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Can’t wait to listen? You should.

Research inspired by driving lapse finds link between album drops, road fatalities


Health

Can’t wait to listen? You should.

Vishal Patel standing in front of a large window.

Vishal Patel.

Photo by Grace DuVal

4 min read

Research inspired by driving lapse finds link between album drops, road fatalities

Researchers seeking to understand the impact of smartphones on driving safety have a warning for music fans: Release day might be dangerous.

The study, described in a working paper published last month by the National Bureau of Economic Research, showed a 43 percent increase in streaming and a 15 percent increase in traffic fatalities on the days that major albums drop.

Vishal Patel, a surgical resident at Brigham and Women’s Hospital, clinical fellow at Harvard Medical School, and the paper’s first author, said that the work was inspired by a moment behind the wheel. His wife, a singer and avid music fan, texted him to listen to a song that had just been released on streaming services. Patel began scrolling through his phone. When he looked up a few seconds later, he realized that he’d started drifting out of his lane.

“It hit me that a split second longer with my eyes off the road could have meant a serious accident,” he said. “Then I thought, if millions of people are doing the same thing at the same time — on the day a big album drops — the cumulative risk on the road must be enormous.”

Smartphones tempt drivers to send emails, search, call up directions, or even find a recipe for dinner. Despite that ceaseless potential for distraction, research into the impact of phones on driving is scarce, according to Patel and the new paper’s senior author, Anupam Bapu Jena, the Joseph P. Newhouse Professor of Health Care Policy at Harvard Medical School. The principal obstacle is ethics: Researchers can’t conduct live experiments that might illuminate what’s going on in the millions of cars on the road today. They can’t, for example, ethically instruct half of a study group to keep their eyes on the road while telling the other half to search for music as they navigate traffic.

Anupam Bapu Jena.

Anupam Bapu Jena.

File photo by Niles Singer/Harvard Staff Photographer

Enter Patel’s insight about the distraction of downloading music, which he recognized as an opportunity for a natural experiment.

The researchers analyzed accident stats on the release days of the 10 most streamed albums between 2017 and 2022, plus, for comparison, on the 10 days both before and after the release dates. Using Spotify data, they found an average of 123.3 million streams on the major album release days, compared with just 86.1 million streams on the days before and after — a 43 percent increase on release days.

Turning to traffic fatalities, they found an average of 139.1 deaths on release days, an increase of 18.2 fatalities over the average of 120.9 traffic deaths on the 10 days before and after the releases. Added together, deaths rose 15.1 percent, totaling 182 additional fatalities on the 10 days when those major albums were released.

“It could be manipulation of the device, it could be general distraction because of the excitement,” Jena said. “It could also be that you’re playing the music louder than you normally would play it, and that you don’t pick up things around you that you otherwise would have picked up. Any of those things are possible.”

Patel and Jena also examined accident characteristics, seeking insights on the potential role of factors other than distraction. Drivers tended to be sober, arguing against the possibility that they had attended boozy parties celebrating the album releases. The increase in fatal accidents was also larger in single-occupant vehicles, missing a passenger who might help manage the music. Drivers also tended to be younger, fitting the profile of younger people as more avid music consumers.

Patel’s investigation into distracted driving continues. Technology has advanced significantly since 2022, when data collection for the current study ended. Vehicle technology has advanced, with cameras and sensors eliminating blind spots and making switching lanes safer. Many vehicles come with automatic braking and other safety features. Among the open questions, Patel said, is the impact of artificial intelligence, which could allow a new array of distracting tasks to be performed while driving. AI could also, however, enhance safety by taking on tasks from the driver, like finding music or drafting a work email.

“People convince themselves they can multitask behind the wheel — scheduling calls, eating, putting on makeup,” Patel said. “Smartphones have dramatically expanded what’s possible to do while driving and, as cars become increasingly connected, the temptation to divide your attention is only going to grow.”


Harvard meets Hollywood: A quiz

What, like it’s hard?


Arts & Culture

Harvard meets Hollywood: A quiz

Illustrations by Liz Zonarich/Harvard Staff; Harvard file photos

1 min read

What, like it’s hard? 

Ahead of the 98th Academy Awards on March 15, we’ve created our own shortlist: movies with a tie to Harvard. Find out how much you know about Crimson cinema by taking our quiz. 


Step 1 of 10

1. What novel set partially at Harvard was written to drum up interest in a movie?


Ex-Trump envoy makes case for Iran attack

President acted in response to ‘culmination of threats,’ says Morgan Ortagus


Nation & World

Ex-Trump envoy makes case for Iran attack

Ned Price, Bahar Moradi, and Morgan Ortagus,.

Morgan Ortagus (far right) with IOP’s Ned Price and student moderator Bahar Moradi ’27.

Photo by Martha Stewart

4 min read

President acted in response to ‘culmination of threats,’ says Morgan Ortagus

The war with Iran is not about regime change but rather an effort to protect Americans from a nuclear threat, according to Morgan Ortagus, who until recently served as deputy U.S. special envoy to the Middle East and special envoy to Lebanon under ambassador Steve Witkoff.

But if the elimination of the Supreme Leader of Iran and leaders in the Islamic Revolutionary Guard Corps helps Iranians choose what their future looks like, then, “I don’t think it was a mistake,” Ortagus said during a talk at the Kennedy School on Tuesday.

“I don’t feel bad for any of these people,” she said. “These are people that tortured and mass executed their own people and plotted to kill my president.”

The strikes by the U.S. and Israel on Feb. 28 were not triggered by one specific event, but a “culmination of threats” from Iran and years of failed diplomatic efforts by both Republican and Democratic presidential administrations, according to Ortagus, who served as a State Department spokesperson during the first Trump administration.

Among the threats she cited were the Iranian regime’s decades of malign influence in the Middle East, its continuing nuclear ambitions, the escalation of threats to U.S. bases and those of U.S. allies in the region, and plots to assassinate President Trump, former national security adviser John Bolton, and former secretary of state Mike Pompeo.

Despite all of that, “President Trump very much wanted a deal with the regime and was willing to give them one” prior to the 12-day war with Israel last June, but he felt Iran was merely “string[ing] along” the U.S., said Ortagus, who was involved in the negotiation.

Ortagus pushed back on criticism of the administration’s actions in the current war. She defended the wide range of rationales the president and top defense and foreign policy officials have offered for the attack, insisting that they give Trump “maximum flexibility” in negotiations with Iran and allow for quick decision-making. She also downplayed the relative inexperience of the lead U.S. negotiators, Witkoff, a New York real estate developer, and Jared Kushner, Trump’s son-in-law.

“What matters is results,” said Ortagus, a former U.S. Navy Reserve intelligence officer.

Asked by co-moderator Ned Price, interim co-director of the HKS Institute of Politics, about the president’s claim that Iran’s nuclear program had been “obliterated” in bombings last year, Ortagus said that Trump was referring only to the specific sites the U.S. had targeted, not Iran’s willingness to develop nuclear weapons.

Trump views the current military action as a means to remove the threat posed by Iran’s navy and to degrade its ballistic missile stockpile, as well as a follow-up on his pledge earlier this year to Iranian protestors that “help is on the way,” she said.

“When you say that, you have to put your money where your mouth is, and I think in this case the president’s done that.”

The administration tried, she said, to coerce Iran’s regime into capitulation before opting for military action.

“The Iranian regime were extended the hand of diplomacy by the president multiple times,” she said. “It’s unfortunate that they’ve chosen, time and time again, to destroy their own country and their own people for some theocratic revolutionary idea of how they are going to reshape the Middle East.”

The event was moderated by Price, who served as deputy to the U.S. representative to the United Nations and as U.S. Department of State spokesperson during the Biden administration, and Bahar Moradi, president of the Harvard Undergraduate Iranian Association.


Atlas Hotel opens at the Enterprise Research Campus

Art, food, views help give Allston space local flavor


Campus & Community

Atlas Hotel opens at the Enterprise Research Campus

Atlas Hotel.

The Atlas Hotel is the latest building to open at the Enterprise Research Campus in Allston.

Credit: Tishman Speyer

5 min read

Art, food, views help give Allston space local flavor

With a variety of seating nooks and a warm, casually elegant aesthetic, the first floor of the new Atlas Hotel in Allston encourages visitors to stay a while. The hope is that this intentional design choice will be availed by hotel guests and local neighbors alike.

“We call this space ‘Allston’s living room,’ and we really want the community to feel comfortable here,” said the hotel’s managing director, Arnaldo Almonte.

And on a recent visit just a few weeks after the Hotel opened at the end of January, people were scattered throughout the space chatting and working on laptops, exactly as intended. 

The Atlas Hotel, designed by Marlon Blackwell Architects, is the latest building to open on Harvard’s Enterprise Research Campus (ERC), with 246 rooms, including 12 suites. Along with the ERC’s David Rubenstein Treehouse at Harvard University, the hotel will support the ERC’s mission to bring diverse groups from teaching, research, business, and learning together in this burgeoning innovation district. The hotel was developed by Tishman Speyer, and is managed by Highgate group.

Directly adjacent to the “living room” is the lounge area for Ama, the hotel’s ground floor restaurant, led by local restaurateurs Biplaw Rai and Nyacko Pearl Perry of Pearl & Law Hospitality, creators and owners of Dorchester’s Comfort Kitchen.

“We call this space ‘Allston’s living room,’ and we really want the community to feel comfortable here.”

Arnaldo Almonte, Atlas managing director
Lobby of the Atlas Hotel.

The lobby in the Atlas Hotel serves as a gathering space for the community and hotel guests.

Photo by Grace DuVal

“Because it’s attached to the hotel, we knew the lounge area was important as a place where people could continue their conversations from meetings or conferences, or just hang out and relax,” explained Rai. The rest of the dining spaces for Ama are tucked behind a large bar with views of the interior courtyard where there is a seasonal outdoor dining area.

Ama, which means “mother” in Nepali, embraces a theme of caregiving, from menu offerings such as soups and pork belly, to the ergonomic design of the bar to support the health of bar staff, to the art create.

“We can only do this kind of project with the community — we understand being in a hotel might be a barrier for neighbors to want to come in, but we really want everyone to come, linger, and enjoy their time here,” said Rai.

The hotel incorporates art and photos from Boston artists throughout the spaces. Among them: Edward Boches’ photos from his “Postcards from Allston” series, which was featured at the Harvard Ed Portal’s Crossings Gallery in 2022. Ama further connects the local Allston-Brighton art community and the Ed Portal with two collaborative pieces from payal kumar and Nina Bhattacharya, both of whom recently exhibited their work at the Crossings Gallery.

Custom paintings are displayed in Ama Restaurant.

Ama restaurant features original artwork by Allston-Brighton artists.

Photo by Grace DuVal

“In collaborating with the Ama at the Atlas team, it became so clear that every person carried a story of a caregiver with them shaping their own journeys as caregivers,” kumar and Bhattacharya wrote in a statement. “It was important to us to uplift these beautiful intergenerational stories through our artwork and to ground the space in what is often unseen. We drew on sense memories elicited during a workshop with staff to design pieces that make visible the care, dignity, and labor at the heart of nourishment.”

Later this spring, the Pearl & Law team will expand their offerings at the Atlas when they open a separate rooftop space called Foxglove Terrace, designed to create the atmosphere of an Asian night market. The indoor and outdoor spaces will offer dramatic views of the Charles River, Cambridge, and Boston, highlighting the Atlas’ unique location.

“We really see the Atlas as not only the hospitality hub for the Enterprise Research Campus, but also as a launching pad for visitors to explore this side of Boston and Cambridge. Allston is easy to access from east, west, north, and south, and we pull together many international influences in this neighborhood, from Lebanese, to Cantonese, and now Nepalese with Ama. I think this combination of diversity and accessibility is an amazing draw for the community and our guests,” said Almonte.

The hotel was created with the proximity to Harvard Business School and the Science and Engineering Complex in mind as those audiences are equally important to the Atlas. Onsite meeting rooms have been designed to complement the larger conference spaces at the Rubenstein Treehouse next door.

“We know there is a wide web of Harvard Schools and programs and we want all Harvard affiliates, from various Schools to alumni, to join us here,” said Almonte. “We want this to be a gathering place for the existing neighbors, for people who are coming to visit, for people who are at the Rubenstein Treehouse for a conference. It really is supposed to be a place to foster organic interactions, and further the vibrancy of the ERC, and the broader neighborhood.”


The downside of winning an Oscar

Alum with Academy Award to his credit details hills and valleys of Hollywood career


oscar statue

Photo by Emma McIntyre/WireImage

Arts & Culture

The downside of winning an Oscar

Alum with Academy Award to his credit details hills and valleys of Hollywood career

6 min read

In film school, writes Edward Zwick ’74 in his 2024 memoir, “We were all contemptuous of awards. As we got older, it turned out we were not so averse to winning them.”

Hits, flops, and other illusions by Ed Zwick book cover

Zwick — who directed the Academy Award-winning “Glory” and won an Oscar for Best Picture for his work as a producer on “Shakespeare in Love,” among other achievements — describes his career in “Hits, Flops, and Other Illusions: My Fortysomething Years in Hollywood” as a roller-coaster ride: days upon days in dingy hotel rooms followed by starstruck nights on the red carpet. 

Ahead of the 98th Academy Awards, the Gazette asked Zwick what he makes of this year’s nominees, and what four decades in Hollywood have taught him about the value of winning a golden statue. This interview has been edited for clarity and length. 


How did your award wins and nominations shape you as a filmmaker, and how do you think about them now? 

Early on I had a kind of adolescent view of most things, a kind of contemptuous view of institutions. In my view, institutions had never been a very good judge of art. But Hollywood is a very seductive place. You’re surrounded by peers and the media. You begin to give these institutions greater importance. I fell prey to that, particularly as I was given a certain amount of attention for some of the things that I had done. 

But for me, because it happened when I was young, it anticipated all sorts of hills and valleys, things that worked and things that didn’t work. It became clear to me eventually that the awards had very little impact on my self-esteem or on my process. The day after you win an award, you still have to get up and face the blank page. In fact, I found that success has this weird counterintuitive effect. There’s something anxiety-provoking about it: Why did this thing work when the others didn’t? 

“The day after you win an award, you still have to get up and face the blank page.”

I found that only through failure do you learn to apply real critical analysis to the process, to why you made the choices that you made. Because there’s an alchemy to things that work that can’t necessarily be replicated. 

How have you seen the film industry change since you were coming up? 

Movies, when they were at the apex of the culture, had an ephemeral quality. A movie came to your local theater and you went to see it without any expectation that you would ever see it again. They had this momentous quality to them. 

But as television became an alternate viewing experience, and then as DVDs and streaming came around, the market just got more difficult. Obviously, COVID had a huge impact on the movie-going experience as well. 

Now we see movie production influenced by the algorithm, which presumes to tell us we should make a film because it has some relevance to another film and will therefore partake in its success. So we begin to see this imitative quality. And then films that are more unique or more challenging become a much more difficult bet and are therefore given smaller budgets and less marketing. 

Add that on top of competition from YouTube, TikTok, and everything else, and movies take on an increasingly secondary place in the culture. Ultimately, audiences have to be trained and educated, and it’s hard to want what you haven’t seen. I worry that as audiences get accustomed to movies that were designed for mass appeal, that cycle will only continue. 

Some would argue that unusual, challenging films are still being made to some degree. Looking at this year’s crop of nominees, for example, there’s “Sinners,” which racked up a record-breaking 16 nominations, and “Train Dreams.” 

Oh, there are certainly wonderful and important films being made. It’s absolutely still possible. 

With that in mind, what sticks out to you from this year’s nominees? 

You mentioned “Sinners” and “Train Dreams.” “Hamnet” is a wonderful movie. And there were some great foreign movies, too. Joachim Trier’s “Sentimental Value” is quite wonderful as well. 

But it’s really like comparing chalk and cheese. How do you compare “Train Dreams” to “Sinners” and say which one is better, or “Sentimental Values” to “Hamnet”? Sometimes a movie wins because it strikes a fashionable chord, or just by virtue of its unique qualities, or because of a clever marketing campaign. 

As someone who’s been there, what advice would you give a nominee when it comes to the emotional roller coaster they’re sure to be on, whether they win or not? 

I’d say to have a sense of humor about it. It’s a chance for some recognition, and that’s not to be diminished, but it’s also not to be overvalued. I think most people in Hollywood came to do what they do out of love and artistic impulse, and that’s what sustains them. 

What made you set out to write a memoir when you did? 

Had COVID not happened, it might never have come to be. I was about to start a project, but we were shut down literally the day before shooting was going to start. We thought, as we all did, that the shutdown might be brief, and we could get back to it, but that turned out not to be the case. So as lockdown went on, I did something I’d never really done, and I looked at some of my old movies. What I saw in them wasn’t their flaws or their virtues, but rather, the situations, the anecdotes, and particularly the people, these relationships that had been so intense and amusing and loving and vexing. 

I just started writing about it. In the beginning I didn’t even think of it as a book. Eventually I labeled the file on my computer “B–k” so as not to offend the gods. But as I wrote, I came to realize that from a 30,000-foot view, there was a trajectory that spoke to a time of remarkable transition in the business. I found there was a kind of autumnal quality to it, that it would reflect something that was not quite a bygone era, but something that’s no longer the center of our culture. 


How Ben Franklin put a charge into American independence

Reputation in science was key to his political power, historian says. On the other hand, ‘Frankenstein.’


Arts & Culture

How Ben Franklin put a charge into American independence

Joyce Chaplin in front of a screen onstage.

Joyce Chaplin.

Photos by Niles Singer/Harvard Staff Photographer

5 min read

Reputation in science was key to his political power, historian says. On the other hand, ‘Frankenstein.’

Benjamin Franklin is known as a leading figure of the American Revolution, a diplomat, a printer and publisher, and an inventor. But in a lecture Thursday, Joyce Chaplin made the case that Franklin’s role as a man of science was central not only to his life but also to American independence.

Science gained cultural significance in the 18th century, as Europe embraced Enlightenment ideals, and Franklin made himself into one of the best-known scientific minds of his era, said Chaplin, James Duncan Phillips Professor of Early American History. That reputation, shaped in part by the publication of the pamphlet “Experiments and Observations on Electricity” in 1751, would pay dividends during the Revolution and beyond. 

“Franklin did experiments that provided the first convincing explanations of electricity, including its manifestation as lightning,” said Chaplin. “Within the context of enthusiasm for science in the 18th century, this was important. His work in science gave Franklin unparalleled authority to defy a monarch who seemed to have become a tyrant … setting off the first political revolution in an age of revolutions that would continue into the early 19th century.”

The event, at the Geological Lecture Hall, was sponsored by the Collection of Historical Scientific Instruments, the Peabody Museum of Archaeology & Ethnology, and the Harvard Museums of Science and Culture. It marked the 250th anniversary of the Declaration of Independence.

“Franklin was interested in science because he was ambitious and knew he needed some extraordinary accomplishment to achieve any kind of prominence.”

Joyce Chaplin
A portrait of Joyce Chaplin.

Franklin was born in Boston in 1706. After a yearslong apprenticeship, he moved to Philadelphia at age 17 to establish himself as an independent printer. A year later he traveled to London, where he not only mastered the printing trade, but also developed a fascination for science to the point where he became “desperate to meet Isaac Newton,” said Chaplin, whose books include “The First Scientific American: Benjamin Franklin and the Pursuit of Genius.” Newton had published “Philosophiæ Naturalis Principia Mathematica” in 1687, in which he formulated the laws of motion and universal gravitation, and London was a hub of discovery and innovation.

It was a time when “participation in science was widespread and unspecialized,” Chaplin said. It was in London that Franklin learned “what a reputation in science might do for him,” she added.

“Franklin was interested in science,” Chaplin said, “because he was ambitious and knew he needed some extraordinary accomplishment to achieve any kind of prominence.”

When Franklin returned to Philadelphia, he quickly became a successful printer. In 1729, he purchased “The Pennsylvania Gazette,” and in 1732, he published “Poor Richard’s Almanack” to share his interest in science, including weather forecasts, and discoveries of the era.

Inspired by the Royal Society of London, which was founded in 1662 to promote scientific research, in 1731 Franklin created the Library Company of Philadelphia, which collected scientific instruments and sponsored lectures in science. He helped establish the American Philosophical Society and the Academy of Philadelphia, which later evolved into the University of Philadelphia.

Franklin’s work with electricity, including the kite experiment, secured him prominence first in Philadelphia and later in Europe, where he was respected and admired. In time, his fame would spread “into Russia and through the Americas, including the Spanish and Portuguese colonies,” said Chaplin.

When Immanuel Kant called Franklin a modern Prometheus for “having drawn fire or electricity from the heavens,” the German philosopher “was implying a similar defiance of the natural and supernatural order of things,” according to Chaplin. The same theme occupied Mary Shelley, who might have had Franklin in mind when she published “Frankenstein: or, The Modern Prometheus,” in 1818. Shelley’s novel presented “a darker vision of the man of science,” Chaplin noted, and delivered a “rather dire warning about scientific prowess.”

“Shelley had many possible targets in mind for this accusation,” she said. “Franklin is definitely one, maybe the major one, in this book. … If anyone ever asked me how Franklin is different from the other American founders, I’d say, in perfect truth, ‘Well, he’s the subtitle to Frankenstein.”’

And yet, as Franklin’s scientific fame grew, so did his political power. In 1753, he was appointed deputy postmaster general of North America. The year after, he was elected to represent the Pennsylvania assembly at the Albany Congress, “something that had never happened when he was just a printer,” Chaplin said. Franklin served as agent of the Pennsylvania assembly in London between 1757 and 1762.

During the Revolution, Franklin’s scientific reputation was an asset in his diplomatic efforts to secure France’s support for the insurgent colonies. He was a key figure in the founding and early years of the republic, helping draft the Declaration of Independence and the Constitution, but all his political power stemmed from his scientific prowess, Chaplin said.

“I do think the United States of America would have come into existence even if Benjamin Franklin never existed,” she said. “But I think most Americans are today unaware of the heavy lifting, starting in 1776, that Franklin’s reputation, as a famous man of science, performed for the United States. Science helped to make a powerful case for the nation at the dawn of its birth.”


Warning signs of alcohol-use disorder relapse

New study focuses on those with long history of sobriety


John Kelly Portrait.

John Kelly.

Niles Singer/Harvard Staff Photographer

Health

Warning signs of alcohol-use disorder relapse

New study focuses on those with long history of sobriety

6 min read

The road to recovery is a lifelong endeavor for those struggling with alcohol use disorder.

People relapse an average of five times before achieving sustained sobriety — and stumbles can happen even after years of abstention, according to John Kelly

Kelly, the Elizabeth R. Spallin Professor of Psychiatry at Harvard Medical School, is the first author of a new study that explores some warning signs for relapse, especially in those who have had long stretches of success.

In an interview with the Gazette, which has been edited for clarity and length, Kelly discussed the lack of research surrounding long-term relapse, and what clinicians and patients in recovery should look out for.


Could you explain what some of the markers look like in day-to-day life?

There were four domains we looked at — biological, psychological, social, and changes in treatment/recovery support services.

Biological factors are things like sleep, appetite, or pain. The psychological are things like anxiety, depression, boredom, or stress. Social factors are loneliness, isolation, or engagement with high-risk others and environments where alcohol or other drugs may be present.

And then treatment and recovery support services would be things like people changing their medication use, if they’re on an anti-relapse, anti-craving medication, or changing their going to meetings, or stopping counseling.

From a biological standpoint, the things that were most notable were pain and recreational drug use. They occurred more rarely, but when they did occur, they were very strong predictors of recurrence of the disorder.

“What can happen is that imperceptibly, under the radar and insidiously, people don’t realize that they’re moving toward a relapse.”

What sparked the decision to do this study?

We’ve got a ton of information — theoretical and empirical data — on short-term relapse. So we’re all quite familiar with the cues and triggers that can lead to relapse after a cessation attempt in these early days, weeks, and months. But there’s almost nothing that is known or was known about longer-term relapse once all of that so-called deconditioning has occurred — the unlearning of the conditioned cues that arouse the craving and the neurophysiological response when people become addicted to alcohol or other drugs.

We were able to uncover and discover some of the dynamics and content areas that were associated with longer-term relapse.

That’s what I think is very important from a disease-management perspective.

We talk about these illnesses as being chronically relapsing conditions, particularly in the first five years. It means that people, particularly in that first five years of their recovery, are still not out of the woods. They’re still susceptible to recurrence of the disorder, and yet we have no protocols in place for disease management in primary care or other clinical settings.

So what I wanted to do here was to try to see if we could uncover some of these warning signs that occur before people have a recurrence of the disorder, to monitor these kind of sobriety-based warning signs, or recovery vital signs that that can be monitored in primary care or other clinical settings.

Because we don’t have good biomarkers that will predict relapse or recurrence of an alcohol or other drug disorder, we have to rely on self-report and the kinds of psychosocial factors and environmental risk factors that can precipitate and increase risk.

In a clinical setting, how do we design the best screening questions to elicit the most useful responses?

I don’t think there’s any reason why people would be defensive about questions about pain, sleep, appetite, social-network changes, going to meetings, medication use. And so what we did is, we delineated a checklist, which is available in the paper as the appendix.

What that is, is a documentation and listing of all the things that people reported that precipitated relapse in the year. It provides a nice way for a clinician to broach the subject and then talk about some of these warning signs.

These signs are coming from people who have relapsed, who didn’t know that the relapse was coming. These people were, on average, in recovery for five or more years. What can happen is that imperceptibly, under the radar and insidiously, people don’t realize that they’re moving toward a relapse.

A good clinician can therefore talk about these things as risk factors, and make the patient more aware of them and even show them that these are potent risk factors for relapse, so pay attention to them.

“A very frequent, potent marker of relapse risk was when people reprioritized other things above their recovery.”

Why is it so important to catch this behavior as early as possible? How much more difficult is it to get back to sobriety after a relapse?

It can be, yes, because there’s a lot more shame and self-stigma that occurs in later relapses when people have been in recovery. So it’s very important to intervene before the recurrence of the disorder, to be proactive about it, rather than wait for some kind of disaster to happen — to end up in the emergency department, or overnight stays in the hospital, or some other thing that’s happened because of the recurrence of the disorder.

It can minimize the mortality rate and morbidity rate, as well as all the other aspects — the social ramifications and the negative ripple effects that occur in the families of people who relapse as well.

Was there anything that you found that was particularly surprising?

I think those biological factors, particularly physical pain. Even though that was a rare one, it was a potent one.

Also recreational drug use, especially with this kind of California sober idea — when if you have a certain type of drug use disorder, like alcohol use disorder, then you use something like cannabis as a kind of a harm-reduction or coping tool. But a lot of these people using something like cannabis relapsed on their primary drug, which was alcohol.

For me, a lot of it was really underscoring potent factors, which we’ve known about for a long time, like cognitive vigilance — the idea of making sure you don’t forget that you’re in recovery from this potentially deadly disorder, and making sure that regardless of how many days, months, years you have behind you, it doesn’t necessarily guarantee that you’re cured and that you still have to maintain vigilance.

So a very frequent, potent marker of relapse risk was when people reprioritized other things above their recovery.


Where have all the public intellectuals gone?

Panel discusses evolving tradition in U.S. due to social, economic shifts, and need for such thinkers in democratic cultures


Anastasia Berg, Jesse McCarthy, and George Scialabba

Anastasia Berg, Jesse McCarthy, and George Scialabba.

Photo by Mira Kaplan

Arts & Culture

Where have all the public intellectuals gone?

Panel discusses evolving tradition in U.S. due to social, economic shifts, and need for such thinkers in democratic cultures

5 min read

If there’s one thing public intellectuals can agree on, it’s the necessity of disagreement. But thoughtful debate in a public forum is becoming increasingly rare, threatening the the future of intellectual life in America, according to George Scialabba ’69, Professor Jesse McCarthy, and Anastasia Berg ’09.

The three spoke about the evolving role of the public intellectual at an event hosted by the Public Culture Project, an initiative of the Division of Arts & Humanities, on Feb. 25.

“Partly, public intellectuals exist to give voice and articulation to as-yet unformed ideas in public, the populace. And hopefully to compare and contrast,” said Scialabba, an essayist and literary critic. “It never works ideally. Usually public intellectuals, like everyone else, are partisan — sometimes rancidly partisan. But in democratic cultures they do help people understand their encoded impulses and desires and see them or hear them represented in public life.”

Scialabba, whose most recent book is the just-published “The Sealed Envelope: Toward an Intelligent Utopia,” said that that despite the longtime stereotype of the U.S. as an anti-intellectual nation, the country has historically produced many public intellectuals across ideological traditions. 

That would include, for instance, representatives of the so-called New York Intellectuals (such as Lionel Trilling, Clement Greenberg), Harlem Renaissance (W.E.B. Dubois, Alain Locke), Cold War liberals (Arthur Schlesinger Jr., Richard Hofstadter), conservatives (William F. Buckley, James Burnham), and individual writers like Hannah Arendt and Susan Sontag

But today, Scialabba said, the conditions that once supported great thinking are eroding. Urban gathering spaces and flexible part-time jobs that offered time and space to pursue intellectual pursuits are disappearing, and small magazines and newspapers can’t financially support writers the way they used to.

Additionally, many intellectuals have been absorbed into academia, where there is less room for public engagement, he said.

“For everyone, it means a narrowing horizon,” Scialabba said. “Students, especially, are affected. The panic currently raging among the young about their career prospects could not be a more effective deradicalizing agent and could not be more unfavorable to producing public intellectuals if it had been designed for that purpose.”

“For everyone, it means a narrowing horizon.”

George Scialabba

McCarthy, John L. Loeb Associate Professor of the Humanities and of the Social Sciences, defines intellectuals as people who believe deeply that ideas matter. He said that at many critical moments in American history, including the Civil War and the end of slavery, there was never a question for Black American intellectuals about whether arguments were important. 

“There was no way to ever imagine that ideas didn’t matter, the stakes of political struggle have always been so stark and so immediate that the question of getting involved in this emerges spontaneously and of necessity,” McCarthy said.

Berg, a philosophy professor at the University of California, Irvine, worries that with the advancement of technology, including AI, young people are increasingly deprived of opportunities to hone linguistic and cognitive skills.

She said it was especially concerning at times like the present when ideas and arguments are more important than ever.

“I really worry that people will not be able to conduct an argument, as their entire cognitive, linguistic lives are being mediated for them,” Berg said.

She warned of the dangers of falling into patterns of habitual, unexamined thinking, citing philosopher Hannah Arendt’s idea that most evil arises from thoughtlessness or a shallow inability to think beyond clichés and stock phrases — such as the kind a large language model may produce.

In fact, the whole reason Socrates insisted on accosting Athenian citizens with existential questions was to promote “perplexity” in others, she said.

In some corners of the country, intellectuals are taking on the cause, passing their passion for inquiry to the next generation through initiatives like the Program for Public Thinking, run by the University of Chicago, and “The Point” magazine, where Berg is an editor.

“Our task has been to inculcate the habit of perplexed thinking,” said Berg. “It’s only such thinking, Arendt insisted, that can condition human beings against that most banal, the most common and most treacherous evildoing. There’s an ethical significance to being able to approach things in a perplexed manner.”

She acknowledged that engaging in intellectual discourse and disagreement with others can be uncomfortable and destabilizing. For hosts and organizers, it can be hard to provoke thought in an audience without alienating or scaring people off.

“How do we stage disagreements? This is a huge focus of what we try to convey to our students,” Berg said. “How do we disagree in public and stage a disagreement that’s antagonistic and exciting and incisive, that draws in rather than alienates our readers or the people who identify with one of those positions? How do we encounter beliefs radically different than our own without condescension or contempt?”

That can help us, she said, at a critical moment in history.

“Today I see this extra task for public intellectuals of safeguarding a public, safeguarding the capacity of people to meaningfully disagree with one another.”


Anne Applebaum inspects the shards of post-war order

Atlantic staff writer weighs Ukraine’s future, ‘radical’ threats to global stability


Anne Applebaum with Serhii Plokhii.

Anne Applebaum and Serhii Plokhii.

Veasey Conway/Harvard Staff Photographer

Nation & World

Anne Applebaum inspects the shards of post-war order

Atlantic staff writer weighs Ukraine’s future, widespread threats to global stability

4 min read

As the Russia-Ukraine war enters its fifth year, and with the U.S. seeming to withdraw from its role as a reliable security and trading partner, there is now a clear understanding in Europe that it’s time to turn the page and prepare to go it alone, says author and journalist Anne Applebaum.

“Everyone you speak to now, not just in Europe but especially in Europe, talks about hedging: ‘How do we hedge against the United States? How do we find other markets? How do we protect ourselves? We’re now in a world where we have America on one side and Russia on the other, and we need to think about what our voice will be,’” Applebaum, a staff writer for The Atlantic, said during a March 4 talk with Serhii Plokhii, the Mykhailo S. Hrushevs’kyi Professor of Ukrainian History at Harvard.

The event was part of a series of talks on Europe in wartime hosted by the Harvard Ukrainian Research Institute, the Davis Center for Russian and Eurasian Studies, and the Center for European Studies at Harvard.

Applebaum, who has written several books on the political histories of Russia, Ukraine, and Europe, said that the current global moment harkens back to the dark politics of a century ago, when ethnonationalism was on the rise. Most striking, she said, is the weakening of the rules-based world order that emerged after World War II and prevailed into the 21st century. At the recent Munich Security Conference, she said, the terms “liberal world order” and “rules-based world order” were being “used as a kind of insult” by some.

“It was a thing you say to dismiss somebody — ‘That’s someone who doesn’t know what’s going on because they’re still stuck in the ideas of the 1990s and 2000s and we moved to something else.’” She added: “It’s a really very radical change, and obviously, it affects Europe, obviously it affects Ukraine, and obviously it affects us.”

Beginning in the 1990s, after the fall of the Soviet Union, the EU thought that trade with Russia, especially for its cheap oil and gas, was the best path toward peace and good relations, Applebaum noted. By providing Russia with some financial stability and integrating it into European markets, the thinking went, the Kremlin would be disincentivized to engage in conflicts with countries along Europe’s Eastern flank, she said.

“The breaking of that belief, especially in Germany, has been profound,” Applebaum said, “and I don’t think it comes back anytime soon.”

One possible outcome of the war could be a Europe that includes Ukraine. With its vast mineral and agricultural wealth, along with its military strength, Ukraine could be a “transformational” member of the EU and NATO, Applebaum said.

While there is a real desire among many in the EU and Ukraine to make the accession happen, she said, the process cannot move forward without approval from all 27 EU nations on numerous governance, trade, and security issues.

“The Ukrainians are frustrated by the EU conversation because they think, ‘You’re blocking us for no reason,’ and Zelensky very much wants to be able to offer Ukrainians something at the end of the war,” Applebaum said. “It’s just that the logistical and institutional complications aren’t small. They’re important.”

It’s too soon to know how the U.S.-Israeli war with Iran will affect Ukraine or Russia, according to Applebaum. Should the conflict continue, the global instability it has caused, including a spike in oil prices, may boost the Russian economy at a critical juncture, she said. Rapid depletion of U.S. weapons could also benefit Russia, she added.

On the other hand, a besieged Iran, which has been an important strategic Russian ally and reportedly used Russian intelligence to hit U.S. military targets, could seriously weaken Russia’s influence in the region, she said.

Applebaum believes that both wars have revealed a fundamental flaw in the informal alliance of autocratic regimes like China, Russia, and Iran. Though their antipathy toward liberal democracy remains constant, she said, they have shown little willingness to provide military support to their fellow autocrats.

“A lot of those regimes turned out to be more fragile than had been previously imagined,” she said. “One of the premises was that they would help each other when in trouble — and that seems to be not true.”


Daily multivitamin may slow biological aging

Greatest gains for participants who were biologically older, researchers say


Elderly man holding a supplement pill in his palm.
Health

Daily multivitamin may slow biological aging

Greatest gains for participants who were biologically older, researchers say

3 min read

How quickly our bodies age on a cellular level — our “biological age” — can differ from how old we actually are in years. Using data from a large randomized clinical trial of older adults, researchers from Harvard and Mass General Brigham evaluated the effects of taking a daily multivitamin over the course of two years on five measures of biological aging and found a slowing equivalent to about four months of aging. The benefits were increased in those who were biologically older than their actual age at the start of the trial. The results are published in Nature Medicine.

“There is a lot of interest today in identifying ways to not just live longer, but to live better,” said senior author Howard Sesso, a preventive medicine specialist at Mass General and a Harvard Chan School epidemiologist. “It was exciting to see the benefits of a multivitamin linked with markers of biological aging. This study opens the door to learning more about accessible, safe interventions that contribute to healthier, higher-quality aging.”

Epigenetic clocks estimate biological aging based on tiny changes in DNA. These clocks look at specific sites in our DNA that regulate gene expression (known as DNA methylation) and change naturally as we get older, helping track mortality and the pace of aging.

The new study, which uses data from the well-established COcoa Supplement Multivitamins Outcomes Study (COSMOS), analyzed DNA methylation data from blood samples of 958 randomly selected healthy participants with an average chronological age of 70.

Participants were randomized to take a daily cocoa extract and multivitamin; daily cocoa extract and placebo; placebo and multivitamin; or placebos only. Samples were analyzed for changes in five epigenetic clocks from the start of the trial and at the end of the first and second years. Compared to the placebo-only group, people in the multivitamin group had slowing in all five epigenetic clocks, including statistically significant slowing in the two clocks that are predictive of mortality. The changes equated to about four months less biological aging over the course of two years. Additionally, people who were biologically older than their actual age at the start of the trial benefited the most.

“We plan to do follow-up research to determine if the slowing of biological aging — observed through these five epigenetic clocks, and additional or new ones — persists after the trial ends,” said co-author and collaborator Yanbin Dong of the Medical College of Georgia, Augusta University.

Said Sesso: “A lot of people take a multivitamin without necessarily knowing any benefits from taking it, so the more we can learn about its potential health benefits, the better.”


The study received funding from the National Institutes of Health.


Like seeing art of Roman chapels in technicolor for first time

Students create relief sculptures in stucco using centuries-old methods to gain deeper insight into how, why artists made choices


Campus & Community

Like seeing art of Roman chapels in technicolor for first time

Elizabeth Jones (left), Shawon Kinew, and Jiwon Lee.

Veasey Conway/Harvard Staff Photographer; photo illustration by Liz Zonarich/Harvard Staff

6 min read

Students create relief sculptures in stucco using centuries-old methods to gain deeper insight into how, why artists made choices

The vibe was festive, with jazz playing in the background. Students worked quickly but didn’t rush to form relief sculptures of fruit — apples, lemon, pomegranate, strawberries, cherries, leaves, all set against an arch.

The group of 11 had gathered at the Harvard Art Museums’ Materials Lab on a recent Friday afternoon to try their hands at sculpting in stucco, a thick, gritty compound made of lime, sand, and marble dust that had been widely used for decorative purposes during the Renaissance and Baroque periods across Europe.

Held as part of the graduate seminar “Sculpture, Theory, Practice: Donatello, Michelangelo, Bernini, Serpotta,” taught by Shawon Kinew, assistant professor in the Department of History of Art and Architecture, the workshop aimed to bridge the theory and practice of sculpture.

“As an art historian, sometimes our discipline can become a little removed or abstracted from the actual materiality or the physical object itself,” said Kinew. “It’s always a valuable experience when you have that tactile understanding of what the artist was doing. Our aim in this workshop is to challenge our knowledge with the practical experience of art-making — what changes for the art historian when she knows how to make.”

Wearing white coats and blue gloves, students followed recipes of stucco mixes, materials, and techniques used centuries ago by artists Alejandro Casella, Pietro da Cortona, and Giacomo Serpotta as they molded relief sculptures from the armature, the framework supporting a sculpture, to the final layer of marmorino, a mix of lime and marble dust.

By the end of the workshop, students left with lessons beyond art history or stucco decoration.

Nathaniel Shields ’26, a master’s student in engineering and business, said the workshop helped him gain a better appreciation of art and what it takes to produce it, as well as a chance to practice what he was learning in class.

“It’s a huge privilege to be able to enter a class like this, where you have the ability to consider things from the historical perspective, but also the practical perspective,” said Shields. “After reading and learning about this material and the artwork in class, obviously the ability to put your hands into some stucco and try to make something yourself is pretty exciting.”

Kinew’s class focuses on artists such as Donatello, Michelangelo, Bernini, and Serpotta, and their use of materials such as bronze, wood, marble, wax, clay, and stucco.

The workshop’s focus on stucco was significant, said Kinew, because art historians have overlooked the material despite its widespread use across Europe between the 16th and 18th centuries.

Giacomo Serpotta’s work in Oratorio di San Lorenzo, located in Palermo, Italy.

Photo by Shawon Kinew

“Stucco sculpture is one of the most important and ubiquitous media of Renaissance and Baroque Italy, and still it is rare for it to get the same scholarly treatment as fresco or marble sculpture,” said Kinew.

Similar to marble but much cheaper and lighter, stucco was mostly used in sculpture and decoration in churches and palaces throughout Italy and Europe.

Due to its lightness, sculptors favored stucco as a “material of flight,” said Kinew. “It could render the most fantastic visions of flight — flying figures that seem suspended in air, rays of light, sunburst figures, all of which could only be achieved in stucco,” she added.

Tony Sigel, a former senior conservator at Harvard Art Museums, aided students during the workshop. He highlighted the role of the Materials Lab, which hosts hands-on classes for the public, campus groups, and students.

“Having a room like this in a museum like this is a very unique thing,” said Sigel, “and having the course taught by conservators is a gift.”

Conservators Alberto Felici and Elisabeth Manship, who led the workshop, said they hoped the students learn lessons that will help them in careers as art historians — or even as art enthusiasts. Felici and Manship are lecturers and researchers in the renowned conservation program of the University of Applied Sciences and Arts of Southern Switzerland.

“The main takeaway for me is that they realize how complicated it is,” said Felici. “It’s important that the students are able to understand the behavior of different materials, the thinking and the work that went into creating the art so that they would be able to better understand the aim of the artist.”

“The main takeaway for me is that they realize how complicated it is.”

Alberto Felici

In addition, students learned how much of this kind of art was a collective effort, Manship said. By working in groups, students replicated the workshop system used by Italian artists, who often collaborated with dozens of assistants and craftsmen on large projects.

“We forget that there were huge groups of people working together even if we only know the name of one artist,” Manship said.

For students, the best part was being able to work with a material they have been studying. They didn’t mind the challenges of dealing with stucco, a self-hardening material that requires fast work and nimble fingers.

“I’m not very good at what I’m doing,” said History of Art & Architecture concentrator Charlie Benjamin ’26 as he worked on sculpting a lemon. “I have a lot more appreciation for the artists themselves … In a way, the workshop demystified the art-making process, which you think of as a spontaneous act of creation, and you realize just how much sweat and forethought has to go into something [like] creating art.”

For Kinew, the workshop was a return to the legacy of art history classes that included making, which began at Harvard with Edward Waldo Forbes’ signature course, “Methods and Processes of Italian Painting,” known to students as the “Egg and Plaster” course, in 1932.

An art historian and pioneer in art conservation, Forbes taught students how to recreate early Italian paintings by using egg tempera, made from pigments mixed with egg yolk.

“Forbes’ students came to understand Giotto and Michelangelo by painting in tempera and in fresco,” Kinew said. “This was a moment when the study of art history was wholly integrated with art-making, a time when art history found its home in the museum.”

Kinew hopes that the workshop will help students and art lovers gain a deeper artistic appreciation of stucco as a decorative and sculptural art form.

“My hope is that now when we visit Roman or Palermitan chapels, we will see these spaces in all their complexity and parts, as stucco confections,” Kinew said. “It will be like seeing these spaces in technicolor for the first time.”


Unlocking hidden pocket on a billion‑dollar drug target

Scientists identify path toward making cancer drugs safer and more selective


Christina Woo standing in front of a chalkboard.

Christina Woo.

Photos by Veasey Conway/Harvard Staff Photographer

Health

Unlocking hidden pocket on a billion‑dollar drug target

Scientists identify path toward making cancer drugs safer and more selective

5 min read

For years, a protein inside our cells has quietly powered billions of dollars’ worth of cancer drugs. Now a team of researchers have discovered that this workhorse protein, called cereblon, in addition to its known functions, can also fine‑tune which proteins live and which are sent to the cellular trash.

The new study, published in Nature, is the first to identify and map an allosteric site — a hidden binding pocket — on cereblon. This research was led by Christina Woo, professor of chemistry and chemical biology, and her research group, in collaboration with a team of scientists at pharmaceutical company GSK and Scripps Research Institute.

Cereblon is part of a protein complex that tags other proteins for destruction. It became infamous because it was targeted by thalidomide, a drug prescribed for morning sickness in the 1950s and 1960s that caused birth defects. Decades later, thalidomide and related compounds were rehabilitated as treatments for blood cancers, precisely because they can redirect cereblon to tag disease‑causing proteins.

That principle is underpinned by a strategy called targeted protein degradation. Chemists design small molecules that bring bad proteins to cereblon, which then marks them for disposal by the cell’s disposal machinery.

Until now, nearly all of that work focused on cereblon’s orthosteric binding site — the same site thalidomide uses. The new study reveals that cereblon also has a second pocket, an allosteric site, that doesn’t replace the main binding site but changes what happens once it is engaged.

“This work is so novel that when I share it with audiences, you can see a ripple effect across the room of just how excited they are to learn about this new binding site on cereblon,” Woo said.

Scientists at GSK first identified a small molecule, SB‑405483, that appeared to boost certain signals, suggesting it might be binding somewhere else on cereblon.

“We immediately recognized that the discovery of an allosteric cereblon binder could represent a fundamentally new area of cereblon biology for exploration,” said Andrew Benowitz, executive director at GSK and former American Cancer Society postdoc at Harvard. “We knew of Professor Woo’s breakthrough contributions to the understanding of cereblon biology, and it seemed like a very natural idea to initiate a collaboration with her to better understand exactly what we had found.”

The Woo Lab led an extensive set of cell‑based studies, using reporter cell lines that produced different cereblon neosubstrates — proteins that can be targeted for degradation — fused to fluorescent tags. When a tagged protein was destroyed, its glow faded. By treating these cells with standard cereblon‑targeting drugs at the main site — with and without the new allosteric ligand — they could watch how the second site changed what was degraded.

Vanessa Dippon.
Vanessa Dippon. Graduate student Vanessa Dippon is seen in a portrait working at a hood in her lab in the Conant Chemistry Laboratory. Dippon helped uncover a hidden control dial on cereblon, a helper protein at the center of many blood cancer drugs. Veasey Conway/Harvard Staff Photographer

In some combinations, the allosteric ligand made certain targets easier to destroy. In others, it protected them, reducing their degradation. In many cases, results depended on the existing cereblon‑binding drug with which it was paired.

“We saw that this small molecule can enhance the degradation of certain neosubstrates in the presence of certain orthosteric ligands, but also that modulating this allosteric site can inhibit neosubstrate degradation,” said first author Vanessa Dippon, a graduate student at the Kenneth C. Griffin Graduate School of Arts and Sciences. “It just completely changed the repertoire and landscape of cereblon neosubstrate degradation.”

For Woo, that selectivity is the heart of the discovery.

“The most immediate application is the potential to enhance efficacy of orthosteric ligands for the desired target, and reduce off‑target toxicity, by reducing the ability to recruit undesirable targets,” she said.

To understand why a hidden site could have such wide‑ranging effects, the team turned to structural biology. Working with cryo‑electron microscopy expert Gabriel Lander at Scripps, they obtained high‑resolution snapshots of cereblon in different shapes.

Those structures revealed that when both the main and the allosteric sites are occupied, cereblon moves through a previously unseen intermediate form and settles into a more closed shape that is especially good at grabbing proteins marked for destruction. They also showed that the allosteric ligand nudges the main‑site drugs into slightly different positions, offering a structural explanation for the shifting degradation patterns seen in cells.

The discovery opens several new possibilities. One is to use allosteric ligands as add‑on modulators for existing cereblon‑based cancer drugs — boosting their action on desired targets while limiting the degradation of proteins linked to side effects. Another is to design new molecular glues or two‑headed degrader molecules that use the allosteric pocket itself.

More broadly, Woo sees the work as a window into how cells may naturally regulate cereblon and related enzymes.

“It implies that there’s so much more to understand about the way that these E3 ligases are regulated in us,” she said. “That likely implies that there are small molecules — endogenous molecules — that are doing those functions already. And we’re just kind of catching up to understanding it.”


The project was partially supported by the National Science Foundation and the National Institutes of Health.


‘A moment of real possibility’ in Alzheimer’s care

Experts explain how recent findings are demystifying disease that afflicts tens of millions worldwide


Health

‘A moment of real possibility’ in Alzheimer’s care

Panel at Radcliffe on Alzheimer's.

Alzheimer’s research panelists Cara Croft (from left), Ganga Bey, Jennifer Gatchel, Leyla Akay, and Immaculata De Vivo.

Veasey Conway/Harvard Staff Photographer

6 min read

Experts explain how recent findings are demystifying disease that afflicts tens of millions worldwide

Alzheimer’s disease is widely believed to be caused by accumulating amyloid plaques in the brain, which trigger cascading effects that cause damage. But efforts to reduce amyloid plaques haven’t reversed cognitive decline, causing some to wonder whether something else is going on.

Leyla Akay, director of biology at the Boston area startup TAC Therapeutics, is among them — and thinks that “something else” might be fat metabolism, or, more precisely, disruptions to normal fat metabolism in the brain.

Akay, who spoke at the Radcliffe Institute for Advanced Study on Thursday, pointed out that the recently approved Alzheimer’s drug donanemab reduces amyloid beta plaques in the brain, but that it only slows cognitive decline and doesn’t reverse it.

“Ultimately, these patients are declining,” said Akay. “It’s fair to ask if we can do better and ask, ‘Are there other potential causes of biological mechanisms contributing to Alzheimer’s disease?’”

During Akay’s doctoral work at MIT, she zeroed in on the APOE4 gene, a mutation of APOE3 and major risk factor for developing Alzheimer’s disease. APOE4 plays a role in lipid transport in the brain but is worse at the task than APOE3. The result is lipids accumulating inside of brain cells and disruption of nerve cells’ fatty myelin coating, which could affect how nerve signals move through the brain.

When Akay’s lab discovered that inhibiting a molecule called GSK3 beta reduced lipid accumulation inside of brain cells and improved myelination, they started TAC Therapeutics to develop the idea further.

Akay told the audience for the panel, which was part of Radcliffe’s Next in Science series, that early results are promising but there’s a lot of work still to be done.

“A lot of work ahead” was also a theme for other speakers at the event, who spoke about modifiable risk factors for Alzheimer’s, the possibility of social drivers influencing the condition, and how work continuing on the amyloid beta front includes a focus on the second step in the destructive cascade: the development of tangles of a protein called tau in the brain.

The event was moderated by Immaculata De Vivo, professor of medicine at Harvard Medical School, professor of epidemiology at the T.H. Chan School of Public Health, and the Melanie Mason Niemiec ’71 Faculty Codirector of the Sciences at Radcliffe. De Vivo said dementia — with Alzheimer’s as the leading cause — already affects 55 million people in the world, and that number is set to almost triple by 2050. Despite that gloomy forecast, De Vivo hailed the research moving ahead on several fronts that continues to push the frontiers of knowledge about the feared condition.

She hailed advances in molecular and cellular neuroscience, genetics, and genomics, in our understanding of how environmental conditions increase risk, and how clinical trials and advances in prevention are working to delay onset and slow progression.

“This is a moment of real possibility,” De Vivo said. “Our speakers today are advancing our understanding of dementia from very different vantage points: epidemiology and social drivers of health, clinical research and prevention, neurobiology and model systems, and the role of lipids — fats — and genetics in neurodegeneration.”

Cara Croft, senior lecturer in neuroscience at Queen Mary University of London described work in her lab using mice and naked mole-rats to explore the role of the protein tau in Alzheimer’s disease. Tau accumulates in fibrous tangles in the brain and is believed to be triggered by the initial accumulation of amyloid beta plaques. A key part of her work is examining how neurons can sometimes unravel tau tangles, allowing them to be cleared rather than accumulate.

“We know that proteins can unravel and unclump and that’s something that we want to boost,” Croft said. “Some neurons already have this fast tau unraveling and we want to normalize them all to have this really fast tau unraveling with the idea that this could be a future treatment for Alzheimer’s disease or dementia.”

Reducing risk of developing Alzheimer’s in the first place is possible and may depend in part on our legs and our appetites. Jennifer Gatchel, assistant professor of psychiatry at HMS and Massachusetts General Hospital, said recent work has shown that there is such a thing as a brain-healthy diet. The Mediterranean diet with legumes, fish, and olive oil; the DASH diet focused on lowering blood pressure; and the MIND diet, which combines elements of the two, have all shown benefits in lowering Alzheimer’s risk. Gatchel also pointed to recent work out of MGH that found that physical activity can affect risk. Those who walked more had reduced risk of the condition. And, though walking more was associated with even lower risk, even the lowest level, 3,000 steps per day, brought positive benefits.

“Even small incremental changes can actually have biological effects on our brain, so it doesn’t have to be all or nothing,” Gatchel said. “That was a very, very exciting finding.”

Our position in society may also play a role in our Alzheimer’s risk, according to Ganga Bey, assistant professor at the University of North Carolina Chapel Hill. Bey’s research focuses on how the stressors that come with social hierarchy, made up of socioeconomic factors such as race, gender, and ethnicity, can increase Alzheimer’s risk through stress, diet, blood pressure, and other physiological factors. The result, Bey said, is that Black Americans have twice the risk of Alzheimer’s, and Hispanics 1.5 times the risk, as non-Hispanic white Americans.

“Alzheimer’s disease and related dementias are patterned along clear racial, ethnic, and socioeconomic lines. Some sex or gender disparities exist as well but they are less consistently observed,” Bey said. “What in the environment that is doing all these things and causing so much disease, but is so poorly understood? What is it exactly that we’re referring to and how does it influence the behavior of our genes?”


Who still goes to the movies?

For some, ease of streaming can’t beat thrill of watching films on the big screen


Arts & Culture

Who still goes to the movies?

movie theater
8 min read

For some, ease of streaming can’t beat thrill of watching films on the big screen

Moviegoing isn’t what it used to be. Rising ticket prices, worsening theater etiquette, and lingering effects of the COVID-19 pandemic have all contributed to sagging box office numbers. A survey from October shows the percentage of moviegoers who frequently see films in theaters decreased from 39 percent in 2019 to 17 percent in 2025. In another poll conducted last year, 75 percent of Americans said they had recently opted to stream a movie at home instead of watching it in the theater.

Yet certain groups of dedicated moviegoers are defying those trends, particularly Gen Z audiences. In-theater events, anniversary screenings, and blockbusters with strong social media marketing have shown the most promise in filling seats, but recent releases shouldn’t be discounted: Ryan Coogler’s record-breaking Oscar nominee “Sinners” (2025) was shown at AMC Theaters in January for the fourth time, not even a year since its opening.

What is bringing some audiences back to theaters when it’s more convenient and cost-effective to watch at home? In a conversation edited for clarity and length, we asked Nathan Roberts, filmmaker, professor, and head instructor at Harvard Extension School, what he’s learned in six years of teaching his course “Why Do Movies Move Us?: The Psychology and Philosophy of Filmgoing.”


The last six years have highlighted the attendance problem facing theaters, but among groups that buck those trends you’d almost think it’s a non-issue.

There’s always been a kind of ritual aspect of going to the cinema that I feel has grown. When something becomes more of a niche activity, it can gain popularity for those who take it seriously. There is a certain identity associated with that activity, a kind of doubling down. There’s a similar kind of ownership that I’ve seen people taking with film that, in some ways, has to be taken if you’re going to justify going out of your way to go to the theater when it’s easier to watch something at home.

When there’s an event or specialness to a certain film, it tends to do well, but when people think of event cinema, they tend to think of things that are really big — films that are expensive, films that are lavish — but I also feel like something to pay attention to is how the event-ness isn’t just a question of size, but a question of delight in collective experience. People who like concerts can go to big festivals, but true lovers of live music often will enjoy going to a smaller venue with an artist they really love, where it feels like there’s a kind of intimacy. I’m curious to see to what degree we can discern whether collective intimacy is as important, if not more important, than the bigness or splashiness of the event. A recent example is the film “Send Help” (2026), which is unique as it held consistently at the box office despite losing screens. It’s a very fun film to watch with the crowd because not only are transgressive things happening — there are some sequences that are kind of violent and crazy — but there’s this psychological element to how these two characters relate, which makes it so fun to see with a full house and people reacting. I think it is a sign that an original studio film — not a piece of intellectual property — can actually do quite well and maintain longevity because of how fun it is to watch with an audience.

Nathan Roberts.

Nathan Roberts.

Photo by Jessica Lim

Is there really a measurable difference between seeing movies at home versus in the theater?

In one study from 2021, they found that it’s not only hardcore cinephiles who like going to the movies. There’s actually an emotional component to how people respond to films that differs depending on whether they watch them in the theaters or at home. That said, empirical studies are difficult because there are so many independent variables that go into every single experience of film viewing. I think that’s why a lot of the scholarship on this issue has been phenomenological, largely drawing on and thinking through aspects of personal experience that can be shared, but come from a subjective place rather than an objective one.

How do reissues fit into the conversation?

Reissues are in part, a response to the broader problems at the box office: a lack of theatrically distributed films across the board. A lot of these theaters — AMC Theatres and so on — are built with a number of auditoriums that are not necessarily being fully utilized. There’s empty space and the theater isn’t making money. So regardless of the number of people who go to these reissues, offering the possibility for people to buy tickets and come to see these films is only a net gain for the theater.

There’s also the question of differentiating the theater experience from the home experience. Home theaters are great — now you can get huge televisions, but you can’t match the quality of IMAX at home. A lot of these reissues are in IMAX, including films not shot on IMAX. One of the more interesting and strange reissues, in my opinion, was “Black Swan” (2010) in IMAX last year. That film was shot on 16 mm, and IMAX is 65 mm. There must have been some post-production processes that they did in order to make it look good when it was blown up to IMAX, but that, to me, suggests that the reason for the reissue is not necessarily even a means of showing the film in the best possible way, but providing a sensory experience for a viewer that they simply can’t have at home. There’s a long history of Hollywood cultivating technologies for theaters to differentiate themselves from home television distribution. It feels to me like this is a continuation of that process. I do wonder if people are thinking, “Wow, this film was amazing to watch at home, how cool would it be to actually see it on the big screen, or to see it in IMAX?” Re-releases offer an opportunity for people who, the first time around, weren’t motivated to see it on the big screen, to catch a full sensory experience of a film.

“Filmmakers desire to create immersive collective experiences, because those are often the experiences that made them love and want to make films in the first place. “

Given how many don’t make it to theaters, are filmmakers still making movies with the theatrical experience in mind?

This is one of the places where it’s important to differentiate between what studios desire and what filmmakers desire. Filmmakers desire to create immersive collective experiences, because those are often the experiences that made them love and want to make films in the first place. It’s only, in my experience, industry incentives that push against that. On the extreme end of the spectrum, something that has grown as a way to make money while the film industry is floundering are these so-called “vertical dramas,” literally designed to be watched on the phone. Often, they’re low production value, nonunion projects that don’t pay very well. From my point of view, living in Los Angeles, being a filmmaker, having talked to filmmakers, I don’t know a single one who’s like, “I can’t wait to make this vertical drama,” or “I can’t wait to make something that people watch at home on streaming.” This is continually backed up by things that you can read in the press and hear at award ceremonies where filmmakers say, “Keep theaters alive!” “Go to theaters!” Part of the desire is to create an image that is so detailed and full that it can be appreciated on a big screen, to craft a kind of overwhelming or sensory experience. There’s a delight in creating a 5.1 surround-sound experience that can only be had on the quality sound system of a theater.

So why do movies move us?

Every time you go to sit down and see a film with a group of people or by yourself, there’s always something that is going to be moving in a new and different way. That is what gives me hope in filmgoing: There isn’t a preset way of how movies move us. There are always possibilities for new forms and new ways of being moved, and new ways of forming collectivities, whether it’s seeing films in the theater, gallery, or seeing films at home. The lack of predictability, or the lack of predictable response, is a beautiful thing.


That’s a book?

Faculty, staff offer recommendations for side trips off the beaten path


Illustration by Liz Zonarich/Harvard Staff

Arts & Culture

That’s a book?

Faculty, staff offer recommendations for side trips off the beaten path

long read

Every book is a doorway into another world, and some worlds are weirder than others. We asked members of the campus community to recommend a few that expand our notions of what literature can be. 


“The Castle of Crossed Destinies”

Italo Calvino

A half-century before the advent of LLMs, Italo Calvino was experimenting with the use of combinatory and computational systems for crafting new literary works.

The automation of writing, he speculated, could open up powerful new horizons of literary expression as machines became increasingly capable of bringing to the page “all those things that we are accustomed to consider as the most jealously guarded attributes of our psychological life, of our daily experience, our unpredictable changes of mood and inner elations, despairs and moments of illumination.”

Frustrated by the limitations of period computer technology, he found his ideal “machine” in the tarot card decks used by card players and cartomancers. 

Such is the storytelling engine deployed in “The Castle of Crossed Destinies” (1973), a novel built out of images instead of words, in which the narrator “plays” two separate decks and each run of cards generates a sequence of intertwined tales that include the stories of Astolfo’s journey to the Moon in the “Orlando Furioso” and the plots of “Hamlet,” “Macbeth,” and “King Lear.”

The novel is divided into two sections: “The Castle of Crossed Destinies” (which takes place in a medieval castle and is built around the mid-15th-century Visconti-Sforza tarot) and “The Tavern of Crossed Destinies” (which occurs in a Renaissance inn and is built around the 17th-century Marseille tarot).

Calvino thought of adding a contemporary, post-apocalyptic coda to the book, titled “The Motel of Crossed Destinies,” generated by remixing fragments of comic strips and popular magazines, but never brought the project to fruition.

Jeffrey Schnapp, Carl A. Pescosolido Chair in Romance and Comparative Literatures, founder of MetaLAB (at) Harvard, and faculty co-director of the Berkman Klein Center for Internet and Society


“People Who Led to My Plays”

Adrienne Kennedy 

Playwright Adrienne Kennedy’s “People Who Led to My Plays” (1987) is an extraordinary memoir, a journey into the mind of a brilliant artist, an explosive collection of lists, thoughts, photographs, and images that takes us into her life and development as an artist.

The memoir begins with her years as a young Black girl in elementary school in Ohio in the 1930s, and it ends with her traveling to Europe and Africa in 1960-61 with her own young family, where she finally discovered the distinct nonlinear style and voice that would make her one of the greatest playwrights of our time.

The structure of the book is exhilarating and unexpected. It is divided into five chronological sections, and each section is full of vignettes — sometimes a few paragraphs and sometimes only a line or two, each one beginning with an italicized name or place. A single page might include headings such as: “People my mother dreamed about,” “Julius Caesar,” “Lorca,” “My father,” “Paul Robeson.”

Threaded between these vignettes are family photos, pictures of movie stars, writers, art — all the people and places that shaped her plays.

Imagine someone taking you into a room that leads to a thousand other rooms — showing you this image and that, telling you what it is that struck their heart as they saw it or thought about it, speaking to you with a powerful directness and candor. This is a book that is at once a work of poetry, a scrapbook, a glimpse into the mind of an artist, and a portrait of the world.

I cherish my copy. Adrienne Kennedy taught at Harvard my freshman year, and her playwriting class was the first course I took. She gave me a copy of “People Who Led to My Plays” after I’d finished her course, over tea, and she wrote words of encouragement inside. It meant so much!

Talaya Adrienne Delaney, research adviser in the humanities and lecturer at Harvard Extension School


"the waste books" book cover

“The Waste Books”

Georg Christoph Lichtenberg

It’s hard to call this experimental fiction since I don’t know that the author is explicitly trying, but it certainly falls under “weird books.” It’s a collection of fragments, aphorisms, short little things that Lichtenberg, the 18th-century German polymath, jotted down for himself. It feels quite modern, like a person’s “drafts” folder for the current social media age. 

Tomer Ullman, Morris Kahn Associate Professor of Psychology


“Moominvalley in November”

Tove Jansson

My pick is Tove Jansson’s “Moominvalley in November”(1970), translated by Kingsley Hart.

Queer Finnish artist and writer Tove Jansson’s balloonish, serene Moomins are popular children’s characters the world over, as are the other figures who populate their world of Moominvalley. But “Moominvalley in November,” the ninth and final book in the series, is an unlikely children’s book about adult problems, written after the death of Jansson’s mother and suffused with suppressed grief and rage, all written in the gentle, sparse style of the earlier books.

The Moomin family are absent — they are having an adventure at sea driven by Moominpappa’s midlife crisis, documented in Moominpappa at Sea — and in their absence, six lonely, neurotic strangers drift into their empty house and wait for them to return. Among them are Fillyjonk, a cleaning obsessive who has developed a phobia of cleaning; Hemulen, who cannot live up to the standards of masculinity he has set for himself; Toft, a small, quiet creature who becomes fixated upon an old biology textbook he finds in the Moomins’ attic, and from it accidentally creates a monster; and Snufkin, who has lost a tune.

It’s a bewildering, beautiful book about letting go of family, deeply weird, and I return to it over and over.

Anna Wilson, assistant professor in the Department of English


“The Book of Margery Kempe”

Margery Kempe

“The Book of Margery Kempe” is, in the words of its most recent editor, astonishing.

Its very existence is something of a miracle. The sole surviving manuscript was discovered in the billiard room of a country house in Derbyshire in 1934. The befuddled owners turned to an expert, Hope Emily Allen (who had studied at Radcliffe) to tell them what they had. Allen immediately recognized it as a long-lost copy of Margery’s “Book” and took the lead as co-editor of the first scholarly edition in 1940. (A translation by B.A. Windeatt was published by Penguin in 1985.)

The book has pride of place as the first autobiography in English, authored around 1430 by a woman who couldn’t read or write, so she dictated her life’s story to two men, one of whom was her son.

Margery herself was no less astonishing than her book. The mother of 14 children, she abandoned her conventional role as a merchant’s wife to devote herself to her spiritual calling. “The Book’s” episodes move between local life in Norfolk and far-flung journeys across Europe, including pilgrimages to Rome and Jerusalem. It tells of Margery’s ecstatic visions and her public bouts of weeping she called “roaring.”

Fearless about professing her faith, she came under scrutiny by church authorities, but like Chaucer’s fictional Wife of Bath, Margery adeptly used the words of scripture to refute her accusers. Weirdly unique, uniquely weird: There’s nothing quite like Margery Kempe and her “Book.” 

Daniel Donoghue, John P. Marquand Professor of English, general editor of the Dumbarton Oaks Medieval Library


“The Invisible Life of Addie LaRue” 

V.E. Schwab

“The Invisible Life of Addie LaRue” book cover

Spanning from the 1600s until today, we see the life of Addie LaRue, who made a bargain to live forever but is cursed to be forgotten by everyone she meets. This story, published in 2020, felt like it was creating a mythos as it was told, spanning centuries of Addie’s life as we learn what it means to be remembered. This feels more like a late summer, early fall book if you are a seasonal reader like me!

Meg McMahon, Harvard Library user experience researcher


“The Canterbury Tales”

Geoffrey Chaucer

Although the medieval writer Geoffrey Chaucer has long been called the Father of English Poetry, his most famous literary work is notably weird. “The Canterbury Tales” recounts how a group of pilgrims travel together from outside London to Canterbury and play a tale-telling game along the way.

So far, so good.

But for a supposed literary masterpiece, the “Tales” is wildly variable and uneven. It includes chivalric romances and stories of Christian virtue, fart jokes, and adulterous trysts. Parts of it are entertaining; parts are beautiful; parts are wickedly funny; parts are dull.

How are readers meant to feel about all this? Should they be offended, or bored? And which tale wins the prize? We’ll never know the answer to the last question because the work is unfinished. Not only that, but it survives only in pieces, which scholars are unsure how to arrange.

This is where the full weirdness of “The Canterbury Tales” emerges, in the murky intersection of historical accident, historical difference, and poetic invention. Chaucer was doing something quite new with the “Tales,” something that would have struck even his contemporaries as weird.

But plenty of the peculiarities we notice derive from the context we’ve lost between 1400 and today. Part of why I love reading Chaucer is the fun of following these tangled threads of the strange.

Julie Orlemanski, Walter Jackson Bate Fellow at the Radcliffe Institute 


“14,000 Things to Be Happy About”

Barbara Ann Kipfer 

Many years ago, I bought a book called simply, “14,000 Things to be Happy About” (1990) by Barbara Ann Kipfer. The premise is so simple it’s almost absurd — the book is just a list of things: “bakery croissants,” “a bedroom library,” “ a stalled car catching,” “the taste of cake batter,” “snappy salutations,” “listening for the sound of a key in the lock,” “the tag on our pillows that says sternly for reasons no one seems to know ‘Do not remove this tag under penalty of law.’”

I smile every time I open the book. Every page has something that I either love or marvel that I can’t stand but someone else loves, which also brings joy. How can someone get happy about “the act of entering a room and forgetting why” or “the gap in the dressing room curtain that can never be completely closed” or “overcoming acalculia (inability to do basic math),” I think, and I laugh at the variety of this world.

I also love the book’s subtle instruction — these words are just words; what brings joy is the meaning we associate with each event it conjures.

It also serves as a reminder that books are objects of craft. So, my tattered copy of the book is right there in the living room next to the others, and I love the strange little book, if we might call it that, so much.

Sarah Lewis, John L. Loeb Associate Professor of the Humanities and associate professor of African and African American Studies


Aging independently, by design

Most older adults say they want to spend their golden years in their own homes. The reality is more complicated, says urban planning expert.


Ann Forsyth standing in a stairwell.

Ann Forsyth.

Niles Singer/Harvard Staff Photographer

Nation & World

Aging independently, by design

Most older adults say they want to spend their golden years in their own homes. The reality is more complicated, says urban planning expert.

7 min read

With the rapid graying of the United States, due to extended lifespans and declining birth rates, concerns among older adults are also on the rise. Their worries range from financial concerns to physical and mental health issues to healthcare and housing.  Most older adults would prefer to stay in their own homes throughout their golden years, according to a recent Pew Research Center poll. But aging in place is not that simple.

In this interview, which has been edited for clarity and length, Ann Forsyth, Ruth and Frank Stanton Professor of Urban Planning at the Graduate School of Design, talks about what aging in place entails, how technology helps older adults, and what communities can do to assist those who want to avoid the nursing home.


In surveys, most older adults say that they would prefer to live in their own home rather than a nursing home. How would you define aging in place?

At its simplest, it is aging in your own home. But that leaves a lot of questions, such as which home is home? Is it the home you lived in in your 40s and 50s? Is it one that you moved into in your 60s and 70s in order to age in place? And then the issue is, for how long? Is it one that you would leave only when you die? Or do you stay in that home as long as you can look after yourself and then move somewhere else in your community, maybe a senior housing development? For many people, aging in place is really about staying outside a nursing home.

What challenges do people face when trying to live independently as they age?

The main issue is uncertainty. There are many positives about staying in your own home. It provides shelter, meaning, and continuity. You may want to stay in your own home, but you’ve got uncertainty about whether you’ll be physically able and mentally able to manage your household. There’s also uncertainty about how long your household will stay intact. If you’re married or have a partner, and something happens to them, then you’ll have to make different kinds of decisions. For older people, there is more potential for surprises that could undermine their ability to stay at home. Some people might worry about mental problems that could affect their ability to manage their home finances and so on. There’s a lot of worry and concern.

Most homes are not equipped for aging in place. Can design help?

It is tricky. What you have to do is balance two factors, one of which is compensation for losses or problems that might come along. For example, being able to get around without having to go upstairs, or when using a walker, or being able to use assistive devices that may need wider, bigger spaces and so on. But you also need to have an environment that provides some challenge and meaning because you need to physically and mentally challenge yourself to maintain your capacities. The stairs dilemma is quite interesting: Do you have a house without stairs so that it’s easier to get around when you are no longer as mobile? Or do you have stairs because they help you maintain capacity through incidental exercise? If you’re wealthy enough, you can have a bit of both because you can have a bedroom and bathroom on the main floor. That’s very complicated; it’s hard to find those houses, and they’re quite expensive. One way to think about it is when your home gets too challenging, you move, but at that moment, you’re facing a lot of challenges, and the thought of actually having to move and deal with all your stuff and emotions may be very difficult.

How can urban planning support aging populations?

This is an area where cities need to bite the bullet. In the U.S., the Americans with Disabilities Act has been terrific for helping make public buildings physically accessible and offering protection for a variety of disabilities. But there is a need to think comprehensively about not only the physical environment, but programming, and other aspects of the social environment, which is key to prevent loneliness and social isolation among older people. That is something that more cities will need to do more of.

In terms of housing, there are two philosophies; one is clustering older people together so it’s easier to provide services like classes or meals, versus integrating them with the wider community. Both of them have benefits, and can be done at different scales, so you don’t have to have a massive retirement community like Sun City with tens of thousands of older people all in one place. You could have an apartment block filled with older people in a part of the city. That configuration allows them to be together, to meet and support each other, and to keep reforming their social networks as people depart.

There’s also age-specific housing for older people, or co-housing programs that try to mix older and younger groups of people, and both can work with or without external support. The debate always centers about how much clustering there is of older people to make services and socializing easier versus how much they’re just scattered throughout the environment, which makes it more complicated for services. But one successful example of the scattered housing is the Village model in Boston and elsewhere now, where people that are scattered throughout the city find each other through this villages group that provides services, social connection, and a sense of community.

What role can technology play in helping older adults age at home?

There are many kinds of technologies that can make aging in place much easier. We’re not only talking about walkers and wheelchairs, but also digital technologies and even ordinary appliances. In a study I did with Yingying Lyu, a Harvard graduate who now works at West Chester University of Pennsylvania, we found that older folks in rural China prefer to use a rice cooker or a slow cooker because it makes them feel much safer than using gas-stoves or wood. Robotic vacuums are also helpful, but there are other kinds of technology that are changing old age. For example, going up and down stairs can be complicated, but with the help of robotic shorts, we might be fine with stairs. Technologies can also help caregivers. A lot of robots can help people lift things, and they could help caregivers transfer someone from a bed to a wheelchair or help get them out of the bathtub. Technology already helps older folks maintain family ties and social relationships through video conferencing on computers and phones.

People are living longer and having fewer children. How might these demographic changes affect the care of older Americans?

There are big challenges these days with smaller families, more mobile populations, and older people living so much longer. As families reduce in size and disperse more, there will be less labor to do that informal, unpaid care that families do for their older relatives. There will be more need for paid care. That’s going to be a huge challenge in most parts of the world.

There are a number of strategies for minimizing the amount of care older people need, and that includes improving people’s health, so that they would need less care. It also includes finding new sources of caregiver labor force, such as attracting people from different industries into caregiving or relying on immigration, which is often used to increase the caregiving workforce. And then promoting cooperation among older people to care for each other, using technologies, both for caregivers and older people, and improving the environment. Of course, all of these strategies need resources, and communities and governments need to be better prepared to deal with the impact of demographic changes on aging populations.


Conan O’Brien ’85 named Commencement speaker

Comedy legend who once led Lampoon will deliver principal address on May 28


Campus & Community

Conan O’Brien ’85 named Commencement speaker

Comedy legend who once led Lampoon will deliver principal address on May 28

2 min read
Conan O'Brien.

Pamela Littky for HBO Max

A collection of stories covering Harvard University’s 375th Commencement.

Comedian, writer, television host, and Harvard alumnus Conan O’Brien will be the principal speaker at Harvard’s 375th Commencement on May 28.

“Conan O’Brien is a singular and outstanding American humorist,” said President Alan M. Garber. “His work, deeply rooted in close listening and keen observation, creates joyful connections between and among ideas and people. I look forward to sharing the stage with him in Tercentenary Theatre later this year. Harvard is tremendously fortunate to call him one of our own.”

One of America’s most beloved comedians, O’Brien rose to prominence as a writer for “Saturday Night Live” and “The Simpsons,” earning an Emmy Award before becoming the host of “Late Night with Conan O’Brien” in 1993. O’Brien’s role as a talk-show host would continue for nearly three decades, over which he built a devoted following attracted to his offbeat, intimate, and self-deprecating humor.

O’Brien’s fans have followed him beyond his late-night work. His travel shows “Conan Without Borders” and “Conan O’Brien Must Go” — which included trips to Armenia, Haiti, South Korea, and Ireland — were praised not only for their humor, but for their warmth and curiosity. His podcast “Conan O’Brien Needs a Friend” has become one of the most popular interview podcasts, offering an even more personal and unscripted setting for O’Brien and his guests. In recognition of his influence on American comedy, O’Brien was awarded the Mark Twain Prize for American Humor in 2025.

A native of Brookline and member of Harvard’s Class of 1985, O’Brien served as a two-term president of the Harvard Lampoon and graduated with a degree in History and Literature. Decades later, a fan handed O’Brien a photocopy of his undergraduate thesis, “Literary Progeria in the Works of William Faulkner and Flannery O’Connor,” minutes before he was set to deliver a performance. “I knew then it was time to die,” he later joked.

O’Brien has remained connected to the University throughout his career, appearing often on campus and speaking at both Harvard’s 2000 Class Day and its 2020 virtual graduation ceremony. He has encouraged students to experiment widely with coursework and extracurriculars and to push through insecurity, which he said he faced as a student and throughout his career.

O’Brien also will be awarded an honorary degree.


‘Harvard Thinking’: Is marriage worth saving?

In podcast, experts dig into why wedlock’s appeal is fading — for one group especially — and how to make it work better


Nation & World

‘Harvard Thinking’: Is marriage worth saving?

Illustrations by Liz Zonarich/Harvard Staff

long read

In podcast, experts dig into why wedlock’s appeal is fading — for one group especially — and how to make it work better

In many ways, marriage began as a real estate transaction. It was also used to corral sexual behavior, establish family units, and provide financial stability to women. Nowadays, people have more freedom to pursue aspects of life such as sex, money, and parenthood without tying the knot.

“Really now the only reason to be married is because you love someone. We don’t need it anymore,” said Debora Spar, the Jaime and Josefina Chua Tiampo Professor of Business Administration at Harvard Business School.

Many women are now questioning the benefits marriage has to offer, said Eve Rodsky, bestselling author of “Fair Play: A Game-Changing Solution for When You Have Too Much to Do (and More Life to Live)” and Harvard Law School alum (’02). Largely because of ingrained expectations, she said, women take on the burden of housework despite having careers of their own. That needs to change, she said, if marriage is to remain valuable to both parties.

Richard Schwartz, associate professor of psychiatry at Harvard Medical School and a consultant to McLean and Massachusetts General hospitals, pointed out that many studies have shown marriage boosts people’s health, happiness, finances, and parenting ability. But he agrees that more recent studies have shown that some of those benefits help men more than women.

In this episode of “Harvard Thinking,” host Samantha Laine Perfas talks with Spar, Rodsky, and Schwartz about the role of marriage in society today.



Listen on: Spotify Apple YouTube


Debora Spar: We desperately need to restore community and restore physical institutions and organizations. That alone won’t save marriage. But I think it will take the burden off. Because it is absurd if you think about it, that one single person, even the most wonderful person in the world, can be your lover, your soulmate, your co-parent, forever.

Samantha Laine Perfas: Just as society has changed, so has marriage, including the problems and rewards that come with it. Research suggests its benefits show up in your physical and mental health, but it might not seem like it when you’re buried in the second job of managing a household. With greater social acceptance of a variety of lifestyle choices, many people, especially young women, are thinking twice before tying the knot. Should you?

Welcome to “Harvard Thinking,” a podcast where the life of the mind meets everyday life. Today we’re joined by:

Spar: Debora Spar. I’m a professor at the Harvard Business School.

Laine Perfas: She’s written a number of books that look at the interplay between technological change and relationships, including marriage. Then:

Richard Schwartz: Richard Schwartz. I’m an associate professor of psychiatry at Harvard Medical School.

Laine Perfas: He studies marriage with his wife, Jacqueline Olds, who is also a psychiatrist at the Medical School. They’ve written about both marriage and loneliness. And finally:

Eve Rodsky: Eve Rodsky. I’m the New York Times bestselling author of “Fair Play.”

Laine Perfas: She’s also a graduate of Harvard Law School, class of 2002. And I’m your host, Samantha Laine Perfas. I’m a writer for The Harvard Gazette. Today, we’re going to talk about marriage and whether the challenges are worth the benefits.

Historically, what role did marriage play in society?

Spar: Well, it’s always very harsh to say this, but marriage as we know it actually emerged as a real estate transaction. If you go way back in time, our early ancestors didn’t marry at all. They lived in tribes and children were sort of raised communally, and it was only with the advent of the agricultural society that marriage became necessary. It was a way of ensuring that property was maintained between generations. It was a way, way before DNA testing, for men to know who their children were, which became important once you invested in property and farming and land. And so marriage emerged as a way of creating these family bonds that would enable property to be maintained and society to be stabilized. And I always hate to say this because I feel like the rat at the party, but if you go to most marriage ceremonies, even today, across religions, you can hear the echoes of the real estate transaction: that the father gives the daughter away, promising that she will remain faithful to one other human being for the rest of her life as long as they both shall live — which as my students are fond of reminding, me is a very long-term contract — and with the promise that they will be fruitful and multiply, which we now hear as romantic. But back then, being fruitful and multiplying was the way of creating labor, which was, along with land, the most valuable commodity. So, sorry to be anti-romantic, but marriage really has a history as an economic transaction.

Rodsky: Up until the third wave of feminism, marriage was assumed to be a man and a woman, and that man would protect and provide for that woman in exchange for that woman doing all of the unpaid labor to allow him to do that. But then as we rose in the third wave of feminism, where we were told that women were getting all of these gains in the workplace —  so I’d say up until today, the way I look at marriage is, well, that social contract needs to be completely rewritten. Because the fourth wave of feminism is not about getting women gains in the workplace; it’s about having men make gains in the home. Otherwise, that social contract to me is completely dead. We’re sort of a downer, Debora and me.

Schwartz: I don’t know if this is cheering things up anymore, but I just add that Debora is describing how marriage begins as basically a land and property arrangement. You extend it, and it becomes a division of labor for the sake of the family-unit arrangement, and those are the primary roles it plays. It seems to me that it has also traditionally played two more roles. One is essentially to corral sexual activity into a defined space where it doesn’t interfere with and get in the way of other kinds of relationships that are important for the functioning of the community. And the other thing that it does, of course, is to stabilize raising children. And I think that was an equally important role that it has played.

Laine Perfas: I am not going to lie, I did not anticipate that our episode on marriage would start on such a depressing note. But marriage has clearly evolved since its inception, same-sex marriage being one obvious example. What other ways has it shifted?

“We desperately need to restore community and restore physical institutions and organizations. That alone won’t save marriage. But I think it will take the burden off.”

Spar: It’s gone through many evolutions, some more subtle than others. But if we take the initial piece as this real estate deal, it was really around the industrial revolution when the farming economy begins to decrease in importance that this idea of companionate marriage or romantic marriage becomes much more prominent. So it’s not our generation that discovered the idea of romance and love in marriage. It’s been around for a long time. And of course, to be less depressing, love’s been around for a really long time. It just wasn’t necessarily connected with marriage. We start to see this idea in the late 19th century, maybe even a little earlier, that love and marriage do in fact go together. I think what we’ve seen most recently, though, is that the other economic reasons and societal reasons for marriage have more or less gone away. A man doesn’t have to be married to have sex. A woman doesn’t have to be married to have sex. Men and women don’t have to be married to have children, because we’ve had the advance of reproductive technologies and the decrease in stigma around single parenthood. So I actually see this as rather a beautiful trend because now the only reason to be married is because you love someone. We don’t need it anymore. Which in many ways, I think, contributes to the decline in marriage because certainly many people, and increasingly women, are saying, if I don’t need to be married, why bother? But there’s still an awful lot of people saying, I don’t need to be married, but I really love this person and I do want to spend the rest of my life with him or her.

Laine Perfas: Let’s unpack that statement: Why bother? There have been many studies out there that show marriage does have benefits. It benefits individuals, it benefits communities, it benefits children. Could one of you talk a little bit about those benefits?

Schwartz: There have been a whole group of studies that have suggested that marriage has benefits in three main areas. One is in health, one is in happiness, and one is in how children do over time. Children raised by two parents do better academically, do better economically. Boys are less likely to end up in prison. Girls are less likely to end up depressed. And most of those studies have held up, although there’s now increasing debate about how it looks. It is clear that the health benefits for men are greater than they are for women. There are recent studies that suggest that maybe the happiness benefits are also greater for men than women. It’s hard to judge that when a new study comes out, that seems different from the historical ones that have shown that women benefit in happiness from marriage. And now there’s a new one that suggests maybe that’s not really true. Hard to know if that’s things changing, if that’s just difficulty in methodology with one study or another. We just have to wait and see on that.

Rodsky: I think what Richard said is very true. We are seeing that the benefits of marriage really do accrue to men — and back to Debora’s romantic love, I’ll just tell you a quick story. I was with nine women, Oscar-winning producer, the head of a stroke and trauma unit at a big hospital. There were 10 of us at this breast cancer march. This was 2011. We were there to honor a friend who had been recently diagnosed, and it was a beautiful morning. We were all covered in pink carrying signs that said things like “not just a women’s problem.” But then around noon, Sam, everyone started looking at their phones and everyone looked desperate to get out of there. We were supposed to go to lunch. And every one of those women married to a man were looking at texts from their partners with things like, “Where did you put Hudson’s soccer bag?” … “If you want me to go to the birthday party, did you leave me a gift?” … “I can’t take the baby to the park because you didn’t leave me any clean diapers.” My favorite was my friend Kate, the one who had been diagnosed with breast cancer. Her husband at noon texted her, “Do the kids need to eat lunch?” And so what I want to say about that day, because I write about it in my first book, “Fair Play,” all those strong women said to me, “I left my partner with too much to do.” Before we left, I asked those women to count up how many phone calls and texts we’d received. We had 30 phone calls and 46 texts for 10 women over 30 minutes. That’s the cost of marriage. Romantic love is pretty much unpaid labor unless you do some serious work at the beginning of your marriage. I think that a lot of women are saying, “What’s in it for me?”

I would say that what Richard said is right: We are actually not sure what the benefits are to women anymore. I think until we rewrite the social contract, it’s going to be really hard to sell the benefits of marriage to women.

Spar: Let me push back a little bit. Going back to what Richard said, it’s almost incontrovertible that marriage is good for children. It doesn’t necessarily have to be a legal marriage. It doesn’t have to be a heterosexual marriage, but as Eve’s talking about, raising kids is hard. It’s really hard. It does take a village, it takes a tribe, it takes cousins and grandparents. And part of the societal problem we’re living with is we’ve all moved away from our birth families. And we know fertility numbers are shrinking, so the village is disappearing, which puts all of the pressure on the marriage, on two feeble, fragile people to raise a child. As Marx and Engels pointed out many years ago, the original division of labor was within the family. And the math is pretty straightforward. If you have two parents, one can be the income earner and one can be the housekeeper. It works. It’s not fun for those, you know —  it’s historically been women who have been stuck with the housework, but the math works. What’s happened in the past 50, 70 years is women have — and God knows, I’m a beneficiary of this — decided, I don’t want to just be changing diapers. I want a job, I want a life, I want friends. I want to go to marches and walks and all these things. The problem is we didn’t find anyone else to take over the housework. And so we’ve created a problem, and this isn’t to get the lazy husbands off the hook. It’s, as I’m fond of saying, it’s a math problem. We don’t have another set of hands to take care of the labor that women are no longer willing to do by themselves. And the last thing I’ll say is, women, for better and worse, have come up with multiple identities since feminism. We can be working moms and we can be single mothers, and we have a range of identities. Men are still largely defined by their role as economic breadwinners. It’s not only that we need to rearrange women’s roles. We need to rearrange men’s roles as well. And we need perhaps to come up with a new version of the nuclear family because the math doesn’t work once women go to work.

Rodsky: Amen. That is right.

Schwartz: I think that’s an incredibly important point. Years ago, my wife and I did a small study of the effect of different work and homemaking responsibilities among men and women with young children. And one of the things that turned up that we didn’t expect and had nothing to do with what we were actually looking at is all the men in this sample had children under 5. And one of the things that they described is that they all wanted to be more involved with their children than their fathers had been with them. And they wanted to be just as involved and committed to work as men have always needed to be. And they couldn’t fit everything in, and something had to give. And what gave for almost all of them was friendships, and they basically fell out of connection with their friends over a long period of time. That speaks to the problem that men have in trying to maintain the work role that they’ve always had while somehow adding something else into it. And you can’t do that without cutting something else out.

“Romantic love is pretty much unpaid labor unless you do some serious work at the beginning of your marriage. I think that a lot of women are saying, ‘What’s in it for me?’”

Laine Perfas: It is meaningful to see the current generation of fathers not having a model and still trying to figure it out anyway, and it’s messy. But one of the things that I saw — I think it was a few years ago — this study came out, it was looking at the division of labor in the house, but then also the perception of that division of labor. And women tend to take on about two-thirds of the workload at home, but men perceive that they are doing it equally, which as you can imagine is incredibly infuriating for both parties. What’s going on there? Why is there that gap in perception?

Rodsky: This is what I study and I will say that what we did with “Fair Play” is we created a system so that perception would be equalized, because there is a perception gap. But there’s a perception gap because, as Arlene Kaplan Daniels — she was a sociologist — in 1987, she said that the work of the home was invisible. So in our studies, we started to ask couples, hetero, cisgender couples especially, who does what in the home? Who handles groceries, who handles middle-of-the-night comfort? Who handles transporting your kids to school? Who handles medical and healthy living? And the answer was, we both do. But the problem with that data was that men were overreporting, women were underreporting. So we changed the question. The question that broke open the data was, instead of asking who handles X, it was, How does mustard get in your refrigerator? Because I could ask that in 27 countries. And the beauty of that question was that we saw that women — even in the Nordic countries where we think that we’re doing it better because there are policies to support marriage — women were the ones who said to me, “I’m the ones who notices that our pediatrician said our son is iron deficient, and that he needs mustard on his protein so that he can get more iron.” In the workplace, we call that conception. And then women were the ones saying that they monitored the mustard for when it ran low, and they got stakeholder buy-in for what that family needed for the grocery list. That’s planning. And then men were involved, but they were going to the store to buy the mustard that Johnny needed. But Richard, you’re bringing home spicy Dijon every time, and I asked you for yellow, and then the presenting problem is not the real problem, right? It’s not about the mustard, or as Debora said, about whether or not somebody is asking, “Do the kids need to eat lunch?” This is about the thing that marriage needs, a home-organization needs, that has been eroding since I’ve been doing this work for 10 years. Women say to me, “I’m not going to trust my husband with my living will because Richard can’t even bring home the right type of mustard.” And then women start to say to themselves, “In the time it would take me to tell him what to do, I should do it myself.” And we start to get into this race to the bottom in marriage. And then what happens to the person who’s just executing and not doing cognitive labor is that they lose psychological safety in that home organization. Men are saying to me, “I’m never going to do anything again in the home because I can’t get anything right.” In 10 years of doing this work, every single divorce that we’ve found, every person we’ve talked about, always has division of labor as part of their story. And so that to me is the crux of the issue.

Schwartz: I think it’s interesting that when you talk about making the invisible work visible, you mentioned the cognitive labor. That’s very hard to make visible, but an important part of the picture: I do my share of the cooking and shopping, but what I don’t do my share of is the meal-planning, of knowing what we’re going to do. And that is a big part of the job that is hard to make visible.

Spar: I’ll throw just one more source of blame here, and there’s data to back this up. One of the things that’s also happened is we’ve sort of raised the bar on homemaking. When I was a kid, for Halloween, you went to the drugstore, you bought a mask and you put it on. Now women are somehow supposed to macrame these elaborate chipmunk costumes for their kids. I mean, it’s nuts.

Laine Perfas: And then come Halloween, your kid won’t put the costume on anyway.

Spar: Exactly! And yet, rather than doing the logical thing —  if I want to have kids and to have a job, which let’s be honest, is a choice for both women and men — if you want to make that choice, then something’s got to give. And yet, rather than normalizing a more minimal version of housekeeping, we’ve actually upped the ante in insane ways. Our houses are too big. We have too many cars. Our yards are too big. So there’s a series of societal decisions that we should at least be aware of.

Schwartz: And I would extend that to child-rearing. One of the most surprising statistics these days is that parents who are both also working are spending more time supervising their children and transporting their children than combined parents did in the days when one parent was just a home worker and just alone with the kids. That obviously is untenable. I think it also has something to do with what Debora was talking about earlier, the falling away of the larger community taking care of children so that it all has to be done by parents.

Laine Perfas: It almost seems like we’ve fallen into the trap of just, more is better. And yes, as a parent of two young children — I have a 4-year-old and a 1-year-old — it is hard. And somehow, no matter how much you do — and I am blessed to have a really great co-parent in my husband — and even then we still fall into, “Well, I thought you were … I need space.” “No, I need space …” It’s just, kids are tough, man. That’s the reality.

Spar: I am sorry, Sam, you haven’t even hit the worst part yet.

Laine Perfas: Don’t tell me that. Don’t tell me that!

Spar: Don’t worry, it only lasts another 25 years and then you’re good.

Laine Perfas: I was thinking about marriage. Back to our pre-kids days. So take kids out of it. I was thinking about how, when we talk about marriage, the language we use: You need to find the one. You need to find someone with whom you have perfect sexual chemistry. You need to find someone who’s going to be a teammate, a partner, who’s also hilarious and going to make you laugh. And I’m wondering if our expectations are just too high?

Schwartz: The way you asked the question, I think, answers it as well: Yes.

“One of the most amazing demographic shifts over the last century is that the number of households that consist of one person living alone has risen every census. … But [it has led to] people much more lonely, disconnected, and unhappy.”

Spar: There’s some realization that we’ve lost community. That Bob Putnam was completely right when he wrote “Bowling Alone” many decades ago. And Richard, you mentioned this with men, but it’s very true, I think, for women as well. We put all of the burden on the nuclear family. We don’t have the friends, the cousins, the bowling leagues, the Elks groups, which helped with these chores. And my great fear about the moment we’re in technologically, just putting marriage aside, is that we’re retreating more and more into an individual focus. People are living their lives by themselves on their phones, and we desperately need to restore community and restore physical institutions and organizations. That alone won’t save marriage, but again, to your point, Sam, I think it will take the burden off. Because it is absurd if you think about it, that one single person, even the most wonderful person in the world, can be your lover, your soulmate, your co-parent, forever. We have to rearrange those expectations — and that doesn’t mean lowering them, it just means shifting them and allocating the burden to some of the other pieces of society.

Schwartz: The ability to do things that you couldn’t do before. You mentioned that a woman can support herself alone, can have a house, an apartment alone. There’s no need to have anybody else involved in it. It’s wonderful to have that freedom, but those choices don’t always lead you to a better place. One of the most amazing demographic shifts over the last century is that the number of households that consist of one person living alone has risen every census over 100 years, which has brought us to a point where I think people are doing that because they’re able to and couldn’t in the past, but doing what they’re able to do has ended up with people much more lonely, disconnected, and unhappy than they would be without making the choice that they want to make.

Laine Perfas: With marriage and birth rates declining, there have been political efforts to encourage people to get married and have kids, or if they already have kids, to have more kids. Should marriage be incentivized?

Rodsky: I think there should be incentives to encourage marriage. There should be incentives. When it works, it’s a great transaction. People are richer. People do have good health outcomes for it. There should be incentives — not the incentives of — not getting rid of no-fault divorce and ways to force people to stay into marriage. But I think tax incentives, childcare incentives, free childcare. I mean, this gets back to what we were saying earlier. It’s too hard to do alone. But the problem is it’s not going to be solved by your PTA, and unfortunately, it’s not going to be solved by your church. The only way it’s going to be solved is by government policies. We have to give people access to more affordable childcare. We have to give people access to ways for them to be able to sustain a family. Affordable housing. Better schools, right? So if we start to reimagine our social contract, actually it would be taking away a lot of the economic scholarship of the ’80s and the ’90s, which is the scholarship that showed that the government is your enemy. So I do say that, yes, more than just tax incentives, we have to start encouraging our government and forcing our government to deal with the affordability crisis in this country, and especially childcare.

Laine Perfas: What tools do you see being beneficial for people to work on changing their marriage into the marriage they want it to be, one that is fulfilling and beneficial for both parties?

Rodsky: I think this is the biggest irony about the expectations, that the three most toxic words that I’ve heard about marriage keep coming up over and over again. When I ask people, how are you going to handle the division of labor in your home, how you can handle all these challenges, almost every single couple that I’ve interviewed over a decade has said, “We’re going to figure it out.” “Figure it out” is a terrible way to enter any sort of social contract. First off, our home is our most important organization. Couples who believe that do really well because they understand that organization, to succeed, needs three things. It needs boundaries, which means, as Richard said, we get time to shut our identities off as a parent, partner, professional, and have those friends, have other experiences that are not just our caretaking responsibilities. We need systems. And we need communication. Now, one of the funniest conversations I had was with this huge systems engineer of this big tech company who is a great dad. And we were talking, and he told me that in their home, their biggest fight is that they wait to decide who’s taking the dog out every single night before it’s about to take a pee on the rug. That is the opposite of the systems that he’s designing. But I think people are so afraid of coming to the table to say, “We need to practice systems; we need to practice boundaries; and especially we need to practice communication.” We did one survey of 1,000 people on social media: What is your most important practice? Some people didn’t understand the question. Some people said religious practices. Some people said meditation. Not one of the thousand people in our survey said communication is their most important practice. And what I’m here to say is that we’ve seen over 10 years of our data that when people practice communication when emotion is low and cognition is high, and really sit for those check-ins, like they would a staff meeting, like they would any other transactional relationship where they sit and invest in communication, that those relationships do a lot better.

Spar: I would just add lower expectations, by which I mean, don’t settle, but going back to what you had mentioned earlier, Sam, trying to understand that this person isn’t going to be the be-all and the end-all for everything for the rest of your life. Try to maintain other people in your life. It’s hard to maintain friendships when you’re in the crazy years of marriage and young kids. Try to maintain those friendships. Try to do the girls’ nights out, the boys’ baseball games, whatever. And try, going back to what I said earlier, try to get rid of the stuff that’s not critical. One of the lightbulb moments for me was when I came home at the end of the day, I was racing around, I was throwing dinner on the table because I had to get out to the PTA meeting. And my son said, indignant at the ripe old age of 7, “Why are you going to the PTA meeting?” And I yelled back, “Because this is for you, this is for your school.” He said, “I don’t care if you go to the meeting.” And it was a lightbulb moment. I thought I was doing something for him, but I wasn’t. He wanted me to stay home and read him a book. And I realized, my hack became, volunteer for cleanup duty. Because I did, I wanted to participate in my kids’ community, but they didn’t really need me at the three-hour PTA meeting. They needed me to clean up the trash after whatever events. And so I was No. 1 trash collector. But it was efficient, and it enabled me to contribute while spending more time with the more important stuff at home. So, outsource whatever you can. Let somebody else do the stuff that they can do. And try to minimize. Cut the corners in ways that matter.

Laine Perfas: What advice do you have for the folks listening who find themselves in a marriage that’s not quite where they want it to be, and perhaps the marriage skeptics out there? What might they consider as they think about whether or not to tie the knot with someone?

Spar: Don’t give up on love. But realize love, like anything else of importance, involves hard work. And don’t sign up for anything, whether it be marriage or children or a job, unless you’re willing to commit and do the work, and be as honest about it as you possibly can be.

Schwartz: For the people in marriage who are questioning whether or not to leave it, there was a wonderful letter from a divorce lawyer, I think, in the Boston Globe many years ago that said, “It’s my business to help you through divorce, but before you do this, think about your life and think about how much in your life is actually dependent on your marriage and how much of it you’ll lose if you leave that. Because everything will be different, and you should appreciate that first.” And I thought that was incredibly useful advice to give.

Rodsky: And what would I say for those marriage skeptics? So what I’d say for them is that there’s ways to practice marriage before you enter the social contract. I say to my son, he’s 17 years old, right? You can start practicing marriage by understanding how much emotional labor the men do around you. There are ways to practice. There’s ways to ask questions. Girls will say to me, how do I know if I want to date this person? I say, you can start to look and see what type of thoughtful person that is. You can see the patterns earlier. You can ask, “What was the last best gift you gave?” If someone says, “Oh, I don’t know, my mom helps me with all that,” or “I’ve never given gifts,” or “Those aren’t important to me.” Or someone who says, as my son just said to me about my 8-year-old daughter, she wants a Labubu, but there’s a new Labubu out there that he wants, and he has to get online and search at Pop Mart to make sure that Labubu is there — that type of emotional labor, investment in relationships, you can see earlier. What I’m saying is, there’s lots of beautiful signs out there of people who are committed to the unpaid labor, to the emotional labor of relationships, who you see are there for their parents and their grandparents. What I would say is, look for those people. There are good ones out there. And you can practice spotting these patterns before you enter the social contract of marriage.

Laine Perfas: Thank you all for this great conversation.

Schwartz: Thank you.

Rodsky: Thank you.

Spar: It’s been a great pleasure. Thanks.

Laine Perfas: Thanks for listening. To find a transcript of this episode and all of our other episodes, visit harvard.edu/thinking. And if you like this podcast, please rate and review us on Apple Podcasts and Spotify. Every review helps others find us. This episode was hosted and produced by me, Samantha Laine Perfas. It was edited by Ryan Mulcahy, Paul Makishima, and Sarah Lamodi. Original music and sound design by Noel Flatt. Produced by Harvard University, copyright 2026.



Singer to step down as senior vice provost for faculty

Education scholar lauded for achievements in overseeing, leading changes in faculty development, support for academics since 2008


Judy Singer.

Judith Singer.

Photo by Suzanne Camarata

Campus & Community

Singer to step down as senior vice provost for faculty

Education scholar lauded for achievements in overseeing, leading changes in faculty development, support for academics since 2008

5 min read

Judith D. Singer, James Bryant Conant Professor of Education, will step down on June 30 from her role as senior vice provost for faculty, the University announced today.

A statistician by training and community-builder by practice, Singer was the first woman to be elected as both a member of the National Academy of Education and a fellow of the American Statistical Association. At Harvard, she is widely known for helping a wide-ranging group of academics pursue meaningful work — recruiting outstanding scholars and nurturing their efforts across decades.

As senior vice provost for faculty, Singer has overseen faculty development across the University since 2008. Her team coordinates efforts to recruit and retain scholars, help advance their research and teaching, and support their work-life balance. She serves as an adviser in the ad hoc tenure process, chairs the Provost’s Review Committee on Faculty Appointments, oversees funding for scholarly appointments, and guides all policies and practices affecting institutional faculty affairs.

“Few people have done as much to nurture and sustain academic excellence across the University as Judy Singer,” said President Alan M. Garber. “When I returned to Harvard in 2011, she quickly became one of my most trusted advisers, a person of great discernment who is valued for her good humor as well as her knowledge and wisdom. I am grateful to Judy for her tireless work to fulfill our mission and to strengthen our community. I wish her all the best for her next chapter.”

“As senior vice provost for faculty, Judy has advanced faculty excellence through tireless and thoughtful work on the appointment and retention of exceptional scholars across disciplines, the shaping of policies that enhance their teaching and scholarship, and the development of initiatives to support work-life balance,” said University Provost John F. Manning. “We are deeply grateful for her extraordinary service to the University over many years.”

Singer has led major changes to every phase of faculty life, from streamlining recruitment and promotion to strengthening retirement benefits. Working alongside partners across all the Schools, she developed best practices for faculty recruitment and retention, creating resources and providing consultation to Schools on faculty appointments, programming, and benefits. She has helped create and implement fair, rigorous, and consistent processes for University-level review of academic, endowed chair, and University Professorship appointments.

Her office also launched the University’s online central faculty hiring portal and, in 2020, supported the transition to remote teaching during the COVID-19 pandemic and explored its long-term implications for faculty.

Singer has also worked to build a broad network of support for faculty. She oversaw the formation of University-wide faculty medical leave policies, childcare and other dependent care resources, financial support programs, and improvements to the faculty mortgage-loan programs. Over the years, she and her team have created professional development events, covering topics such as op-ed writing, academic publishing, and media training, as well as networking events for faculty members and their partners. She has also worked to collect and analyze data that help support recruitment and retention policy and decision-making across all areas of faculty affairs.

“Judy Singer began her role at a time of turmoil at the University,” said Steven Hyman, who was University provost in 2008 when Singer was appointed. “With energy, intelligence, great judgment, and relentless determination, she improved processes for faculty hiring, promotion, retention, and even quality of life. Her success served equity, the prioritization of excellence, and much else that the University prizes.”

Drew Faust, Harvard president at the time of Singer’s appointment, echoed the sentiment: “Judy Singer has brought fierce energy and a deep commitment to excellence and intellectual rigor to her role as senior vice provost. Her dedication to the fundamental values of scholarship and of universities has had an impact on the quality of the faculty that will be her enduring legacy.”

A prominent member of the faculty herself, Singer has focused her academic work on improving the quantitative methods used in social, educational, and behavioral research. Her scholarship has been especially influential in the development and application of multilevel modeling, survival analysis, and individual growth modeling — and in making these and other sophisticated methodologies more accessible for applied researchers.

A scholar with wide expertise, she has published prolifically across statistics, education, psychology, medicine, and public health, including nearly 100 academic papers and book chapters as well as three co-authored books: “By Design: Planning Better Research in Higher Education,” “Who Will Teach: Policies that Matter,” and “Applied Longitudinal Data Analysis: Modeling Change and Event Occurrence.”

She serves as a fellow of the American Educational Research Association; previously she served on the board of directors of the National Board of Education Sciences and as a founding board member of the Society for Research on Educational Effectiveness.

Singer began her academic career in 1984 as an assistant professor at the Harvard Graduate School of Education. In 2001, she was named James Bryant Conant Professor of Education. She served as academic dean of HGSE from 1999 to 2004 and, along with her longtime research collaborator, John B. Willett, was acting dean from 2001 to 2002.

She holds a B.A. in mathematics from the State University of New York at Albany and a Ph.D. in statistics from Harvard University.

“It has been an honor to work closely with presidents, provosts, and deans these last 18 years toward our shared goal of supporting excellence across Harvard’s faculty,” said Singer. “I have been fortunate to lead a remarkable team in building the frameworks, practices, and resources that enable Harvard to attract and retain the best and brightest scholars from around the world and support them in their work.”

To learn more about faculty affairs at Harvard, see the Office of the Senior Vice Provost for Faculty website.


Thomas Noel Bisson, 94

Memorial Minute — Faculty of Arts and Sciences


Thomas BIsson.

Thomas Bisson, 1987.

Harvard file photo

Campus & Community

Thomas Noel Bisson, 94

Memorial Minute — Faculty of Arts and Sciences

6 min read

At a meeting of the Faculty of Arts and Sciences on March 3, 2026, the following tribute to the life and service of the late Thomas Noel Bisson was spread upon the permanent records of the Faculty.

Born: March 30, 1931
Died: June 28, 2025

Thomas Noel Bisson, Henry Charles Lea Professor of Medieval History, Emeritus, died on June 28, 2025, at the age of 94. A distinguished historian and teacher of medieval Europe, he focused on institutions, the transpersonal structures of governance that emerged painfully and fitfully from the doings of those in service to the great and the powerful, particularly in the portentous 12th century C.E.

Bisson was born in New York City in 1931, but his formal schooling began in China; he remembered riding to school in a rickshaw. His father, the American political writer and journalist T. A. Bisson, was studying Japan and China. His maternal grandfather, John E. Williams, had been Vice-President of the new Nanking University and was murdered during the Nanking Incident (1927). The elder Bisson ultimately lost his academic appointment during the McCarthy era, finishing his career in Canada.

Thomas Bisson was educated at Haverford College (B.A. 1953) and Princeton University. At Princeton he took his Ph.D. (1958) with Joseph R. Strayer, the eminent historian of medieval institutions, and studied also with Ernst Hartwig Kantorowicz of the Institute for Advanced Study. Bisson taught at Amherst College, Brown University, and Swarthmore College before moving to the University of California, Berkeley, for 20 distinguished years (1967–1987). He came to Harvard in 1987, where he was the Henry Charles Lea Professor of Medieval History from 1988 until he retired in 2005. He chaired the Department of History from 1991 to 1995 and, at both great institutions, trained as graduate students many of the next generations’ leading medievalists, of whom he was justifiably proud. After his retirement, Bisson continued to prove his dedication to the liberal arts through his quietly thoughtful undergraduate teaching, including First-Year Seminars. Many of his former students gathered joyously at his home on Hammond Street to honor him for his 94th birthday in the spring of 2025.

Bisson pursued his abiding interests in medieval Europe’s history in ways that typify the man and the scholar: quietly, rigorously, and thoroughly. He had a profound respect for others and the rare ability to listen carefully. As a mentor of graduate students, he was famously strict while always remaining deeply humane. Despite a discipline of steel, Bisson’s gentle laugh abetted a modest sidelong glance and quiet thoughtfulness that endeared him to those around him. As a close colleague, Tom was simply wonderful. Bisson’s seven monographs and five edited volumes of his own and others’ articles are mostly weighty tomes whose rigorous scholarship illuminates the medieval forms of what would lead to big institutions in the modern world; they continue to serve as foundational works across the later medieval history of Europe. Their impact can be judged by their translations into the native languages of the places he studied: French, Catalan, and Italian.

Bisson’s “Assemblies and Representation in Languedoc in the Thirteenth Century” (1964) shed light on the rising institutional power of new socioeconomic groups before and after the incorporation of this region into the Capetian kingdom of France. The book was followed by his innovative “Conservation of Coinage” (1979), where Bisson’s meticulous study of charters and coins brought to light a remarkable manifestation of what he saw as the spirit of suspicion against arbitrary rule across France, Catalonia, and Aragon in the 11th and 12th centuries. Both books bear witness to the broad European range of Bisson’s historical curiosity. His austere 1984 study, “Fiscal Accounts of Catalonia Under the Early Count-Kings” — the money trail in contemporary parlance — was another impressive contribution to understanding the early mechanisms of secular governance. Bisson’s deeply empathetic experiment with microhistory yielded in 1998 those medieval Catalan peasants’ “Tormented Voices” that echo the violent impact of fast economic change; perhaps his favorite work, this Catalan story resonated with Bisson’s personal concern with the public good in our own time. His greatest monograph is surely the 2009 “Crisis of the Twelfth Century,” where he tracked how arbitrary lordship shifted toward more settled forms of power. Crisis displayed Bisson’s virtuosic command of the evidence across all of Europe, down to Magna Carta and “a Parliamentary Custom of Consent.” He distilled much of his deep research into “The Medieval Crown of Aragon: A Short History” (1986). His final work was, again, one of austere and lasting scholarship: a critical edition, translation, and commentary of Robert of Torigni’s “Chronography” (2020), a crucial source for Anglo-Norman history, whose mysteries Bisson unraveled and clarified as none before him.

Bisson earned all the major fellowships and awards, including All Souls College and Guggenheim fellowships. His work was recognized by elections to the American Philosophical Society, American Academy of Arts and Sciences, British Academy, Royal Historical Society, Reial Acadèmia de Bones Lletres, and Institut d’Estudis Catalans. His North American peers signaled their esteem by electing him President of the Medieval Academy of America, and the government of Catalonia awarded him the Cross of St. George, one of their highest civil distinctions.

Bisson lost his beloved wife, Carroll (Webb), a deeply cultivated Classicist, in 2005, after 43 harmonious years of shared pleasure in literature, music, and travel. A lifelong baseball fan, Bisson avidly followed the Red Sox. He was a talented and dedicated pianist, whose later musical life centered on the interplay of music and text in Schubert’s Lieder. Just a few weeks before his passing, he described with quiet joy the last time he had played “Wandrers Nachtlied” with family. Among scholars, Bisson will be remembered as an immensely productive yet meticulous historian whose painstaking research and writing bowed to few fashions. He did not fear tackling deep and difficult questions on the basis of the original, often unknown archival documents; the impact of his teaching has already stretched over three or four generations of medieval historians. Bisson is survived by his daughters, Noël Bisson, Dean for Academic Programs in the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences, and Susan Bisson Lambert, as well as by four cherished grandchildren.

Respectfully submitted,

Dimiter Angelov
Charles S. Maier
Michael McCormick, Chair


Wonder served him well

Curiosity ignited Alan Garber’s sense of purpose. Classmates, mentors, and patients helped deepen it.


Alan Garber.

Veasey Conway/Harvard Staff Photographer

Campus & Community

Wonder served him well

long read

Curiosity ignited Alan Garber’s sense of purpose. Classmates, mentors, and patients helped deepen it.

Scholars at Harvard tell their stories in the Experience series.

Before becoming Harvard’s 31st president, Alan Garber served as provost and chief academic officer for more than 12 years, a role that gave him an expansive view and an intimate understanding of the teaching and research that define the University’s mission. The lessons of that experience have stayed with him.

Garber’s Harvard roots run deep, starting with his arrival in the early 1970s as a freshman from Rock Island, Illinois. After graduating in three years, he went on to earn two advanced degrees: A Harvard Ph.D. in economics and an M.D. at Stanford University. That was immediately followed by internal medicine training at Brigham and Women’s Hospital, where he met his future wife. He returned to Stanford, where he spent the next 25 years as a teacher, researcher, and VA physician.

In this edited interview, Garber notes that he’d never aspired to a top post in higher education before President Drew Faust called to gauge his interest in the provost’s job. Years later, when he stepped into the presidency, he was once again pushing the boundaries he’d imagined for himself. But in both cases, he says, Harvard had given him too much for the answer to be anything but a wholehearted “Yes.”


Tell me about your childhood in Rock Island.

Rock Island, across the Mississippi River from Davenport, Iowa, was a city of about 50,000 then. My father was born there, and my mother grew up in Wisconsin.

I have a twin sister and an older brother. As you might expect, my twin and I have always been especially close. My mother was a social worker. When children arrived, she became a stay-at-home mom who did extensive volunteer work. My father was the oldest male in his family, so when his parents grew very sick and died young, he effectively became the head of the family. He worked and did not attend college. He ended up owning a liquor store and playing the violin in the Tri-City Symphony Orchestra. Both of my parents believed deeply in the importance and value of education.

During high school, I had a few jobs. They included summer work stacking paving bricks from a torn-up street and delivering plumbing supplies. During the school year, I worked as an usher in the multiplex cinema in the adjacent town, Milan. Milan was mostly rural — the cornfields started just a few blocks away. I looked forward to sitting in one of the theaters during my break, eating my bucket of popcorn and drinking a quart of Coke. When the first “Godfather” movie played, I’d usually drop in during the baptism scene. Another favorite was the chase scene in “The French Connection.” I felt listless, and my head ached, on my days off. That’s how I discovered caffeine withdrawal.

We weren’t near a big city. It was about a 3½-hour drive from Chicago. Growing up, I had the feeling that there was a lot going on in the wider world that wasn’t happening where we lived.

Was music a big part of your upbringing?

We went to classical concerts every month, and my father played string quartets with his colleagues at our home. I didn’t really appreciate chamber music until I was much older, but from an early age I loved Beethoven and the great violin and piano concertos. Sometimes my father would invite guest soloists to our house for a cocktail party after the Saturday evening concert. At one of those parties, our dog bit Itzhak Perlman on his bow hand.

That probably killed the conversation.

Not for long. Perlman was charming and incredibly gracious. He just laughed it off.

When did you set your sights on Harvard?

Harvard seemed a grand, remote, historic, and unattainable institution that stood for excellence. At the end of my junior year of high school, I traveled to Boston and saw the school for the first time. Whatever interest I had was multiplied manyfold by visiting the campus and meeting people there.

What brought you to Boston?

I stopped there on the way to a summer science program for high school students at the Weizmann Institute of Science in Israel. I had a glimpse of both Harvard and MIT, where my cousin worked. I applied to several other colleges but didn’t visit them.

My summer experience made me think about completing high school in a new environment. A plan came together quickly. Somehow my brother, a yeshiva student in Chicago, and I convinced my parents that I should join him, studying at the yeshiva at night while attending public high school in the daytime. I had no desire to become a rabbi but wanted to explore Judaism at a deeper level than had been possible going to Hebrew school twice a week. And that’s what I did. It was an incredible experience.

In what sense?

I’d studied Hebrew, the Bible, and the Jewish religion for many years, but not in a serious way. Now I was thrown in with people who were real scholars. It made me appreciate how little I knew. We studied the Talmud and rabbinical commentaries as partners. Each one of them had far more experience and knowledge than I did. I am grateful to this day for their patience and encouragement. As I had hoped, my appreciation and understanding of Judaism deepened greatly.

Alan Garber's Harvard yearbook photo.
Garber’s Harvard yearbook photo.

You arrived on campus in 1973. How would you describe Harvard’s student body at the time?

It struck me then as diverse and international, though it wasn’t by today’s standards. My House, Dunster, was very friendly. You could sit down in the dining hall with anybody and feel comfortable speaking about almost any issue. I like to think the conversation was usually profound, and sometimes it was. But we probably talked about weekend parties, the food, and music more than anything else. My classmates were impressive. Everyone seemed to know something interesting.

Although surveys indicate that students are more reluctant to speak about sensitive topics today, in other respects the experience was similar. There was a real sense that you were around people who were going to make a difference and that, when you did have discussions, you couldn’t get by with sloppy thinking.

You finished in three years. Tell me about that experience.

The barrier to graduating in three years was low. You needed enough Advanced Placement credits when you matriculated, and you had to do enough work in three years. Only a fraction of eligible students chose to graduate early.

Like many of my classmates who took less than four years, I was motivated in part by financial considerations. Losing a year of the Harvard College experience was a real sacrifice, but those of us who entered graduate or professional school at Harvard were able to continue to spend time with many of our College friends. Under the circumstances, it didn’t seem like a bad idea.

At that point you were interested in premed?

I was interested in science, especially the life sciences. I didn’t have firm plans but assumed that I’d become a physician. I later learned my parents shared that assumption. If you plan to graduate in three years, you need to declare your concentration within a couple of months of starting college. I declared in biochemistry, one of the most popular concentrations for premeds. So I was on a path that would at least give me the option to apply to med school.

But two courses I took in the first year opened my eyes to other possibilities. They were Physics 12, taught by Edward Purcell, a Nobel laureate, and Ec 10. I loved both of them. When I moved into Dunster House the next year, I became friends with Jerome Culp, the resident tutor in economics. We talked about economics and how much I’d enjoyed it. He soon convinced me that I should change direction and concentrate in economics.

I liked physics, too, but my interest wasn’t deep, and my roommates (they later became prominent professors, two in physics and one in chemistry) set the bar impossibly high. Physics 12 contributed to my decision to pursue economics in an unexpected way: by teaching me how to structure and solve applied mathematics problems, a vital skill for an economist.

Jerome gave me other good advice. He said that I should start taking graduate courses and told me which were most important. He also urged me to become a research assistant, arranging for me to work for a prolific young labor economist who is still a member of our faculty, Richard Freeman. It was an invaluable experience. So that is how conversations in the Dunster dining hall set me on a path that led to where I am now.

“I was sure that in the long run I’d find my work as both an economist and physician more meaningful than pursuing only one of those vocations. And all these years later, I can say that I’ve never regretted that choice.”

What did you like about economics?

It was a compelling frame through which to view human behavior. It provided a set of questions and a quantitative mode of thinking about important, real-world phenomena. You learn how to formulate and rigorously test hypotheses, a skill that is important in many fields and in life.

After you graduated, you pursued a Ph.D. in economics at Harvard and an M.D. at Stanford at the same time. This is long before online learning, so how did that work, logistically?

First came the decision to do both. To get advice about whether to get an M.D. or a Ph.D. in economics, I met with distinguished faculty across the University. Economists encouraged me to go into economics. Marty Feldstein, who later became one of my dissertation advisers, was one of them. As a Harvard undergrad, he’d planned to attend medical school himself but deferred admission to Harvard Medical School while he pursued a fellowship leading to his doctorate at Oxford. After a few years, he decided against the M.D.

The dean of the School of Public Health, a physician, thought I should get a Ph.D. in public health. The other physicians urged me to pursue an M.D.

As I digested the conflicting advice, I realized that by the time I graduated college, I would have done half of the required Ph.D. coursework. If I took an additional year, I could complete the coursework, earning a master’s degree in the process. So I decided to apply both to medical schools and economics departments, figuring that I should at least get the master’s in economics. One evening, the chair of the economics graduate admissions committee saw me poring over piles of computer output and asked whether I planned to pursue the entire Ph.D. I’d been thinking of it anyway and committed on the spot. He later became the chair of my dissertation committee.

I took a deferral from medical school at Stanford, where two of the nation’s most prominent health economists taught, spending the next year at Harvard with my classmates and finishing my Ph.D. coursework as planned. Then I took a leave from graduate school and went to medical school. I did two years, took a leave from med school, worked on my dissertation, and then came back to med school. I finished the two degrees, on two coasts, nearly simultaneously.

Where was your clinical work during medical school?

At Stanford Hospital and the Palo Alto VA hospital. I was also a research assistant during my first years of medical school. One of my mentors was Hal Sox, the chief of the Division of General Internal Medicine for Stanford and also the head of general medicine at the VA hospital. When I took a leave of absence to work on my dissertation, he arranged for me to have a student general medicine clinic at the Palo Alto VA.

Thanks to that experience, when I started clinical clerkships upon my formal return to medical school, I was as well-prepared as medical students who had gone straight through. My attraction to the VA was reinforced by my first inpatient medicine clerkship, which was also at the VA. That also led to my decision to go into general internal medicine and later, when I became a faculty member, to do my clinical work at the same hospital.

Were there particular patients who made a deep impression?

There were several, but one, a Mr. Campbell, really stood out. He was a World War II veteran, dying of advanced lung cancer. The main hospital building was old enough to still have wards with as many as 12 patients in a room. That sounds unpleasant, but the wards had important advantages over private and semi-private rooms. The patients in the wards came to know each other and looked out for one another. That vigilance was better in some ways than fancy monitoring equipment. He had a prolonged hospitalization and knew the ropes by the time I met him. He always looked out for his wardmates.

He was a wonderful person and very kind to me. He knew that I was learning by taking care of him and was so accommodating, generous, and uncomplaining. In many ways, he was one of my greatest teachers. It really hit me hard when he died.

It sounds like a tight-knit group of patients.

If somebody was having trouble breathing, another patient would find a nurse to help. Most were stoical and would not complain if they were feeling worse. They might hide it, even if they had a worrying symptom, like shortness of breath. Their wardmates would make sure the doctors and nurses knew. Mr. Campbell did that and set an example for other patients. I saw firsthand what people meant when they referred to World War II veterans as the “Greatest Generation.”

Your Ph.D.-M.D. experience was clearly a marathon. Did you ever get discouraged?

When I was looking at residency programs, the interviewers at Mass General asked: Do you think you’ll regret spending all of this time in training when you could have just been an economist? I replied that one of my grad school roommates — the economist Jeff Sachs — had just been promoted to full professor with tenure at Harvard, and here I was about to start an internship in six months. It was completely possible, I said, that when I would be called in the middle of the night to do a fever workup, I might think, “If I had just done economics, what would I be doing right now? Certainly something better than this.”

But I was sure that in the long run I’d find my work as both an economist and physician more meaningful than pursuing only one of those vocations. And all these years later, I can say that I’ve never regretted that choice.

“Fear is not conducive to learning. It’s not conducive to doing great research. Sometimes we need to take risks to make progress.”

When you were hired as an assistant professor at Stanford, you went back to the VA to do your clinical work?

Yes. Just as when I was a student, taking care of veterans was a source of great satisfaction and pride. I continued to see patients at the Palo Alto VA until I returned here to be provost in 2011.

Were there certain health issues that were particular to that population?

Compared to many academic medical centers, we saw more lung disease, liver disease, and heart disease. The Palo Alto VA was also a major referral center for the care of dual (medical and psychiatric) diagnosis patients and for spinal cord injury. I taught and supervised care of patients both on the inpatient service and in clinic. For several years, I was the only tenured Stanford faculty member in general medicine at the VA hospital. During that time I took care of many former prisoners of war, some of whom had ongoing illness related to their imprisonment, like the neurological impairments resulting from beriberi acquired in World War II prison camps.

During your time at Stanford, you authored more than 100 articles on healthcare economics. Tell me about your research.

I became very interested in applying the tools of economics to evaluate medical and public health practices. In my dissertation, I examined antibiotic resistance, where one person’s overuse of antibiotics puts others at risk of becoming infected by a resistant organism. It sounded like a negative externality, where one person’s economic activity harms others. I thought that the tools of economics could be helpful in measuring and ultimately controlling the harms that antibiotic users impose on others.

Over the years, I studied areas like cardiovascular disease prevention, including cholesterol control. I used and taught the tools of decision analysis, cost-effectiveness analysis, and the application of econometric techniques to the prevention, diagnosis, and treatment of disease.

You started two centers related to health policy and economics at Stanford. Was that when you first began to think about higher education administration?

I wasn’t interested in academic leadership positions and would have been even less inclined to pursue them if they were described as administration. However, not long after I started on the Stanford faculty, my division chief went on sabbatical, and I ended up becoming the director and principal investigator of a postdoctoral fellowship program that he led. That role basically continued throughout my time on the Stanford faculty. Later, I became the acting division chief. I had no interest in doing this on a longer-term basis, so creating the centers was kind of an aberration.

The chair of the Department of Medicine came up with the idea for a center for me to run — why it became two centers is a long story. She and my mentors at Stanford somehow convinced me that the centers’ mission would be sufficiently close to my research interests that running them would not be burdensome. I was overly optimistic about that, but leading the centers turned out to be gratifying in unexpected ways. Most importantly, I discovered that I loved mentoring students at all levels, postdocs, and eventually faculty. But I wasn’t attracted to positions with greater leadership responsibilities, like department chairmanships. I never would have expected to be a candidate for provost.

Alan Garber, Anne Yahanda, Hopi Hoekstra, and David Deming.

Garber welcomes first-years during move-in day in Harvard Yard with wife Anne Yahanda (from left) and Deans Hopi Hoekstra and David Deming.

File photo by Stephanie Mitchell/Harvard Staff Photographer

You started as Harvard provost in 2011. Did the idea of someday becoming president ever cross your mind?

People ask about it, but it was not something I was thinking about. When I started as provost, I didn’t have as much leadership experience as was typical for the position. I accepted the offer because I hoped to repay my debt to Harvard for all that it gave me. I didn’t think I needed to be president to do that.

As is typical for U.S. universities, the provost is the chief academic officer and is uniquely focused on the academic life of the University as a whole. Anyone with broad intellectual curiosity can’t help but feel a sense of wonder when they learn about the work faculty do at the frontiers of the fields represented at Harvard. That promise of intellectual stimulation combined with the opportunity to do my part to help the University succeed was irresistible.

At some point during your tenure as provost, you started to notice that the community was having trouble talking across differences and remaining open to a range of views on political and cultural issues. How did that realization develop?

Over the years, there was a growing reluctance — notably among students, but also among faculty and staff — to speak openly about sensitive issues, especially with people who might have different views. A fear of being misunderstood, of giving offense, and of ostracism chilled speech. Fear is not conducive to learning. It’s not conducive to doing great research. Sometimes we need to take risks to make progress. We shouldn’t offend people gratuitously, but if the consequences of inadvertently or even intentionally giving offense become too great, dialogue about difficult issues will be a casualty.

As these problems grew, I realized that traditional debates about what speech is permissible in different settings, and other traditional speech concerns, only addressed part of the challenge we faced. There still needed to be an understanding about speech rights, but it became apparent that we also needed to ensure that our entire community had the skills to participate in difficult conversations.

Among our faculty are renowned experts on these issues. And many more can demonstrate how to facilitate dialogue with extraordinary finesse and grace. I realized that we should look at this set of speech challenges as an opportunity to empower students, faculty, staff, and all the members of our community to be able to handle difficult situations better. In other words, we have an obligation to give people the tools they need to fully participate in the life of the community. That includes exposing, discussing, and working through differences.

Are there lessons you can learn by engaging with differences that you can’t learn any other way?

By doing so, you better understand perspectives that differ from your own. More importantly, you develop general skills in listening, speaking, and identifying areas of agreement and disagreement. You might even change your mind and be better for it. Engaging with differences is important right now because there is an overwhelming sentiment in our community that we need to be brought closer together, that we should not retreat into our own corners and avoid people whom we believe to be different from us.

Do you see intolerance of opposing views and intolerance of other people as two sides of the same coin?

Yes. People associate views with identities. If you’re a wealthy white student who went to a small private school in California, people assume that you will have a particular set of political views. If you’re a Black student from the urban Northeast, they assume that you will have another set of political views. And both might happen to be wrong. There’s a diversity of views from people with different economic, social, or religious backgrounds. We all want to be treated as individuals, not as types. We don’t want anyone to prejudge us based on our demographic characteristics or any other group identity.

The University has been locked in a dispute with the Trump administration for the past year. Did you see this coming before the election? Also, how do you strike a balance between today’s challenges and longer-term planning?

In the wake of October 7, 2023, the decline in trust in institutions, especially universities, accelerated. Academic institutions were blamed, often unfairly, for many of the problems the nation faced. But there were real problems at Harvard and other campuses. Attacking universities seemed to be a successful political strategy. As a candidate, Trump warned that his administration would investigate and seek to transform universities.

So harsh scrutiny was to be expected. However, we did not anticipate the form and the severity of the attack on Harvard and other universities, nor the readiness with which precedent would be abandoned, for example in Title VI investigations and enforcement. In navigating all that has followed we have, as always, been guided by principle. In developing our responses in the past 13 months, we have always confirmed that we will follow the law. We have always strived to protect the mission of Harvard and of higher education more broadly. We will go to great lengths to protect that mission, because in the end, when we carry out our mission, we serve the public.

You mentioned that the community wants to be brought together. Is it happening? Do you see a more unified institution?

Many people have told me how pleased they are at the way we have come together as a community. We still have our differences, but we also are committed to our mission, our common goals, and each other with a dedication that would be elusive when threats to the institution seem neither imminent nor serious. Now, more than at any other time in memory, we appreciate that this is a great and precious community — and it’s extensive. It includes not only the faculty, staff, students, and alumni, but also the many friends who may have no formal affiliation with Harvard but share our aspirations for higher education and its role in the world. That’s something that validates our mission and should give us all hope for the future.


Immersed in Toni Morrison’s multitudes

Professor’s book is an appreciation of Nobel-winning novelist’s ‘difficult’ oeuvre — and a defense


Namwali Serpell sitting on a bench outside.

Namwali Serpell.

Photo by Jordan Kines

Arts & Culture

Immersed in Toni Morrison’s multitudes

Namwali Serpell’s book is an appreciation of ‘difficult’ oeuvre — and a defense

5 min read

The true genius of Toni Morrison, says Namwali Serpell, isn’t found in the first read, but in the second, third, or fourth. This was how Serpell fell in love with Morrison’s prose, which she argues is designed to be a simultaneously cerebral and beautiful experience for readers.

“If you have to read and reread in order to put together what’s happening, then you are a co-creator of that literary experience,” said Serpell, a prize-winning novelist and a professor of English. “She saw this as specifically important for Black literature. Her highest aspiration, as she put it, was to create something at the level of jazz, which she saw as the highest form of Black art.”

Serpell’s new book, “On Morrison,” is a chronological walk through the Nobel laureate’s novels, from “The Bluest Eye” (1970) to “God Help the Child” (2015). It also explores the short story “Recitatif” (1983) and the play “Desdemona” (2011).

The ideas that animate the book took shape in the classroom, in a Morrison course Serpell first taught in the English Department in 2021. “The book is like the experience of taking a class with me,” she said. “My aim is to give you an appreciation for how carefully constructed Morrison’s works are, and how successful they are in using form to make you feel things you’ve never felt before.”

In this edited conversation, Serpell discusses Morrison’s approach to form, her talent for self-reading, and the value of being “difficult.”


What was it like to spend so much time with Morrison’s work for this project?

“The book is like the experience of taking a class with me.” 

Namwali Serpell
Book Cover "On Morrison".

A lot of my thinking about Morrison is influenced by Morrison herself, who was an incredible reader of her own work. She was a critic herself, but she also had what I like to think of as the beautiful audacity to write about her own work. She was very good at close-reading even the meter, the rhythm of her own sentences, or explaining why she included certain colors at the beginning of a novel. She also spoke a lot in interviews about what she was and wasn’t trying to do. Her own practice of self-reading is so inspiring.

You’ve said that Morrison’s skill as a writer is too often overshadowed by her public persona. Could you explain what you mean by this?

Turning her into a kind of institution, or monument to Black excellence, I think, does a disservice to her legacy. She was deeply interested in form, but her novels often get read only in terms of their political content or their political aim or their representational goals. While we have a wonderful icon and a model of success, what we don’t have is a deeper understanding of how she changed the novel: the experiments she did, the ways she broke open the form, and infused other forms into it. The ambition that she had as an artist has been so influential on other writers that some of her techniques we now take for granted. She’s much more interesting on the page than we take her to be.

Did you learn anything new about Morrison?

I never met Morrison and I didn’t really want to. As they say, never meet your heroes. I have also loved having a purely literary relationship with someone who had purely literary relationships with a lot of other writers herself. But whenever I told someone that I was writing the book, I immediately got anecdotes about the time that they met Toni Morrison. Some of the things that I learned from them were that she had a wonderful sense of humor, bordering on the raunchy sometimes. Her sensibility was oriented toward class politics, but Morrison also delighted and luxuriated in beautiful, well-made things. Fashion was important to her. And when she got the phone call about winning her Nobel, apparently she closed the door to her office and danced.

You have written about Morrison’s “difficulty,” both in her texts and in her personality. Can you share more?

I felt that she was in need of a defense. It felt to me like she had not been taken seriously for the difficulty of her work, but rather rejected for what was perceived as the difficulty of her personality. She had a very contrarian sensibility when it came to politics. She also suffered no fools. She came to believe that it was a good thing for Black women to be seen as “difficult,” because that meant that they had insisted on being taken seriously. I thought that was a very interesting way of thinking about the attribution of difficulty to Black femalehood: If you lean into it, it is a way of asserting the importance of what you’re doing.

Morrison articulated, over the years, many different reasons why difficulty in a text was not simply a sign of showing off your intelligence, but was, for her, about engaging the reader and drawing them into participating in the making of the book.

Where should a first-time Morrison reader begin?

People often want to start with “The Bluest Eye” but it’s actually one of her most difficult books. I think it’s better to ease in with “Sula” (1973) or “Home” (2012). She described “Sula” as “hermetic,” by which I think she meant it’s tight — well-crafted and well-shaped, like a poem. It’s not very long, but it’s very, very moving and very beautiful. If you want to start with later Morrison, “Home” is pretty straightforward. One of the characters will, in certain chapters, talk back to the narrator. It’s a little experimental, but actually pretty easy to figure out. It’s delightful.


Which is worse, a soda or a beer?

Experts seek to clarify the health effects of alcohol and sugary drinks


Walter Willett Eric Rimm (center), Timothy Rebbeck.

Walter Willett (from left), Eric Rimm, and Timothy Rebbeck. Anna Grummon of Stanford joined the conversation via Zoom.

Photos by Veasey Conway/Harvard Staff Photographer

Health

Which is worse, a soda or a beer?

Experts seek to clarify the health effects of alcohol and sugary drinks

5 min read

Pure, clear water: yes. Soda and other sugary drinks: no. Alcohol in its many forms: maybe, but always in moderation.

In a conversation Thursday at the Harvard Chan School, experts zeroed in on beverages, emphasizing health effects that are no less serious than the risks and benefits that come with food.

“From our first cup of coffee in the morning, to a glass of wine at night, to an energy drink, these beverages are woven into our lifestyles, our celebrations, and our cultures,” said Timothy Rebbeck, the Vincent L. Gregory Jr. Professor of Cancer Prevention and director of the Chan School’s Zhu Family Center for Global Cancer Prevention. “Yet the health impacts of the beverages, especially when it comes to cancer and the long-term effects on chronic disease and health, have been confusing and sometimes controversial.”

Alcohol, with its mixed health profile, took center stage, with Professor of Medicine and of Epidemiology Eric Rimm and Professor of Epidemiology and of Nutrition Walter Willett outlining the pros and cons. On one hand, Rimm said, moderate alcohol use has been shown to protect from heart attack and, on a population scale, lower mortality for those consuming between half a drink and a drink a day. On the other hand, studies have shown that alcohol increases the risk of several types of cancer, including breast cancer.

“What we know is that people that drink about a half a drink to a drink a day live the longest, so they die less of heart attacks,” Rimm said. “They may have a bit more cancer, but the absolute risk of heart attacks is much greater than the absolute risk of breast cancer or colon cancer.”

Willett acknowledged that the increased cancer risk can be small, especially compared with major hazards like smoking. Still, on a population scale, the increased risk of breast cancer due to drinking is large enough to counterbalance the benefits of screening, he said.

Willett and Rimm also offered practical advice to help consumers understand what the competing statistics might mean at the individual level. One has to evaluate these risks within one’s own context, they noted. For example, Willett said, a young woman with a healthy heart may want to focus squarely on alcohol’s breast cancer threat. That calculus may be different for others, depending on their specific circumstances and family background.

Though the discussion focused on the health claims surrounding moderate drinking (one drink per day for women, two for men), another panelist, Stanford’s Anna Grummon, noted that alcohol’s biggest societal impact comes from dependence and heavy drinking, conditions that lead to dangerous behaviors like drunk driving and physical violence, and can devastate families.

Anna Grummon,.
Anna Grummon.

“What we see in the data is that many of the harms that we worry about with alcohol consumption, a lot of those are not necessarily around heart disease or cancer, but around addiction and motor vehicle crashes, and these are significant contributors to the overall death rate in the U.S.,” said Grummon, director of Stanford’s Food Policy Lab. These effects suggest that policy makers might want to “nudge” consumption downward so that more people are meeting the level of “moderate” drinking, she added.

“I don’t think any policymaker is interested in getting to zero consumption. I don’t think we want to go back to prohibition,” Grummon said, “but I think there’s interest in moving the curve a little bit to the left towards lower consumption and more people meeting the guidelines that Eric mentioned.”

The mixed picture for alcohol consumption was in contrast to what panelists agreed is a much clearer one for soda, energy drinks, and other sugar-sweetened beverages, including sugary fruit juices. A 12-ounce can of a popular soda brand has 10 teaspoons of sugar, an amount almost nobody would add to a cup of coffee or tea, Rimm said. Sugar-sweetened beverage consumption is linked to rising obesity, which itself raises cancer risk, and diabetes, which increases risk of heart attack and stroke.

“When you compare a soda to water, or soda to coffee, or soda to tea, whatever you’re comparing it to always wins,” Rimm said.

One answer for those who don’t want to give up sugar is to switch to drinks with artificial sweeteners. Willett said that sweeteners, especially aspartame, have largely proven to be safe and significantly improve a drink’s health profile. But the best choice is water, he said. And since the water supplies in most major cities are safe, a person can take it right from the tap.

Willett pointed out that the failure of the national government to act on regulating these drinks isn’t unique. Campaigns that wound up curbing smoking and banning trans fats, for example, both started at the local level, grew to the state level and then gathered enough momentum that the national government acted.

“That’s where the action is,” Willett said. “It’s state and local, even sublocal —institutional — and people can make a difference there.”


Audiobooks don’t really count as reading? Think again.

Education scholars say rigor, learning same as paper, stigma an unnecessary hurdle


books between headphones

Illustration by Liz Zonarich/Harvard Staff

Arts & Culture

Audiobooks don’t really count as reading? Think again.

Education scholars say rigor, learning same as paper, stigma an unnecessary hurdle

4 min read

More than 40 percent of Americans think that listening to audiobooks is less rigorous and really doesn’t count as reading.

Cognitive neuroscientist Nadine Gaab disagrees, and she and other education scholars say the view is counterproductive when it comes to learning and development.

Not only does the brain operate the same when reading print books or listening to audiobooks, Gaab said, but the learning process is also the same.

“The theory of learning styles has been debunked,” said Gaab, the Silvana and Chris Pascucci Professor in Learning Differences at Harvard Graduate School of Education. “It’s not the case that someone learns better by listening or by reading. You may have a preference, but learning is sort of the same regardless of the modality. ”

Reading is a complex skill that involves the early development of brain regions that support sound and language processing, the essential milestone skills for learning to read, said Gaab. The neural networks that process written and oral language are deeply intertwined and largely overlap when reading print books or listening to audiobooks.

“There isn’t much of a difference between the brain network for reading and the brain network for language comprehension,” said Gaab. “The brain area we call the ‘letter box,’ which processes print, is not as engaged when you listen, but it has been shown that when some people listen to words, they visualize them, so the letter box gets activated as well.”

“There isn’t much of a difference between the brain network for reading and the brain network for language comprehension.”

Nadine Gaab

Listening to audiobooks meets derision in some circles, where it may be seen as “cheating,” but Gaab rejects that notion. Both print books and audiobooks offer advantages to readers, she said. While readers can review and go back to print books easily, audiobooks offer voices and sounds that make the story compelling and attractive.

Librarians wholeheartedly agree.

Readers should reflect on their choices by focusing on the purpose of their reading, said Alessandra Seiter, community engagement librarian at the Harvard Kennedy School. Some might favor print text because it helps them absorb information better, and others might prefer audiobooks because they allow them to multitask and save time.

“There is nothing wrong with audiobooks,” Seiter said. “There is no purity about reading words on a page.”

There are clear practical implications, said Alex Hodges, director of the Monroe C. Gutman Library at the Graduate School of Education. Print texts offer readers the chance to highlight passages or write notes that might help them retain information better, Hodges said. Audiobooks, on the other hand, may impart a more relaxed experience.

Laura Sherriff, librarian for the Cabot Science, Fine Arts, and Lamont libraries, would like to remove the stigma around audiobooks. In her former life working at a bookstore, she saw kids starting out with “Harry Potter” audiobooks and coming back to buy the print books. “It was their gateway to reading,” she said.

Regardless of their form, either print or audio, books introduce readers to new knowledge, imagined worlds, and complex language, said educational linguist Paola Uccelli, John H. and Elisabeth A. Hobbs Professor of Cognition and Education at the Graduate School of Education.

“In both formats, readers encounter not only new information but also text-specific linguistic patterns — and new possibilities for making meaning through language — well beyond what they are likely to experience in casual conversations,” said Uccelli.

“Audiobooks, particularly when students find them engaging and have opportunities to participate in book discussions, can be a powerful tool for helping developing readers expand not only their background knowledge but language resources essential for making meaning from text.”

Gaab’s lab examines how people learn from infancy through adulthood, with an emphasis on language and reading. She often recommends that parents of children with reading difficulties try audiobooks, along with print books, and reminds them that “the most important thing is that children are motivated to learn and excited to read.”

And adults, she said, should be less critical of audiobooks because that’s essentially how we all started.

“If you’re a good reader as an adult, it does not matter whether you read it or you listen to an audiobook,” said Gaab. “We all start as listeners to audiobooks. As children, we were sitting in our parents’ laps while they read books to us. So, we all have been audiobook lovers at some point in our lives.”


‘I think I know how to fix this.’

How a discovery in a Harvard lab is offering hope for patients with hard-to-treat heart disease


Health

‘I think I know how to fix this.’

Andrew Kruse

Andrew Kruse.

Niles Singer/Harvard Staff Photographer

6 min read

How a discovery in a Harvard lab is offering hope for patients with hard-to-treat heart disease

Some 1 million patients in the U.S. live with a type of heart disease called heart failure with preserved ejection fraction, or HFpEF, caused by a stiffening of a chamber of the heart that makes it much more challenging to distribute blood throughout the body. The condition has few approved therapies and high mortality rates.

For years, researchers have suspected that the hormone relaxin could be an effective treatment for certain cardiovascular diseases — including possibly HFpEF. It helps counteract fibrosis, prevents veins and arteries from hardening, and promotes essential vascular and cardiac remodeling to support the mother’s heart during pregnancy. However, a major challenge has been keeping relaxin in the body long enough to be effective. The pharmaceutical industry tested a similar compound in clinical trials but encountered the same challenge as many hormone-based treatments: These molecules are generally small, and the body filters them out too quickly for them to be effective. 

“The pharmacokinetics are not really suitable to use it as a drug,” said Grant Zimmermann, director of business development at Harvard Office of Technology Development (OTD).

That started to change in 2017, soon after a discovery in the lab of Andrew Kruse, professor of biological chemistry and molecular pharmacology in the Blavatnik Institute at Harvard Medical School. “Andrew came to us,” Zimmermann recalls, “and said, ‘I think I know how to fix this.’”

Kruse had been interested in the structural biology of relaxin, which he calls a “very unusual member” of the family of proteins his lab has researched for years. Researchers in the Kruse Lab were studying the structure of the relaxin receptor to understand how it binds to its ligand and induces changes in the body. In the process, the research team made an important discovery: They were able to convert relaxin from a naturally occurring two-chain molecule to a one-chain molecule using protein engineering, and they were able to attach the Fc-domain of an antibody to extend relaxin’s half-life in the body. Native relaxin is complicated to produce in the lab because of its two-chain structure, according to Sarah Erlandson, the graduate student leading the project. Creating a single-chain design made it possible to fuse the antibody Fc to relaxin, allowing it to stay in the body longer.

There wasn’t one moment that illuminated how consequential the discovery would be, says Erlandson. Instead, the process involved the types of continuous progress that often define scientific research and development. Their work “relied on iterative design improvements,” she said. “I remember our growing excitement as we made progress on the engineered protein. That’s when it started to feel like we could have a tangible impact on relaxin therapeutics.”

What they designed as a tool to study structural biology, Kruse realized, could have significant therapeutic potential.

OTD protected the innovations related to the research and got to work on strategies to further advance the research toward commercialization opportunities. Zimmermann brought the project to his colleagues at the Blavatnik Biomedical Accelerator (BBA). That team immediately saw promise in the research and provided funding through pilot and development grants, along with business development support.

Relaxin represents a “prototypical example” of the type of innovations that the BBA funds, says Zimmermann. The accelerator specifically looks for technologies with a clear path to clinical development that need a boost to attract potential industry partners that can further the development of beneficial innovations through sponsored research or license it for commercial use.

The BBA helped fund pharmacokinetic evaluations of the molecule’s use in mice and validate the research to the point that Kruse was able to form a startup and license the technology, launching Tectonic Therapeutic to further advance the research to the clinic.

“All of these things were really critical for us to be able to out-license this molecule, to show that it actually had some real promise,” Kruse said. “The Blavatnik Accelerator is really what allowed us to go from a pure research compound to something that was ultimately a clinical candidate.”

“All of these things were really critical for us to be able to out-license this molecule, to show that it actually had some real promise.”

Andrew Kruse

Kruse also received guidance and ultimately partnered with Timothy A. Springer, the Latham Family Professor of Biological Chemistry and Molecular Pharmacology in the Blavatnik Institute at Harvard Medical School, whose lab studies protein-based therapeutics and who has helped found numerous biotech companies. What began as a lunchtime conversation about progressing academic discovery into a company grew into a collaboration. Springer helped co-found Tectonic, worked with Kruse on fundraising pitches, and provided pivotal early funding, along with his technical expertise.

Since licensing the relaxin technology, Tectonic has conducted additional engineering on the molecule devised in Kruse’s lab — with Kruse as an adviser and Springer on the board of directors — and created a larger platform to develop treatments targeting other G-protein coupled receptors (GPCRs), the class of receptors that Kruse’s lab studies. About 30 percent of all approved drugs target GPCRs, but currently-approved treatments target “just a small fraction” of all known GPCRs, says Alise Reicin, Tectonic’s CEO.

“There is a lot of biology there that could be important in drug discovery and development, but many of those GPCRs, for a variety of reasons, were considered hard to drug or undruggable,” said Reicin. Targeting them with unique biological engineering, the team thought, could unlock new treatments.

For cardiovascular disease, the company’s focus is the RXFP1 receptor, a GPCR that is involved in numerous processes throughout the body, including in the cardiovascular system. Relaxin binds to the RXFP1 receptor and can make tissues, including veins, stretchier and softer. Tectonic’s relaxin treatment, known as TX45, is now in a Phase 2 clinical trial.

“I think there’s lots of reason for optimism that this story is going to play out in the way we envisioned all those years ago,” said Zimmermann.

In January 2025, Tectonic received data suggesting its relaxin therapeutic could work in a subset of patients, those with pulmonary hypertension associated with HFpEF. In the fall, they received a similar dataset in patients with pulmonary hypertension associated with reduced ejection fraction heart failure. These patients typically have reduced exercise tolerance and increased mortality compared with heart failure patients without pulmonary hypertension. In the coming year, the company will also begin working on treating a new form of pulmonary hypertension, associated with interstitial lung disease, with relaxin. For patients, this would mean a potential new treatment for challenging and, at times, fatal conditions. 

“I’m a big believer that it’s the academic-pharma-biotech partnership that has driven innovation in all of the great drug-development programs over the last few decades that have improved the lives of patients,” said Reicin.


Is social media responsible for what happens to users?

Landmark suit to examine 1996 law, questions about mental health, other harms, role of website design


Nation & World

Is social media responsible for what happens to users?

Parents of children who have died due to alleged social media-related harms hold photos of their at the Los Angeles Superior Courthouse.

Parents of children who have died due to alleged social media-related harms hold a vigil on Feb. 5 at the Los Angeles Superior Courthouse, ahead of the landmark social media addiction trial.

Jordan Strauss/AP Content Services for ParentsTogether Action

8 min read

Landmark suit to examine 1996 law, questions about mental health, other harms, role of website design

A Los Angeles jury will decide whether Meta’s Instagram and Google’s YouTube are addictive and causing harm to teenagers and children — and whether they can be held responsible for it.

The lawsuit involves a 20-year-old California woman who says her compulsive use of Instagram and YouTube since childhood resulted in mental health struggles. She argues the platforms are intentionally designed to be addictive in order to boost user engagement.

A 1996 law protects online platforms from liability from content posted by users.

Meta and Google have denied that their popular services pose mental health dangers to young people. But a growing body of research, along with real-life observations of parents and teachers, suggests otherwise.

Glenn Cohen is deputy dean and the James A. Attwood and Leslie Williams Professor of Law at Harvard Law School, and faculty director at the Petrie-Flom Center for Health Law Policy, Biotechnology & Bioethics.

In this edited conversation, Cohen explains why the Los Angeles trial, which began Feb. 9, is testing tech’s insulation from liability and may reshape the public’s relationship with social media.


Many are calling this a landmark trial. Do you share that view?

This is a case that initially was against Meta, Google, TikTok, and Snapchat. It’s currently against Meta and Google; Snapchat and TikTok settled out of court. It’s a so-called bellwether trial.

There are about 1,600 cases that are in multidistrict litigation, which is a procedure for consolidating cases for some parts of the adjudication process. This is the first, but there’s going to be about two dozen bellwether trials. And these cases are selected as representative litigation for the larger pool of litigants.

I think it’s going to be quite an important case in part because it’s a theory that has a serious consequence for Meta and Google should they lose. They tried to get the case resolved in an earlier stage of the proceedings. When the court refused to grant them that resolution in November, that’s when Snapchat and TikTok decided to settle and not to take their chances at trial.

Meta and Google are risking a lot. This is one of the very first cases where we saw Meta CEO Mark Zuckerberg take the stand, and so this is a pretty unprecedented sort of thing.

Meta and Google are alleged to have deliberately designed their products to be addictive to teenagers and younger children. What does the plaintiff have to prove?

Her claim is that she became addicted to these sites as a child, and now experiences anxiety, depression, and body image issues as a result.

The opening statement by her lawyer, Mark Lanier, said things like it’s addictive to the brains of children and that Meta engineered addiction in children’s brains. He draws explicit comparisons to tobacco. Tobacco and gambling are the two public health analogues that you’re going to see come up multiple times.

The allegation is that, just as slot machines and cigarettes use particular techniques from behavioral science and neurobiology, the design decisions here were done in a way to maximize the engagement of youth to increase advertising revenue. That’s a main claim the plaintiffs use to frame their case.

One of the most interesting legal questions has to do with Section 230 of the Communications Decency Act. This was a 1996 law that shielded online platforms from liability for third-party content posted on websites.

The issue of whether the Act protects Meta in this case came up at prior stages of this litigation where the court disagreed with Meta. Should Meta lose this case, it is likely to come up on appeal.

Glenn Cohen.

Glenn Cohen.

File photo by Niles Singer/Harvard Staff Photographer

Tech firms are involved in lots of litigation. What makes this particular lawsuit so compelling?

What’s novel about this case is that the plaintiffs frame their claim as having nothing to do with content. They claim this is about design and functionality and design aspects like infinite scroll. So, they argue, a court can adjudicate liability for the design without running afoul of either Section 230 or facing First Amendment questions about content regulation and the like.

The trial court has accepted those arguments at this stage of the proceeding. But on appeal, should Meta lose this case, I suspect that ruling will be front and center.

The other thing to look for in the litigation is about causation — that is, for the plaintiffs to show that the harms would have been avoided if Meta had not designed the product in this way, that the health issues arose because of Meta product design.

We’re going to see back-and-forth and jousting about whether it’s the content versus the design that’s causing the damage to this young woman that she alleges.

And I think we’re going to see a bunch of back and forth on what’s called “failure to warn” questions.

The mother of the plaintiff has alleged that she had never seen any of the warnings on the subject. She learned about it after watching “60 Minutes” after her daughter had been using the Meta products. There’s going to be questions about what kinds of warnings were provided, whether they were sufficient, and whether that negates the liability of Meta.

One more thing will be the quality of social science research linking the platform features to the alleged harms to this young woman and to children in general. That’s going to be another pressure point.

Those are probably three or four things that I would keep my eye on that are going to be significant.

There’s a real chance that Meta will lose this case at trial. Some of their best arguments were ones that have been rejected in an earlier decision by the court. Still, those are mostly legal questions that I think will be taken up on appeal.

So, it’s possible that Meta will lose the trial and yet ultimately be vindicated at the end of the day.

What are the strengths and weaknesses of their arguments, in your view?

The plaintiff seems to have a very compelling story to tell, and that often is helpful, especially in front of a jury.

And I think they’ve already gotten some good stuff out of Mr. Zuckerberg on the stand. I don’t think he cratered, but the sound bites they’ve generated have been helpful to the plaintiff and the general mood around this litigation.

So those are two of the things that are strongest for the plaintiff side.

On the other side, there is this issue about content versus design. It’s quite hard to disentangle, and that will be something that Meta will be hitting repeatedly.

And then, this question of causation will come up repeatedly, as well, and whether the plaintiff’s attorneys can demonstrate the relationship between the design features and the injuries the young woman sustained.

I imagine that we’ll see the lawyers argue these issues both in the trial court proceeding and certainly on appeal if they should lose.

Many countries in Europe, Australia, and others now regulate social media, as well as AI. Could this case accelerate regulations either here or abroad?

I think so. The things that are most likely on the table would be much more age verification and age gating.

Zuckerberg, in his testimony, says that phone makers bear more responsibility and having a reliable way to verify a young user’s age without a driver’s license would be, he said, a “very wise and simple way” to do it.

So that will be part of Meta and the other social media companies’ story too: that regulators should be focused on the main place where adolescents and children access social media — their phones — and that phone makers should be regulated. That’s going to be an argument they make to stave off regulation on them.

One of the biggest challenges we’ve seen with a bunch of the cases that have made it to the U.S. Supreme Court is Section 230. And then, on the flip side, the First Amendment and a reluctance to be regulating anything that approaches content.

Now, I do think there are probably congressional bills that could be passed that could protect minors without touching content and potentially running afoul of the First Amendment. But the social media companies have been fairly adept, thus far, in avoiding a lot of regulation.

There’s also an argument that if these trials are successful, some might point to them and say, “We don’t need governmental one-size-fits-all regulations. Tort liability is doing the work here for us.” So, there’s a way in which a win for the plaintiffs might also be an argument against too much top-down regulation.

Apart from the ultimate decision at trial, the trial itself is generating all sorts of sound bites and things that might make regulators more interested. We’ve seen increased interest in regulation outside the U.S.; we’ve seen a little bit within the U.S. with some of the states regulating in this space.

Notwithstanding the fact that social media companies are good at lobbying, there’s a real chance that some of the stuff that will be revealed in the course of these trials may change the average American’s relationship with social media companies.


American heart health worsening

New statistical snapshot finds disappointing trend despite advances in treatment, ways to prevent nation’s leading cause of death


Rishi Wadhera.

Rishi Wadhera.

File photo by Stephanie Mitchell/Harvard Staff Photographer

Health

American heart health worsening

New statistical snapshot finds disappointing trend despite advances in treatment, ways to prevent nation’s leading cause of death

4 min read

Treatments for cardiovascular conditions have never been better. Knowledge about how to improve heart health has steadily improved. Yet, in the U.S., progress in cardiovascular health has largely stalled out and in some ways worsened — even as increasingly effective treatments and interventions come to market.

The problem, said Rishi Wadhera, lead author of the Inaugural Journal of American College of Cardiology (JACC) Cardiovascular Statistics 2026 report, is “uniquely American.”

“Many other higher-income countries are grappling with rising obesity and diabetes,” said Wadhera, Harvard Medical School associate professor of medicine at Beth Israel Deaconess Medical Center and associate professor in the Department of Health Policy and Management at the Harvard T. H. Chan School of Public Health. “But the U.S. stands out for how consistently those risks translate into worse cardiovascular outcomes, and how wide the gaps are by income, race, ethnicity, and geography.”

And, in fact, there is growing concern about a worsening problem among younger adults with just-released research showing a sharp rise in hospital death rates from severe first heart attacks among those aged 18 to 54. Most of the deaths were men, but women succumbed at higher rates.

In the JACC report, Wadhera and his colleagues presented a comprehensive picture of cardiovascular risk factors in the U.S., highlighting the disparity between medical knowledge and treatments and the chronic problems faced by tens of millions.

Among other stark statistics, the paper showed that one in two U.S. adults suffer from high blood pressure — with little change between 2009 and 2023.

Though interventions have improved, many who need help don’t get it. The report states that only two in three American adults with hypertension, considered among the most dangerous cardiovascular risk factors, receive medical treatment, with no improvement in the figure since 2009-2010.

This lack of treatment leads to deaths. From 2000 to 2019, hypertension-related cardiovascular deaths nearly doubled, from 23 to 43 per 100,000 — with men experiencing higher rates than women and Black adults higher than white adults.

Among other stark statistics, the paper showed that one in two U.S. adults suffer from high blood pressure — with little change between 2009 and 2023.

Especially concerning to Wadhera and his colleagues is that younger Americans are facing a greater burden of heart problems.

“We’re seeing cardiovascular risks factors and diseases show up earlier in life, which changes the entire arc of health for individuals and also increases the likelihood of decades of chronic illness and catastrophic health events later on,” Wadhera said. “The story of young adults was stark and compelling.”

Wadhera stressed that the report also highlighted some positive trends. Mortality from coronary artery disease dropped by about 50 percent between 2000 and 2020, and the quality of care for those who suffer a heart attack or stroke improved. Far fewer people smoke, too, limiting a major factor that plays into heart problems.

Wadhera cited the decline in smoking as an example of how research and public health campaigns can lead to meaningful improvements in health.

“The declines didn’t happen by accident,” he said. “They were the consequence of sustained education, prevention, public health efforts, health system efforts, and so on.”

He hopes that the report’s accessible presentation of trends not only helps researchers and clinicians, but also policymakers who make decisions that directly affect cardiovascular health — including on structural factors that drive disparities.

“There are obviously genetic determinants of obesity,” Wadhera said, “but at the same time, we do have to think about how our communities are constructed, how our environments are constructed, and whether they make it easy for people to make healthy choices.”

Despite overall decreases in smoking, he pointed out that smoking rates are much higher in lower-income than higher-income adults. Similarly, though most people understand the importance of diet and exercise in preventing hypertension and obesity, millions of Americans live in obesogenic environments with little public space, low-quality food, and poor transit options outside of driving.

“There’s a widening gap between what’s possible and what’s delivered,” Wadhera said. Until the nation aligns its health system, public policy, and community investments around prevention and risk-factor control, he added, the U.S. will continue to experience avoidable heart attacks, strokes, and cardiovascular deaths.


Retelling Frederick Douglass’ story, with a soundtrack

Senior composes musical about abolitionist’s early life


Dree Palimore standing for portrait with arms folded.

Quadree “Dree” Palimore.

Lauren Fabiszak/Harvard College

Arts & Culture

Retelling Frederick Douglass’ story, with a soundtrack

Senior composes musical about abolitionist’s early life

6 min read

Quadree “Dree” Palimore paced the floor in a campus studio recently as Yerim Colin prepared to sing. The students were workshopping a number from Palimore’s original musical — an ambitious retelling of the life of Frederick Douglass.

“It’s been 30 days of your freedom, 30 days of you having your own identity,” Palimore prompted Colin. “What’s on your face, how are you going to express that to an audience? Think about that during the opening segment.”

The idea for the musical came to Palimore, now a senior, as a first-year, when a writing course on slave chronicles had him read the abolitionist’s memoir, “Narrative of the Life of Frederick Douglass.” He was inspired, in part, by Douglass’ relationship to music.

“In his ‘Narrative,’ he writes a lot about the role music had played for him as a slave, how he remembered hearing slave songs,” Palimore explained. “He wrote a lot about what he believed the power of music to be. That was compelling to me. There is power in a story. I think the use of song and music can elevate these emotions and experiences that this young man was facing.”

The first song came to him one day during sophomore year, while jamming with friends in Eliot House. His friends set down their guitars and left to take a break, but Palimore stayed, chasing notes on the keyboard.

“I had never written my own song. But I knew when I played that melody for the first time, that it felt different,” he recalled. “Out of the blue, I started playing the first melody ever for the musical.”

Now in his final College semester, Palimore is finishing the writing process for his musical, titled “Bailey: An American Narrative” after the abolitionist’s birth name. The show spans the seven-year period from October 1838 (about a month after 20-year-old Frederick Bailey escaped slavery in Maryland) to 1845, the year he published his memoir.

“The moments right before changing his name to Frederick Douglass feel important to me, because those were the days when he was making the big moves to do the things that he really wanted to do,” Palimore said. “I constantly think about how he reconciled being free with having that history attached to his name. How did he cry about it? How did he overcome it? How did he try to run from it?”

Palimore conducted extensive historical research, dug in the archives, and consulted Harvard experts, including Evelyn Brooks Higginbotham, Victor S. Thomas Professor of History and of African and African American Studies; Henry Louis Gates Jr., Alphonse Fletcher Jr. University Professor; and John Stauffer, Sumner R. and Marshall S. Kates Professor of English and of African and African American Studies.

But much of his writing process has also been imaginative. Palimore is fascinated by the idea of Douglass at his own age, and while writing his sections of dialogue tries to envision what the young abolitionist would have thought, journaled, and prayed about.

The music in the show is a mix of genres: rap and spoken word, some jazz, gospel, and orchestral. Palimore was also inspired by 19th-century music and has arranged what he’s calling a “2025 version” of the 1840s anti-slavery song “Come Join the Abolitionists.”

A vocalist and member of Harvard Glee Club, Palimore had only beginner piano chops and no composing experience when he began the musical, but he dove into learning. He declared a secondary in Theater, Dance & Media, signing up for courses such as “The Making of a Musical: The Creative Process” with Professor of the Practice of Theatre Diane Paulus and head of dramaturgy Ryan McKittrick, and “Beginning Acting” with head of directing Marcus Stern. He transferred from Mather House to Eliot, to be closer to the friends with whom he freestyled.

“Just being at Harvard, there are a million opportunities, so I tried to take as many as I could. Academic opportunities, of course, but also having access to piano rooms in the music building.”

Quadree “Dree” Palimore
Yerim Colin '27 with Dree Palimore at the piano.

Yerim Colin ’27 with Palimore at the piano.

Lauren Fabiszak/Harvard College

In the summer of 2024, Palimore did a directing internship at the A.R.T. for “Romeo and Juliet.” He attended an Office for the Arts vocal workshop with “Hamilton” actor A.D. Weaver and presented material from “Bailey” at the OFA’s Creative Careers Conference.

“Just being at Harvard, there are a million opportunities, so I tried to take as many as I could,” Palimore said. “Academic opportunities, of course, but also having access to piano rooms in the music building.”

Stew Stewart, professor of the practice of musical theater writing, has served as a mentor to Palimore during this project.

“Dree is a bracingly unique student whose fierce intelligence and visionary ambition fuels a passion for learning and creating that gave me the feeling of collaborating with an equal, more so than merely a professor passing on wisdom and knowledge,” Stewart said. “The more a student brings to the table the more we have to work with, and Dree’s got enough stuff for a few tables.”

Realizing he needed time to focus solely on writing the musical, Palimore took a gap year after junior year. He lived at his family home in Urbandale, Iowa, and worked at Target, melodies running through his head as he operated the elevated lift in the stockroom.

“I would take my 15-minute breaks and put my AirPods in and listen to the songs that I was composing, and I would take notes in my Pages app on my phone,” Palimore recalled. “I would be excited to go home to work on it.”

Palimore is planning a first table read of the show for April. He dreams about his work being performed on bigger stages in the future.

“Nothing else had ever brought me such fulfillment, staying up until 3 a.m. composing a work and then dreaming about it that same night, and then waking up at 7 a.m. and immediately pick up my laptop to implement those cello parts,” Palimore said. “I had never felt a certain way about anything before. The opportunities and experiences at Harvard revealed to me that art is what I want to do for the rest of my life.”


Tracking mysteries of loss of Y chromosome, cancer

Research suggests it may explain higher incidence, severity of some disease in men


Esther Rheinbay (left) and Luis Antonio Corchete Sánchez.

Esther Rheinbay and Luis Antonio Corchete Sánchez.

Veasey Conway/Harvard Staff Photographer

Health

Tracking mysteries of loss of Y chromosome, cancer

Research suggests it may explain higher incidence, severity of some disease in men 

4 min read

The Y chromosome is among the smallest in the human body and carries the fewest genes. Researchers are paying renewed attention to its role in cancer — specifically, what happens when it vanishes. 

Women typically have two X chromosomes, and men an X and a Y. Men generally face a higher cancer risk than women in most shared anatomy, with the biggest differences in bladder, gastric cardia, and larynx disease. Researchers think lifestyle factors, such as diet, exercise, and exposure to carcinogens, explain some of the disparity, but not all.

Recent evidence suggests the disappearance of the Y chromosome in tumor cells may explain some of the gender gap in some cancer types, like kidney cancer. Understanding the connection could eventually lead to new therapies.

The gradual loss of the Y isn’t unusual. By the time they’re 70 years old, about 40 percent of men have lost at least some of the Y chromosome in their blood cells. In addition, the chromosome is frequently lost in tumors.

The Y chromosome primarily carries genes that provide instructions for male sex differentiation and fertility. But it also carries some known to suppress tumor growth — a protective ability that is lost if those genes are damaged or destroyed.

Luis Antonio Corchete Sánchez, a postdoctoral research fellow at the Krantz Family Center for Cancer Research at Mass General Brigham Cancer Institute and co-author of a recent review article on the issue in the journal Trends in Cancer, likens Y-chromosome gene loss to library books sent through a paper shredder: “You’ve lost those books forever; you can never recover that information,” he said. 

Loss of the Y chromosome, or LOY, in tumors is a separate process from aging-related LOY, said Esther Rheinbay, Corchete Sánchez’s co-author. About 30 percent of primary tumors in men harbor either complete or partial LOY. In papillary renal cell carcinoma, a type of kidney cancer, the rates may be as high as 80 percent. 

But the causality is far from clear. Scientists don’t know whether LOY causes tumors to grow, or whether LOY and tumor growth both result from some third process. The answer may vary by type of cancer, or even by individual patient. 

“We know, at least in some tumor types, Y chromosome loss occurs very early in tumor evolution, but probably along with other alterations,” said Rheinbay, an assistant professor at Harvard Medical School and principal investigator at the Krantz Family Center. “One thing we’re trying to understand is: What’s the order of events? Is [LOY] oncogenic on its own, or does it need collaborators? That’s something we simply don’t know yet.” 

“Every time we find more insight into the loss of the Y chromosome, we find more questions and more potential research gaps,” said Corchete Sánchez. 

Studies of people with less common chromosome patterns, like males with an extra X chromosome or females missing or partly missing an X chromosome, suggest that X chromosomes may offer some protection against solid tumors, while the presence of a Y chromosome is associated with greater cancer risk.

But the little chromosome has proven frustratingly difficult to study.

“The Y chromosome is really rich in repetitive regions, so it’s hard to decide where the signal is coming from,” Rheinbay explained. “Together with the fact that it’s small, and there are very few genes relevant for cancer, it’s been deprioritized in analysis.”

Rheinbay’s team has been developing specialized tools to better define the status of the Y chromosome in cancer.

The same peculiarities that make the Y chromosome hard to study also offer promising opportunities for new cancer therapies. 

“LOY in cancer cells leads to this exposed X chromosome,” Rheinbay said. “Because that doesn’t happen in most other cells, there’s a therapeutic window where we can potentially treat those cancer cells, and they will be way more sensitive to the drug than the normal cells with Y chromosome. That’s what we want: a treatment that kills the cancer but doesn’t hurt normal cells.”

“It’s exciting to venture into an area that has not been explored,” added Rheinbay. “And always thinking about the impact we could have on patient treatment makes it very exciting and very motivating.”


Muriel Siebert kicked down the door so others could follow 

Baker Library exhibit showcases life of analyst who opened doors for women on Wall Street


Work & Economy

Muriel Siebert kicked down the door so others could follow 

Images courtesy of Baker Library Special Collections; photo illustration by Liz Zonarich/Harvard Staff

7 min read

Baker Library exhibit showcases life of analyst who opened doors for women on Wall Street 

Muriel Siebert arrived in New York City in 1954 with $500 and a dream. But from her first job as a “glorified gofer” at a small financial analysis firm, she would go on to become the first woman to buy a seat on the New York Stock Exchange, the first woman to own and operate a brokerage firm on the NYSE, and the first woman to serve as Superintendent of Banks for the State of New York. 

A new exhibit, “Muriel Siebert: Redefining Power and Possibility on Wall Street,” on display now at the Harvard Business School’s Baker Library, highlights Siebert’s remarkable career, which opened doors for women in finance. This exhibit introduces the extensive holdings of the Muriel Siebert Collection at Baker Library, which the Muriel Siebert Foundation donated to the library in 2019. The Siebert archive comprises a wide range of materials, including correspondence, research reports, speeches, articles, press releases, photographs, and audiovisual materials.


“Now, this is exciting.”

Muriel Siebert was born in Cleveland, Ohio, in 1928, the daughter of a homemaker and a dentist. She attended Flora Stone Mather College intending to become an accountant, but before she could graduate, her father was diagnosed with cancer. She dropped out to care for him in her junior year.  

In 1953, Siebert visited New York City with some friends and toured the New York Stock Exchange.  

“What I saw as I looked down from the visitors’ gallery was a sea of men in dark suits,” she wrote in her autobiography. “But after absorbing all that fierce energy, I turned to my friends and said, ‘Now, this is exciting.'”  

The following year, Siebert returned to New York to look for work. 

After being turned down for several jobs, Siebert found work as a research trainee at Bache & Co. for $65 per week. She considered herself a “glorified gofer,” but she learned about the art and science of market analysis.

“I can look at a page of numbers and they light up and tell me a story,” she said. 

A seat at the table

An advertisement proclaims Siebert the “first lady member” of the New York Stock Exchange (left). Siebert’s NYSE membership badge. Siebert on the floor of the New York Stock Exchange.

Siebert rose through the ranks of the research analysts at smaller brokerage firms.  

She encountered gender discrimination on many fronts.  

“Mentors for women didn’t exist when I started on Wall Street,” she wrote. “It makes you a feminist when you’re making $150 a week and the man sitting next to you is making $300.”  

“When I applied for a seat on the exchange, there was an uproar. Some people who felt that women should not be admitted to the stock exchange came to me and said so. But for every one person who resented my action, I found there were others who were happy for me. . . . I did a lot of soul-searching and talked to some of my other clients and I worked up enough strength to approach the exchange.”

Muriel Siebert, 1971

In 1967, a client suggested she buy a seat on the New York Stock Exchange and start her own firm. Siebert read the NYSE constitution and found no rules against women buying a seat. She bought her membership for $445,000, the equivalent of more than $4 million today. She called her membership badge “the most expensive piece of jewelry going.” 

Going into business

“The Advertising Club of Greater Boston, Night at Harvard, January 31, 1968.”

Notes for keynote speech by Siebert for “Women in Management Day Program,” HBS, May 3, 1972.

 Siebert quickly earned a reputation as a trailblazer. She was invited to speak at Harvard Business School in 1968, shortly after she bought her seat on the exchange (HBS had first admitted women into its full MBA program five years earlier). 

In 1972, she was invited back to be the keynote speaker at a program called “The Impact of Women on Today’s Business Environment.” She began her address, “When I received the invitation to speak here — I thought of the Virginia Slim Cigarette Ad — You’ve come a long way baby. As a woman who has succeeded in a man’s world — I’d like to say ‘Baby — you’ve got a long way to go.'” 

Aiming for bigger reforms 

Siebert for U.S. Senator campaign brochure, 1982.

In 1977, Siebert was appointed New York State’s Superintendent of Banks, making her the first woman to hold the position. She oversaw about 500 banking institutions, $400 billion in assets, and $100 billion in trust accounts. 

The role made her acutely aware of the need for financial reform. In 1982, she ran for the U.S. Senate seat held by Democrat Daniel Patrick Moynihan, losing in the Republican primary to Assemblywoman Florence M. Sullivan.  

“Pride, principal, and profit” 

While she was Superintendent of Banks and running for Senate, Siebert relinquished control of her firm into a blind trust. But after her primary loss, she returned to her company. 

She grew the firm significantly, opening new offices, expanding into new services, and adopting new technologies, including an early computerized trading site.  

“When I left my position with New York State, I had some offers from major firms. Had I taken any of them, I probably would have made a lot more money, but … I felt an obligation to other women. Had there been ten other woman-owned firms, I might have chosen differently,” 

Throughout her career, Siebert championed women in business. She was a founder of the Women’s Forum in the Committee of 200, organizations supporting women in business. In 1990, she established the Siebert Entrepreneurial Philanthropic Plan (SEPP), which directed to charity 50 percent of profits, after clearing costs, from the fees associated with the underwriting or purchasing of new securities.  

“My motives have always been pride, principle and profit. I don’t know how you stay afloat and sleep at night without all three.”

Muriel Siebert

“Giving back is more than an obligation, it’s a privilege,” she said. 

Siebert was inducted into the National Women’s Hall of Fame and the International Forum Women’s Hall of Fame. In 2016, three years after her death, the NYSE opened Siebert Hall, the first and only room in the Exchange dedicated to an individual.  

“Muriel Siebert: Redefining Power and Possibility on Wall Street” is open at Harvard Business School’s Baker Library through December 2026. This article includes text drawn from the digital exhibition and exhibition catalog. 


‘The sound stopped suddenly’

After rare condition robbed drummer of ability to play music, science led him back


Arts & Culture

‘The sound stopped suddenly’

Satoshi Yamaguchi

Satoshi Yamaguchi.

Veasey Conway/Harvard Staff Photographer

4 min read

After rare condition robbed drummer of ability to play music, science led him back

The first symptoms appeared during a concert.

In 2009, Satoshi Yamaguchi, a drummer with the Japanese rock quartet RADWIMPS, found himself lost during a familiar bridge.

“The sound stopped suddenly,” Yamaguchi recalled in a 2023 TV news interview with NHK World-Japan. “I wanted to use my right foot to hit the drum twice, but I ended with the first try. At that instant, my brain really drew a blank. I thought, ‘What’s going on?’”

It took five years to receive the diagnosis of musician’s dystonia, which causes involuntary muscle spasms. The neurological disorder, impacting roughly 1 percent of professional musicians globally, eventually forced Yamaguchi’s exit from the band he had co-founded in 2003. But it also opened a remarkable new chapter in the percussionist’s story.

In a recent event hosted by the Reischauer Institute of Japanese Studies, Yamaguchi recalled his journey from rock stardom to scientific researcher intent on solving the mysteries of his condition. He also showed off the voice-activated drum kit that enabled his return to live performance in 2024, nearly a decade after he left RADWIMPS.

“My children had only ever seen me play the drums on the screen,” Yamaguchi recalled, sharing a photo of his family of five. “This was the first time they heard me perform live.”

Key to Yamaguchi’s trajectory was drummer-turned-scientist Shinya Fujii of Keio University’s NeuroMusicLab. The pair, who met when Yamaguchi arrived as a visiting researcher in 2021, went on to pursue a series of academic inquiries into musician’s dystonia.

Their first paper, published in 2024, charted the disorder’s impact on Yamaguchi’s musicianship. The effects may seem subtle to the untrained ear. But when symptoms appeared, the researchers confirmed, the drummer fell out of rhythm with a metronome.

For Yamaguchi, the findings came as a relief. “When I was still active in the band, I had no way to share the difference or the struggle with the people around me,” he told a packed house at Smith Campus Center. “But through science, I was finally able to reveal the true nature of that ghost.”

“When I was still active in the band, I had no way to share the difference or the struggle with the people around me. But through science, I was finally able to reveal the true nature of that ghost.”

Satoshi Yamaguchi

Inspired, Yamaguchi went on to conduct a large-scale survey of professional and amateur Japanese musicians. Results show musician’s dystonia is more prevalent among pros, with the right lower limbs most frequently afflicted.

Also uncovered was a potential link with the stress caused by in-ear metronomes, increasingly used in the music world by drummers, conductors, and other designated timekeepers. The devices dictate the rhythm of each piece, with a click track delivered directly to the eardrum.

“In recent years,” Yamaguchi explained, “large-scale live performance has evolved into a total entertainment experience that includes not only listening to performance, but also synchronizing the music with visuals, lighting, special effects, and programmed sound sources.”

In 2023, Yamaguchi moved to the Bay Area for a residency at Stanford University’s Center for Computer Research in Music and Acoustics. It was an unlikely place to discover the joys of taiko drumming, a traditional Japanese art form. He ended up performing in a 50th anniversary concert with the group San Jose Taiko.

The art form’s whole-body rhythms are taught orally — not via sheet music, Yamaguchi noted. While learning this way, he was struck by an idea. “What if I could use my voice to create the sound of the bass drum?” he recalled wondering. “My voice could become my instrument.”

Developed in collaboration with Yamaha, VXD is a bass-drum interface operated via vocal cues and throat sensor. Yamaguchi met privately last week with scientists from the Harvard Biodesign Lab, who wanted to understand how the system works. At the public event, Yamaguchi showed off VXD by playing a few RADWIMPS favorites.

An audience member gasped with delight when he started drumming “Sparkle,” featured in the 2016 hit anime film “Your Name.” Also performed were early releases “25-kome no senshokutai” (“The 25th Chromosome”) and “Iindesuka?” (“Is It Alright?”).

“Music has given me life,” Yamaguchi said near the end of his talk. “Music has also caused me pain. I lost it once, and then I found my way back to it — and it saved me.”

The event closed with the high-energy “Zenzenzense” (“Past Past Past Life”), which was also featured in “Your Name.” Yamaguchi pursed his lips into the microphone as he repeated the “don” syllable that triggers the VXD system’s bass drum. His right foot, pressed firmly to the floor, appeared as an anchor. The rest of his body was lifted by the beat.


How realistic is ‘The Pitt’?

Doctors weigh in on what hit TV show gets right and wrong about life in the ER — from pacing and caseloads to workplace culture (and that waiting room from hell)


Health

How realistic is ‘The Pitt’?

various scenes from the show "the pitt"

Photos by Warrick Page/HBO Max

8 min read

Doctors weigh in on what hit TV show gets right and wrong about life in the ER — from pacing and caseloads to workplace culture (and that waiting room from hell)

Every Thursday, viewers of the Emmy Award-winning HBO Max show “The Pitt” clock into their shift at Pittsburgh Trauma Medical Center’s emergency department to watch their favorite fictional doctors tackle any number of crises. But does “The Pitt” capture the reality of life as an emergency physician? The Gazette talked to four doctors at Harvard-affiliated hospitals about what the show gets right, what it doesn’t, and why they watch (or don’t). Their answers have been edited for clarity and length.


Ali Raja

Mooney-Reed Endowed Chair in the Department of Emergency Medicine at Massachusetts General Hospital; Professor of Emergency Medicine and Radiology at Harvard Medical School

The pacing is exceptionally accurate. But it’s not just the pacing. It’s also the fact that the characters are constantly getting interrupted. They’ll be talking about one case and be in the middle of a conversation, but they’re pulled into another case, or they’re answering pages and they’re juggling multiple patients at once.

It’s also the whiplash of going from one patient to another, and the emotional whiplash of going from a heartbreaking case in one room to a minor complaint in the next room, and trying to juggle the back and forth there.

There are a lot of cases that they get right. We have a huge mental health crisis in this country, and the show does a good job of portraying things like suicidal ideation or acute psychosis without sensationalizing it. These are often sad and complicated cases, and the show does a good job of showing that there’s not an easy solution, and sometimes there’s not a solution at all for the mental health crises that some patients experience. One other example they are not shying away from is the fact that a lot of our patients have crises of homelessness, of lacking insurance, of having unsafe home situations, of having immigration concerns.

“One other example they are not shying away from is the fact that a lot of our patients have crises of homelessness, of lacking insurance, of having unsafe home situations, of having immigration concerns.”

But there is a little bit of time compression. There are conditions that take days to unfold, but they unfold on the show in a couple of hours. Patients are being discharged after a big illness or injury a lot faster than they would be in the emergency department because they’ve magically recovered. There are lab results that come back within the same episode and these episodes are all one hour. If we’re getting a CAT scan on a patient in the emergency department, it normally takes an hour or two to wait, then you get the CAT scan that takes an hour or two to read. But on TV, that would be three episodes later and that story arc is already gone.

No medical show is going to be perfect.


Gianmichel Corrado

Director of Emergency Sports Medicine at Mass General Brigham; Senior Associate Athletic Director and Chief Medical Officer at Northeastern University; Head Team Physician for the New England Patriots

I can’t make it through a whole episode without turning it off, because it nails a lot of it really. I practiced emergency medicine solely for about six years, and then I continued to practice it part-time with sports medicine for another eight years or so. But I haven’t been in the ED for four years. I tried to go back when I joined Mass General and do a couple shifts, and I can’t do it. I can’t handle it, and I’m not good at it anymore. You have to be your best at every moment there.

“The Pitt” really, really nails the psychosocial stuff. I thought it was a little much when that guy was on the roof thinking about jumping. But there’s not one of us, I bet you, that hasn’t had the thought crossing your mind, especially when you’re going in to do an overnight shift and you know it’s going to be hell, or when it’s Christmas Eve and you’re not with your kids and you’re going through hell.

If you’re thinking about going into emergency medicine, watch the show and try to remember, as you get older, you get tired. You couldn’t get into a good emergency medicine residency when “ER” was on. And now “The Pitt” is here, and over the past 10 years or so, programs aren’t filling anymore. The word’s out that this is a tough job. Go look at 50-year-old ED physicians that stuck with it. They don’t look good.


Michael VanRooyen

Chair of the Department of Emergency Medicine at Mass General Brigham

I find the medical parts of the show realistic. Those of us who grew up in the era of “ER” years ago with Noah Wyle — that was an early kind of semi-realistic, not super realistic, view of the emergency department.

The way that they describe presentation of patients, the pathology that we see, procedures we do is realistic, surprisingly, more than any other show that I’ve seen. It’s the variety of patients that we get as they come through the door, the movement, all of it. It’s realistic in a way that it makes you feel like you’re at work.

“It’s realistic in a way that it makes you feel like you’re at work.”

The stuff that is not so realistic are the kinds of behavioral issues. While there’s cheeky commentary between people all the time, the sort of tense drama or interplay that we see that makes good drama is not necessarily standard in the emergency department.

It’s actually a quite collegial place to work. That’s why people like to work there, because it’s very much a team approach. We all like to work with the team.

Also there are times when the emergency room waits can be really long, because everybody’s coming at once. But that’s not the norm. It’s a busy place, but we are equipped to move people through. In the series, every time they go out to the waiting room, it’s absolute pandemonium, and it’s terrible out there. And that’s not exactly accurate.


Shan Liu

Attending physician in the Department of Emergency Medicine at Massachusetts General Hospital; Associate Professor of Emergency Medicine at Harvard Medical School

“ER” veered into a lot of the drama. And I really love that “The Pitt” is just the emergency department and the relationships that happen there. And I love that they’re highlighting the nurses and the security and how it really is a village. I think they added respiratory tech this year because we can’t function without our respiratory tech.

There are probably a handful of cases that no, we would never do it like that or you would have that once in your career, maybe, and they happen to have it in the first five hours of a shift. But I would say 97 percent of those cases are totally what we see.

We see a lot of abdominal pain that’s not featured. Or a cold. You’re not going to feature that every time, which is a little bit more of our cadence of like, ankle sprain, ankle sprain, ankle sprain, or back pain, back pain. Not every case is this amazing case report, but certainly all of that stuff is very plausible and real.

And then also, they illustrated COVID and the difficulty of it, and those decisions that many people had to make about resources and who was going to get what. We fortunately never ran out of ventilators, but there was a whole mask issue, and they were very tough times.

In the end, I’m very grateful for it, for the entertainment, but also the messaging. If people understand when they come to the emergency department that it is crazy, and have a little bit of better understanding that it’s not for lack of not wanting you to go upstairs, or not wanting you to be in the hallway, it makes my job easier when people are not so upset.

Oftentimes, MGH is crowded, and we’re always apologizing to our patients. Suddenly it’s a little more palatable, because they’re like, ‘It’s like “The Pitt.”’


What exactly is consciousness? (And does my Venus flytrap have it too?)

In new book, author Michael Pollan explores nonhuman sentience, stream of thought, AI


Science & Tech

What exactly is consciousness? (And does my Venus flytrap have it too?)

In new book, author Michael Pollan explores nonhuman sentience, stream of thought, AI

9 min read
Michael Pollan sitting in a chair and listening.

Michael Pollan.

File photo by Niles Singer/Harvard Staff Photographer

The brain is constantly managing a myriad of bodily functions, and most of them happen without our being aware of it. So why do some operations rise to the level of awareness? 

That’s the question at the heart of Michael Pollan’s just released new book, “A World Appears: A Journey Into Consciousness.”

Pollan is the award-winning author of 10 books, including “This Is Your Mind on Plants” and “How to Change Your Mind,” and is the Lewis K. Chan Arts Lecturer and professor of the practice of nonfiction, emeritus. His latest book takes insights from science, literature, philosophy, spirituality, and psychedelics to turn the spotlight of consciousness on itself and explore what it is — and whether only humans have it. 

Pollan will discuss the book with Louisa Thomas, a staff writer at The New Yorker and a lecturer in creative writing at Harvard University, on Thursday at the First Parish Church in Cambridge. 

This interview has been edited for length and clarity. 


You start by defining the “hard problem” of consciousness that the book sets out to explore. What is that hard problem? 

It was set forth by a philosopher named David Chalmers back in 1994, and he basically said, “How do you get from matter to mind? How do you get from three pounds of brain tissue to subjective experience, having a voice in your head? You’re not aware of about 90 percent of what the brain does, so why do we have this space of interiority? Why isn’t everything the brain does completely automatic?” 

This is a problem that neuroscientists have been working on since about the late ’80s. Before that, consciousness was not considered a respectable subject for scientists to delve into, so there was remarkably little work done.

 So the book is really a look at the modern attempt to understand consciousness by both scientists and other kinds of thinkers.

Book cover for A World Appears.

There are a lot of theories about what consciousness is, and Chalmers is kind of a key figure in judging the relative success of each. 

Yes, he’s very good at that. He takes any new theory of consciousness and applies himself to it until he hits a wall. He sort of serves the field as a kind of superego.

But a surprising number of scientists look to him as an arbiter of what is or isn’t a good theory. It’s an interesting phenomenon, because you don’t usually have science deferring to philosophy, but this is an area where that’s the case. 

Why do you think that is? 

It’s possible that we don’t have the right kind of science to solve this particular problem. All we have to understand consciousness is consciousness: The whole scientific enterprise is a manifestation of human consciousness. We can never step outside of it, and that makes it a uniquely difficult problem. 

Also, for the last 400 years, science has organized itself around the idea that it should focus on objective, measurable, quantifiable reality, and leave subjectivity to the church. That was Galileo’s bargain, and it still holds.

The tools we have to understand what is finally a subjective experience are limited, and I argue it may take a revolution in science to solve the problem. It may take science learning how to incorporate phenomenology — lived experience — into its methodology before we can solve this problem. 

That’s not to say we can’t learn a lot about consciousness. We’re all experts in it. Novelists and poets also know an awful lot about consciousness, so I turn to them as well as scientists. 

What are we actually talking about when we talk about consciousness? 

In the book I move from the simplest to the most complex manifestations of consciousness, starting with sentience. There are people who would say consciousness and sentience are the same thing, but I see an important difference.

I think sentience is a simpler, more basic form of consciousness. All it requires is an awareness of one’s environment, the ability to distinguish beneficial changes from destructive changes, and to move toward one and away from the other. Even bacteria have this: Chemotaxis is the bacteria’s ability to recognize dangerous molecules and food.

I think sentience may be a property of life that you need to deal with in a world that’s complex and ever-changing and unpredictable, and it may be that every living thing does sentience in a different way that suits their needs, the scale at which they live. 

A group of researchers who call themselves plant neurobiologists (it isn’t exactly neurobiology, since no neurons are involved; I think the name is meant to troll more conventional botanists) are doing fascinating experiments that show, for example, that plants can be rendered insentient.

If you expose a Venus flytrap to xenon gas, which is a bizarre kind of anesthetic, they won’t react when a fly crosses their threshold. Another plant, Mimosa pudica, can be taught not to react, not to close its leaves, to false stimuli. It can remember the lesson for 28 days.

Also, the root of a corn plant can navigate a maze to find fertilizer. There are vines that change leaf shape depending on what plant they’re curling their way around. 

I wouldn’t call that consciousness. I don’t think plants have interiority the way we do. But plants have more than instinct. They’re capable of intelligent decision-making. 

You go on to talk about feeling as this next layer of consciousness. Why do feelings play such a big role in your framework for consciousness? 

For a long time, scientists assumed consciousness had to be this cortical phenomenon. It had to be tied to rational thought, the kinds of things only we humans can do.

But a neurologist named Antonio Damasio, beginning with his book “Descartes’ Error,” showed that maybe feelings come first, that consciousness may be a product not of the cortex but of the upper brainstem. I think he makes a persuasive case. 

Let’s say you have a feeling of hunger. That’s a basic sensation generated in your body, and your cortex is enlisted to make a reservation for dinner or imagine various counterfactuals that could get you fed. So the cortex is involved, but it comes into the picture later. 

If you believe that feelings are the basis of consciousness, there are a couple of implications. One is that it helps make the case that animals, which have similar structures in their brain stems, are conscious. The other implication is questioning whether machines can become conscious. Machines are pretty good at thinking, but they’re much less good at feeling.

Feelings are grounded in biology; feelings are the way the body communicates with the brain. And feelings depend, I think, on the fact that we can suffer, perhaps on the fact that we’re mortal. You could ignore a feeling completely if there wasn’t a sense of vulnerability attached to it.

So I’m just not convinced that computation can describe everything a brain does. Our thought processes are so nuanced and subtle, it’s hard to attribute that to computation. 

What did you learn about your own thought process through writing the book? 

Scientists seldom look at the contents of consciousness, which is our thoughts. But I worked with a psychologist named Russel Hurlburt, who has spent the last 50 years sampling what he calls inner experience.

If you participate in his experiment, as I did, you wear a beeper, and over the course of the day, at completely random times, it sends a beep into your ear, and you have to write down exactly what you were thinking at that moment, however banal or profound. (In my case, it was always banal.)

And then he interrogates you. He says, “Were you thinking in words, in images, or in unsymbolized thought?” If you were thinking in words, were you speaking them or hearing them? He really drills down.

In my case, he came to the conclusion that I had very little inner experience. I was offended by that, because I think I have plenty of inner experience, but he couldn’t find it. 

After 50 years, his biggest finding is that we don’t know that much about how we think, and that different people think in different ways. 

At certain points reading the book, I got so interested in analyzing my own thinking that I stumbled over the act of reading.

Yes! One of the things I’m trying to do is defamiliarize consciousness. You know, my experience with psychedelics is partly what got me interested in consciousness, as has happened to millions of other people who have used them.

Going through life, reality seems transparent to us. We forget we’re looking through the windowpane of our consciousness. But it takes consciousness for the world to appear to us.

Psychedelics kind of smudge the windowpane so that we become aware of this miracle. I’m hoping the book will do the same, without any chemical assistance. 

In the end, I shift from focusing on the problem of consciousness to focusing on the astounding fact of it. We’re given this gift of consciousness, and we’re giving it away thoughtlessly to companies that want to profit from it — by buying and selling our attention, and, with AI, our emotional attachment.

I’m hoping people will leave with a sense that this is really precious, this space of privacy and freedom that we have, and we have to defend it.


Yoga can help cut severe, initial opioid-withdrawal period in half, study finds

Researchers say results could dramatically increase chances of recovery


person meditating at lake
Health

Yoga can help cut severe, initial opioid-withdrawal period in half, study finds

Researchers say results could dramatically increase chances of recovery

4 min read

Just 10 sessions of yoga can cut the length of the initial, most severe period of opioid withdrawal nearly in half, dramatically increasing the odds of successful recovery, new research shows.

The first days of withdrawal pose highest risk of dropout and relapse as they are marked by often severe sleeplessness, anxiety, pain, and other symptoms, according to Associate Professor of Psychiatry Kevin Hill of Beth Israel Deaconess Medical Center’s Division of Addiction Psychiatry and an author of the study.

“If we can make the treatment period shorter and more pleasant we have a better chance of success,” Hill said.

In the study, which ran April 2023-March 2024, researchers from India’s National Institute of Mental Health and Neuroscience, Harvard Medical School, and Beth Israel Deaconess Medical Center found that 10 group sessions of 45 minutes each spread out over two weeks cut the withdrawal period from nine days to five.

Researchers also saw improvement in secondary measures, including anxiety reduction, reduced time to fall asleep, and average pain perception.

“If we can make the treatment period shorter and more pleasant we have a better chance of success.”

Kevin Hill

The study, published in January in JAMA Psychiatry, examined 59 men, ages 18 to 50, who were experiencing mild to moderate withdrawal symptoms. The subjects also received treatment with buprenorphine, a drug that reduces cravings without intoxicating effects.

Opioid addiction has become a global problem, with an estimated 60 million nonmedical users worldwide, according to the study’s authors. Only one in 11 of those with an opioid use disorder receives treatment. The study, led by Hemant Bhargav of the National Institute of Mental Health and Neurosciences, was conducted in India, where opioid use is growing and users make up an estimated 2.1 percent of the population.

Matcheri Keshavan, the Stanley Cobb Professor of Psychiatry at HMS and BIDMC and an author of the paper, said that during withdrawal, the normal balance between the sympathetic and parasympathetic nervous systems becomes disrupted.

The sympathetic nervous system, responsible for “fight or flight” responses, becomes overly active, boosting stress, anxiety, and cravings. That imbalance is manifested by sweating, shakiness, and increased heart rate variability, a key measure linked to greater cravings and increased risk of relapse.

Yoga and other meditative practices promote the parasympathetic nervous system, calming the body and regulating breathing and heart rate.

While medication is used to blunt cravings, meditation and cognitive behavioral therapy are often used to address sleeplessness, anxiety, and stress reactions due to the sympathetic nervous system imbalance.

The problem, however, is that the distress and impaired concentration common during withdrawal can make initiating meditation or cognitive behavior therapy a challenge. Yoga’s blend of physical postures, breathing techniques, meditation, and relaxation can be initiated more easily during withdrawal.

The study, supported by private funding, used yoga modules designed to address sympathetic nervous system hyperactivity. They included relaxation practices, mindfully performed postures, sectional breathing, stimulation and relaxation through slow breathing practices, and guided relaxation with affirmation.

A shorter withdrawal period is associated with recovery success but is just the first step of a long process, Hill said.

Withdrawal, often done in an inpatient setting, is usually followed by an outpatient program that allows greater freedom while continuing intensive daily therapy. Subsequent phases become less restrictive as the patient resumes the activities of daily life.

“If you complete treatment and get to one to three months of abstinence, the odds of success go up dramatically,” Hill said.

The beneficial impact of yoga on withdrawal wasn’t completely unexpected, Keshavan said, since yoga’s calming, parasympathetic-boosting effects are well known. In fact, he said, because of those effects, it is already used to treat anxiety and depression.

The study, however, is the first randomized control trial to document its utility in the context of addiction and withdrawal, providing counselors and addiction specialists evidence for an effective and inexpensive tool that could improve prospects for recovery success.

“We are excited about this,” Keshavan said. “Hopefully, this will stimulate a larger application of this mode of intervention across multiple substance-use disorders, not just opioid dependence.”  

Also important, Keshavan said, is that yoga is relatively easy to learn. Those 10 sessions provide a foundation for individuals to develop their own practice, a potential resource in their battle with addiction.

“An intervention like yoga is something that these individuals are likely going to practice even after they end the treatment,” Keshavan said. “So it could have long-term benefits.”


6 keys to a long, healthy life (ice cream included)

Also, why reading Ben Franklin beats climbing Mount Everest


ice cream cone with figures walking

Illustration by Liz Zonarich/Harvard Staff

Health

6 keys to a long, healthy life (ice cream included)

Also, why reading Ben Franklin beats climbing Mount Everest

6 min read

Leading a healthy life is simple, said Ezekiel J. Emanuel, M.D. ’88, Ph.D. ’89, professor at the University of Pennsylvania Perelman School of Medicine, in his latest book “Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life.”

In this interview, which has been edited for length and clarity, Emanuel talks about his six no-nonsense rules for achieving wellness and longevity, which includes having the occasional ice cream as part of your healthy diet.


Your book starts with the first rule, “Don’t be a schmuck,” and ends with a plea to “Be a mensch.” How can these two principles help us live a long and healthy life?

“Don’t be a schmuck” is mostly a recommendation to not do risky, stupid things such as smoking, drinking alcohol, doing drugs, or not taking your vaccines. But there are other schmucky things you can do. When I was writing this chapter, I was thinking, “What’s the stupidest thing you could do?” I thought it was BASE jumping, which is jumping off a mountain in one of those wingsuits. I looked up the data, and the chance of dying doing that is one in 2,300, and I went, “Wow, that’s pretty bad.” But then I learned that the risk of dying climbing Mount Everest, even if you’re an expert mountaineer and a Sherpa, is one in 100. That takes the cake. Almost nothing can be schmuckier than that. It’s true that the riskiest thing we do every day is start the ignition on our car, but we have to calibrate the risks by recognizing the risks that are worth it and the risks that are not.

When I say, “Be a mensch,” what I want to communicate is that the purpose of your life should not just be to live longer. It should be greater than that; it should be trying to make the world a better place. Benjamin Franklin said it best when he said, “The noblest question in the world is, ‘What good may I do in it?” That’s part of what being a mensch is.

Social relationships are considered one of the strongest predictors of a long healthy life, but how can they affect our physical health?

When you tell people that having social interactions is good, they immediately think you’re talking about psychology or spirituality, but interacting with people actually changes the brain as well as the body. A social interaction leads to the release of oxytocin, the so-called love hormone in the brain that makes us feel better and promotes bonding. It also increases dopamine in the brain, which is the neurotransmitter related to the reward system, so it feels like a reward to interact with people. We also know that social interactions regulate the sympathetic nervous system by decreasing the release of cortisol, the stress hormone. Most recently, researchers who used data from the UK Biobank, where hundreds of thousands of people have donated their genetic codes and have filled out lots of questionnaires about their social life, compared people who are lonely and don’t have a lot of social interactions to people who do. They found specific proteins that are elevated in people who are more lonely and socially isolated that relate to increased inflammation and lead to increased heart disease and risk for cardiovascular problems, including stroke.

What is the most effective way to keep our minds active?

Keeping your brain healthy is about creating neural connections and making them stronger so that they don’t deteriorate. You can’t just do the same thing over and over again. You have to do new things and do them seriously, so that they actually make solid brain connections. But as you age, you’re going to inevitably lose neuron connectivity. The best way to keep your brain healthy is by learning new things and challenging yourself by taking up new hobbies or activities. About a little more than a decade ago, I committed myself to doing something totally new every year. One year, I learned how to make chocolate bars from bean to bar. I went to Madagascar, harvested beans, and made a chocolate bar. My most recent one, the Zeke Bar 4.0, is a dark chocolate with dried cherry in it, and it’s a big award winner. In 2025, I began raising bees and put hives in my backyard and harvested the honey and put it in contests and also got awards. This year, I’ve begun ballroom dancing. I’m a terrible dancer, but I’m going to learn to be better. It will force different parts of my brain to work, and it’s all to strengthen the brain and keep it active.

“The best way to keep your brain healthy is by learning new things and challenging yourself by taking up new hobbies or activities.”

Eating healthy is key to a long and healthy life, but what about diets and fasting? And how bad is the occasional indulgence in treats like ice cream?

We have to do the wellness behaviors for years and decades if they are going to do any good. Constant deprivation requiring great expenditures of willpower are not the way to wellness. Indeed, people who constantly diet with willpower fail at it and never lose weight.

We have to develop good habits and stick to them. Habits we enjoy are ones we will stick to. Furthermore, wellness behaviors are not like an Olympic gymnastics event. Perfection is not required. Ninety-percent is an A, and eighty-five percent is a B+ — good grades for wellness and organic chemistry. That is what is needed. Eating should be pleasurable — eating good food with people you like, and an occasional treat is a wellness trifecta.  

What are the biggest misconceptions about exercise and sleep?

On exercise, one misconception is that people focus on aerobics, or vigorous exercise, but you actually need three different kinds of exercise. You need the aerobics to get your heart rate up; it’s good for the heart and your brain circulation. But you also need strength training because it keeps us from becoming frail. You also need to exercise for balance and flexibility, and the best answer is yoga. The second big misconception about exercise is that more is better. You reach a plateau after about 150 minutes a week of vigorous exercise, and you get no added benefit. Plus, you risk repetitive motion injuries. Many of the wellness gurus talk about 10 hours a week of exercise, and that’s way too much, in my opinion.

About sleep, the biggest misconception is that sleeping pills work. They don’t. There are other things you can do to sleep better: Sleep in a cool, dark room. Don’t look at your phone for the hour before. The dinner glass of wine can disrupt your sleep. Don’t take a nap or consume caffeine after 2 p.m.


Updating Cold War-era Outer Space Treaty long overdue. But big hurdles loom.

Tech policy expert cites global divisiveness, urges creating annual conference like that for climate change to advance talks


Ely Sandler seated in a chair.

Ely Sandler.

Niles Singer/Harvard Staff Photographer

Nation & World

Updating Cold War-era Outer Space Treaty long overdue. But big hurdles loom.

Tech policy expert cites global divisiveness, urges creating annual conference like that for climate change to advance talks

8 min read

There is widespread agreement the Outer Space Treaty needs updating, but it won’t be easy given the current state of international political division. Ely Sandler has an idea.

The international accord, which governs activities in space, was first established under the auspices of the U.N. in January 1967. Back then, few nations had ventured into space. “Star Trek” had just debuted on TV, and the Apollo 11 moon landing was still two years away.

Since then, military and exploratory activity by the U.S., China, the European Union, Russia, India, and Japan has surged. Private U.S. firms, like SpaceX and Blue Origin of the U.S. and China’s Orienspace, have launched rockets and satellites. Technologies have evolved, but the treaty has not kept up.

Sandler, a Belfer Center research fellow at Harvard Kennedy School, recently published an analysis of the dilemma. In this edited conversation, he details his proposal to advance discussions on space by adopting an approach being used to work on contentious climate change issues.


How is space governed currently?

At the international level, space is essentially not governed. There’s one treaty that covers all of outer space — that’s the Outer Space Treaty. It was signed in 1967, at the height of the Cold War, and came out of arms control to try to stop the buildup of nuclear weapons in space.

It has a few general principles about how you should behave in space. For example, you’re supposed to give something called “due regard” to other spacecraft; you’re supposed to rescue other astronauts if they’re in distress. But those terms were never defined.

At the moment, almost all space law is domestic. If you want to launch a satellite from the U.S., you comply with domestic U.S. legislation. Same goes for Russia; same goes for China; same goes for the European Union.

Theoretically, the Outer Space Treaty has protocols for liability. If your object hits someone else’s object, it has a very theoretical standard for how you could resolve that dispute. But this treaty was never built upon. We didn’t have secondary legislation; we didn’t have common law; we didn’t have regulations. There are no standards for what you are and are not supposed to do.

So, in essence, there is no protocol for adjudicating disputes in space.

“There are about 1.4 million objects larger than an inch that are floating around the Earth. The debris is little pieces of former satellites, stuff that’s come from spacecraft, that’s going many, many, many times faster than a bullet.”

What are the most urgent issues?

Very short-term, I think the most pressing issue, together with space debris and space traffic management, is space situational awareness. We need to make sure that we put stuff in space that 1) doesn’t hit anything else, and 2) it comes down and doesn’t stay in space and create more debris. That is the issue we want to solve just based on the fact that we’re putting more satellites in space.

Looking out into the future, we’re going to have to figure out how to circumnavigate the lunar surface.

Within the next five years, you’re going to have at the very least Russia, China, the U.S., and India all back on the moon with semi-permanent presences. That’s going to start to be crunch time for figuring out how we interact with each other.

When you land on the moon, it spews up loads and loads of lunar regolith, the dust, rock, and other loose material on the surface. And so, you need rules of the road. This is also going to apply to Mars and further celestial exploration.

Where is the Outer Space Treaty, and the smaller accords that followed, falling short?

I think there’s two main problems. One is that they were not designed for the current era of space-faring which is driven by commercial companies. They were not designed to be regulating private companies. Technically speaking, what they say is that private organizations, if they were to launch satellites or spacecraft, would be governed by the launching state. But that was thought to be an impossibility — private space flight.

That meant also, because space was so much less used, they didn’t anticipate things like orbital debris. There is no international protocol for space situational awareness — making sure you know where your items are in space.

The other main one is space debris — making sure that we don’t accidentally have collisions that then create more collisions and eventually, there’s so much debris in space that we can’t, for example, use low Earth orbit.

Right now, there are about 14,000, maybe 15,000 satellites in orbit, but there are about 1.4 million objects larger than an inch that are floating around the Earth. The debris is little pieces of former satellites, stuff that’s come from spacecraft, that’s going many, many, many times faster than a bullet. And so, if it hits a space station or if it hits a person, it’s deadly.

There are many, many more things happening in space that we need to think about: The Outer Space Treaty doesn’t ensure safe circumnavigation of the moon, which is now a big deal. It’s unclear on whether or not you can use the resources you find in space.

But maybe the bigger problem is, even those issues which it set out to solve, there are so many undefined terms that it renders them essentially legally meaningless. It’s not just that it was not written for the current context, it’s that we never added meat to the bones of the treaty, and so it’s rendered it, in practice, empty of any binding constraints.

You say drafting a new treaty to address these things would be impossible and instead, propose establishing a Conference of the Parties, or COP, to create a set of definitions and protocols that guide everyone. How might that work and what are the benefits?

The irony is while there are some really contentious issues in space, there are a lot of things we all agree on. We all agree that once you put your satellites in space, you should deorbit them. We all agree that if you have a robust liability regime, it’s going to disincentivize collisions, which is good. We all agree that we should have protocols to communicate between satellites so they don’t crash.

The issue is we don’t really have a mechanism for that to become binding international law that we can then all use, and that’s because the era of treaty-making is definitely over.

What COPs allow you to do, and what they’ve done in other international areas including the environment, is make incremental progress by “thickening” the existing obligations of the treaties. The negotiators all get together and discuss the treaty itself and how it’s going and then, essentially, the minutes of those meetings almost become guidance to the original treaty.

The special thing about COPs is it becomes international law.

For example, there’s a U.N. subcommittee called the U.N. Committee on the Peaceful Use of Outer Space, where we have agreed on loads of things. But the U.N. subcommittee, by definition, is nonbinding. With a COP, those things become the definition under the treaty.

The other thing is if you have the same negotiators every year returning to the COP, talking about the same issues, it also maybe creates a forum where the U.S. and China can talk about space issues. At the moment, we don’t talk about it at all.

You can criticize the climate COP and say they’ve not been effective, but almost every year, almost every world leader comes together and talks about climate. That is an incredible venue for creating momentum, and that’s exactly what we need in space.

What would need to happen for a COP to move forward?

In writing the paper, I spoke with almost every space-faring nation. People really want regulation of space because everyone recognizes the benefits are high, and unlike climate, where decarbonization has an incredibly high cost, the costs here are really low, so it is to everyone’s benefit to do this.

The question is: Does skepticism between Russia and China, between China and the U.S., prevent everyone from acting in their own self-interest and coming together, combined with the current U.S. administration’s broader skepticism of international agreements and the U.N.? This is a political question.

And so, what we’re hoping to do in the next year is to do more work, talking to all of the different space-faring countries, in particular the British or the Indians, who are less politically sensitive to the U.S.-China divide, and try to see if this, or something like this, could begin to be proposed.

What is the likelihood that will happen?

The chances that in the next year we actually have a space COP are vanishingly slim. What we’re trying to do is say that there is more that can be done than signing a new international treaty that hands over custodianship of the moon to a sub–U.N. body and giving up entirely on international organizations. There are many, many ways in which nations can come together and solve very, very complex problems with solutions they all agree to.


Tracing Harvard’s ties to slavery: Recovering names and histories

Researchers delve into probate records, tax lists, and estate inventories to identify enslaved people


Gabriel Raeburn and Christine Bachman-Sanders inspect archival documents.

Researchers Gabriel Raeburn and Christine Bachman-Sanders review documents.

Photo courtesy of Claire Vail at American Ancestors

Campus & Community

Tracing Harvard’s ties to slavery: Recovering names and histories

Researchers delve into probate records, tax lists, and estate inventories to identify enslaved people

6 min read

Second in a series about the ongoing work of American Ancestors and the Harvard & the Legacy of Slavery Initiative

When the Presidential Committee on Harvard & the Legacy of Slavery released its 2022 report, it identified 79 people who had been enslaved by Harvard leaders, faculty, and staff before the Civil War but noted the figure would likely rise as research continued.

After building a list of about 3,000 members of Harvard’s faculty, staff, and leadership who worked at the University when slavery was legal in the U.S., American Ancestors has turned to the next critical step: determining which individuals enslaved people and uncovering the names of those they enslaved.

The work reflects the Harvard & the Legacy of Slavery Initiative’s founding commitment to identify, engage, and support direct descendants of people enslaved by Harvard leaders, faculty, and staff.

To date, researchers have identified 1,314 formerly enslaved people connected to Harvard and 601 living descendants.

The process of identifying enslaved people is complicated. Institutions often didn’t keep robust records on them the way they did for free people. Instead, the records of the enslaved are often connected to those who owned them. To discover living descendants, researchers at American Ancestors, a genealogical nonprofit that has partnered with Harvard, examine the family histories of both enslavers and the people they enslaved.

“There’s an incredible interconnectedness between all of these families,” said the organization’s chief research officer, Lindsay Fulton, “not just between the enslaver family and the enslaved family, but also in the greater community of Harvard faculty, leadership, and staff. It’s a community of people.”

Understanding whether a certain member of Harvard’s community held enslaved people involves careful research. For each member of Harvard’s faculty, leadership, and staff, researchers go through a specified list of documents. These include probate records, land and property deeds, birth and death records, marriage records, town records, newspaper records, court records, tax records, church records, census data, and personal papers.

The group also uses targeted internet searches and an AI-assisted search tool to search quickly through large amounts of archival material.

A rigorous search for humans once considered property

Often, not every source proves fruitful. Some documents have disappeared. In other cases, information that would indicate whether someone held enslaved people is missing or excluded. Some families have well-preserved sets of personal papers; others have none at all.

Different sources vary in usefulness for free versus enslaved people — largely because the enslaved were considered property.

Harvard faculty, leadership, and staff are much more likely than enslaved people to have accessible birth, marriage, and death records. They are also easier to search in a database than enslaved people, in part because they are likelier to be recorded with a first and last name.

When identifying enslaved people in documents, researchers are often most successful looking through Colonial probate, church, vital, and tax records. Probate filings might note that enslaved people were bequeathed in wills and appraised by estate inventories. Enslaved people within a certain age range were considered taxable property, and so would appear in the tax records of their enslavers.

Church records are also useful, often recording baptisms, as well as the civil marriages of enslaved people, which Massachusetts began to allow in 1705. The First Church of Cambridge, for example, recorded the 1729 baptism of “Titus, an Indian manservant of Pres. Wadsworth” — one of four enslaved people who lived and worked in Harvard’s Wadsworth House.

Puritan churches also recorded the public confessions of churchgoers, which sometimes included enslaved people, who were often identified as property of their enslaver.

Court records are also useful for identifying enslaved people throughout the Colonial period and beyond. They appeared in various legal proceedings, including property disputes and criminal cases. In the second half of the 18th century, enslaved people increasingly sued for their own freedom, appearing in records alongside the person who enslaved them.

However, even when enslaved people are referred to in historical documents, they are not always easy to identify. Some probate records are brief, but in estate disputes, filings can stretch to several hundred pages — with the names of the enslaved mentioned only in passing. Names can also shift over time, with enslaved people sometimes being referred to only by first name, sometimes in association with their owner, and sometimes with a different first or last name.

In personal papers, those discovered to be enslavers often reference free and enslaved people without clear distinctions. Gabriel Raeburn, senior research project manager at American Ancestors, recalled reading someone’s letters that referenced family members alongside people they were enslaving. He knew one man was enslaved only because he had previously reviewed his bill of sale.

Researchers also point out that the term “slave” was often not used in official documents. Instead, enslaved people are often referred to as servants along with a racial descriptor. Raeburn adds, “The archives are created by the enslavers themselves for the most part,” and they often didn’t seem to believe it was worth recording the life events of those they enslaved.

The complexity of the research makes it crucial that American Ancestors researchers systematically study and record every source that could be associated with a member of faculty, staff, and leadership.

Building on collaborative work

Researchers at American Ancestors underscore that their efforts build on archival work by Harvard-affiliated researchers and exist among a broader landscape of organizations seeking to document American slavery. Those include the Universities Studying Slavery (USS) consortium, run out of the University of Virginia, as well as the Northeast Slavery Index, which indexes records and identifies enslaved people throughout the region.

Raeburn also pointed to research by organizations like the Boston Task Force on Reparations, Medford’s Royall House and Slave Quarters, the Longfellow House, and local churches and historical societies, whose work has helped document enslaved people in Massachusetts.

Kirt von Daacke, managing director of USS and an assistant dean and professor at the University of Virginia, emphasized the importance of schools working together as they research institutional slavery.

“[O]ne cannot really tell the history of slavery at a university without expanding the research lens to include the many communities beyond the university gates that the school was embedded in,” he said.

He thinks that the efforts universities have taken in the past 10 years to collaborate on best practices and share findings have produced “excellent results, even if they are all imperfect and incomplete.”

Fulton agrees.

“Standing on the shoulders of people who have done this before is really important to this particular work,” she said, “because we’re looking for records that are typically overlooked.”

As the work continues, researchers expect to identify many more enslaved people connected with the University. The team will continue to build on existing research — and leave a fuller picture of a long-obscured history.


Six cancers rising faster in younger adults than older ones

Large new global study fuels growing concern over trend of increases in several types


Health

Six cancers rising faster in younger adults than older ones

Large new global study fuels growing concern over trend of increases in several types

5 min read
Tomotaka Ugai.

Tomotaka Ugai, senior author of a new global cancer study.

Veasey Conway/Harvard Staff Photographer

Six cancer types are rising faster in younger adults than in those who are older in at least five countries, a new study of global cancer incidence shows, and two types — colorectal and uterine — are becoming both more common and more deadly among the young.

The massive study combed through data from two large cancer databases to better understand the recent rise of cases in adults under 50, a trend that belies the traditional understanding of the disease as one that disproportionately affects the elderly. Though still relatively rare among those in middle age and younger, the rising incidence of several cancer types in that cohort has raised concern among experts.

The work, published in November, painted a disturbing yet complex picture that varies globally according to cancer type, sex, and national context. The study examined cases that occurred between 2000 and 2017 and found 13 cancers on the rise in those under 50 in at least 10 countries, and six cancers — colorectal, cervical, pancreatic, prostate, kidney and multiple myeloma — rising faster in younger adults than in older adults in at least five.

The trends of both higher incidence and mortality in those under 50 occurred in fewer countries — in five for uterine cancer and, for colorectal cancer, three nations for females and five for males.

Colorectal cancer, particularly in North America, Europe and Oceania, drew particular attention from the authors, who said that 10 percent of global cases already occur in those under 50.

They cited estimates that, by 2030, colorectal cancer incidence in those ages 20 to 34 will rise by 90 percent, and, in those ages 35 to 49, by 46 percent.

The news is better, however, for late-onset colorectal cancer, with several countries showing incidence declining, likely in part due to screening programs that target older adults and detect precancerous growths early.

Tomotaka Ugai, an instructor in pathology at Harvard Medical School and Brigham and Women’s Hospital, a department associate in epidemiology at the Harvard T.H. Chan School of Public Health, and the study’s senior author, said though additional work is needed, the study does fill in some blanks in a concerning global cancer picture.

“There is a possibility that exposures like obesity or Western diet or sedentary lifestyle might be shifted toward younger populations.”

Despite the broad patterns seen, however, the study was limited by the fact that the databases used do not cover every nation. Missing are parts of Asia, Africa, and South and Central America.

Ugai said that a more detailed understanding of the young-onset cancer picture in every nation is needed to design interventions such as enhanced screening guidelines.

Some countries have already taken such steps.

In the U.S., for example, screening guidelines have shifted younger in recent years. In 2021, the U.S. Preventive Services Task Force lowered the recommended age to begin screening for colorectal cancer from 50 to 45. Similarly, in 2024, it recommended all women begin breast cancer screening at age 40. Their earlier guidance was that women start screening between ages of 40 and 50, based on individual circumstances.

In their results, in fact, the researchers, from the U.S., Japan, and South Korea, detected evidence of already improved screening procedures for some cancers, which the authors said may be one factor in rising incidence rates.

In those cancers, including thyroid, prostate, and non-melanoma skin cancers, there was no increase in mortality despite rising incidence, likely an indication that improved screening is detecting more cases early enough that they are treatable, or that are clinically insignificant and may have been missed before.

The analysis, published in the journal Military Medical Research and supported by private funding, also provided clues about the reason for the rise in young-onset cancers. The increase in cancer among younger adults is strongly tied to rising rates of obesity, the authors said, and is climbing most rapidly in wealthy nations.

“There is a possibility that exposures like obesity or Western diet or sedentary lifestyle might be shifted toward younger populations,” Ugai said. “And younger populations might be exposed to new risk factors for the early onset cancers, which might be unknown or still need investigation.”

Future work, Ugai said, will involve international collaborations to better understand what’s going on in these cases. They’ll also augment data from large-scale studies with analyses of individual tumor tissues in an effort to better understand mechanisms in tumor biology and microenvironments that might be at work.

“Many studies, including our studies, indicate that the incidence of early onset cancer has been increasing in many parts of the world,” Ugai said. “But that doesn’t mean that many cancer types have been increasing similarly everywhere. All over the world, the situation is very, very different, so we need to know more about what’s happening now, what are the risk factors, and how to prevent these cancers.”


Ballot order set for Overseer and HAA director elections

Candidates finalized ahead of spring voting period


Campus & Community

Ballot order set for Overseer and HAA director elections

Veritas shield on Johnston Gate.

Johnston Gate.

Photo by Grace DuVal

5 min read

Candidates finalized ahead of spring voting period

This spring, Harvard degree holders will have the opportunity to vote for new members of the Harvard Board of Overseers and for elected directors of the Harvard Alumni Association.

The election begins April 1, with completed ballots accepted until 5 p.m. on May 19. Harvard degree holders may vote online or by paper ballot to fill six anticipated vacancies on the Board of Overseers and six openings among HAA elected directors. An additional vacancy on the Board of Overseers is due to the resignation of Vikas Sukhatme, M.D. ’79, Robert W. Woodruff Professor of Medicine at Emory University; the sixth-place finisher will serve the remaining two years of Sukhatme’s term.

All Harvard degree holders as of Jan. 1, with the exception of officers of instruction and government at Harvard and members of the Harvard Corporation, are eligible to vote for Overseer candidates. All Harvard degree holders as of Jan. 1 are eligible to vote for HAA elected directors.

The candidates listed below were nominated by a committee appointed by the Harvard Alumni Association’s volunteer leadership. Candidates appear in ballot order, as determined by lot.

Overseer candidates

Nisha Kumar Behringer ’91, magna cum laude, M.B.A. ’95
Independent Director and Audit Committee Chair, Birkenstock Holding PLC
Greenwich, Connecticut

Arti Garg, Ph.D. ’08
A.B. & B.S. ’99, M.S. ’01, Stanford University; M.S. ’02, University of Washington
EVP and Chief Technologist, AVEVA
Hayward, California

Teresa Hillary Clarke ’84, cum laude, J.D. ’89, M.B.A. ’89
Chair and Executive Editor, Africa.com; Former Managing Director, Goldman Sachs & Co.
Miami

Nadine Burke Harris, M.P.H. ’02
B.A. ’96, University of California, Berkeley; M.D. ’01, University of California, Davis
Pediatrician and Former Surgeon General of California
Sebastopol, California

Alfredo Gutiérrez Ortiz Mena, L.L.M. ’98
J.D. ’95, Universidad Nacional Autónoma de México
Former Justice, Supreme Court of Justice of the Nation (Mexico)
Mexico City, Mexico

Philip L. Harrison ’86, magna cum laude, M.A.R. ’93 with distinction
Chief Executive Officer, Perkins&Will
Atlanta

Clive Chang, M.B.A. ’11
B.Mus. ’07 with honors, B.Com. ’07, McGill University; M.F.A. ’09, New York University
President and CEO, YoungArts: The National Foundation for the Advancement of Artists
Miami

Salvo Arena, L.L.M. ’00
J.D. ’93, Ph.D. ’99, University of Catania
Partner, Chiomenti
New York

Trey Grayson ’94, cum laude
J.D. ’98, M.B.A. ’98, University of Kentucky
Partner, FBT Gibbons; Former Secretary of State, Commonwealth of Kentucky
Walton, Kentucky

HAA elected director candidates

Allison Charney Epstein ’89, magna cum laude with highest honors
M.M. ’91, A.D. ’94, Peabody Institute of the Johns Hopkins University
Opera Singer, Producer
New York

Jakob Haesler, M.P.A. ’99
M.Sc. ’97, University of St. Gallen
Global Head of Consulting, Forvis Mazars Group
Paris

Mia Esther Alpert ’99, cum laude
Founder and President Emerita, Harvardwood
Los Angeles

Jeffrey H. Tignor ’96, cum laude
J.D. ’99, Duke University
Attorney-Adviser, Federal Communications Commission; Senior Lecturing Fellow, Duke University School of Law
Washington, D.C.

Yoshiko “June” Nagao ’96, cum laude
Private Investor
Tokyo

Jimmy Biblarz ’14, magna cum laude, J.D. ’21, cum laude, Ph.D. ’23
Attorney, Hueston Hennigan; Lecturer in Law, UCLA School of Law
Los Angeles

Margarita Montoto-Escalera ’78, M.B.A. ’85
Consultant, Reichard & Escalera LLC
San Juan, Puerto Rico

Medha Gargeya ’14, magna cum laude, J.D. ’19
Senior Associate, WilmerHale; Lecturer on Law, Harvard Law School; Captain, U.S. Air Force Reserves
Washington, D.C.

David G. Lefer ’93, cum laude
M.Sc. ’95, Columbia University
Director of the Innovation and Technology Forum and Industry Associate Professor, New York University
New York

The nominating committee brings together 13 alumni with varied backgrounds and includes three current or former Overseers who have direct experience with the workings and needs of the board. The committee invites and receives suggestions about possible candidates from across the alumni community and reviews information on hundreds of prospective candidates as part of extensive deliberations throughout the fall term.

The committee seeks to develop a set of Overseer candidates that takes account of the board’s present composition and the University’s future needs. The committee considers experience and accomplishment in an academic or professional domain important to the University; interest in and concern for higher education and for Harvard University as a whole; commitment to the overall quality and continual improvement of Harvard’s programs of education and research; readiness to invest significant time in the visitation process, standing committees, advisory functions, and plenary deliberations of the board; understanding of complex organizations, and leadership and consensus-building skills.

The Board of Overseers is one of Harvard’s two governing boards, along with the President and Fellows, also known as the Corporation. Formally established in 1642, the board plays an integral role in the governance of the University, complementing the Corporation’s work as Harvard’s principal fiduciary board. As a central part of its work, the Board of Overseers directs the visitation process, the primary means for periodic external assessment of Harvard’s Schools and departments. Through its array of standing committees, and the roughly 50 visiting committees that report to them, the board probes the quality of Harvard’s programs and assures that the University remains true to its charter as a place of learning, bringing broad, informed perspective to issues of academic excellence, long-term planning, and institutional priorities. More generally, drawing on its members’ diverse experience and expertise, the board provides counsel to the University’s leadership on priorities, plans, and strategic initiatives, helping to inform decision-making across the University. The board also has the power of consent to certain actions, such as the election of Corporation members. The current membership of the board is listed here.

The HAA board, including its elected directors, is an advisory board that aims to foster a sense of community, engagement, and University citizenship among Harvard alumni around the world. The work focuses on developing volunteer leadership and increasing and deepening alumni engagement through an array of programs that support alumni communities worldwide. In recent years, the board’s priorities have included strengthening outreach to recent graduates and graduate school alumni and continuing to build and promote inclusive communities.


Can a chatbot be a co-author?

Physicists take souped-up ChatGPT out for a spin, return home with significant discovery 


Science & Tech

Can a chatbot be a co-author?

Alfredo Guevara, Andrew Strominger, and David Skinner in front of a chalkboard.

Alfredo Guevara (from left), Andrew Strominger, and David Skinner.

Photo by Jeffrey Yang ’26

6 min read

Physicists take souped-up ChatGPT out for a spin, return home with significant discovery 

Like many scientists, theoretical physicist Andrew Strominger was unimpressed with early attempts at probing ChatGPT, receiving clever-sounding answers that didn’t stand up to scrutiny. So he was skeptical when a talented former graduate student paused a promising academic career to take a job with OpenAI. Strominger told him physics needed him more than Silicon Valley.

Still, Strominger, the Gwill E. York Professor of Physics, was intrigued enough by AI that he agreed when the former student, Alex Lupsasca ’11, Ph.D. ’17, invited him to visit OpenAI last month to pose a thorny problem to the firm’s powerful in-house version of ChatGPT.

Strominger came away with much more than he expected — and the field of theoretical physics appears to have gained a little something too.

“Incredible,” Strominger put it, acknowledging that AI quickly reasoned through a problem he wasn’t sure he could solve himself without unlimited time.

Strominger had carefully chosen a problem that had eluded concerted collaborative efforts at solving but was understood well enough to clearly pose to AI.

Neither scientist expected a breakthrough.

Even Lupsasca, who has served as a research scientist at OpenAI since last fall, imagined the problem would probably trip up the AI, giving them an opportunity to provide feedback and help improve the large language model’s reasoning around complex theoretical physics.  

Instead, the internal ChatGPT — what Strominger dubbed “Super Chat” — eventually solved the problem in its entirety.

Four physicists — Strominger, Lupsasca, Cambridge University’s David Skinner, and the Institute for Advanced Study’s Alfredo Guevara (who had worked with Strominger as a junior fellow in the Society of Fellows from 2020-2024) — worked with ChatGPT as a powerful fifth collaborator.

ChatGPT-5.2 pro broke the logjam, proposing an answer, and Super Chat proved it was correct after 12 hours of running.

The group then spent a week breaking down the solution, checking the calculations by hand, and turning it into a paper, the result of which (“Single-minus gluon tree amplitudes are nonzero”) published as a preprint on arXiv. Kevin Weil ’05, an OpenAI vice president who leads the organization’s new science initiative, joined them as co-author.

“I think AI will empower us to do more, but we have to retool. Good scientists have to retool all the time.”

Andrew Strominger

While the specific findings will interest what Strominger called “the cognoscenti in some sub-field of theoretical physics,” the broader takeaway for those without a physics Ph.D. requires no fluency with gluon amplitudes.

“It’s the first significant discovery in theoretical physics that is done by an AI,” said Lupsasca, who is also a former junior fellow.

“Maybe we’d have figured out a clever trick the next day,” Strominger said about the efforts of the team of physicists. “Maybe we’d have never gotten it.”  

The scientists collaborated using both the publicly available ChatGPT-5.2 pro and the in-house Super Chat, which can “think” through complex problems for 12 hours at a time.

Strominger found the experience exhilarating.

“There was a moment when I felt like I was working with a creative person,” he said. “Not just a machine that was crunching through stuff. You know, that’s all psychological, but it felt that way.”

Strominger typically works on three or four problems at a time, progressing incrementally but steadily. In this case, though, he had stalled while attempting to prove a conjecture about gluons, the particles that mediate the strong force binding the nucleus of an atom together.

Amplitudes are the complex quantities used in quantum mechanics to provide probabilities for the outcomes when atomic particles interact. Physicists sometimes presumed a certain kind of gluon amplitude could not exist. Strominger, Skinner, and Guevara thought otherwise.

Guevara worked out an exceedingly complex expression of these amplitudes, but they could not finesse it into something simple. They even tried feeding it into ChatGPT last spring, without success.

“It just fumbled,” Strominger said. “The latest model is a whole new ballgame.”

Enter Lupsasca, who had recently transformed from skeptic to proselyte.

A year ago, having tried only the free version of ChatGPT, he considered it useful mainly for proofreading grant proposals. Then he got stuck trying to find a solution to a differential equation describing magnetic fields around pulsars.

“Usually in this game, there’s always some trick that you have to pull out of a hat,” a “special identity,” or formula, to unlock the answer, he said.

A friend with a subscription to the pro version of ChatGPT-3 suggested he feed it an experiment. In 11 minutes, it solved the problem using a special identity published in an obscure Norwegian mathematical journal in the 1950s. (Still, it made a very “human” mistake, resolving the hard part but adding a typo to the answer.)

Last June, Lupsasca published a paper after deriving new black-hole symmetries, what he called “one of my coolest calculations.” He was feeling good — “I can count on my hands the number of people in the world that could have done that” — until he tested out the new ChatGPT-5.2 pro upon its release in August.

In less than 30 minutes, AI crunched through calculations that had taken him considerable time and brainpower.

“That’s when I became ‘AI-pilled,’ as people say,” Lupsasca said, determined to join the vanguard of what he called “the most significant change in theoretical physics in my lifetime.”

He reached out to OpenAI, which had prioritized the model’s ability to transform coding but hadn’t taught it to work on complex physics problems.

ChatGPT simply learned while absorbing oceans of information. So the company accelerated the launch of OpenAI for Science, a program to hire specialized faculty to reinforce ChatGPT’s reasoning, starting with math and theoretical physics.

In October, they made Lupsasca their first hire; he took leave from the faculty at Vanderbilt and made his mentor Strominger his first invitation to test ChatGPT.

Since Strominger’s return to campus, people have asked whether AI might render him obsolete.

“Call it vanity. I think I’m irreplaceable,” he mused. “I think it’s just the opposite. I think it will empower us to do more, but we have to retool. Good scientists have to retool all the time.”


How to end polarization? Schools may be best hope.

Journalist blends history, on-the-ground reporting, finds answer may be civic education that goes far beyond 3 branches of government


James Traub sitting for portrait with hands folded on lap.

James Traub.

Photo by Elizabeth Easton ©

Nation & World

How to end polarization? Schools may be best hope.

Journalist blends history, on-the-ground reporting, finds answer may be civic education that goes far beyond 3 branches of government

long read

Excerpted from “The Cradle of Citizenship: How Schools Can Help Save Our Democracy” by James Traub ’76.

Schools are not the cause of our polarization. The same deep forces that afflict many Western nations have wrenched us apart: the transition to a postindustrial economy and the attendant erosion of working-class security, the demographic shift toward a “majority minority” nation, the cultural upheaval that has dethroned men, and especially white men, from their age-old dominance — and the rise of entrepreneurs of outrage eager to exploit all that free-floating anger. Schools cannot make us a more just or equal society. Nor can we expect schools to cause young people to treat one another with respect and tolerance when the larger culture is aflame with disrespect and intolerance. Nevertheless, school and society have a reciprocal relationship: just as an increasingly coarse and intemperate culture is infecting our schools, so a conscious and thoughtful effort to promote civic education can help knit us back together.

What’s more, schools matter more than they have in the past. First of all, the crisis that we now face is not just partisan but cognitive. Americans don’t simply disagree, as we always have, on what is and is not true; rather, we no longer have common criteria for truth. Social media imparts a specious, but very powerful, authority to our prejudices and illusions. In “The Constitution of Knowledge: A Defense of Truth,” social critic Jonathan Rauch describes an “epistemic” crisis in which institutions to which the public once looked as sources of knowledge, whether universities or newspapers, have given way to “platforms” that disseminate information not according to its accuracy but its popularity. We cannot return to the world before social media; we can only seek to strengthen the institutions — above all, school — that once constituted our epistemic foundation.

Book cover for "The Cradle of Citizenship."

That is a very great deal to ask of any institution, even one that reaches all children during their docile and teachable years. Yet we do so in part because of another new phenomenon. Schools were not traditionally expected to bear the civic burden on their own. The remarkable civic bonds to which Alexis de Tocqueville attributed the underlying strength of American democracy had been fostered far more by the astonishing profusion of newspapers and “voluntary associations” than by schools, of which he barely took notice in his great work, “Democracy in America.” This civic vitality remained central to American life through the middle of the 20th century. But local newspapers, once the heart of small-town America, have been heading toward extinction since 1970; older Americans get their news from television, younger ones from social media. At the same time, the union hiring halls and churches and PTAs and Rotary Clubs where Americans once gathered suffered a steady decline in attendance and membership. We have very few civic levers other than school left to pull.

Yet today’s schools are not the kind of instruments that Horace Mann or Thomas Jefferson imagined they would be. Despite all those years of schooling, the typical American student is stunningly ignorant of her history and government. In the 2022 tests administered by the National Assessment of Educational Progress (NAEP), only 20 percent of students scored at the “proficient” level in civics; 31 percent fell “below basic.” (Two percent were “advanced.”) In history, the figure for proficient was an astonishing 13 percent, with 40 percent below basic. Though American students do poorly on almost everything, they recorded higher levels of proficiency on every other tested subject. School is scarcely the only place where Americans learn about their history and government, but adults do little better on such tests than students do. Studies regularly find that no more than one-third of Americans can pass the test administered to would-be citizens, which requires six out of ten correct answers on questions such as who the United States fought in World War II, why the colonists fought the British, or what — anything — Ben Franklin did.

Ignorance is not the sum of our problem. Mann imagined schooling as a bulwark against our fallen nature; yet a universal public institution is bound to reflect the culture in which it is embedded. Red and blue America have, inevitably, spawned red and blue curricula, pedagogy, state standards, “evidence-based research,” and the like. The publication by The New York Times Magazine in 2019 of the “1619 Project,” with its claim that America is a “slavocracy” defined by white supremacy, provoked a counterblast by the Trump administration, the “1776 Report,” which offered a patriotic account of America as an exceptional nation dedicated, if imperfectly, to its founding principles. There aren’t, as I found, very many ideologically pure 1619 or 1776 schools out there, but there are a great many 1619 or 1776 state legislators, curriculum experts, district and state superintendents, and college professors who shape the larger debate over the schools as well as the particulars of what students learn.

The adoption of state history and civics standards, once a sleepy affair conducted by professionals, has sunk to the level of gladiatorial spectacle; so, too, with school board elections. The idea of a national narrative in which all Americans can find a place seems an artifact of a vanished era of consensus. The culture war has so deeply pervaded the schools that many states have adopted standards in history and civics that are either blatantly red, blatantly blue, or, yet more common, blatantly vapid. A 2021 study of such standards by the Fordham Institute, an education think tank and advocacy body, found only five states with “exemplary” standards and a full half of them with “inadequate” ones — a D or an F. Some states apparently concluded that the only way to escape public wrath was, as Fordham put it, to “paper over differences, avoid specifics and settle for vague generalizations.”

Yet despite nostalgia for a supposed golden age of civic awareness, American students are probably no more ignorant today than they were 40 years ago when NAEP first administered tests of historical and literary knowledge. At that time the majority of high school juniors thought the Jim Crow laws had been enacted to protect Black people; only a third could place the Civil War in the second half of the 19th century. Yet three-quarters of those students reported that they were taking an American history class at the time. Nevertheless, the results did not provoke fears that American democracy was going into eclipse — because it wasn’t. Republican President Ronald Reagan spoke of democracy in mystical terms and earnestly sought to propagate it abroad. Reagan ridiculed, but never demonized, his opponents; he formed a close bond with House Speaker Tip O’Neill, an unreconstructed New Deal Democrat. Civic ignorance does not cause polarization; but civic education matters more when so many other forces pull us apart.

But what, exactly, do we expect it to do? Is civic education only a question of mastering a certain body of knowledge? The answer depends on one’s conception of democratic citizenship. If citizenship can be reduced to “voting wisely,” then “knowing well” is enough. But if we understand democracy as a system where each of us is responsible for our destiny, and we are called on not merely to vote and serve on a jury but to think and debate and even organize and protest, then civic education must also entail preparation for a full democratic life. Civic philosophers speak of the “dispositions” that students need to acquire: tolerance for difference, the capacity to listen, the negotiating skills that help us bring people with unlike views to agree on a common course of action. The political scientist Danielle Allen has described the ultimate goal of civic education as “participatory readiness,” by which she means the ability to adopt a wide range of civic identities, whether as voter, advocate, or protestor.

Civic education must impart knowledge and democratic dispositions. Should we also look to schools to shape the moral nature of children? The Founders, whose own views of citizenship were deeply shaped by the work of the classic republican thinkers, believed, like Aristotle and Cicero, that republics ultimately rested on the virtue of citizens. As James Madison put it, “To suppose that any form of government will secure liberty or happiness without any form of virtue in the people, is a chimerical idea.” The true patriot set aside his merely personal interest for the honor and glory of the nation. He was endowed with the virtues that enabled this ethos of self-sacrifice — prudence, courage, disinterestedness.

Why do American schools seem to do such a poor job of teaching the subject matter of civic education? The most common explanation is that at some point, schools lost faith in their civic function and stopped teaching that material. Virtually everyone over a certain age believes that when they went to school, they got a firm grounding in the rudiments of American government. There is some evidence that this is true, though the chronology seems all wrong. A leading education historian concludes that the civic focus of public schools began to erode around 1950. Yet even in the supposed golden age, students took on average only one more civically oriented course than they do today. What changed most drastically was not the curriculum but the pervading civic culture.

A second explanation, which clearly also contains a good deal of truth, is that teachers are now so afraid of discussing anything in detail that they content themselves, as the Fordham study put it, with vapid bromides. Yet that hardly explains why students did so poorly on tests of historical and civic knowledge 40 years ago, when classrooms were not yet burning ground. It appears that we have been doing something wrong for a long time, something that applies to subject-matter knowledge more broadly. How we have failed is itself a matter of bitter contention, because the education world is every bit as polarized on questions of pedagogy as it is on content.

Pedagogical progressives believe that students are not learning history — or other topics — because most teachers are intent on jamming disjointed facts and dates into the heads of bored, passive students in an exercise mocked as “drill and kill.” Schools fail because they do not encourage “critical thinking.” Schools shy away from the issues of identity that preoccupy non-white students or from the controversial questions that would make young people care about their classes.

The rival, “traditionalist,” diagnosis is, in effect, the exact opposite: students haven’t learned history or government — or science or literature — because most schools have adopted some version of the progressive pedagogy that emphasizes the acquisition of content-neutral skills such as critical thinking rather than building the foundations of understanding through the teaching of vocabulary, the reading of difficult texts, and the study of chronology and narrative. Few teachers have the subject-matter knowledge that would allow them to bring their subject fully alive; their own training emphasizes skills acquisition rather than knowledge. During my time in classrooms, I saw very little evidence of drill and kill but all too many signs of flimsy understanding producing dull and empty lessons.

I spent the 2023–24 school year sitting in classrooms around the country, talking to scholars and reformers of all stripes, studying the historical development of curriculum and pedagogy, and wading into the battles over state standards in history and government. In the course of that year I visited schools in Texas, Illinois, Oklahoma, New York City, Arizona, Massachusetts, and Minnesota; in some cases I went back a second time. All of the schools I visited had some illustrative value: some offered unusual civics programs and some specialized in history; some were blue and some were red; some were exemplary and some very much not. When I wasn’t visiting schools I was reading curricular manifestos, state standards, foundation reports, ideological screeds — and talking to their authors as well as to teachers, school board members, instructional providers, and others.

My ultimate goal was not to expose the bad but to unearth, and explain, and celebrate the good. I found that the growing concern over our civic life has produced promising new buds. Dozens of nonprofit instructional providers now provide nutritious, often winsome, curricular material on American history and government for teachers who do not have the background knowledge or the time to assemble it. States are mandating more classes in government and, at least in some cases, devising more rigorous standards in history. Thanks to a genuinely bipartisan effort among scholars and educators, “Educating for American Democracy,” a new “roadmap” — not, to be sure, a curriculum — is available to schools that want to steer clear of red-blue mayhem. Among the most intriguing of recent school reforms is the so-called “classical school,” a model based on the study of great books and the conscious molding of character. Classical schools constitute a throwback to an earlier age, or perhaps an imagined era, of verities — the good and the true—widely shared and unironically pursued. They are, not surprisingly, far more popular in red America than blue; yet they speak to a hunger for civic, moral, and intellectual coherence that may well transcend politics. It is that wish to escape the steel cage of our culture wars, to find our way to a deeper and less ideological connection to our history and ideals, that gives me some small, modest hope for our future.

Copyright 2026 by James Traub. Used with permission of the publisher, W.W. Norton & Company, Inc. All rights reserved.


Did I say too much?

‘Revealing’ author explains difference between TMI and the kind of healthy ‘oversharing’ that deepens relationships


Work & Economy

Did I say too much?

‘Revealing’ author explains difference between TMI and the kind of healthy ‘oversharing’ that deepens relationships

9 min read

Leslie K. John.

Photo by Grace DuVal

Opening up to others and disclosing something personal is a powerful tool that can build rapport, enhance likeability, and bring people closer together, says Leslie John, a behavioral scientist at Harvard Business School.

But too often, people avoid sharing more of themselves out of fear they may say the wrong thing and look foolish, or worse, say too much and make everyone uncomfortable. It’s a caution that carries more risks than we realize, she writes in a new book, “Revealing: The Underrated Power of Oversharing.”

In this conversation edited for clarity and length, John, the James E. Burke Professor of Business Administration at HBS, explains that “exposing your belly” to others, if done at the right time and in a purposeful way, can deepen relationships and build credibility. Most importantly, it’s a skill that can be learned.


What is “revealing” and how does it help us make and keep friends, romantic partners, and colleagues at work?

The key active ingredient is trust. When you reveal something sensitive to someone, that’s a kind of social risk. I’m relinquishing control to the universe, and I’m showing you that I trust you to not make a fool out of me. That is contagious. Because when you show that you trust someone, it causes them to trust you. Tons of studies have shown this.

“When you show that you trust someone, it causes them to trust you. Tons of studies have shown this.”

Saying “You can trust me” doesn’t work. To be trusted, you have to take a risk and show that you trust the other person, and then that will make them trust you. And then once we have trust, that’s the social currency. The basis of all healthy relationships is trust.

You say a common mistake is people share very little, thinking it will minimize the risk of embarrassment or making a bad impression. But that also has risks, more than we realize. Can you explain?

There are a couple of core things. Number one is we don’t even realize the opportunities to share more. We don’t even appreciate them because we’re so good at defaulting to not saying anything that we don’t even think about opening up.

The point isn’t to say everything that comes to mind. We withhold for very good reasons. Sometimes it’s kind to withhold; sometimes we’re busy; sometimes there are status or power imbalances. But it’s still a decision. If we think about them as actual decisions and consider them more, then we will say a lot more of the things that are left unsaid. And when we approach these decisions wisely, all of the research says we’ll be better off for it.

Number two is that when we do think about these decisions, everyone fixates on the risks of revealing.

Suppose your colleague doesn’t give you credit for something that was your idea at work and you’re thinking about saying something. What do you think about? You think, “Oh, they’ll think I’m petty; it’s going to be an awkward conversation; there’s going to be friction.” Everyone stops there.

If you want to make a good decision, you have to think not just about the risks of revealing, but also of the potential benefits. We’re hardwired, in some ways, to be overly fixated on the risks, and so, in my book, I want to correct that.

Where is the line between sharing something that builds rapport and going too far, like discussing your dating adventures with co-workers?

That’s TMI [too much information]. That’s a mistake people sometimes make in acquaintanceships and early friendships. We are exquisitely sensitive to this unspoken rule of reciprocity. You don’t want to be sharing everything, and you don’t want them to. That’s an overshare if you share out of sequence. The goal is they share something, and you reciprocate with something as sensitive or a little bit more, and you go back and forth. But if one person is doing all the sharing, that’s not a functional relationship. And it’s annoying.

You tell the story about how during the interview to join the HBS faculty, you were perhaps a little too “authentic” and thought you had accidentally cost yourself the job.

I share a lot of personal anecdotes in the book looking back at these points in my life where I thought I had overshared, like insulting my prospective colleague who was interviewing me.

It was not strategic. It was a stupid blurt I made when I was nervous, which I sometimes do. In the moment, their faces were shocked and I thought: This is the end. Poof, my job’s gone. But then, three days later, I got a phone call. They said: When you sassed us like that, we thought, you’ll fit right in here. The senior colleague I insulted became one of my closest mentors.

There are studies by Dan Cable and other organizational scholars that show that qualified job candidates who show a bit of themselves, who don’t sound scripted, are more likely to get the job. This isn’t: Tell them your deepest, darkest secrets. The conclusion that I’ve been coming to is that most people stand to gain from sharing a bit more in most situations.

Which kinds of topics do people tend to overshare or under-share?

The things that are the most sensitive to talk about are sex, finances, and health. But context matters so much. Health in a doctor’s office is different than health talking to your boss.

A chronic overshare is gossip, saying negative things about other people behind their backs. It’s not nice, but it is also bad because it erodes trust. We all know people who gossip a lot. Would you tell your secrets to that person? No. You can’t have a close relationship with someone who gossips all the time.

“There are things that we tend to under-share. One is praise — saying that you love certain things about people, about what they do.”

There are things that we tend to under-share. One is praise — saying that you love certain things about people, about what they do. We hold back on this. As an academic, academics are so freaking stingy with praise. And yet praise brings everybody joy and we don’t do it enough. Recently, I’ve been practicing doing this more. So far, I’m loving it.

Another category of under-share is your successes. I don’t mean bragging on LinkedIn, I mean telling a very close friend about a success, say, that you got a promotion. We have a hard time sharing our successes with some of our best friends because we don’t want them to feel bad. But that can backfire, especially if they find out another way. And when they do, that’s bad for your relationship because they may ask themselves, “I wonder why they didn’t tell me that? Hmm. I guess we’re not as close as I thought we were.”

What about work — presumably there are different rules for sharing there?

The workplace is tough because there are strong norms and people worry a lot about oversharing there. One way to think about it in the workplace is a distinction between transparency and vulnerability.

Transparency is — think of it as cognitive openness — sharing the way your brain works to someone.

In a job interview, if you get asked, “What’s your biggest weakness?” don’t do the annoying, eyerolling, “I work too hard.” But you also don’t want to share something that’s really damaging.

Suppose the weakness is you don’t like being put on the spot in meetings? Congratulations, you’re human. How might you respond in a way that shows some openness without getting into vulnerability territory? Well, you could say something like, “The way my mind works is that I like to have two minutes to prep my thoughts before I make a presentation because I find that even after just a moment of reflection, I’m way more organized and articulate.” That’s transparency. It’s more powerful than just saying, “Please give me a heads up for meetings.”

When sharing sensitive thoughts and sharing feelings in the workplace, you need to be very careful about vulnerability. When making these disclosure decisions, situational awareness is key. You have to read the room. And, at any time, if you’re starting to open up, and it doesn’t feel right, you should stop and regroup. Because you can’t put the genie back in the bottle.

What should people ask themselves when deciding whether to “overshare”?

I think it starts with knowing your why: What are you trying to achieve with potentially revealing the thing?

It’s often lots of things at once. If I share this edgy joke, I want to have fun; I want to build rapport. Maybe I’m a high-status person at work, and I want people to feel comfortable; I want to be relatable; I want to motivate my employees. Or is it more like, I want all the attention? Figuring out your why requires a kind of brutal honesty with yourself. If you do that, you’ll start to question some of your goals and hone them. In turn, you will make wiser, more intentional, decisions about what to reveal and what not to reveal.

Timing is super important, and that’s another thing to consider.

Revealing wisely is a skill. It’s not something we’re born with or without. The way we get better is by practicing and doing it and reflecting.


What’s next for GLP-1s?

Scientists eye new treatment targets for popular weight-loss drugs, from heart failure to addiction


Health

What’s next for GLP-1s?

Insulin pens.
8 min read

Scientists eye new treatment targets for popular weight-loss drugs, from heart failure to addiction

Now that GLP-1 drugs have revolutionized how millions of Americans treat obesity and Type 2 diabetes, scientists are exploring the benefits of using the drugs for a host of other chronic diseases — many with few treatment options — such as heart failure, chronic liver disease, obstructive sleep apnea, and even substance use disorders.

“Their role is now being understood to be much, much more fundamental to human health, and to promoting longevity and preventing chronic illness progression,” said Muthiah Vaduganathan, a cardiologist at Brigham and Women’s Hospital and faculty at Harvard Medical School.

GLP-1 receptor agonists — sold under brand names like Ozempic and Mounjaro — were initially developed to treat diabetes. But instead of addressing biomarkers linked to certain disease outcomes, these drugs influence the central cardio-kidney metabolic process, Vaduganathan said. This overarching approach has made GLP-1 drugs the most effective and tolerable choice for most patients treating diabetes and obesity. It’s also what makes it likely that they influence a number of closely related diseases.

“Excess weight and adiposity and obesity are the fundamental drivers of why these conditions are not only occurring but also progressing over time,” said Vaduganathan. “And so that reframing has allowed us now to rapidly target those fundamental drivers of adiposity with really effective and safe therapies like GLP-1 receptor agonists.”

‘That’s something you don’t see for every drug’

Nils Krüger, an instructor at Harvard Medical School and Brigham and Women’s Hospital, has investigated a wide range of positive effects for GLP-1 drugs in clinical practice. In a recent study, he and his team found that GLP-1s were highly effective for patients with heart failure with preserved ejection fraction, in which the heart’s muscle becomes so stiff that the ventricle holds less blood than usual; the GLP-1s showed a 40 percent relative risk reduction compared to older diabetes medication. “That’s something you don’t see for every drug,” Krüger said.

Like Vaduganathan, he believes it’s largely because GLP-1 drugs lower excess fat in the body, which drives the disease. “It’s just astonishing how many indications those medications seem to be effective for or have some beneficial effects,” Krüger said.

“What was surprising and amazing was they were found to reduce the risk of major adverse cardiovascular events like cardiovascular death, nonfatal myocardial infarction, nonfatal stroke.”

Josephine Li

Josephine Li, the clinical director of the Diabetes Center at MGH and assistant professor at Harvard Medical School, also finds GLP-1s more broadly effective than previous generations of diabetes drugs. “There were older diabetes medications where there were issues with increased risk of heart failure,” Li said. With GLP-1 drugs, “What was surprising and amazing was they were found to reduce the risk of major adverse cardiovascular events like cardiovascular death, nonfatal myocardial infarction, nonfatal stroke. And this has been shown over and over with different GLP-1s within the class.”

‘Revolutionary for patients’

These combined benefits have changed the way Vaduganathan and Li practice medicine. “When I initially completed medical training, everyone in practice recognized the major role of obesity,” said Vaduganathan, “but our tool kit was so limited in terms of effective options to actually address this issue.” GLP-1 drugs have made treatment more palatable — and effective — for patients who might have otherwise elected for bariatric surgery.

For Li, the options for treating diabetes just years ago were similarly narrow. “It was a couple of oral meds and then it’s like, ‘Too bad, you have to start insulin,’” she recalled. Now, there are far more options, with new oral GLP-1 drugs and oral incretin drugs that are being evaluated in clinical trials. “It really changes the treatment landscape,” she said. “You don’t have to be doing an injection multiple times a day. From a delivery perspective, that’s been revolutionary for patients.”

Doctors still run into issues prescribing GLP-1s. The FDA has approved them to treat Type 2 diabetes and obesity, but many conditions, including Type 1 diabetes, lack approval. Insurance companies sometimes reject claims for alternative uses of GLP-1 drugs, which are expensive, even for patients who are overweight or obese.

Josephine Li.

Niles Singer/Harvard Staff Photographer

Muthiah Vaduganathan.

Veasey Conway/Harvard Staff Photographer

Other demographic groups have been understudied in clinical trials so far, Li said, including pregnant women, children, and people who are suffering from advanced kidney disease or who are on dialysis. “These are people who are typically excluded from the trials, but they’re patients we take care of,” Li said, “so it’s just thinking about these subpopulations and whether the drugs can be safely used and how to modify how you use them.”

Despite these limitations, doctors said that these drugs have increased communication between healthcare professionals across specialties. “Because we are using these therapies together, individual clinicians may be prescribing them, but other clinicians may be adjusting them,” said Vaduganathan. “A positive effect of these therapies has actually been on the structure of healthcare delivery for complex conditions.”

“A positive effect of these therapies has actually been on the structure of healthcare delivery for complex conditions.”

Muthiah Vaduganathan

Li agreed. “I find myself in my practice reaching out to someone’s cardiologist, reaching out to someone’s nephrologist, getting someone seen by a dietitian,” she said. She also finds herself having a lot of conversations with other physicians, thinking through potential safety concerns and side effects of the medicines. Over the past few years, doctors have seen an increase in reports of pulmonary aspiration during procedures, for instance, because GLP-1 drugs slow digestion.

Promise treating addiction

This communication spans specialties beyond what one might expect for GLP-1 drugs. Mary Shen, a resident physician at Brigham and Women’s Hospital who studies substance use disorders, said that studies have shown a growing relationship between GLP-1 drugs and addiction. “It started because, anecdotally, physicians were starting to see that their patients were reporting, ‘Oh, I haven’t smoked in a while,’ and ‘Oh, I haven’t had alcohol in a while.’”

The results spurred case reports, which led to preclinical studies and mouse models — with often promising results. “In the past few years, there’s been a huge increase in studies examining GLP-1s and substance use disorder,” Shen said.

In 2024, she said, researchers conducted a review of five clinical trials for GLP-1 drugs related to substance use disorder. That year, she and her mentor, Joji Suzuki, director of Brigham and Women’s Hospital’s Division of Addiction Psychiatry, found that given the small number of studies, there was not yet enough data to recommend GLP-1 agonist drugs across tobacco, alcohol, and cocaine use disorders. Kwadwo Owusu-Boaitey and Laura Holsen were co-authors of that study.

A year later, Shen said, the landscape is changing. Although the use of GLP-1s has not been approved by the FDA to treat substance use disorders, there are more than 15 clinical trials in progress globally. The Suzuki lab is also running two clinical trials, one for opioid use disorder and one for alcohol use disorder.

“We’re still exploring what formulations are most useful, what conditions they’re most useful for, and which patients they’re the most effective in,” said Shen. “But it does look like there’s some promising evidence.”

Shen said the same mechanism that modulates pathways in the gut and the pancreas also affects the brain. “We see addiction is closely tied to the reward systems in the brain and now we know that GLP-1 receptors are also found in the same brain structures,” said Shen. “By targeting this, it may help regulate some of the responses to these substances.”

Researchers acknowledge that there is still much work to be done for these drugs to safely and effectively treat more people. But the result could fundamentally change the options for those struggling with addiction. Effective medications exist for opioid and alcohol use disorders, but a lot of patients struggle to follow through with treatment. Those suffering from opioid use disorder often must go in person every day to take methadone. Other addictions, like cannabis use disorder and cocaine use disorder, don’t yet have FDA-approved treatment.

It often takes years for new indications to be approved, with more time needed for certain groups. Li, whose research lies largely in pharmacogenetics — the study of how genes influence medication response — said it’s important that new research shows how different people experience GLP-1s. She also said there are more questions to ask about the long-term use of these drugs. The weight and metabolic effects of GLP-1s seem to wane after people stop the medication, but doctors don’t yet have much long-term data on these effects.

“To make sure that this is safe and accessible for patients, it really requires adequate funding to support these research endeavors,” Shen said.

Despite the hurdles to approval, researchers remain positive — and largely, so do patients. Vaduganathan said that patients often initiate conversations about GLP-1 prescriptions, which they’ve rarely done for any other class of drugs, including other highly effective ones.

“That has actually improved shared decision-making,” he said, “because often we now have two invested parties that are united with shared goals.”


Kicking back with Rose Byrne

Australian actress feted, roasted as Hasty Pudding Woman of the Year


Campus & Community

Kicking back with Rose Byrne

Rose Byrne (center) and members of the Hasty Pudding Theatricals do a kick line together in front of Farkas Hall. V

Rose Byrne (center) and members of the Hasty Pudding Theatricals do a kick line.

Niles Singer/Harvard Staff Photographer

3 min read

Australian actress feted, roasted as Hasty Pudding Woman of the Year

Spectators in Harvard Square looked on with a mix of confusion, amusement, and appreciation last week as the Hasty Pudding Theatrical Society honored actress Rose Byrne with a parade down Massachusetts Avenue. As the Pudding’s 2026 Woman of the Year, Byrne rode slowly down the street in a Bentley convertible — flanked by costumed students, kazoo players, and people squeezing rubber chickens.

Byrne, a Golden Globe winner and Oscar nominee for her leading role in “If I Had Legs I’d Kick You,” waved to fans on her jaunt. Also known for her performances in “Bridesmaids,” “Insidious,” and “Neighbors,” the Australian actress had a whirlwind day at Harvard, which included a roast by members of the Pudding, a press conference, and a viewing of the Theatricals’ 177th production, “Salooney Tunes.”

The roast, co-hosted by Pudding President Daisy Nussbaum and Cast Vice President Isabel Wilson, praised Byrne’s versatility while poking fun at, among other subjects, the box-office numbers for “If I Had Legs,” her lack of Oscar win (to this point), and her American accent.

Playfully referencing the praise Byrne has received for dramatic roles, the Pudding had her read through a heart-wrenching scene alongside an undergraduate dressed as a rabbit. “How am I supposed to stay calm when you’re ruining our lives?” she demanded, as the rabbit struggled to articulate why he had returned so late from work.

After teasing Byrne for her longtime relationship with actor Bobby Cannavale (the two call themselves married, though they are not, officially), Nussbaum and Wilson conducted a brief ceremony that joined Byrne and the Hasty Pudding’s prize, a pudding pot, as husband and wife.

“I want to start these vows by acknowledging that you are way out of my league,” Byrne said, reading from a script. “I am also a little bit upset that before me, you were with 75 other women, including Cynthia Erivo, Jennifer Coolidge, Julia Roberts, Liza Minnelli, Cher, and the list goes on.”

After the roast, Byrne took questions from the media. She had not, she said, started writing an acceptance speech for a potential Academy Award. She claimed that playing Linda from “If I Had Legs” was a creative highlight of her career, and responded to another question that she prepares for comedic and dramatic roles in the same rigorous way.

Asked how she was feeling during this award season, she said that it was meaningful that a complex film with a relatively low budget garnered such support. “I think it really will live on,” she said, “and it’s very fearless and sort of radical. And I’m really proud of that.”

Despite the silliness of the roast, Byrne joked that the time on stage — and her mini-performance — might help her prepare for her upcoming role in the Broadway revival of the comedy “Fallen Angels.”

“It was actually fun being on the stage and doing a little scene,” she said. “I was like, ‘Maybe I can still do this!’”


Preserving learning in the age of AI shortcuts

In podcast, teachers talk about how they’re using technology to supercharge critical thinking rather than replace it


Science & Tech

‘Harvard Thinking’: Preserving learning in the age of AI shortcuts

Illustration of a boy reading with class in background.

Illustrations by Liz Zonarich/Harvard Staff

long read

In podcast, teachers talk about how they’re using technology to supercharge critical thinking rather than replace it 

Concerns of artificial intelligence supplanting human thinking are rising amid the exponential growth in recent years of generative AI’s capabilities. One thing is clear: The technology is not going away. 

“I feel it would be irresponsible for me not to embrace it entirely, both in the classroom and in research,” said Michael Brenner, the Catalyst professor of Applied Mathematics in the School of Engineering and Applied Sciences. In his view, anyone who doesn’t is going to lag in their careers and their ability to advance science. “It’s just changed everything.” 

Reports of AI harming the social, emotional, and cognitive development of students need to be taken seriously, said Tina Grotzer, a cognitive scientist at the Graduate School of Education. The challenge for educators is determining how to incorporate the technology in the classroom so that it enhances learning rather than replaces it.  

Ying Xu, an assistant professor at the Graduate School of Education, meanwhile, encourages parents who are worried about how to introduce AI to their kids to consider it in relationship to “the larger ecosystem of a child’s life,” including building healthy relationships, spending time outdoors, and pursuing hobbies. 

In this episode of “Harvard Thinking,” host Samantha Laine Perfas talks with Brenner, Grotzer, and Xu about how educators and parents can harness AI’s educational benefits while mitigating potential risks. 



Listen on: Spotify Apple YouTube


Tina Grotzer: Once you start to know what your mind can do that’s so much better than AI, it kind of makes sense that some tasks are well-relegated to AI and other tasks are not. That is going to be a constant challenge to figure out those relationships and lines over time.  

Samantha Laine Perfas: As generative AI tools become more ubiquitous, there’s a debate around whether or not they should be embraced in spaces of learning. Recent reports suggest that the risks of using these tools might outweigh the benefits, threatening cognitive development by doing the thinking for their users. Homework that used to take hours of practice and comprehension is now completed in minutes, potentially undercutting students’ development of basic skills. This is forcing educators into a dilemma: How do they make the most of AI’s potential, while also protecting students’ ability to think for themselves? 

Welcome to “Harvard Thinking,” a podcast where the life of the mind meets everyday life. Today we’re joined by: 

Michael Brenner: I’m Michael Brenner. I’m the Catalyst Professor of Applied Mathematics in the School of Engineering and Applied Sciences at Harvard.  

Laine Perfas: He is also a research scientist at Google, where he runs a team that studies how large language models can accelerate science. Then: 

Grotzer: Tina Grotzer. I am on the faculty at the Graduate School of Education.  

Laine Perfas: She’s a cognitive scientist and studies how people learn. And our final guest:  

Ying Xu: Ying Xu. I’m an assistant professor of education at Harvard Graduate School of Education.  

Laine Perfas: She researches how to best design and evaluate AI technologies so they enhance children’s development rather than harm it.  

And I’m Samantha Laine Perfas, your host and a writer for The Harvard Gazette. Today we’ll talk about the role of AI in our educational settings and how we might best use it to enhance our learning rather than replace it. 

There are concerns that generative AI tools will increasingly affect our ability to learn. So I want to talk about the act of learning itself and critical thinking. What is it that we’re afraid will be affected?  

Grotzer: We’ve been a knowledge economy, so a lot of what we do in schools is about learning facts, memorizing things, getting a lot of information that we can then hopefully transfer forward and use in the real world. But learning also involves thinking about your mind, how we use our minds well, understanding our minds, understanding what critical thinking is, whatcreative thinking is. And so much of it we do so naturally that I think kids don’t even realize that they need to learn to do it. They don’t reflect on the amazing learning that their minds are doing day after day. That’s really important for this conversation. 

Xu: We are thinking about learning along two dimensions. One is what they learn, like the facts and the information. And the other one is their ability to learn. And those are really the foundational capacities that allow students to acquire new knowledge and skills in the future, and critical thinking is one of these very important foundational capacities. 

Brenner: I’m very interested in what Ying and Tina just said. I see the problem from maybe the other side, which is that my teaching focuses on advanced undergraduates and graduate students who are basically trying to learn to make models to understand or improve the world. For example, making large language models, the foundation of generative AI. And my career has really been driven by making scientific advances and trying to make discoveries using all of the tools in actual practice. And I should say upfront before I say the next thing that I am quite concerned about generative AI and its use and what it’s going to do to the people learning basic skills. Having said that, I feel it would be irresponsible for me not to embrace it entirely, both in the classroom and in research. And the reason is that anyone who doesn’t embrace it is going to lose. They’re going to get behind in terms of their careers, they’re going to get behind in terms of not making the greatest advances; it’s just changed everything. I’m excited that Tina and Ying are here because I’ve always worried that I don’t know how to teach people how to do the chain rule, which is the first thing you have to learn when you do calculus. But once you know that, then you need to proceed as I’m describing. But I have no idea what we’re supposed to do about actual learning.  

Laine Perfas: I think that brings up an important point. Learning is obviously a lifelong endeavor, so when we talk about AI tools, I imagine there is a huge difference between incorporating it into an elementary or middle school or high school classroom. Does it matter the age at which these tools are being introduced and incorporated into learning? 

Grotzer: I work with a lot of teachers who are thinking about instructional design, and what I often see in their work is that for the youngest children, they think that the kids need to learn a lot of information, and then once they have a lot of information they can learn how to think with it. And I think that’s unfortunate because you see the very youngest kids experimenting, exploring, demonstrating curiosity. This is all to Michael’s point, really, that AI is in the world, and why would we stop them from learning about the things that are out there? I do think that the very youngest children don’t have a reflective sense of what it is. But they’re going to interact with it, so I think figuring out how it can be a part of their world and a part of their exploration and their play without creating assumptions around — you know, it’s not really your friend, the anthropomorphizing of AI, things like that — are important. When we start to look at placing developmental limits, that becomes problematic when we’re talking about learning in the real world every day.  

Xu: When I talk to parents, the question that gets asked the most is at what age should we introduce AI toys at my home and at what age it starts to be safe for my kids to interact with AI tools. And what I would say is, “What kinds of tools are we thinking of introducing?” There are some tools that are more specialized, like the ones designed specifically to teach phonics and to support math and science. And there are also some tools that are designed with kids in mind that support this safe exploration, like Tina just mentioned. But there is another category that is more of this general tool that could be an assistant for almost everything. I do feel that to be able to use this kind of general tool, it does require some cognitive skills that our students need time to develop. For example, what we found was self-regulation is one of the very important skills that students need to be able to interact with AI tools effectively because they need to actually make a plan. And this is the kind of learning that I wanted to engage: I am going to do the thinking myself but only use AI for some scaffolding. And this needs some regulation to control the temptation: “I’m not going to ask AI for answers for all the questions.” 

We did a survey with 7,000 high school students. We asked them, “Do you feel that you are relying on AI too much for your learning?” And almost half of those students said that, “Yes, I feel that I’m using AI a bit too much.” And then over 40 percent said, “I tried to limit my usage, but it was so difficult I failed.” 

Laine Perfas: It’s interesting that there is the self-identification of I don’t want to be using it as much, and also, I can’t help myself, which I think may be why technology in general can be such a tricky thing for young people. It seems that there’s this tension: AI is in the world. It’s going to be around us. How do we bring it in in a way that enhances learning versus replaces learning?  

Brenner: I think that because we have AI, students should do more, they should solve harder problems. They should learn more. That’s my answer. And I’ve done this in various ways through classes at Harvard. One example is from a class that I teach, which is a graduate class in applied mathematics, which has always been thought of as one of the harder classes that we have.  

“I think that because we have AI, students should do more, they should solve harder problems. They should learn more.” 

I taught it last spring, and the day before I went to lecture, just for fun, I stuck in my last homework problem set into Gemini and asked it if it could solve it. And it basically solved everything. I was quite shocked because these are things that people spend their lives learning how to do. But I decided that I would walk in and just say to the students, “Well, this now happened. And so my syllabus is now invalid.” Basically, I’m not going to read problem sets given by ChatGPT. And so instead what I did is I completely changed the class and made two different things, which I think raised the level significantly. One is that every week, instead of giving them a problem set where I gave problems and asked them to solve it — which is the way I’d always done it — I instead told them that they needed to invent a problem that was in a particular category, and that the problem had to have the characteristic that the following chatbots could not solve the problem. And if they found the problem that the best chatbot couldn’t solve, they got extra credit. Meanwhile, they had to verify that their solution was correct by doing certain numerical calculations, and they had to convince someone else in the class that it was correct. We did that every week. There were 60 students in the class. By the end of the semester, we had 600 problems that, for the most part, the best chatbots at the moment couldn’t solve. We as a class wrote a paper about this and it was just published with everybody in the class as authors.  

But then that was not enough, because of course, teaching students, you still have to know that they understand. So what I did — and I’ve now started doing — is in lieu of a final exam, I basically carried out oral exams with each of the students in which they had to walk in, and I said, “You’ve invented these 10 problems,” and I made them go to my blackboard, and I picked one — I didn’t let them choose — and I made them go and solve it, basically, then explain to me how they came up with it. I learned more about the students than I ever have in the past in such a class. Subjectively, they knew more than anyone that I’d ever taught before because they were forced to go and read things that they ordinarily wouldn’t need to read because they had to push the state of the art.  

Grotzer: I have an assignment that I give to my students that I’ve given them for the last 20 years, and it has a number of points in this semester where they turn it in and they get feedback. And this was the first year where I could clearly see significant use of AI in the assignment. And what was supposed to be a 20- or 30-page assignment — I’m reading 60 pages of glop, it’s not terribly thoughtful.  

We had a long talk about, if you are designing instruction for the next generation, do you want to design the very best instruction that you can? You’re paying to come to school to learn how to do these things. Do you want to leave without pushing at the edges of your own learning and your own competence? So let’s talk about the ways that you’re using this. Some of the ways that students used it made a lot of sense. They had it quiz them about things they were trying to do. They asked for feedback on certain aspects, they explored possibilities and then went through and selected the ones that were most powerful for their own instructional designs. They also — very interestingly, some of them used it to create different perspectives on something that they were creating. So if you were a parent reading about this assignment, what would you wonder about? If you were a kid reading this assignment, what problems would be confusing to you? I think it’s really encouraging them to continue to work at the edge of their competence. Use it as a tool to transform what they’re doing. Which is really what I was hearing from Michael when he’s thinking about these assignments that he’s getting that are just much more advanced than you otherwise would’ve gotten.  

One of the issues is that we have a crisis of purpose in education, and we need to be rethinking what it is that young people learn as they progress through our educational system. Ying talked about the importance of self-regulation, so that’s important all the way through. We can all get behind that, but they’re always going to be in a world where there are going to be new innovations, and the innovations are going to get better and better in some respects. I think it forces us to look at what it is that we’re teaching and why.  

Xu: I wanted to linger on the purpose of education. In the same survey that we asked the 7,000 high school students, “What is the purpose of your learning?”, we asked whether they feel that learning math and learning English is still as important as before AI was introduced. Not surprisingly, we saw a huge decrease of students’ motivation in those two important subjects. This is a wake-up call and a moment for educators to think about how we could restructure education and restructure the classroom and learning so that it’s more relatable for what students want to do in their life. 

“This is a wake-up call and a moment for educators to think about how we could restructure education so that it’s more relatable for what students want to do in their life.” 

Laine Perfas: Thinking about the purpose of education and classrooms and how they are needing to evolve to account for this technology, which is a tale as old as time. We had to evolve when calculators were invented, when computers were invented. But just thinking about that and thinking about the traditional assignment as we have known them or as I knew them growing up, so many of them were transactional in nature. An example might be writing an email. It’s not about, “I want to have a really good grasp of language so I’m a good communicator.” It’s, “I want to get this email written as quick as possible.” I’m wondering how you see things needing to switch so that students remember that the point is learning, versus getting work done as efficiently as possible. 

Grotzer: I’d like to put a plug in for metacognition, which is understanding and thinking about your own mind and your own thinking, as one of the shifts that we need to make in terms of the purposes of education. We talk a lot about getting to know how human-embodied minds are powerful. And we contrast that with what AI can presently do. Once you start to know what your mind can do that’s so much better than AI, it makes sense that some tasks are well-relegated to AI and other tasks are not. That is going to be a constant challenge to figure out those relationships and lines over time, especially given how much AI is advancing and that it’s really a moving target.  

“Once you start to know what your mind can do that’s so much better than AI, it makes sense that some tasks are well-relegated to AI and other tasks are not.” 

In my “Becoming an Expert Learner” class, we look at aspects of human-embodied minds. And in every class, I ask them to start thinking about, Can AI do these things? How does AI contrast to the human mind in this sense? And then they make a great big Venn diagram and really think about it. Our minds are very different from what AI is doing.  

But that’s my plug for metacognition. I think we need to be metacognitive both about our minds and about AI, and that’s a new purpose for education. 

Brenner: Just to respond to that briefly, I agree that we should be metacognitive about what we’re learning and why we’re learning it, and we should think about it and we should teach our students how to do that. I agree that’s important. On the other hand, the one thing where I would push back slightly — and again, this only applies to my world, which is teaching people towards the end of their formal education — is that, I used to think I was a kind of creative person, basically. I’ve written a lot of papers in my life and I’ve done a lot of things, and these machines are basically as good as I am, if not better, at the moment, across many tasks. There’s a real question in my mind about whether we should be teaching people how to program computers at all, right? I actually think we should, and I’m not arguing against it, but I think it’s at least a reasonable question to ask given the fact that it is extraordinary what can be created by a person without technical expertise.  

To give you an example of this, I spent some time in a previous rendition of myself working with the ALS community, and I befriended a person who’s an amazing human being named Steve who has ALS. Steve uses a piece of software, which is called Dasher, that was written in a computer programming language that basically doesn’t really exist anymore, like 30 years ago. And it’s his primary communication, and he was always bothering me to fix the code for him so that it could do more things. Steve emailed me the other day, and to be clear, Steve types with his eyes — if he’s listening to this, hi, Steve. He emailed me the other day that he’s now using GPT-5 to fix the code himself. I think that we’re just living in a different world and that we need to rethink what the goals of education are, what we’re trying to teach people so that they can actually innovate.  

Laine Perfas: I feel like each of you have mentioned in various capacities, we should let the machines do the things that they’re really good at and also focus on the value of the human. And one of the things that I keep coming across is we learn from each other so much, the value of the teacher in a young student’s life, or Michael, thinking about how you redesigned your class. And part of it was to have students explain to you what they did and how they came up with it. So I’d love to talk about how you see an opportunity for things like chatbots to be there for instruction, while also not losing that critical human-to-human interaction.  

Grotzer: There was a piece in the Chronicle where a student was asking the writer about use of AI, and he had written an essay and he showed the feedback that he had gotten from his professor to this writer. And he said, “I used AI to write my essay.” And the writer said, “Yes, I can see that.” And then he said, “But look at the feedback I got from my professor.” And the writer looked at it and said, “And you know that your professor used AI to respond to you?” It was beautiful feedback if you looked at what was given, but it wasn’t feedback that was going help anyone because it wasn’t about anything that someone had generated. So, you know, the machines are talking to the machines at that point. And then we’ve truly lost the purpose of education. The social piece is so important and that ability for two minds to really grapple with something. The other thing we know from the tutoring research is that what good tutors do is they manage motivation and they give information in certain ways while constantly managing the social-emotional context and the kinds of things that we might expect a tutor to respond with. They might not fill in the information. They might just let it sit there. They might let someone get to a certain level and hold back, and then the next time they might come to that level. AI isn’t like an expert human tutor. That social piece of really knowing the social-emotional component is critical. 

Xu: I would agree with that. I think AI could do a really good job in generating the kinds of information that is very similar with what humans could provide. But learning is much more than just exchanging information and receiving feedback. And there is this relationship-building piece in the learning process that is very difficult to be replaced by AI. In my own studies, I looked at how much kids learn from an AI tutor versus a human tutor, although sometimes I do find that the learning outcomes are similar, just the amount of information the kids are able to retain was similar across the different learning formats. But kids reported that they had a higher level of enjoyment when they talked to a human tutor. Also, throughout observation, they are just more animated and more engaged in the entire learning process. It does improve the kids’ interest in learning, their confidence, their communication. Those are the aspects that are very difficult to be replaced by AI. In my own class, I did a small experiment with my students to understand the kind of social aspects in learning. We gave them identical essay feedback, but I just told one group of students, “This is the essay feedback generated by an AI,” and the other group of students, I told them, “This is your feedback generated by me,” but they looked at exactly identical feedback. I asked them to tell me, “How useful do you think the feedback is?” And just knowing that the feedback coming from an instructor actually significantly increased students’ perception of the usefulness of the feedback. What really matters is not only the kind of information students receive, but they know that the instructors really care about them and want them to succeed. I think that is a very useful ingredient in learning. 

Grotzer: The way that we structure schools — I think about middle schools and high schools where, so many kids are coming through a classroom that teachers don’t have good time to really get to know each one. As we think about this shift in purpose of education, that’s something else we could be thinking about a shift in. Because a good teacher is holding so much social-emotional information about a student. They’re balancing motivational factors with cognitive factors. They are giving very subtle hints to get somebody to think about stuff without giving it away. They often escalate how much support they’re given so that a student doesn’t totally fail, so that they walk away with some sense of success and that they can take on something the next time. As we rethink schooling in the age of AI, we should be rethinking how we enable the context that allows teachers to get to know their students deeply and well. I have young people in my household, some who went to large, urban public schools and didn’t really feel so known. And I have some who went to little tiny schools, six kids in your graduating class or 20 in your graduating class. And that difference of really feeling known, it reverberated throughout their early adolescence and how they felt about themselves, how they felt about grownups. Those relationships are holding environments as kids launch into what’s been called the rocket years, you know, the years in their 20s as they’re establishing careers and their own sense of competence in the world. I think we should be rethinking the structures of schools to accommodate these very kinds of social relationships that you’re talking about, Sam. 

Laine Perfas: Thinking about everything we’ve talked about at the end of the day, the goal here is to think through how we put guardrails in place so that we can protect and foster the next generation of thinkers, whether it’s Michael’s camp of using AI to bring the sciences further than they’ve ever been before, but also making sure that we are protecting the relational, emotional, critical-thinking component of learning that’s so vital. So, as we close, what should educators be thinking about when they think about their classrooms and incorporating tools, and what should parents be thinking about when they’re having conversations with their children about the purpose and role of AI in their life? 

Brenner: What I think about, is: Can I prove or measure that students are learning more by the use of tools? I think people should be experimenting and trying and just see what works and what doesn’t. But I think what’s very important in that type of an environment is to have some way of actually measuring that it’s working, because in the end, it really does matter if we’regoing to change the way people are educated.  

Grotzer: One of the things that I think is so important for young people coming up through our educational system is that they have a sense of agency about their learning and they feel empowered to use it and to use it well. AI is going to be a part of that. Sometimes you might see limits on your use of it in certain ways, but that is in service of protecting your ability to learn and use your mind well in the future to be able to achieve your goals out in the world. What is your moonshot? How do you want to see your contribution to the world? How can AI and your amazing mind work in service of that? For that reason, sometimes in educational contexts we might put guardrails, but those guardrails are really ones that are in service of your future abilities. 

Xu: What I would add is that I think AI is very important, but there are also many other things going on in young people’s lives that are equally important. So if we zoom out, it’s likely AI could be a good resource, but there are so many other opportunities and experiences kids are engaged in. For example, like their families, their friends, their time spent on their hobbies, and time in nature. Those are very important things that are playing a role in shaping children’s development. From a kind of a broader bird’s-eye view, AI probably doesn’t matter as much in isolation. What does matter is how it fits into the larger ecosystem of a child’s life. So maybe this is a message to parents and educators, and yes, it’s important to think about AI, but don’t forget that there are many other things in your child’s world that matter just as much. 

Laine Perfas: Thank you all for joining me for such a great conversation. 

Xu: Thank you, Sam. This was really fun.  

Grotzer: Thank you for the opportunity. It’s been a pleasure. 

Laine Perfas: Thanks for listening. For a transcript of this episode and to listen to our other episodes, visit harvard.edu/thinking. If you’re a fan of this podcast, rate and review us on Apple and Spotify. It helps others discover us. This episode was hosted and produced by me, Samantha Laine Perfas. It was edited by Ryan Mulcahy, Paul Makishima, and Sarah Lamodi. Original music and sound design by Noel Flatt. Produced by Harvard University, copyright 2026. 



Crush your goals the Ohtani way

Baseball superstar’s method for acing ambitions can help anyone, says Business School professor


Nation & World

Crush your goals the Ohtani way

Shohei Ohtani

Photo by Gregory Shamus/Getty Images

7 min read

Baseball superstar’s method for acing ambitions can help anyone, says Business School professor

When a professional baseball player gets that coveted call-up to the major league, it’s a life-changing entree into the big time known as “The Show.” So it’s fitting that fans have dubbed Shohei Ohtani, the Los Angeles Dodgers superstar pitcher and hitter who has dominated baseball over the last eight seasons, “Sho Time.” With two World Series championships (2024 and 2025) and four MVP awards — he’s the first to win the award twice in both the National and American league — Ohtani is widely seen as one of the best to ever play the game.

Talent and hard work have been integral to Ohtani’s success, but a new Harvard Business School case study suggests a simple goal-setting technique that the ballplayer began following while in high school in Japan can help anyone, not just athletes, turn ambition into reality.

The case study’s author, Frances X. Frei, UPS Foundation Professor of Service Management at the Business School, explains in this conversation edited for clarity and length.


Ohtani followed a training program called the Harada Method that guided him from a promising high school player to MVP. Tell me about this method.

Takashi Harada, the person who created it, turned around underperforming high school teams at a pretty massive scale using this method and made them startlingly overperforming. So, this didn’t just work for Shohei, loads of people did it and got outsized success. That’s when I started to think it might also be for the rest of us. But then, honestly, it was in my teaching it to students and watching them get captivated by it and do it and start telling me stories of how it has helped them. They notice a before and after in how they’re spending their time and their intentionality on things.

How does it work?

You come up with a multiyear ambition; so really dare to dream. And then, the first step of the chart is, “What are the set of things that if I concentrated on this year, I’d make meaningful progress on my multiyear ambition?” You have one thing in the center: my multiyear ambition. For him, it was “be the No. 1 draft pick” four years later. And then, what are the eight things that if I did this year, I would make progress on my ambition? He had “physical conditioning” and “mental strength” and then four pitching things — “control,” “sharpness,” “speed,” and “trickery.” He had “character” and “karma” for No. 7 and No. 8.

To me, one of the most compelling parts of the method was the inclusion of karma. If karma wasn’t included, I don’t know that it would have captivated my attention.

Chart filled out by Shohei Ohtani in high school.

Then the method asks you to do that one thing surrounded by eight, do it again, one more time. So, each of the eight yearly goals — physical conditioning, mental strength, character, karma, etc. — bring those out and surround them by the eight things I have to do on a daily basis to achieve that.

What’s amazing about the Harada Method is it breaks down your multiyear ambition. Students have found this so captivating because you either are thinking at the broad, multiyear ambition or you’re thinking at the micro — what do I have to do every day? This bridges them in a way that really provides forward momentum.

What did you find so intriguing about Ohtani’s process?

One is how he filled out the grids. There’s the No. 1 ambition, and then there are eight things surrounding it. Four of them having to do with pitching all the way down to the detailed behavior, the body, the mental. “Cool head, hot heart” was one of them. I have since learned it is common Japanese vernacular. I didn’t know it at the time, but that one really struck me. But it was “character” and “karma” that just weakened my knees. And indeed, I encourage everyone who uses this method to include character and karma regardless of if you want to be a pitcher or not. I’ve taught it now to 800 students — 100 percent used “character” and “karma” on theirs because they felt it.

“Pick up the trash” — that one really spoke to me; “clean room” because that’s private. Nobody else is going to see that. “Respect towards umpires.” He is known as the most respectful player. He does a greeting to the umpires at every single at bat. The one that I really wish I had learned a lot earlier was “be a person that people root for.” That one really hit me between the eyes because when I was that age, and for a lot longer, I thought “be a person who was right.” [laughs]

If he only had the four pitching things, I don’t think he would be as successful. I think it takes all of us, every ounce of us, to give ourselves the best position to achieve greatness. I don’t want to call it an insurance policy, but it’s not a bad word for it.

You’ve tried the Harada Method. What did you learn from that exercise?

Yes, my wife and I did it. We’re pretty ambitious people, and it helped us to clarify and articulate to each other, so we knew how to be helpful to one another: What am I going to do today that’s going to help make progress? It separates the signal from the noise of progress and really channels it. The articulation of it really helps you know what to do and stimulates progress.

My mission in the world is to add a zero for me and others. I’m very ambitious. I’m recovering from cancer and I have a new lease on life. And I’m a woman of a certain age. Jane Fonda taught me you’ve got three acts and I’m in my third act.

“Add a zero” is, instead of selling 100 books, how are you going to sell 1,000 books? Instead of having 1,000 customers, how are you going to get 10,000 customers? My philosophy now is how do we add a zero, and I’m trying to teach that to everyone. I’m trying to unleash ambition in people. I’ve never had such a great technique.

My wife, Anne Morriss, and I are writing our fourth book, which we want to retitle “Add A Zero.” That’s how much this has captivated us. We have our podcast called “Fixable.” I now do weekly office hours that are open to anyone where I teach a lot of these things. I call it Office Hours Live — we usually get about 1,000 people a week to come from all over the world. I taught this method on the goal-setting one.

So even those who aren’t aspiring athletes can benefit from Ohtani’s approach?

I’ve done it with hundreds and hundreds of people who are not athletes who either have ambition or I’m trying to encourage to have more ambition. Because what we know is that if you have a stretch goal, you achieve more than if you don’t.

The individual aspect of this, to me, is the compelling unit of analysis. This is a personal thing, and I think it’s for all ages. Lots of people are reading the case with their family and then decide who in the family wants to do the Harada Method. And then they start talking about the grids and then they talk about how their relationship shifts, how it just opens up pathways in doing it.


How academia can help America heal

First step, says columnist David Brooks, is to understand its role in the problem


David Brooks.

David Brooks.

Photos by Veasey Conway/Harvard Staff Photographer

Nation & World

How academia can help America heal

First step, says columnist David Brooks, is to understand its role in the problem

4 min read

During a campus talk Thursday, conservative columnist David Brooks spoke about what he sees as the flaws in higher education that perpetuate social and economic inequality, and the leading role that schools like Harvard can and should play in bringing about change.

The Kim and Judy Davis Dean’s Lecture in the Social Sciences was part of a five-year initiative at the Harvard Radcliffe Institute to confront threats to academic freedom and examine how Harvard and other American colleges and universities have sometimes fallen short of their own intellectual ideals, said Tomiko Brown-Nagin, dean of the Harvard Radcliffe Institute.

Brooks, a former New York Times columnist who is now a staff writer for The Atlantic, attributed the current embrace of political populism on the right and left and the vilification of academia largely to an educational “caste system” that vaults graduates of a small number of elite universities to the apex of society while constraining social mobility for those without a college degree.

This inequity of opportunity leaves many Americans feeling resentful and distrustful of higher education, expertise, and institutions.

David Brooks and Tomiko Brown-Nagin talk at Radcliffe.

Gripped by a growing sense of isolation and interpersonal distrust, particularly among younger Americans, the country finds itself today in “a mess,” said Brooks, who’s also a senior fellow at the Jackson School for Global Affairs at Yale University.

“I think populism grows out of this pervasive loss of trust, of faith in the system,” Brooks said. “And you get this sense from people across the political spectrum, ‘We’ve just got to burn it all down.’”

Brooks expounded on his 2024 piece for The Atlantic, “How The Ivy League Broke America,” laying out what he sees as the many failures of higher education, particularly what he views as a false meritocracy.

Making student intelligence, rather than legacy status, the basis for college admissions over the last century has been a well-intentioned shift toward greater fairness, Brooks said. But schools now “overrate” intellect while traits like creativity, drive, good judgement, or the ability to get along with others, which are also important predictors of life outcomes, get overlooked.

That shift toward meritocracy has not had the kind of broad, democratizing effect on social mobility as was hoped, he said. Wealthy parents have gamed the system by providing their children with help that greatly boosts their chances for admission over similarly capable but less affluent kids.

“And so, you can have all the free tuition you want, but if you’re measuring kids by how they do on these metrics, rich kids just have a huge advantage,” Brooks said.

Brown-Nagin, who co-chaired a working group on fostering open and constructive dialogue on campus, asked what College faculty can do to help make everyone feel comfortable expressing their views.

Brooks suggested faculty assign more ideologically diverse syllabuses that expose students to different, even conflicting, points of view on topics. He also suggested they teach social and negotiation skills so that students learn to work well on a team and tackle the issue at the heart of a disagreement without getting caught up in emotion.

Social distrust, he said, which is at the root of the nation’s loneliness epidemic and a source of populist anger, can be overcome if enough people step up and promote unity — whether through sports and social activity clubs, civic groups, or neighborhood volunteering.

One of the most consequential things that can inspire and transform lives, he said, is getting to know people from different walks of life. “The act of meeting somebody and seeing a role model and seeing a pathway — that’s tremendously powerful,” Brooks said. “To create a society where there’s fluidity, to me, that ameliorates a lot of the wrongs that come with inequality.”


Can Russia be denied?

Ex-POW joins discussion of four-year conflict ahead of another round of negotiations


Nation & World

Can Russia be denied?

Yevhen Malik gestures toward a map of Ukraine.

Photos by Veasey Conway/Harvard Staff Photographer

4 min read

Ex-POW joins discussion of four-year conflict ahead of another round of negotiations

Will the Kremlin budge on its territorial demands in peace talks with Ukraine?

Only if Russian President Vladimir Putin “runs out of the resources to recruit new soldiers and finance his own army,” argued Yevhen Malik, a veteran of Ukraine’s armed forces and former prisoner of war.

A recent event, hosted by the Davis Center for Russian and Eurasian Studies, put Malik’s observations from the front lines in conversation with empirical findings on conflict resolution. It was titled “How Does Russia’s War Against Ukraine End?”

“I long for the day where we will look up on the on the screen and see a talk titled, ‘How did this war end?’” offered moderator Steven Solnick, the Davis Center’s new executive director.

Solnick’s predecessor, Alexandra Vacroux, now vice president for strategic engagement at the Kyiv School of Economics, has been surveying the academic literature on historical peace talks, ceasefires, and outright victories. Drawing on a well-known text in the genre, she dismissed the poker-themed assessment President Trump offered Ukraine President Volodymyr Zelensky in the Oval Office last year.

“You might have heard that some people think that the Ukrainians don’t have the cards,” Vacroux said. “But if you look at war outcomes, it is not true that the stronger army always wins.”

“You might have heard that some people think that the Ukrainians don’t have the cards. But if you look at war outcomes, it is not true that the stronger army always wins.”

Alexandra Vacroux

Malik’s remarks went further, countering the common presumption of Russian military superiority. The combat veteran, who holds degrees in law and public administration, was held captive from April 2022 to September 2024. During this time, Russian forces failed to advance into several strategically important cities in eastern Ukraine’s Donetsk region, currently the epicenter of Putin’s military campaign.

Russia, whose invasion of Ukraine launched in February 2022, also appears to be taking far more battlefield casualties, Malik noted. According to one analysis, Russia’s 1.2 million dead, wounded, and missing over the four years of its invasion outnumber Ukraine’s by a factor of (at least) two-to-one. By Putin’s own accounting, his army totaled 700,000 soldiers in December 2025. Estimates from the UK Ministry of Defence put Russian casualties well over 400,000 for both 2024 and ’25, suggesting the need for a constant flow of recruits.

Yevhen Malik (right) and Alexandra Vacroux.
Yevhen Malik (right) and Alexandra Vacroux.

Also under stress is funding for Russia’s military benefits, including signing bonuses of up to $35,000 per recruit. According to media reports, some Russian regions have started to reduce the size of these bonuses due to stress on municipal budgets.

Malik says that these declining human and financial resources explain the Kremlin’s stubborn push for all remaining territory in the Donetsk region during peace talks. Today, a key sliver remains under Kyiv’s control.

“They try to win in negotiations something they can’t win with their military,” he said.

Vacroux shared recently published data on the circumstances that have stopped — or at least paused — more than 230 armed conflicts between 1945 and 2005. The majority of cases, she noted, lacked a decisive outcome. “Most end in ceasefires or peace talks, but the negotiations can take three or four or five years,” Vacroux said, noting that it took 158 meetings to end the Korean war.

So far, officials from Russia and Ukraine have sat for just a handful of peace talks, including U.S.-backed meetings in Abu Dhabi early this month. Within days of Malik and Vacroux’s Feb. 4 talk, Zelensky told reporters that President Trump had given both sides a June deadline for reaching a peace deal. Envoys from all three countries will meet again in Geneva on Tuesday and Wednesday.

“The Russians have an interest in trying to get Ukraine to make concessions as fast as possible,” Vacroux said, suggesting that the Ukrainian position may see stronger support following U.S. midterm elections this fall.


Yes, China has embraced renewables – but don’t call it a transition, expert says

Kennedy School panelists ponder next chapter in a tale of two superpowers


Work & Economy

Yes, China has embraced renewables – but don’t call it a transition, expert says

Wind turbines and photovoltaic panels are at a clean energy power plant at the foot of the Helan Mountains in Shizuishan City, Ningxia Hui Autonomous Region, China.

Wind turbines and photovoltaic panels at a power plant in Shizuishan City, Ningxia Hui Autonomous Region, China.

Costfoto/NurPhoto via AP

4 min read

Kennedy School panelists ponder next chapter in a tale of two superpowers

China’s embrace of electric vehicles and renewable energy technology has less to do with a clean energy transition than a hunger for energy of all kinds, analysts on a Kennedy School panel said Monday.

The nation, which has dominated the global trade in solar panels and has the world’s largest wind power industry, nonetheless generates 60 percent of its power from coal and has not hit the brakes on fossil fuel plants even as it aggressively pursues renewable energy initiatives.

“We see addition, not transition,” said Yasheng Huang, a professor of global economics and management at the MIT Sloan School. “China is building alternative sources of energy as well as fossil energy sources, simultaneously. In terms of the global footprint on CO2, China is emitting twice as much as Europe and the United States. I don’t think there’s a transition going on.”

Huang spoke at a seminar sponsored by the Mossavar-Rahmani Center for Business and Government. The event, “The Great Energy Divide: Petro America vs. Electro China,” focused in part on the perception of divergent energy policies in the first year of the second Trump administration.

In fact, if one leaves out China’s massive hydropower industry, the two nations have similar energy mixes, Huang said, with China’s fossil fuel portfolio favoring coal, much of which is mined domestically, and the U.S. favoring natural gas, most of which, similarly, is produced at home. Huang noted that security interests may also play a role in China’s embrace of renewables. Despite its massive coal industry, the country imports a significant amount of coal from Australia.

There remain key differences between the superpowers. China relies entirely on imports for oil, while the U.S. has become the world’s largest producer of oil and among the top global producers of natural gas.

According to Elaine Buckberg, a visiting scholar at Harvard’s Salata Institute for Climate and Sustainability and a lecturer in environmental science and public policy, another difference lies in the coherent industrial policy China has developed. If such a policy were emulated to support the U.S. auto industry, it would likely focus on electric vehicles, she said.

“I believe the future of the auto industry is EVs,” said Buckberg, a former chief economist for General Motors. “So you need to define your policy in that direction if you want to think about an industrial-policy approach and assume that’s where the industry is going.”

Such a move would help the U.S. auto industry transition to EVs in part through a suite of policy initiatives. Instead, Obama-era EV tax credits were pulled back in the first Trump administration, revived in the Biden years, and then squashed again.

“That constantly shifting policy means that the companies are going back and forth,” Buckberg said. “Have a stable policy, policy oriented towards EVs, but narrowly targeted on EVs. Invest especially in batteries and battery development, because that is really the decider, batteries and technology and research — that would be my recommendation.”

Addressing the prospect of Chinese EVs coming to the U.S., Buckberg pointed to two national security issues. One is a surveillance concern, since modern EVs are equipped with sensors and cameras that gather information that could potentially be shared. The second, she said, is that the U.S. has a strong interest in protecting its own heavy-industry manufacturing base — one that can transition to supporting national objectives in times of crisis.

The development of Chinese EVs has been planned and supported by Beijing, Buckberg noted. At one point, she said, there were some 800 Chinese EV companies. That number has been winnowed to fewer than 100, but the process drove innovation and efficiencies in production that resulted in high-quality, inexpensive vehicles that compete well internationally, Buckberg said.

Despite China’s global strength, there are signs of economic stress at home, with a glut in the housing market that has hurt local governments and left developers teetering. Huang questioned whether the booming economy is approaching an inflection point. The government, he said, should focus on strengthening benefits to workers, through investments in social security, health insurance, and education.

“I think we’re beginning to see something fundamentally shifting in the Chinese economy,” he said. “The money simply is no longer there.”


Pricey blockbuster GLP-1s are costing users — and most of the rest of us, too

Health insurers are passing along cost for coverage in form of higher rates across the board, policy researcher says


GLP-1s in manufacturing
Work & Economy

Pricey blockbuster GLP-1s are costing users — and most of the rest of us, too

Health insurers are passing along cost for coverage in form of higher rates across the board, policy researcher says

7 min read

The popularity of pricey GLP-1 drugs has hit the budgets of users — and just about everyone else.

In the U.S., about 12 percent of adults say they’re already on them. And worldwide, more than 25 percent of adults could benefit from the weight-loss treatment, according to new research from Mass General Brigham.

The Trump administration in November announced new deals to lower the cost of the notoriously pricey drugs to a $50 monthly copay for people who rely on Medicare for health insurance. But costs vary widely — causing some states to end coverage or restrict who qualifies for them under Medicaid plans.

And the newly launched TrumpRX platform offers some GLP-1 discounts aimed at those who lack insurance or would pay more under their coverage.

The drugs’ popularity and price are already driving up the cost of health insurance across the board, says Luca Maini, assistant professor of health care policy at Harvard Medical School. 

“If you look at the change in your health insurance premium this year over last year, about 30 percent of that is GLP-1s,” Maini said. 

The Gazette spoke with Maini about how public and private insurers are adjusting to the surging use of GLP-1s.

This conversation has been edited for length and clarity. 


Why have these drugs been so expensive? 

They’re expensive in part because they’re effective, and patients value what they offer. But they’re also patent-protected, so generic drug manufacturers can’t produce these compounds for another few years. The companies that make these products are effectively monopolists. 

“They’re expensive in part because they’re effective, and patients value what they offer.”

Now, there is some competition, because there are a handful of these molecules that can be used for weight loss. And the price has come down quite a bit, even in the last few years. A recently approved Wegovy pill will cost $150 a month for patients without insurance. But we can expect the cost to remain relatively high, at least while the patents are in effect. 

Why is there so much variety in what a patient ends up paying for these drugs? 

It depends on the type of coverage you have. Medicaid has very low out-of-pocket costs and covers virtually all drugs, but only a few states cover anti-obesity medications. Even patients in one of those states that do face substantial access restrictions. A Medicaid patient would need access to a physician who can write a prescription, and to go through administrative hurdles like prior authorization. Medicare Part D, which is the part that covers prescription drugs, does not cover drugs that treat obesity — though that may be changing under the Trump administration’s recent deals with manufacturers.

Employer-sponsored plans tend to be more generous when it comes to coverage, but they also require more cost-sharing and, again, administrative hurdles like prior authorization.

And lastly, out-of-pocket payers can access these drugs through the direct-to-consumer, telehealth services that are popping up online, which offer prescriptions at around $100 or $200 per month these days. 

How unusual is it for so many patients to be eligible for a new class of drugs but face such a high cost? 

It’s pretty much unprecedented, especially when you’re talking about one in four adults being eligible for these drugs under the widest standards. The only comparison I can think of is statins [commonly prescribed to lower cholesterol].

“It’s pretty much unprecedented, especially when you’re talking about one in four adults being eligible for these drugs under the widest standards.’

A similar share of adults is eligible for those drugs, but much cheaper generics are available — and when they first came out, they weren’t nearly as widely prescribed. 

On the flip side, I’m reminded of the treatments for hepatitis C that arrived on the market a little more than 10 years ago. Of course, fewer people need treatment for hepatitis C, but the products were much more expensive when they first came out, so the burden on the healthcare system was comparable.

What happened in that situation was that the drugs were heavily rationed — in a sense that’s the natural solution, and the same thing is happening with GLP-1s. It’s part of why the fully out-of-pocket, direct-to-consumer channel is so popular: because a lot of patients can’t get the drug reimbursed through their insurance. 

How disruptive have these drugs been for insurance companies? 

Well, it’s certainly disruptive, but the solution, from the insurers’ perspectives, is clear: Raise the cost of coverage, or at least the cost of insurance plans that cover these drugs.

One thing that’s different about these drugs is that at least when it comes to treatment for obesity, patients can basically predict perfectly whether they’ll need them, and that means the insurer can do the same thing. So it’s actually fairly easy for them to figure out what kind of budget impact this will have on their bottom lines, and how much they need to raise premiums to make up the difference.

That’s already happening. If you look at the change in your health insurance premium this year over last year, about 30 percent of that is GLP-1s. 

Should we expect those insurance premiums to keep going up or has the impact of GLP-1s mostly been factored in at this point? 

I would say the biggest adjustment has been factored in, though some uncertainty remains.

The biggest uncertainty is how long patients continue to take these drugs. They’re meant for long-term use. But evidence shows that as of now, GLP-1s have pretty unpleasant side effects, and a lot of patients stop taking them. So the financial impact may not be as steep as it would appear.

The other factor is whether or not these drugs end up having benefits that reduce costs in other areas. Obesity is a comorbidity that tends to worsen other outcomes, whether that’s cardiovascular health, risk of falls, things like that.

So it remains to be seen how much money is saved if some of those outcomes are improved. 

How is this shaking out in other countries?

The main difference is that in most other countries the fraction of people who would benefit from these drugs is smaller. Still, the majority of European countries, for example, have imposed very strict utilization controls, generally limiting use to patients with high body mass index.

Is there any relief on the horizon? 

Yes. In the short term, the Centers for Medicare and Medicaid Services, the federal agency that administers Medicare and partners with state governments to manage Medicaid, is testing what would happen if Medicare Part D covered GLP-1s for obesity — to get a sense for how much it would cost, and what those positive externalities might be. 

And finally, even if it turns out these drugs have to be taken for life — and most people do — in about next five years or so, these patents will start to expire, and we’ll have generic manufacturers making their own GLP-1s.

At that point, they’ll be very, very cheap. So even in the worst-case scenario, from a spending perspective, we can think of this moment as a very expensive blip.