit of happiness” can be traced to James Wilson, a signer of the Declaration and the Constitution, said Danielle Allen, James Bryant Conant University Professor.
Wilson is one of the least-known founders, but a recent book, “The Lost Founder: James Wilson and The Forgotten Fight for a People’s Constitution” by journalist Jesse Wegman, sheds more light on his role in the country’s founding, Allen said.
Essentially, Wilson advanced the idea that one of the central purposes of government should be something broader and higher than the preservation of individual property.
“Wilson drew on the Scottish Enlightenment for a common-sense approach to human morality that put happiness at the center, as a concept of human flourishing and well-being.”
Danielle Allen
“Wilson drew on the Scottish Enlightenment for a common-sense approach to human morality that put happiness at the center, as a concept of human flourishing and well-being,” according to political philosopher Allen. “And then John Adams picked up that line of argument and used the vocabulary of happiness to make the case for what kinds of government should be formed throughout the fall of 1775 and the spring of 1776.”
Also by the spring of 1776, the right to property had been connected to a defense of enslavement and had become a contested term, she said. “The Lockean triad was life, liberty, and property. So, life, liberty and the pursuit of happiness was keeping the issue of slavery out of that important preamble.”
As well-educated people, and as British subjects themselves, the founders were well-versed in 17th and early 18th century English history, a turbulent period during which England became a constitutional monarchy, in which the king could no longer act without Parliament’s support.
“This was part of the cultural formation of the people who made the revolution,” said Eric Nelson, Robert M. Beren Professor of Government. “These were people who considered themselves as Englishmen, and they were familiar with the entire tradition of English constitutional history, including the fearsome debates over liberty, sovereignty, monarchy, and property going back at that point nearly 600 years.”
The founders drew upon many Enlightenment intellectuals, including Locke and his influential “Two Treatises of Government” (1690). But Locke was only one of many thinkers who influenced the founders, said Nelson.
“Locke was a major figure within the traditional of political thought and constitutional refection that the founders were familiar with,” said Nelson. “He was a very important source, but it’s wrong to say that it was ‘The John Locke Show.’”
Among other political theorists of the era was James Harrington, who wrote “The Commonwealth of Oceana” (1656) on what makes an ideal republic and what makes a government stable.
Also influential were Algernon Sidney, author of “Discourses Concerning Government” (1698), a critique of royal absolutism and a defense of republicanism and popular government and the natural equality of all men; John Trenchard and Thomas Gordon, who wrote “Cato’s Letters” (1720-1723) on the importance of liberty, government limits, and the rule of law; and David Hume, who penned “A Treatise of Human Nature” (1739-1740) on liberty and checks on powers.
In addition, the 1215 Magna Carta, which set limits on royal power, and the English Bill of Rights of 1689, which limited the powers of the monarchy and established Parliament’s rule over the British Crown, were part of the intellectual origins of the founders’ vision for the new republic.
“The most important intellectual source they had was an understanding of 17th and early 18th century England, when there had been a big fight over the role of Parliament versus the role of the Crown, and they were really versed in that whole political world as though it was yesterday,” said Allison.
Even as the ideas of liberty and self-governance drew popular support to the independence movement in the colonies and abroad, there was considerable disagreement among the founders about the new kind of political system they were building.
“We spend a lot of time in our political culture asking, ‘What did the founders think about X?’” said Nelson, the government professor. “The founders were a very heterogeneous group of people who thought very different things and had very different political and constitutional preferences and ideas. So, the question ‘What did the founders think about X?’ is almost always badly posed.”
The result was a lot of compromise, improvisation, and much experimentation.
For that reason, Klarman, who wrote “The Framers’ Coup: The Making of the United States Constitution,” warns of the dangers of treating the nation’s foundational documents as “divinely inspired” and its framers as “demigods.”
“I think the framers were pretty virtuous, and they were trying to do what was good for the country, but they had interests, just like everybody has interests, and among them was to protect property rights.”
Michael Klarman
“I think the framers were pretty virtuous, and they were trying to do what was good for the country, but they had interests, just like everybody has interests, and among them was to protect property rights,” said Klarman. “But we turn the founders into God-like creatures, who were ultra-virtuous statesmen who had no interests or prejudices, but simply were divining the best form of government.”
It’s an argument that prevents necessary changes in the Constitution, he said, to make institutions more responsive to these modern times and the union more perfect.
“Throughout American history, there has always been this tendency, usually a conservative-leaning tendency, to say, ‘How dare you touch the Constitution? How dare you criticize how the Senate is constructed? How dare you criticize the Electoral College?’ and that we ought to be reluctant to change any of these things because the framers were so extraordinary, so selfless, so divinely inspired … We should decide these questions on their merits, not with a heavy thumb on the scales in favor of what the founding generation believed.”
Celebrating nation’s natural wonders through art on 250th anniversary
Part of a series of occasional features marking the 250th anniversary of the Declaration of Independence.
The U.S. boasts a diverse array of stunning natural landscapes, from the dense Louisiana bayous to the peaks of the Rockies.
“Nature is our commonwealth — our common wealth,” said Horace D. Ballard, Theodore E. Stebbens Jr. Curator of American Art at the Harvard Art Museums.
Early European colonists in the Americas, Ballard explained, sent friends and colleagues plants, seeds, and the bones of mastodons, as evidence of the marvelous landscapes that produced them. Later, in the 1850s and ’60s, Americans with little ability to travel would pay to crowd into tight rooms for a chance to view a single painting of Niagara Falls.
“When it comes to the United States, with all of its thousands of microclimates and ecosystems, it’s dizzying,” Ballard said. “One of the most profound and simple — but not naive — pronouncements we can make and hold onto on the country’s 250th anniversary is this incredible, dizzying diversity we’re all so proud of, and we all benefit from, socially and environmentally. E pluribus unum — out of many, one — defines the way the world has always seen the U.S.”
You can find many examples of artwork documenting the nation’s natural beauty at Harvard Art Museums. Ballard and other experts walk us through a selection below.
The tradition of American landscape painting traces back to the Hudson River School, founded by British-born painter Thomas Cole in the mid-19th century. Troubled by the nation’s rapid industrialization, Cole and his pupils portrayed America as a “wild, sparsely inhabited Eden, which it was not,” Ballard said.
Frederic Edwin Church (1826-1990) was one of Cole’s star pupils. Church bought a hillside farm in New York State, which he named Olana, across the Hudson River from his old mentor’s home. In the last years of his life, struggling with painful arthritis, Church completed a sequence of small landscape paintings of the views from Olana.
“This is Frederic Church at his most abstract and expressive; this is him at his most nostalgic,” Ballard said. “I think he’s contemplating the fulfillment and joy of being completely unified with the natural world, but also what it means to grow older. A sunset gives him the space to be fully alive to his humanity.”
Around the turn of the 20th century, New York State’s Adirondack region saw an influx of urbanites — wealthy New Yorkers with summer homes as well as lower-income and immigrant communities — looking to reconnect with nature.
A prodigious painter of maritime scenes, war dispatches, and landscapes, Winslow Homer (1836-1910) often turned to nature to evoke nostalgia for a simpler, less politicized ideal of America. His 1892 painting, “Hunter in the Adirondacks,” shows a lone figure carrying a shotgun and some sort of animal or pelt, in the moment of stepping over a fallen tree.
“It’s a sweet moment, an everyday moment of profundity for both the subject and the viewer, as the senses of touch, smell, and sight are activated,” Ballard said.
Ships have a long legacy in painting as metaphors for the freedom of the individual and the nation, Ballard said.
“For those of us in New England, we know that kind of vessel,” he went on about the painting from Winslow Homer’s period in Gloucester, Massachusetts. “There’s commerce here, as well as joy. There’s a sense of craft here, a sense of home.”
An artist with U.S. government survey expeditions, Albert Bierstadt (1830-1902) painted “Lander’s Peak” not based on any specific location but as a composite of various views in the Rocky Mountains. Though Bierstadt met with and sketched Shoshone tribe members during his travels, he omitted them from the landscape.
“There will always be a question of what exactly he was looking at, what he did not paint, what he did paint that wasn’t there,” Ballard said.
Photography was invented in the early 19th century, after the Revolutionary War and on the eve of the Civil War — a time of claiming land through westward expansion as well as an effort to learn the land. Many early American landscape photographs were made on behalf of railroad companies as they cleared the way for tracks across the continent.
“The camera, paired with this moment of study and discovery and claiming, all wrapped into the aesthetics of the raw landscape discovered in its pristineness — quite ironically, it was the beginning of the land being claimed for this American project that would become great development and great ecological devastation,” said Audrey Sands, Richard L. Menschel Associate Curator of Photography at the Harvard Art Museums.
John Hillers (1843-1925) was a photographer for U.S. government survey efforts at a time when, to most people living on the East Coast, the American West was seen as an unmapped and dangerous place.
Though his photos were taken to help the government better understand the land, they were often reprinted for purchase by ordinary Americans. “These images were revelations for many people living on the East Coast or in the eastern half of the United States,” said Sands.
Photographer Carleton Emmons Watkins (1829-1916) was commissioned by the Pacific Improvement Company, a real estate division of a railroad company, to promote the luxury resort complex the Hotel Del Monte.
He captured a series of images along California’s now-famous 17-mile drive along the Monterey coast. The project was a part of the creation of the idea of California, Sands said, as a place of “a different kind of raw nature.”
This photo is part of Andrea Modica’s book “Real Indians: Portraits of Contemporary Native Americans and America’s Tribal Colleges.”
Named in response to Christopher Columbus’ belief that he had found a sea route to India and encountered “real Indians,” the book sought to highlight the true diversity of America’s Native peoples, Sands said.
Vernell Lane was a site coordinator for the Lummi Cedar Project, a community group that helped reintroduce the sport of canoe-pulling to Native young people.
Untitled (a native hunter from Point Hope, Chukchi Sea, Alaska)
Gordon W. Gahan, 1971
National Geographic photographer Gordon Gahan (1945-1984), an outsider to the region and to Inuit culture, captured this image of a native hunter in Alaska.
“The photo really makes you think about the lengths different peoples have had to go to preserve certain practices,” Sands said.
Decades after the photo was taken, “It’s hard not to see these icy formations and think about climate change, and how little may be left in another 30 or 50 years of what was already a rare and special cultural phenomenon,” she added.
For 90 years, the Mante Sano Bayou outside Baton Rouge was used as a dumping site for the petrochemical industry, says Pulitzer Prize-winning photographer Stacy Kranitz.
And yet, something of the ecosystem’s beauty and resilience remains. In her series “Fulcrum of Malice,” Kranitz invites us to shift from passive appreciation to active reckoning with our own way of life.
“The photograph’s composition relies on an act of exclusion,” said Kranitz, who is also a 2026-2027 fellow at the Nieman Foundation for Journalism at Harvard University. “By omitting that the stream is wedged between an ExxonMobil chemical plant and a Copolymer Rubber facility, the framing offers a deceptive pastoral pleasure.”
For women in menopause, ‘not all healthy diets are equal’
Study comparing 11 eating patterns finds two clear paths to curbing weight gain
Alvin Powell
Harvard Staff Writer
4 min read
A recent study examining how 11 different diets affect weight gain and obesity during menopause found that two — the Planetary Health Diet and a diet that supports healthy insulin metabolism — are best for weight management.
The research, published in the journal JAMA Network Open, seeks to fill a gap in studies of diet and weight gain involving women around the age of menopause, during which weight gain is common. The researchers, led by Tong Xia, a postdoctoral fellow in epidemiology and nutrition at the Harvard T.H. Chan School of Public Health and the Channing Division of Network Medicine at Harvard Medical School and Brigham and Women’s Hospital, examined the diets of 38,283 women who participated in the Nurses’ Health Study II, a long-running study of the lifestyle habits of registered nurses who were between the ages of 25 and 42 in 1989. As part of the study, the nurses filled out detailed dietary questionnaires every four years. Researchers examined dietary and weight records during the six years before and after menopause.
“Weight gain during menopause is common, but until now we didn’t know which specific diet actually helps most,” Xia said. “Our study is the first to directly compare 11 major dietary patterns, plus ultra-processed food intake, in the same group of women around menopause. What we found is that not all healthy diets are equal — a low-insulinemic diet and the Planetary Health Diet stood out as most effective for managing weight during this transition, giving women and their doctors concrete, evidence-based guidance for a stage of life when few such answers have existed.”
“Weight gain during menopause is common, but until now we didn’t know which specific diet actually helps most.”
Tong Xia
Researchers found that the Planetary Health and low-insulinemic diets were associated with the lowest weight gain and with the lowest risk of obesity. The Planetary Health Diet was developed by the EAT-Lancet Commission in recent years and has been shown to be both healthy and have environmental impacts that are lower than other diets.
“These two dietary patterns are low in red and processed meats, potatoes, french fries, sodium, and high in nuts, fruits, vegetables, whole grains,” Xia said.
Though the diets can be broadly categorized as either healthy or unhealthy, according to nutritional studies in recent years, the researchers said the dietary details matter so even diets with ample evidence for their health-promoting characteristics, such as the Mediterranean diet and Dietary Approaches to Stop Hypertension, also known as the DASH diet, are distinct because they include different proportions of healthful foods.
The study, supported by the National Institutes of Health and the Julie Wilcox Women’s Health and Nutrition Novel Research Fund, included the Planetary Health Diet, the Mediterranean Diet, and the DASH diet, as well as healthy and unhealthy plant-based diets, those high in ultra-processed foods, those known to promote insulin resistance and inflammation, and healthy and unhealthy low carbohydrate diets — which are often chosen by people looking to lose weight.
A surprise in the study, Xia said, is that one of the unhealthy diets, the unhealthy plant diet —which emphasizes less-healthy plant foods such as french fries — had a slight association with weight loss. That warrants further investigation and the explanation should be interpreted cautiously, Xia said, but is likely because it is low in protein at a time of life — menopause — associated with a loss of muscle, which is a dense tissue.
“Women already lose more muscle, and the low protein intake may make this process quicker,” Xia said.
Xia said she became interested in diet and menopause during her doctoral work on pregnancy, when she noticed how little work was being done about the time when fertility declines. A potential next step, she said, would be a trial where women entering menopause get a dietary intervention to see if it helps weight management and promotes longer term health.
Total keto or veganism? Daniel Lieberman considers how humans evolved to eat.Excerpt from evolutionary biologist’s new book ‘Fed Up’
While still a student at the University of Bristol in the mid-1990s, the future pop star James Blunt decided to eat nothing but minced beef, chicken, and mayonnaise. By his own admission, he thought the diet would assert his masculinity. It didn’t go well. According to Mr. Blunt, “It took me about six to eight weeks to get very unhealthy and see a doctor, who then said, ‘I think you’ve got the symptoms of scurvy.’” Thankfully, eating plants with vitamin C was a quick remedy, but Blunt’s troubles are just one of many potential problems caused by never eating plants. And in this respect, by experimenting on themselves, hardcore carnivore dieters are doing a favor to others who have no intention of following their example.
The first health problem carnivore dieters (keto dieters, too) usually encounter is a condition called a keto flu — so named because suddenly flooding the body with ketone bodies can cause flu-like symptoms. These include headache, nausea, constipation or diarrhea (take your pick), cramps, fatigue, irritability, and brain fog. But as your body slowly adapts, these symptoms usually resolve in a few weeks, especially if one drinks plenty of water and eats enough salt.
A more serious suite of problems from never eating plants arises from lacking certain nutrients. To be sure, meat has all the amino acids one needs, plus fat, a smidgeon of carbohydrate (in the form of glycogen), and some minerals and vitamins. But the most glaring thing missing from meat is fiber. As a reminder, fiber helps you feel full, regulates how fast and efficiently your gut absorbs nutrients, prevents constipation, and absorbs toxins. Why would anyone not want those benefits? Fiber’s other critical role is to nourish the microbiome. We evolved to have trillions of microbes coexist in our gut, especially the colon, which survive and thrive by fermenting the undigested fiber in our food. In turn, we evolved to use the various by-products of that fermentation including vitamins (B and K) and short-chain fatty acids (SCFAs). Believe me, you want these fiber-derived SCFAs. They provide you with energy. They stimulate the production of vital neurotransmitters like dopamine and serotonin that keep you happy. They induce the production of hormones (like GLP-1) that control your appetite. They help keep the lining of your gut from being “leaky,” thereby preventing inflammation. Although no one has studied the effect of a carnivore diet on the microbiome, studies show that a fiber-depleted ketogenic diet drastically alters the microbiome, substantially reducing the abundance of many beneficial microbes. Altogether, diets rich in fiber help prevent obesity, metabolic diseases, cancer, inflammatory conditions, and other illnesses.
It’s not just fiber. Also missing from meat are those wonderful, medicinal phytochemicals that plants produce. While carnivore diet alarmists worry that these diverse compounds are toxins, many are antioxidants that neutralize harmful reactive molecules; others reduce inflammation, protect cells from cancer, support the immune system, help regulate blood sugar, and more. To be sure, a fraction of phytochemicals can inhibit nutrient absorption, but cooking and other methods of food processing neutralize almost all these chemicals or reduce them to harmless doses.
Yet another concern with eating only meat is saturated fat. It is true that saturated fat may not be as harmful as previously believed, but it’s generally healthier to replace saturated fat with unsaturated fats. For this reason, serious carnivore dieters try to eat only grass-fed meat and game, which has a lower percentage of saturated fat and more mono- and polyunsaturated fats than industrial grain-fed meat. Game and grass-fed meat, however, are expensive.
A final and nontrivial health concern is that red meat can increase chronic, systemic inflammation. One contributor to this problem is a protein-sugar compound with the unpronounceable name of Neu5Gc, which is abundant in all red meat. Between three and two million years ago, a mutation arose that caused humans to lose the ability to make this compound, possibly to protect us from malaria and to enhance our endurance capacities (if you knock out this gene in mice they can run twice as far). However, because we do not make Neu5Gc, our immune systems think red meat is a foreign invader. That response triggers an inflammatory reaction associated with increased rates of cancer, atherosclerosis, and some autoimmune diseases. A similarly unwelcome protein in red meat is carnitine, which induces gut microbes to produce a nasty molecule called TMAO (trimethylamine-N-oxide). Regrettably, TMAO promotes inflammation linked to atherosclerosis and other diseases like cancer.
All things considered, the evidence is overwhelming. Meat is nutritious and played a pivotal role in our evolutionary history, but our ancestors were selected to eat meat, among other foods, to benefit their reproductive success, not to prolong their long-term health. Plenty of statistics testify to that legacy. For example, two prospective studies that followed more than 37,000 men and 83,000 women for 22 years found eating one serving (84 grams) of red meat a day increased the risk of dying by 13 percent, and eating processed meats like salami increased the risk to 20 percent. Eating two servings a day of meat increases the approximate mortality risk to 35 to 50 percent. Other studies report similar results.
For these and other reasons, many people conclude they are better off eating less meat or no meat. How does that go?
Today vegetarianism and veganism are widely associated with health, but such diets were impossible prior to the invention of agriculture, and meat-free diets have long raised nutritional concerns. One issue is protein. While meat provides a complete, dense dose of protein, including all the essential amino acids, vegetarians must eat animal products like eggs or combine different plant types to avoid protein deficiencies. Vegans must be even more careful. Fortunately, every farming culture has created effective combinations of cereals and legumes plus other plant foods to satisfy people’s protein needs. Classic examples are corn with beans, rice with soy, and lentils or chickpeas with cereals like wheat. Although many traditional cuisines combine these foods in the same meal, one gets the same benefit by eating them in the same day. Studies confirm what any vegetarian knows: eating enough of these foods in combination can provide sufficient protein even for world-class athletes. A two-cup bowl of rice and beans has as much protein as a four-ounce hamburger.
We can cross protein worries off the list of reasons not to be a vegetarian, but it is true that some nutrients are absent or rare in most plants and thus harder to replace in a meat-free diet. Vegetarians thus need to be strategic about the foods they eat, and vegans require nutritional supplements. Here’s a quick review:
Omega-3 fatty acids. Not consuming 1.0 to 1.5 grams per day of these essential fatty acids (which our bodies can’t synthesize) can trigger health problems, including depression and dementia, joint pain, dry skin, and hair loss. Children also require plentiful omega-3s for proper brain growth. One complexity vegetarians should know is that we use three different kinds of omega-3s: EPA, DHA, and ALA.
EPA is eicosapentaenoic acid, DHA is docosahexaenoic acid, and ALA is alpha-linolenic acid. Of these, EPA and DHA are plentiful in fish, and to a lesser extent in grass-fed animals, but not plants; ALA, however, is reasonably abundant in a few plants, namely walnuts, flax, and chia seeds, and less so soy. Unfortunately, humans are capable of converting only a small proportion of ALA into much-needed EPA and DHA. For this reason, many vegetarians take omega-3 supplements from algae (which, strictly speaking, are not plants); other near-vegetarians choose to be pescatarians by eating fish and shellfish, which are rich in all omega-3s.
Vitamin B12. This vitamin is critical for the nervous system, producing red blood cells, synthesizing DNA, and other vital functions. Although abundant in meat and dairy, it is absent in plants, which means that vegans must either eat foods fortified with B12 or take supplements.
Vitamin D. This vitamin helps the gut absorb calcium to maintain the immune system, the brain, the circulatory system, and elsewhere. Cells in the skin normally synthesize vitamin D in response to sunlight except at high and low latitudes during the winter months, when food becomes the major source. While red meat and unfortified milk contain very little vitamin D, fatty fish is the richest source, and eggs have some. How much vitamin D one needs is debated, but vegans, most vegetarians, and even omnivores in temperate habitats far from the equator are often advised to supplement in the winter.
Iron. To produce enough red blood cells, adults generally need 10 to 20 milligrams of iron a day, and pregnant or menstruating women require even more. While red meat has moderate amounts of iron, there is more iron per gram in legumes like lentils and soy and in a few vegetables like spinach. However, effective absorption of iron from most plants occurs only when consumed with some vitamin C. This may explain why many traditional cuisines add vinegar, lemon, or other sources of vitamin C such as tomatoes or peppers to these foods.
Calcium. Most people need at least a gram of calcium a day for bones, muscles, nerve cells, and numerous physiological functions. Red meat is not a major source of calcium, but it’s reasonably plentiful in milk, yogurt, and cheese. Vegetarians and vegans can get calcium from soy and leafy green vegetables like kale, as well as certain nuts.
Iodine. This mineral is essential for synthesizing thyroid hormone, which regulates your metabolism. Not enough can cause severe developmental problems in children and goiter in adults. Apart from being plentiful in seaweed and seafood, iodine can be found in potato skins (depending on the soil in which they were grown) and egg yolks. Fortunately, iodized salt is an effective way to eliminate iodine deficiency.
Selenium. Your body requires trace amounts of this mineral. While present in meat and dairy, it’s also reasonably abundant in most whole grains (wheat, rice, oats, barley). Nothing beats Brazil nuts as a source of this mineral. But beware: too much selenium is toxic.
Zinc. You need trace amounts of this mineral for the immune system and other cellular functions. It’s abundant and readily absorbed from meat, but also present in some legumes, seeds, and nuts.
The bottom line is that we evolved to include animal foods in our diet, which explains why it’s much easier to consume a nutritionally complete diet if you eat dairy and some meat, including fish. But with information, experience, and resources, 100 percent plant diets can be nutritionally complete. But is being a vegetarian and vegan healthier than being an omnivore?
Four major reviews of research studies have been published in the last few years on associations between vegetarian and vegan versus non-vegetarian diets and cardiovascular disease, cancer, and other health outcomes. All told, these highly respected analyses incorporate data from scores of studies involving millions of people. The big-picture conclusion they paint is fascinating and nuanced, with both good and bad news for vegetarians and vegans.
The bad news is that plant-based diets are associated with some increased health risks, more so in vegans than vegetarians. These health risks, moreover, make sense in light of the nutritional challenges of never eating meat and, in the case of vegans, also dairy. The most prevalent problems stem from vitamin B12 deficiencies. Without enough of this vitamin, which is abundant in meat and dairy but virtually absent in plants, you are more likely to suffer from anemia, hence fatigue. Compounding the risk of anemia are low levels of dietary iron and reduced iron absorption from plant foods. Vitamin B12 is also necessary to maintain nerve cells, which may explain the evidence for slightly increased levels of depression and other mood disorders in vegans and to a lesser extent vegetarians. And there is conflicting evidence that low B12 levels could increase the risk of strokes. A potential mechanism for this debated concern is that low B12 (along with B6 and folic acid) elevates levels of the amino acid homocysteine, which is associated with increased risks of not just stroke, but also other conditions like osteoporosis. Sure enough, vegetarians and vegans especially tend to have slightly (4 to 6 percent) lower bone-mineral densities, perhaps also from less vitamin D and calcium absorption.
Balancing out the bad news, however, is some good news for people who eat only plants. Study after study finds that, compared to omnivores, vegetarians and vegans tend to have lower blood pressure, a reduced risk of heart attacks, a decreased risk of Type 2 diabetes, and a lessened risk of some cancers. Since cardiovascular disease and cancer are the two leading causes of death, it’s no surprise that many—but not all — studies report that individuals who are vegetarian, vegan, or who otherwise eat a mostly plant-based diet have a moderately lower relative risk of all-cause mortality than those who eat lots of meat. It’s unwise, however, to put a concrete number on this reduction in risk because these broad-brush statistics mask considerable variation. In addition, despite the best efforts of researchers to control for the effects of factors other than diet, vegetarianism may seem healthier than it is simply because vegetarians typically live healthier lifestyles. Even so, studies that analyze the available evidence agree that plant-based diets are generally associated with modest reductions in disease and modest increases in lifespan. From a mechanistic perspective, that’s not unexpected, since vegetarians and vegans are less likely to be obese, and they tend to have lower levels of inflammation and lipoproteins that cause arterial plaques.
Historically, vegetarianism’s salubrious reputation is relatively new — at least in the West. As the vegetarian movement in Europe and America grew in the mid-19th century, most doctors opined that eating only plants was unhealthy and uncivilized. One fierce critic of vegetarianism wrote in 1914, “It may be stated that vegetarianism is the diet of the enslaved, stagnant, and conquered races, and a diet rich in meat is that of the progressive, the dominant, and the conquering strains.” Early health concerns about vegetarianism also had some merit before the development of nutritional science and the modern food system. Vegetarians today have information about vitamins and essential fatty acids, and they enjoy year-round access to a stunning diversity of nutritious foods from all over the world, along with algae supplements and other sources of needed vitamins and minerals. Yet vegetarians and vegans are still sometimes the subject of scorn. The late chef, author, and TV star Anthony Bourdain once wrote in The New Yorker that vegetarians are “enemies of everything that’s good and decent in the human spirit. To live life without veal or chicken stock, fish cheeks, sausages, cheese, or organ meats is treasonous.”
Well, it’s true Hitler was a vegetarian. But according to the evidence, it’s also true that being a vegetarian is as healthy if not healthier than being an omnivore. When asked what his doctors thought about his vegetarian diet, George Bernard Shaw is reputed to have replied, “I don’t know, I’ve outlived them all.”
Yet not eating meat is no panacea. Vegetarians also have heart attacks, get cancer, and develop metabolic syndrome and other diseases. In addition, because we evolved to include meat in our diet, our bodies run better with a few nutrients present mostly or only in animal foods. Vegetarians and vegans thus need to be knowledgeable about and then compensate for their diet’s deficiencies. And just because one’s diet is plant-based doesn’t mean it’s healthy. A study of over 126,000 people in the United Kingdom found that every 10 percent increase in plant-sourced foods that were not highly processed was associated with a 13 percent lower risk of dying from heart disease, but every 10 percent increase in ultra-processed plant foods was associated with a 12 percent higher risk of dying from heart disease.
Or as Michael Pollan famously concluded, “Eat food. Not too much. Mostly plants.”
When AI goes rogueComputer security expert says recent OpenAI, Anthropic breaches highlight need for regulations that balance safety, speed of development
James Mickens. Stephanie Mitchell/Harvard Staff Photographer
Christina Pazzanese
Harvard Staff Writer
9 min read
Computer security expert says recent OpenAI, Anthropic breaches highlight need for regulations that balance safety, speed of development
It has become a science fiction trope come to life.
Tech giants OpenAI and Anthropic disclosed in July that versions of their AI models broke through safeguards known as a “sandbox, gained access to the internet, and hacked servers of outside companies during internal tests of their cybersecurity capabilities.
This week, AI Security Institute, a U.K. government research entity reported additional incidents, saying AI agents created fake online personas in order to improperly access real people and companies during security tests it conducted on the two tech firms.
OpenAI CEO Sam Altman characterized the July breach as an “unprecedented” and “significant security incident” caused by rogue AI agents. Its investigation has since uncovered evidence of additional breakouts. Anthropic blamed human error involving an evaluation partner.
In this edited conversation, James Mickens, Gordon McKay Professor of Computer Science at SEAS and director of the Berkman Klein Center at Harvard, explains what these breaches mean for the future of AI security.
Gazette: How plausible are the explanations offered by OpenAI and Anthropic?
James Mickens: It’s hard to say. I think it is very commendable that both OpenAI and Anthropic decided to release public incident reports about what happened. They could have very easily kept this to themselves and not let people know that these models have these autonomous abilities to get past these sandboxes.
However, because the public doesn’t really know the details of what happened, it’s hard to fully verify the timeline and the narrative.
The explanations put out by OpenAI and Anthropic are certainly plausible. Those public-facing stories are certainly what could have happened. Is that literally what happened? Was there anything left out? We don’t know.
We do know both companies have talked to third-party security companies to validate stuff. But we don’t really know what’s going on.
And this points to one of the tensions with this dangerous technology. One can understand why OpenAI might not want to say, “Here’s a detailed description of our sandboxing environment.”
But on the other hand, there’s this very well-known security principle, which is that sunlight disinfects. The more eyes you have on something, the more brains you have to try to find problems.
Two of the biggest players in AI report similar incidents within weeks of each other. Is that troubling?
Yes, it’s quite concerning. I would also say these are not threats that the security community and the AI safety community are just realizing were possible.
Here at Harvard, we’ve been saying for a long time that security researchers need to be thinking more critically about strengthening sandbox mechanisms and making it more difficult for models to break out of them. Last year, my research group published a paper specifically about how to create new types of software and hardware to make sandbox escapes more difficult.
Even as recently as last year, there were some people saying, “You’re guarding against a sci-fi eventuality. You’re worried about things that really are not top of mind for people using these AI systems in the real world.”
Yes, there are frontline risks that are harmful and relatively mundane, but then there are other risks that are exceptionally pernicious and quite alarming in terms of how quickly they can affect huge numbers of people in society.
For example, what would happen if one of these models tried to break into the power grid or tried to tamper with financial systems to affect the stock market? These are very real concerns.
I think with what we’ve seen over the past week or so, we should be worried about this problem more generally.
“These models are very difficult to understand.”
These models are very difficult to understand. There’s a whole field of AI interpretability, which seeks to understand why models do the things that they do. They’ve made some progress, but it’s still an open challenge to guarantee that a model will always act in ways that are aligned with human preferences.
So yes, these incidents are quite concerning.
Is that a concern about the technology or about the people overseeing the technology and their priorities?
Both. First and foremost, there are technical challenges in defining what alignment means, determining whether models are acting in aligned ways, and then enforcing human-defined alignment policies when models misbehave.
Those challenges are technical inasmuch as they require us to build new software and new hardware to enforce alignment policies.
However, there are also social problems of governance. Who are the humans who decide what misalignment and alignment mean? Are they mostly people who live in the U.S.? Who work for U.S. companies? Are they people who live in China, or in India, or in Brazil? Are these questions that should be answered by companies or should governments be doing this? And how do we ensure international coherence of approaches toward these things?
So, there are some very thorny technical and socio-technical issues here that are intrinsically difficult to solve and that require thoughtful responses that are at odds with the breakneck speed that companies want to move at.
Do these incidents suggest that AI models have now moved beyond human control?
I would say these incidents demonstrate that even frontier lab companies cannot guarantee model alignment in all scenarios. We’ve actually known for some time that defining aligned behavior is difficult, enforcing aligned behavior is difficult, and that models are already sufficiently complicated and sophisticated to press us on those two issues.
“We have safety problems now. We can’t wait to think about this.”
In other words, AI safety risks are not a theoretical problem. They haven’t been for quite some time. And it’s naive for people to think that we can afford to not think about safety risks because we want these AIs to solve cancer or things like this. We have safety problems now. We can’t wait to think about this.
Given the winner-take-all stakes in AI, could such unflattering disclosures be a kind of humblebrag by OpenAI and Anthropic to show how cutting-edge their AI models are?
Yes, it’s certainly possible.
This is why a lot of security researchers, a healthy minority, take all of these releases with a grain of salt because first of all, the public has no way of knowing whether these types of incidents have happened 100 times this year. And we’re just hearing about the recent ones now because why?
Could it be that all the companies want to race toward Artificial General Intelligence [AI capability that matches or exceeds human-level skills] and claim the AGI mantle first? AGI is less a crisply defined technical achievement and more of a “we’ve decided that we have it and now we’re going to claim it.”
And so, cynics in the security community are saying, “We bet that sandbox escapes have happened before. You just didn’t tell us. The reason you’re telling us about these sandbox escapes now is you’re trying to pave the way for this declaration of AGI unilaterally, and you’ll be able to point to this press release and say, ‘See? That was the first glimmering of our model which has AGI.’”
There’s a lot of stuff these companies put out that technical folks and policy folks don’t take fully at face value.
Is it too late to impose regulations on AI to try to prevent this from happening again?
It’s not too late to impose regulations.
Getting the right regulations in place will be tricky because this is a socio-technical problem that requires both robust technical mechanisms for sandboxing models and societal consensus on what the trade-off should be between speed of AI development and reining in potential harmful behaviors from these models. We don’t have that second part either.
Different reasonable people will have different ideas of how we should be striking those trade-offs. The important thing, though, is that we at least have to have the conversation seriously. That’s, I think, the big thing.
What types of interventions might be most effective?
There’s been a variety of mechanisms, technical, legal, and otherwise, that have been proposed for making models safer.
I think a key challenge, though, is how do we ensure that the model vendors are actually using these mechanisms? How do we get more insight into what happens when something goes wrong? How do we understand who should be held accountable for these things?
It’s important for us to not be unnecessarily restrictive. We do want to allow these companies to engage in cutting-edge research. But, at this point, the risks are getting so large and so unavoidable that it would be irresponsible for us as a society to not think about how to reckon with these things.
It’s not as if we have no levers that we can push to try to make safety better. There are a lot of people who are thinking about how do we interpret what models are doing, how do we steer them to act in ways that are more societally aligned, and so on.
There are also regulators and people in government thinking about this too, so it’s not as if there aren’t people who care about AI safety risks.
Hopefully, this past week can be a fulcrum moment where we have a series of incidents that are so clear in terms of their implication that society will have to organize around this and try to think critically about AI safety.
A bond stronger than bloodTayari Jones digs into themes of latest novel, ‘Kin’: ‘We all need chosen family.’
Tayari Jones digs into themes of latest novel, ‘Kin’: ‘We all need chosen family.’
Anna Lamb
Harvard Staff Writer
3 min read
Tayari Jones.
Kin, by definition, are the people with whom we share a common ancestor. Author Tayari Jones takes it a step further, defining kin as the family we inherit from our mothers — either through birth or circumstance.
“It’s about matrilinearity,” said Jones, whose latest novel, “Kin,” was published in February. She calls the work “a novel about the things we inherit and carry through the women in our biological families, but also the women in our lives.”
Jones, a 2012 Radcliffe fellow, discussed the book and its characters in a recent Virtual Radcliffe Book Talk.
“I think that we know one another to the extent to which we allow ourselves to be known.”
“Kin” follows lifelong friends Annie and Vernice, Black girls growing up motherless in Jim Crow Louisiana. Vernice’s mother was killed by her father while she was an infant; Annie’s mother abandons her for life outside of their tiny town of Honeysuckle. Despite growing up extremely close, the pair take different paths in life before ultimately coming back together.
Their bond, Jones said, exemplifies how our most important familial ties are not always those born of blood.
“So often when we talk about curated family or chosen family, we say that people choose family when their biological family isn’t there, but I think that puts chosen family in a second-place position, almost like a contingency plan,” Jones said. “I believe we all need chosen family.”
Annie seeks to find her mother while Vernice pursues college and marriage. They both face racism and classism while navigating romantic relationships and other life experiences. There are moments of deep connectedness, and of withholding from each other as they grow and change.
For instance, Vernice is conflicted when a same-sex relationship challenges her ideas of the future. Unlike Annie, who openly shares her first love with her best friend, Vernice holds off on sharing this aspect of her life with her closest confidante.
The story, said Jones, is partially about how we let others in — or hesitate to do so.
“I think that we know one another to the extent to which we allow ourselves to be known,” she said. “I think that’s one of the fundamental questions of this story: Every secret you hold is a withholding of intimacy, and every secret disclosed creates intimacy.”
Despite the sometimes-heartbreaking ups and downs in the women’s lives, Jones said “Kin” is also full of humor — just like life.
“There is this expectation that the gravitas of Black life necessarily involves just unrelenting misery,” she said. “And while I think a lot of sad things happen … there were a number of times when these people tickled me, and I laughed out loud.”
As for the process of writing “Kin,” her fifth novel, Jones said she knew it was done when she had answered all the questions its characters’ dynamics raised.
“I feel like I satisfied my curiosity in writing this book, and I think this is a novel ultimately about, can you have dignity and shame at the same time?” she said. “I came to understand that what is most important in your life is that you have dignity, and that is what I think the book is about: motherhood, friendship, but ultimately it’s about dignity.”
Why we need to break the grip of ‘oldigarchy’Legal historian’s new book argues older Americans control power, wealth — and lack sense of urgency to fix nation’s most pressing problems
Excerpted from “Gerontocracy in America: How the Old Are Hoarding Power and Wealth ― and What to Do About It” by Samuel Moyn, J.D. ’01, and published by Farrar, Straus and Giroux
For two centuries, “Democracy in America,” published by the Frenchman Alexis de Tocqueville starting in 1835, has been the most famous book about the United States. It deserves to stay that way. But it might need an update.
There have always been older people. A psalm of the Bible says that, unless they die early for some reason, human beings get 70 years — 80 if they’re lucky. Genesis mentions generations of superagers at the start of humanity — like Adam, Noah, and Methuselah, the latter of whom celebrated his 969th birthday. And elders have long been accorded preferences and priorities. Whenever seniority is used to allocate positions or resources, an impulse toward gerontocracy — the empowerment of the old — is at work. Another biblical passage, this one from Proverbs, holds that “gray hair is a crown of glory.” The “preference for age and seniority,” one historian has remarked, has been “shared by all those corporate institutions which set a value on hierarchy, stability, and continuity.”
But there is something new that has supercharged elder power. Starting in Tocqueville’s 19th century, a “great aging” took place as average life expectancies increased, thanks to the reduction of childhood mortality and eventually adult disease. Today, a new crop of Methuselahs is living beyond 110 or even 120, in the case of Frenchwoman Jeanne Calment, who died in 1997 at 122, the oldest age on record. But the real change is not that more people live to 100 but that so many reach 80 or 90, even as fewer are born. The political effects of a citizenry with a higher median age have been mounting.
At the dawn of modernity, Tocqueville commented that a new political science was needed for a new age; in the 21st century, an even newer political science is needed for the new aging.
The virtue of life extension, obviously, is that life is generally preferable to death — especially if the debilitating effects of age are also driven into the future. I remember my father, as he progressed toward the unavoidable, often counseling me never to get old; one of my mother’s nuggets of wisdom, as she has lived past 80, is that the alternative to aging is even worse. “Death, no matter how inevitable, is an abrupt cancellation of indefinitely extensive possible goods,” the philosopher Thomas Nagel writes, adding that death is no less tragic for those lucky enough to live long rather than short lives.
But there are vices to a culture of extended life — and one of the biggest is political, in the broadest sense. An aging society is more set on preservation than on renovation. And then there’s the unfairness involved in blocking the young and hoarding their inheritance while mandating them to care for the old and requiring them to serve a government helmed by their elders.
Americans definitely worry today that our democracy is at risk — that new forms of oligarchy are a frightening possibility. But what if we have long been drifting into an unsuspected form of rule, one less apparent because it is only sometimes visible in government: a new kind of society that privileges many older Americans — to the detriment of all, including many senior citizens themselves?
Welcome to gerontocracy in America.
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President Donald Trump is old. His predecessor, Joe Biden, is old, too — and was even older-seeming when it counted. The evidence of Biden’s decline during the 2024 election campaign altered the course of American history, leaving a storied republic on the brink.
For years, loud voices had cautioned against even broaching the topic of Biden’s debilitation. One observer went so far as to boast that gerontocracy serves America well. Even he flip-flopped in the face of Biden’s undeniable limits. The experience of 2024 brought the political consequences of aging leadership home to millions of American citizens. Of course, Democrats continued to show a default respect for the aged — except for when they were combating Trump by highlighting his own age-related dysfunction.
Of course, not all aging politicians are decrepit. Nor is the cognitive and physical decline of politicians — a genuine problem beyond the presidency, with the median age of congresspeople spiking to over 60 and of federal judges to 68 — the main effect of aging on politics.
An aging society is more set on preservation than on renovation.
Our political system is democratic, meaning that the authorities — no matter their age — depend on electoral and other popular support to rule. And our society is capitalist, so most actual power is exercised by people outside government, especially the wealthy. To inveigh merely about the age of politicians is, in many ways, to miss the point of how power works today. If the voters and the wealthy are old, it may not even matter whether the politicians are young.
To a gobsmacking extent, seniors, with their high rates of participation, dominate elections, especially the apparently boring local and off-cycle ones. The median age of actual voters these days — meaning that equal numbers of voters are older and younger — is about 52, and on the way up. Outside presidential contests, it is 55 or 56; in primaries, it is 65. Even older funders disproportionately finance the races. The most common age of donors in recent elections can run as high as 70. Finally, older Americans are backed by the best-funded advocacy group in world history — the AARP — and enjoy the most governmental benefits by a vast degree. The government is bought and paid for by those who are up in years and is organized for their sake. Trump’s “big beautiful bill” is only the most recent exacerbation, cutting down the welfare state — except elder entitlements — to make up for lost taxes.
It doesn’t stop there. Aging Americans control the biggest bank accounts and stock portfolios, partly as a function of living long enough to accumulate more and more wealth without giving much away. In our time, the old rich have pulled away from everyone else. In the two decades or so straddling 2000, households headed by adults older than 65 improved their median net worth by 42 percent, while the wealth of families of adults 18 to 34 fell by 68 percent. American oligarchy is, by and large, an “oldigarchy.”
Older people are also hoarding jobs. Following the abolition of mandatory retirement in most professions, older people are choosing to stay in some of the best positions, accumulating more money and blocking pipelines. The average age of CEOs and professors alike has gone through the roof. The United States, which has the highest wage inequality by age in the world, has seen the numbers gallop: Between 1979 and 2018, the pay gap between those over 55 and under 35 has increased by 61 percent. In those same years, the proportion of older people in the workforce has also exploded: The share of workers over 55 rose a shocking 88 percent.
The elderly possess the choicest real estate in great cities. The housing crisis, now well-known, is partly a story of old people refusing to downsize as they age. The age group most likely to own a home in America, at a rate of over 80 percent, is 70 to 74, with those 75 and older second highest. Shockingly, the age of the median homebuyer leaped from barely 30 in 1981 to 53 in 2022. The failure of abundant supply is also partly the fault of the elderly, since their political mobilization arrests development and blocks new builds. In defense of their incomes, wealth, homes, or land, they have driven tax revolts so that they don’t have to contribute to the common good.
In short, it’s not just that presidents and other politicians are old. It’s not just the cognitive or bodily decline they suffer. Rather, what’s most important is that such leaders represent an aging constituency that controls the political system. They are also the visible face of the elder domination of private forms of power, especially wealth. What’s more, with millions privileged by gerontocracy, there is no way to separate the age of our elites from their ascendancy. In America today, age is the modality in which class is lived (with apologies to the great, late cultural theorist Stuart Hall, who said the same thing about race).
Today’s gerontocracy is not anybody’s malevolent plan, exactly. It is more an accidental by-product of a legitimate and understandable desire to survive, with political effects that nobody has reckoned with. Another day, month, or year among loved ones — what downside could that have? Such a question would have been rhetorical until recently, but it has now snuck up on unsuspecting societies. Boomers aren’t distinctively evil (well, some are). Rather, the fact that they are so numerous, and the fact that they are aging in an era when the extension of life is normalized, makes an endemic syndrome more obvious.
That syndrome is a gerontocratic crisis of succession on the scale of American society itself. It often involves a deathwatch for old people. The melodrama of succession — waiting for the old to make way for the new and give up effective power — is a feature not only of our politics but also of our economy and of our culture writ large.
Should Trump fail, for whatever reason, to survive beyond the midpoint of his second term, J.D. Vance would succeed him as the youngest president in all American history, beating Theodore Roosevelt, who occupied the office just shy of his 43rd birthday. Even then, American gerontocracy would remain. It would retain its grip on the rest of government, and on our society as a whole.
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If Americans deserve a society that is oriented to innovation and problem-solving and equips and launches the young into the prime of life, the country is heading in the wrong direction. “They live in memory rather than hope,” the Greek philosopher Aristotle observed in his ancient diatribe against the aging and in defense of people in their prime.
The presumption that people grow more conservative as they age is one of the hoariest political clichés — but it is nonetheless true. Of course, these days the far right often draws from the very young. Even so, it’s abundantly clear that age and outlook tend to correlate. Who believes the children are our future? Not American seniors. The politics of educational funding for public primary and secondary schools shows a definite connection between aging and stinginess — with voters beyond their child-raising years preferring lower taxes to decent schools. Far beyond education, elder priorities, according to experts, have come “at the expense of investments” that “promote long-term growth” such as housing and infrastructure. Enterprise in the broadest sense is not a priority of gerontocratic societies. And it has been demonstrated that older voters register more sensitivity to inflationary pressure on the continuity of their way of life than to low growth, which they do not feel affects them.
Shockingly, the age of the median homebuyer leaped from barely 30 in 1981 to 53 in 2022.
The oldest are also the most implacable opponents of immigration — even though newcomers are the likeliest to provide the care an aging American population needs. One reason for the disconnect is that older Americans incarnate the demography of the past. Ethnic and racial diversity in the United States is at its maximum in current infants and lowers all the way up the age continuum to the 85 to 99 set. The most common age for whites is 58 — more than double the most frequent age for minorities. This wide disparity, partly due to existing immigration, sets up a choice between preserving older people’s conception of the America they knew and allowing immigrants to fulfill the basic needs of older people themselves.
Most important, gerontocracies are prone to let long-term problems fester and worsen. As the individual life dwindles, playing for time in the face of impending catastrophe is a psychologically appealing stratagem of avoidance and denial. The aged preference for addressing the short term leads to the imposition of heavier and heavier consequences for the future — as those understandably concerned about an indebted nation or a warming planet stress.
A fundamental imperative is therefore at stake. Americans must transcend gerontocracy if we are to realize our collective aspiration to innovation, as well as achieve other important goals such as intergenerational equity, fair political representation, and even an existential acceptance of limits as we age. Everyone likes to think of themselves as ageless, but we are finite, with just one passing life to live. Ultimately, gerontocracy is built on a denial of this transience. The aging often respond to mortality by holding on to power as long as they can — but if life is inevitably lived in stages, then succession doesn’t need to be as melodramatic or unfair as it is now.
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If modern gerontocracy functions through a new political environment, it follows that a new range of solutions is required. Age limits for political office are a must. Other fixes range from amplifying the political voice of younger voters and disrupting the stranglehold of the old people’s lobby on our politics to policies that facilitate intergenerational wealth transfer. The schemes I offer seek to advance “intergenerational equity.” But unlike the most vocal partisans of the cause, I don’t oppose the American entitlement state for seniors. Such voices insist that an end or reduction of perquisites like Social Security must occur in the name of fairness. The truth is the opposite: only an expansion of our generosity, including the promise of long-term care, can overcome the iron grip of old people on power.
While gerontocracy is hardly the only source of our difficulties, no one interested in how injustice and social strains are shaped and reproduced in America today should ignore how deep it goes. Gerontocracy has to be assessed properly, for the sake of a new intergenerational political compact. In the end, taking it seriously is essential for treating everyone appropriately and fairly.
There is still a chance for a reset. The extension of the lifespan has had political consequences, many for the worse. It has already brought an ancient phenomenon — the authority of elders over everyone else — back in a dangerous new guise. Biden and Trump have exposed one part of our gerontocracy. Ripping away the curtain that hides the rest can prepare us to dismantle the system and create something new.
How somewhat obscure English duke helped stoke American revolutionary ambitionsDanielle Allen’s new book unearths role of Charles Lennox in supporting ‘radical’ writers, thinkers including Thomas Paine, Benjamin Franklin
How somewhat obscure English duke helped stoke American revolutionary ambitions
Danielle Allen’s new book unearths role of Charles Lennox in supporting ‘radical’ writers, thinkers including Thomas Paine, Benjamin Franklin
Christina Pazzanese
Harvard Staff Writer
9 min read
Danielle Allen never imagined that a hunt a decade ago to track down every early copy of the Declaration of Independence would lead her to a lesser-known British aristocrat who stoked the revolutionary ambitions of Thomas Paine and America’s founders beginning in the 1760s.
In a new book, “Radical Duke: How One Aristocrat — and the American Revolution — Transformed Britain,” Allen reveals that Charles Lennox, the third Duke of Richmond, was a rarely cited but important champion of then-radical democratic ideals, like popular sovereignty, grassroots political movements, universal male suffrage, and parliamentary reform.
Allen, the James Bryant Conant University Professor and director of the Allen Lab for Democracy Renovation at Harvard Kennedy School, discusses the mysterious duke’s hidden hand advancing the cause of democracy in Britian and an emergent U.S. The interview has been edited for clarity and length.
Gazette: You came upon the duke and his story somewhat by accident. What happened?
Danielle Allen: It was definitely an accident.
I published a book about the Declaration of Independence a bit more than a decade ago. That book led to a research project to try to track down every copy of the declaration produced between 1776 and 1826. That yielded the incredibly surprising discovery of a ceremonial parchment of the declaration in a small archive in southern England.
The world thought there was one ceremonial parchment; it’s in the National Archives. Lo and behold, it turned out there were two.
“So, there was suddenly this huge window into this world of radical politics that had completely disappeared from view for historians.”
It quickly emerged that it seemed to have made it to the archives from the papers of Charles Lennox, the third Duke of Richmond.
But there was still a big mystery: How on earth did he get this document?
He was known to be a supporter of the Americans. He was the first member of Parliament to recommend recognizing American independence. So, it was in the pursuit of solving that mystery that I started researching the duke of Richmond, and then, to my great astonishment, found evidence that he was the first political patron of Thomas Paine and that Thomas Paine, who had said he never published anything before “Common Sense” in America in January 1776, had, in fact, been a radical writer in England for almost 20 years and had worked closely with the duke.
So, there was suddenly this huge window into this world of radical politics that had completely disappeared from view for historians.
You describe the duke as one of three major figures who shaped modern British constitutionalism, along with Edmund Burke and King George III. What made Lennox so significant?
He was the most unusual and interesting reformer. He introduced a bill for universal manhood suffrage in 1780, and that bill was a part of his vision about what it would take to constrain the executive power of the monarch.
His theory of the case for how to protect the liberty of British subjects depended on a strong Parliament and a Parliament that was fully connected to the whole people. That was a pretty novel conception. He had some allies at developing it, but he had that picture in view by the early 1770s, and he stayed on the case for decades.
He was an aristocratic Whig, was part of their political world, but he was also allied with the city radicals because they were interested in universal manhood suffrage. The aristocrats mostly didn’t get there except for him.
He also had a foot in with the county reformers because he was the lord lieutenant for Sussex County. He did a lot of work for his county.
Landed property owners who weren’t part of the aristocracy had a third vision for reform. He was the only person who was really allied with all three camps, and that made it possible for him to embed reform politics in the center of British politics from 1780 onward. He really laid the foundation for reform.
While the duke had a personal beef with King George III, he wasn’t necessarily pushing for a break from the crown as the Americans were. What was his aim?
His basic commitment was to British liberty, the liberty of subjects in the monarchy of Britain, but those liberties meant freedom of the press, freedom of trial by jury, freedom to have Parliament make decisions and not the king. His greatest concern was that the king was concentrating power in himself, and he was absolutely committed to blocking that.
The king had essentially a big slush fund that he used to both help people buy their seats in Parliament and that he also used to give people sinecures and rewards so he could command loyalty from enough members of Parliament to control the voting patterns. That meant Parliament had ceased to function in the 1770s as an independent body and that’s what Richmond objected to.
Tell me about the book’s big revelations: that the duke and Thomas Paine had been collaborating and that the duke quietly bankrolled and recruited writers to submit provocative political essays, known as the Junius letters.
It’s a pretty big deal from a historical point of view of understanding the dynamics of radical politics at the time. Richmond, in the 1760s, was in and out of government. He was extremely frustrated with the direction of British politics. He was also frustrated with the direction of his aristocratic peers.
Out of that frustration, he started hiring writers to write anonymous pieces in the newspaper that aligned with his agenda, and that practice evolved into a series called the Junius letters.
They’re a bit like the Federalist Papers. They offer a theory of constitutionalism, but they also had this really intense critique of the king and his government. In fact, they caused the collapse of one of the king’s ministries. And so, that’s the astonishing thing — who was behind those papers and how they fit into a broader agenda of reform.
How were you able to establish that so conclusively?
I was able to identify writers that the duke had worked with and had independent evidence for each of his specific relationships.
And then, reading the Junius letters really carefully, minutely, it’s very clear that their agenda tracks the duke of Richmond’s agenda. The details in them track his knowledge base and pieces of knowledge that he specifically would have had access to, things about the royal court, things about the cabinet, stuff like that.
So, there’s all these kinds of circumstantial evidence that made it very clear that there was this network of people working together and that they appear to be working on these Junius letters.
There were two other pieces of evidence that came into play. The first was the duke and his library. The library still exists. It’s beautiful; it’s like Thomas Jefferson’s library. The library includes anonymous and pseudonymous political pamphlets from the era. Some of those have inscriptions dedicating them to the duke.
One of those was this pamphlet nobody has really ever known about called “The Juryman’s Touchstone,” which is directly about the Junius letters and the sedition trials that came out of them. It has a long, handwritten dedication to the duke. I looked at it for three years, and finally, I was like, “Is it possible that this handwriting is Thomas Paine’s handwriting?”
“That was the smoking gun, the final proof that Paine and the duke were working together, and working together specifically on the Junius letters and the agenda connected to the Junius letters.”
I checked, and it was Thomas Paine’s handwriting. That was the smoking gun, the final proof that Paine and the duke were working together, and working together specifically on the Junius letters and the agenda connected to the Junius letters.
Then, I reached out to the people editing a new edition of Thomas Paine’s works that’s come out this summer to seek confirmation of my handwriting identification, and they provided that.
But then they also said, “Oh, by the way, we have developed this computer-assisted author authentication methodology to identify the authors behind pseudonymous works from the period. Can we check ‘Juryman’s Touchstone’?” They checked it and identified Paine and also Benjamin Franklin as the main authors of the text.
The duke had also contributed a paragraph about the House of Lords. As it happens, those scholars had also been working to identify the Junius authors, and, completely independently from me, they had come up with the same set of authors. So that was the clincher.
What is it about the duke’s story that so resonated with you and your work on democracy reform?
The 1760s and the 1770s were this amazing period when there was this problem of concentration of executive power. People were trying to figure out how to protect freedom in that context. That’s directly analogous to our current moment.
Modern political parties were just coming into existence for the first time, so people were trying to figure out how to balance alliances with specific people versus ideological agreements. When those things are in tension, what do I do? I think the democracy reform ecosystem right now has a lot of that going on in it.
Also, there’s a question of how do you navigate the politics to actually bring change? The duke was an incredible navigator of politics, really inventive and creative in producing new alliances and coalitions. Learning from somebody who is navigating similar dynamics is really helpful and fascinating.
Part grueling race, part field studyFrom a bicycle seat, Harvard postdoc sees roadblocks facing rural medicine
George Usmanov traverses Wyoming’s Great Divide Basin. Photo by Chad Ament
From a bicycle seat, Harvard postdoc sees roadblocks facing rural medicine
George Usmanov did some unforgettable sightseeing this summer.
Over 25 days in June and July, he passed by ghost towns from both the 19th and 20th centuries and acres of forest, “completely charred.” He saw a river run yellow out of a Superfund site and the sun rise purple, thanks to a mix of “desert dust, mist from the Rockies, smoke that was coming in from wildfires.”
Typically, though, he had no one with whom to share those moments. Usmanov was taking part in the Tour Divide, widely regarded as the world’s most difficult bike race. It stretches over 2,700 mostly unpaved miles from Banff in southern Alberta, Canada, to the U.S.-Mexico border. And during his biking days, “about 70 percent of the time, I was entirely alone,” he said. “Even if you’re only separated from other racers by a couple of miles, the trails are extremely twisty and you don’t see them.”
This was in part a working holiday for Usmanov — and that kind of isolation was his object of investigation.
The Harvard Medical School research fellow in neurology at Massachusetts General Hospital is engaged in postdoctoral research on stroke — the nation’s fourth-most-common cause of death, and a condition in which every minute counts. The distances he covered are the same ones that separate some of the continental U.S.’s most isolated communities from centers of effective treatment.
Veasey Conway/Harvard Staff Photographer
Usmanov, 28, is not a doctor but a medical sociologist. His studies focus on “illness experiences”: how felt symptoms, social connections, and cultural norms encounter and shape treatment.
Stroke — with its various forms and subtle symptoms — is of obvious interest. Most stroke patients don’t feel pain. Instead, at onset, they experience “numbness, tingling, or some sense of disruption: you’re driving a car and suddenly you can’t turn the steering wheel. Or you’re using the TV remote and suddenly you don’t know how to change the channel,” Usmanov said.
Meanwhile, though, a clock has started ticking. “From that moment, parts of your brain are dying, at a rate of around 1.9 million neurons a minute,” Usmanov said.
In cases of acute stroke, the field of neurology has come to see the first 60 minutes after onset as the “golden hour”: If patients are examined and treated with an intravenous clot-busting drug like alteplase within that window, their odds of a full recovery improve dramatically. And clot-busting drugs can be used effectively for up to 4½ hours after a stroke’s onset.
The trouble, Usmanov said, is that “in the United States, the vast majority of people don’t get to a hospital in time, meaning they’re missing out on the most effective treatment.” (Mechanical thrombectomy — using a stent or vacuum to remove a clot physically — can be used up to 24 hours after onset, but it’s more invasive.)
To be sure, even most acute strokes are not lethal. But up to one-quarter of acute stroke survivors die within a year of onset, and survival and recovery rates vary greatly by stroke type, patient age, and the speed and type of treatment. In general, Usmanov endorses what has become a neurological maxim: that in cases of stroke, “time is brain” — meaning there’s an immense public health interest in shortening the gap between onset and appropriate treatment.
Usmanov noted that this country has made important strides toward making “golden hour” arrivals more likely — at least in theory. Individual medical centers have worked to shorten “door-to-needle” time: from intake to radiology and infusion. And not only can ambulances or helicopters shorten trips from homes to “stroke-capable hospitals,” there are more of those than ever before.
A team of Harvard researchers found that in 2019, 91 percent of Americans lived within one hour (by ambulance) of a center that could deliver alteplase; in 2011, it was just 80 percent. Further, they found an additional five percent can be reached by “telestroke”: a remote examination over video that has proven effective in lowering mortality and improving outcomes.
But one large region has remained stubbornly above the national average — the Mountain West, the “exact corridor” through which the Tour Divide passes, Usmanov said.
Usmanov has been an avid biker since his youth in Minneapolis. And this isn’t the first time he’s used his bike as a platform for rolling ethnography. During his graduate studies at Georgia State University, he took a similar ride to visit the informal communities that arise at campsites and RV parks across the Deep South.
“A bike is just an extremely useful and effective way to witness space, I think,” he said from his office in Somerville.
But in the Rockies, he found community harder to come by. There are fundamental problems of logistics — long distances, snowed-over mountain passes closed each year, unmaintained roads even in summer. Isolation is the rule even when ties are close. “The cost of seeing each other is so high,” he said. “Your daughter could live on the ranch next door, and that could still be an hour away.”
Moreover, the videoconferencing solutions behind telestroke — and much of post-COVID work and socializing — are not yet adapted to the heights Usmanov traveled. For about two-thirds of his ride, his phone had no connection at all, and simple sites could take minutes to load even when service was available.
Again — even with the benefit of sick leave, broadband internet, modern roads, and denser neighborhoods — Americans still tend to begin treatment too long after a stroke’s onset. So Usmanov has some justification for arguing that we need to focus on the first phase of stroke’s unforgiving timeline: between onset and calling 911.
For years, the public health establishment has tried education paradigms. Since 2013, they’ve used acronyms like F.A.S.T. to help laypeople recognize the telltale signs of stroke. But further study found that 30 days after an educational video, many participants had forgotten the symptoms, and that rates of timely 911 calling declined as well.
And in the Rockies, as in many lower-income precincts, there’s an element of class at play. “Generally, I met people who have done highly laborious work for years: construction, ranching, in the service industry,” Usmanov said. “And they tended to tell me similar things: ‘I’ve been in pain my whole life.’ ‘I broke something, but I had to work through it.’ Or ‘I experience weird sensations as part of my job: tingling, dizziness, numbness.’ Those are just the demands of the job — but they’re also symptoms of stroke.”
Usmanov in southern Wyoming. Photo by Chad Ament
In January, Usmanov was the lead author of an American Heart Association paper finding that patients who were with family or trusted bystanders at onset tended to arrive at hospitals earlier than those who weren’t — or even than those who were with large crowds of strangers.
And his Great Divide ride underscored how much community matters in unforgiving terrain.
Some nights he’d camp serendipitously with other racers, for camaraderie as much as for safety. He made a “good friend” in one fellow racer, only to watch him drop out after developing nerve damage: the consequence of biking over bumpy dirt track with inadequate suspension.
And 500 miles from the finish line, Usmanov was contemplating dropping out after a crash and without water. “A rider named Bob passed me, gave me a little Gatorade, a kind of a pep talk, and went on his way.” (Only about half of the roughly 260 racers completed, with Usmanov middle of the pack.)
Usmanov’s ride had one last goal in mind: it served as a fundraiser for the Global Brain Care Coalition, a nonprofit that shares his ambition to find preventative care for neurological ailments. (It has raised $20,000 at time of publication.) And the Rockies taught him that there may be promising interventions to be made between individual vigilance and institutional change.
“Spouses, neighbors, church members can take blood pressure together, can discuss health behaviors — and that will do a lot more than this ad hoc approach, of one individual at a time,” Usmanov said. “We’re social creatures, and that’s where we have to target change.”
It’s a fitting takeaway for a sociologist after a long, lonely ride through the mountains.
AI use surging for mental health help among young peopleSurvey researcher says popularity may help fill gap between rising national problem, shortage of clinicians — provided counsel is sound
AI use surging for mental health help among young people
Hao Yu.
File photo by Stephanie Mitchell/Harvard Staff Photographer
Alvin Powell
Harvard Staff Writer
6 min read
Survey researcher says popularity may help fill gap between rising national problem, shortage of clinicians — provided counsel is sound
The question is no longer whether young people are using AI for mental health care, but the soundness of the advice they receive, health officials say.
A recent survey showed that the use of AI chatbots for mental health care among adolescents and young adults has increased 60 percent in just a year, a trend that survey organizers said is likely to continue.
Hao Yu, Harvard Medical School associate professor of population medicine at the Harvard Pilgrim Healthcare Institute, led the study, which had 1,727 participants.
Yu said as AI helps fill a treatment gap left by a rising problem among young people in the U.S. amid a shortage of mental health professionals, the focus should now turn to ensuring the counsel being offered is helpful and not harmful. The interview has been edited for clarity and length.
Gazette:What did your survey find?
Hao Yu: We did a similar study last year, and at that time we found one in eight young people, between the ages of 12 and 21, use AI for mental health problems. This year we found an even higher proportion, almost one in five. That means nearly 20 percent of young people in this country are using AI for mental health advice. That’s a rapid increase in one year.
Not surprisingly, we found variation in AI use across youth groups, with relatively older youth more likely to be using AI, and females more likely to use AI for mental health issues.
It may surprise some that we found the majority of youth using AI did not disclose their use to any adults, either parents or physicians. That might be concerning, because there is misinformation available through different AI models, which are not designed to provide mental health advice.
So, we would encourage parents and physicians to talk with their youth regarding their potential use of AI. They may be able to identify if their child has a mental health issue or help their child distinguish between accurate information and the misinformation we know is available online.
What does this tell us about the state of young adult and adolescent mental health care today?
This definitely shows that there’s a big issue facing the U.S. today. On one side, we have a rapid adoption of AI across different parts of our society. On the other, there is an increased prevalence of mental health issues among young people. Putting these two together makes it not so surprising when we see that youth are increasingly turning to AI for mental health advice.
Does it also highlight that there’s not enough capacity in our mental health care system?
Our healthcare system has an acute shortage of psychiatrists, especially child psychiatrists, and only half of those with mental health needs actually receive mental health treatment.
So, if a youth has mental health issues, AI offers some advantages. AI is patient. AI is available anytime, 24/7. You don’t need an appointment to talk with AI, and AI is nice. It’s rare for AI to be harsh or become impatient. So there are advantages, especially for people living in rural or remote areas with severe mental health workforce shortages.
How much do we know about the quality of the responses that come from these general-use AI chatbots? Is it still a concern that that kids and young adults may get bad, even harmful advice?
That’s still a concern. And it’s true that tragedies like suicide attempts have happened when youth talked with AI about mental health issues. AI companies promised they would install guardrails but there’s a lack of empirical evidence about how those promises are being kept.
Beyond this specific study, many researchers are interested in assessing the safety and efficacy of mental health advice offered by AI. More people are paying attention, so we’d hope there would be some improvement, but that remains to be seen.
The paper mentions that these AI models are designed to be friendly, agreeable, and flattering. Might kids also be getting information that is reinforcing in a positive, but still unhelpful way?
Most AI models try to be appealing, flattering, as a way to keep their customers, and many people, especially youth, easily hooked. But it’s still a concern that the advice, the information provided by AI, be really useful.
In our study, we found that the vast majority of youth, over 90 percent, say the advice is useful, but that’s still an empirical question we need to assess: Is AI-provided mental health advice really helpful and accurate?
The safety and efficacy of AI models is a priority for research because, as we said in the beginning, these things are already happening, and the trend among youth is increasing. As a society, we have the responsibility to make sure that what they are receiving is accurate and helpful.
You mentioned that there are AI chatbots that are designed to be therapeutic. I’ve seen earlier studies that show that they can be very good, but their development has been slow. Is a key message that we need to accelerate the development of these therapeutically trained bots?
Yes. We have an acute shortage of child psychiatrists who can meet unmet needs among our youth, so we want AI models that can mitigate the shortage. It’s not surprising, though, to see people concerned about the potential quality and safety implications of even the specifically trained, mental-health-oriented AI.
That’s why some policymakers, as in Illinois, have taken actions. Ultimately this is an issue of patient safety.
Where do you see this trend going? We’ve seen an increase from one in eight adolescents and young adults using AI for mental health needs to one in five. Are you planning on doing the survey next year, and do you expect it to be an even greater percentage?
We definitely will have follow-up surveys, and most likely will see an increased number. It’s not surprising given that AI is now part of daily life for youth, and that there are unmet mental health needs. AI is readily available and endlessly patient.
Were there any surprises in this for you?
One surprise is that we didn’t find a significant difference between rural and metropolitan areas, even though we know that a rural-urban digital divide exists and that rural and remote areas have a severe shortage of child psychiatrists.
If confirmed by future research that rural and urban kids are equally likely to use AI, that might help reduce the adverse effects of a workforce shortage in rural areas. AI has that potential for sure. But we want to make sure these specific AI models meet clinical standards for mental health advice.
The research described in this interview received funding from the National Institute of Mental Health.
Gen Z puts high priority on jobs with meaning, purpose, but sees daunting hurdles School of Ed report says they have concerns over low pay for caring professions, emotionally draining nature of work
Gen Z puts high priority on jobs with meaning, purpose, but sees daunting hurdles
Sy Boles
Harvard Staff Writer
7 min read
School of Ed report says they have concerns over low pay for caring professions, emotionally draining nature of work
Seventy-nine percent of Gen Z want a job mainly focused on helping people or making a positive difference in others’ lives. But only about half of workers in that 18-29 age bracket who want such a position say they have one.
Those are the findings of a new report from the Harvard Graduate School of Education’s Making Caring Common project, in collaboration with Gallup and the Walton Family Foundation. The survey examines what members of Gen Z want from their work and how it affects their emotional well-being.
The data, taken from a representative sample of 2,436 people born 1997-2012, goes against popular stereotypes, according to Richard Weissbourd, faculty director of Making Caring Common and a senior lecturer at HGSE.
“Gen Z is often characterized — in my mind, cartooned — as selfish and lazy, as not wanting to really invest in anything deeply. So I was really surprised, partly because of this misconception, to see that 79 percent of our respondents report that they wanted to have a job in the future that was mainly focused on helping other people,” Weissbourd said. “It was just a very high percentage. And it’s not just talk. Many Gen Zers are taking concrete actions based on their desire to do good, according to Deloitte surveys, such as choosing companies based on their social impact.”
Weissbourd explains why helping Gen Z find meaningful work could have a big impact both on the culture and in the lives of the young adults — and why there may be some good news on the horizon. The interview has been edited for clarity and length.
Gazette:What kinds of jobs do Gen Z find meaningful?
Richard Weissbourd: We asked two different questions: whether they found their jobs meaningful, and whether their job was primarily focused on helping other people.
Among Gen Zers who told us they found their jobs meaningful, about twice as many (84 percent) worked in jobs focused on helping people — such as jobs in healthcare, education, and the military, as those who did not work in these kinds of jobs (44 percent).
In response to an open-ended question about where they find meaning at work, we also found that many Gen Zers focused on those aspects of their jobs that helped others, such as a dishwasher who finds meaning in playing an important role in providing people food or a retail sales worker who finds meaning in helping people find clothes that make them feel good about themselves.
So I think two things are true. One is that a lot of young people want a job that’s directly helping others, like a job in healthcare or social work or teaching. But also, many young people are finding meaning in the aspects of their jobs that involve helping others, even if it might not be as obvious.
This research only spoke to Gen Zers. So this can’t really tell us how Gen Z compares to other generations, is that right?
That’s correct. From this and other data, there isn’t clear evidence that this generation is more altruistic or more socially active than other generations in general, but there certainly isn’t clear data showing that they’re less altruistic or less socially active.
What’s different among Gen Zers who report feeling purpose and meaning in their lives?
Over half of Gen Zers report mild (30 percent), moderate (18 percent), or severe (10 percent) anxiety and depression, and a whopping 70 percent of Gen Zers over 18 report mild to severe anxiety and depression. But those who say they have felt a sense of meaning or purpose in their lives in the past month are much less likely to report symptoms of anxiety and depression than those who do not feel their life has felt meaningful or purposeful.
Meaning and purpose are the deep engines of our lives. They provide this deep gratification that’s beyond hedonism, beyond temporary joy. We can talk about banning cellphones in schools, which I think is a good thing, and providing more therapists, which I also think is a good thing, but my guess is that helping other people and making a positive difference in others’ lives is significantly more likely to strengthen Gen Zers’ mental health than those other strategies.
You found that just over half of Gen Z adults (56 percent) who want a job mainly focused on helping people have one. When asked about perceived barriers to taking those jobs, many of them said they perceived care-oriented jobs to be low-paying and emotionally draining. Are they right?
They are right in the sense that a lot of these jobs aren’t affordable. I mean, if you want to be a childcare worker or preschool provider in a city like Boston or New York, it’s very tough. We need to figure out ways to pay people more, reduce housing costs, provide loan forgiveness for people in helping professions in under-resourced areas, et cetera.
Certainly there are helping jobs in ed tech, philanthropy, and other industries that pay well. But we should also be creating-less expensive pathways into careers in healthcare and education.
The emotionally draining aspect is interesting to me. These jobs can certainly be emotionally draining, yet in our data, when people feel they’re making a positive difference in other peoples’ lives, they also report less anxiety and depression. Teaching, for example, can be very depleting, but it’s also very gratifying for a lot of people. Both of these are true.
So is it fair to say that Gen Zers see helping jobs as a nice-to-have in principle, but only as long as they can pay their bills?
It’s possible. Here’s one finding that speaks to that question. We asked people: “You have a job that provides you with a feeling of meaning and purpose. You’re offered a new job that has double the salary but will have significantly less meaning and purpose. Would you take it?”
To summarize, people were roughly split: 46 percent said they would take the higher-paying job, 28 said they would keep the meaningful job, and 26 said it would depend on the specifics.
Now, when we dug a little deeper, we found that perceived financial security clearly mattered. No matter their actual income, adult Gen Zers who felt financially insecure were more likely to take the higher-paying job (53 percent) compared to those who were living very well (41 percent). But a significant number of people with low financial security are also taking up helping jobs. So it’s a complicated picture.
With an aging population in need of care and potential AI disruptions to knowledge-economy jobs, is this a rare moment where this population’s desire for helping jobs could align with where the economy is headed?
Yes. I’m not an expert in the economy, but I can say a very common view is that we’re shifting from an economy that values information and knowledge to an economy that values interpersonal skills, social-emotional skills, and the capacity to care for other people.
In healthcare, for example, you can imagine AI taking over a lot of the knowledge functions that a hospital might rely on, freeing up more people to do really high-quality patient care. The gist of it is that this is a time when what young people are interested in and what the economy demands may rhyme.