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Long career in search of ‘how to improve the human condition’

Medical anthropology pioneer Arthur Kleinman takes a bow


Arthur Kleinman.

Professor Arthur Kleinman gave his final “Future of Medical Anthropology” seminar on April 29.

Photos by Grace DuVal

Campus & Community

Long career in search of ‘how to improve the human condition’

4 min read

Medical anthropology pioneer Arthur Kleinman takes a bow

A long career bridging medicine, social science, and the humanities has left Arthur Kleinman with one critical insight.

“Care, critically understood and practiced, matters most,” he told a packed lecture hall last week. “This is at the center of whatever claim I can make to wisdom and truth.”

Kleinman, M.A. ’74, a psychiatrist whose many titles include Esther and Sidney Rabb Professor of Anthropology, plans to officially retire next year after a total of nearly 50 years at Harvard. But his work in the classroom ended Tuesday with the final meeting of his “Future of Medical Anthropology” seminar.

The occasion drew nearly 200 current and former students to Sever Hall, with dozens more joining via Zoom. Five former students also testified to Kleinman’s impact as a teacher, author, mentor, and moral anchor committed to building cross-cultural understanding and advancing well-being.

“The gift that he leaves us with is the idea that knowledge is not only linked to patents and businesses,” offered Adams House Faculty Dean Salmaan A. Keshavjee, Ph.D. ’98, who also serves as director of the Center for Global Health Delivery at Harvard Medical School (HMS) and professor of Global Health and Social Medicine in the Department of Global Health and Social Medicine (GHSM). “It’s linked to a better understanding of how to improve the human condition.”

The meeting drew nearly 200 current and former students to Sever Hall.
The final seminar drew nearly 200 current and former students to Sever Hall. He was joined by Jim Yong Kim, Salmaan Keshavjee, Anne Becker, and Davíd Carrasco.

Kleinman, who is also a professor of medical anthropology in GHSM and professor of psychiatry at HMS, first landed at Harvard with his wife, Joan, in the fall of 1970. With support from the National Science Foundation, the Stanford-trained M.D. came to do a comparative study of medical systems across cultures.

“I quickly figured out that for me, anthropology was a suitable way forward,” Kleinman explained.

He taught Harvard’s very first course in medical anthropology in 1973. He left in 1976 for an associate professorship at the University of Washington, but the expert on health care in Chinese culture was back in Cambridge by 1982, now in a senior position split between the Faculty of Arts and Sciences and HMS.

“And that is the position I will be retiring from in July 2026 when I formally retire, and from which today — 43 years later — I deliver this, my final lecture,” Kleinman said.

He honored the contributions of the late Harvard social medicine/psychiatry professor Leon Eisenberg and former students including the late Paul Farmer, M.D/Ph.D. ’90, the celebrated co-founder of Partners In Health. Kleinman also name-checked a long line of staffers and faculty assistants who over the decades helped build the medical anthropology program.

“We’ve had about 100 doctoral students, 25 of whom are M.D./Ph.D.’s; more than 250 postdoctoral fellows, including researchers from much of the world; over 50 M.A. students; dozens of students from the Chan School of Public Health and other Harvard Schools; hundreds of medical students; and thousands of undergraduates,” he said.

Veterans of the program praised more than Kleinman’s intellectual rigor and moral mentorship. His influential body of work also figured prominently. In the final class, former World Bank President Jim Yong Kim, M.D. ’91, Ph.D. ’93, who co-founded Partners In Health with Farmer, testified to the career-altering discovery of Kleinman’s “Patients and Healers in the Context of Culture” (1980).

Anne E. Becker ’83, M.D./Ph.D. ’90, the Medical School’s dean for Clinical and Academic Affairs and its Maude and Lillian Presley Professor of Global Health and Social Medicine, spoke to the inspiration provided by “The Soul of Care” (2019), Kleinman’s account of navigating the healthcare system as a family caregiver from Joan’s Alzheimer’s diagnosis until her death in 2011.

“This book has become my touchstone as a clinician — and quite frankly, in my responsibilities as an educator, mentor, and colleague,” Becker said.


When foreign governments took aim at universities

Scholars look to historical examples for insights amid current U.S. tensions


Nation & World

When foreign governments took aim at universities

Scholars look to historical examples for insights amid current U.S. tensions

6 min read
Sven Beckert makes introductory remarks.

“Little did we know then how important this issue would become to the very institution in which we are meeting today,” said Sven Beckert.

Photos by Stephanie Mitchell/Harvard Staff Photographer

Recent government demands on U.S. universities have some scholars searching for the right historical analogue for insights.

“I’ve been thinking about this budding conflict between the state and universities as possibly a replay of the 1950s” and the McCarthy era, said William C. Kirby, T.M. Chang Professor of China Studies in the Faculty of Arts and Sciences and Spangler Family Professor of Business Administration at Harvard Business School.

Kirby and other Harvard faculty with expertise on higher ed crackdowns in various national contexts came together on a recent panel hosted at the Minda de Gunzburg Center for European Studies (CES). Stories emerged of governments in other countries muzzling student speech, placing universities under receivership, or hobbling institutions with bureaucratic red tape.

The event, offered as part of the center’s Democracy and Its Critics Initiative, had been in the works since December. “Little did we know then how important this issue would become to the very institution in which we are meeting today,” said moderator Sven Beckert, Laird Bell Professor of History.

The history starts in the heart of Berlin, began Kirby, author of “Empire of Ideas: Creating the Modern University from Germany to America to China” (2022). The University of Berlin, founded in 1810, was the world’s premier research university. It was the first dedicated to the creation as well as the transmission of knowledge. It pioneered the concept of academic freedom for students and faculty. It also placed liberal arts, rather than professional training, at its core.

“It became the model for all great research universities,” said Kirby, who served as FAS dean from 2002 to 2006.

The panel seated at a table.
Sugata Bose (from left), Sven Beckert, William C. Kirby, Laura Jakli, and Daniel Ziblatt.

As late as 1930, he noted, the University of Berlin — known today as Humboldt University — was the world’s most respected institution of higher learning. But its reputation collapsed with the rise of the Nazi movement, with its book burnings, mass firings of Jewish professors, and curbing of curriculum deemed insufficiently German.

Some of South Asia’s great universities were patterned after the University of Berlin, said panelist Sugata Bose, Gardiner Professor of Oceanic History and Affairs. He spoke of “the Humboldtian project” being implemented at his own alma mater — Kolkata’s Presidency College, founded in 1817 — “with later echoes in Dhaka, Lahore, Aligarh, Allahabad, and Bangalore.”

The decline of those situated in India started in 2016, Bose said, when supporters of Prime Minister Narendra Modi launched what he characterized as “an unbridled attack on India’s best universities.”

A former member of India’s parliament, Bose shared a clip from a speech he delivered to the chamber that year. At the time, students nationwide were demonstrating against caste discrimination. They adopted slogans broadly viewed as in opposition to the government.

“That was the first term of the Modi government,” he recalled. “It was still possible, standing in the Indian parliament, to offer principled opposition.”

For nearly a century, the strongest of India’s universities were funded directly by the central government, Bose explained. “Now it’s the central universities, such as Jawaharlal Nehru University or Hyderabad Central University, which are directly under the thumb of the central government.”

Also impacted are otherstate universities, now controlled by chancellors aligned with Modi’s Hindu nationalist Bharatiya Janata Party (BJP).

“The private universities and other autonomous institutes in the south of India are doing much better,” said Bose, noting a string of states in the region not controlled by the BJP. “These are the spaces for resistance and for standing up for the academic values, which sustain universities.”

Laura V. Jakli, an assistant professor of business administration at the Business School, outlined the recent assault on Hungarian universities. She recalled giving a lecture at Budapest’s Central European University (CEU) in 2017.

“At some point near the end, someone came up to me and whispered that parliament just passed something that might mean this university is no longer operational,” Jakli said. The student body wasted no time in taking to the streets to protest Lex CEU, an educational rule that effectively forced the U.S.accredited CEU out of Hungary.

Subsequent measures by Prime Minister Viktor Orbán brought schools including the Hungarian Academy of Sciences and the University of Theatre and Film Arts, both in Budapest, under the control of foundations closely aligned with the Orban government.

The “note of hope,” said Jakli, is Hungary’s membership in the European Union. EU leadership has acted to curb these moves, by limiting funds to schools run by quasi-public foundations, for example. It also litigated Lex CEU before the EU’s Court of Justice, which struck down the rule in 2020.

But by then, Jakli submitted, “It was too little too late.” CEU had already relocated its core academic programs to Austria.

Kirby, a historian of modern China, took the conversation back to Asia for a final case study. During its late-Qing and Republican periods, China was home to an “extraordinary group of small universities,” he said. But these institutions were seized or shuttered after Chairman Mao Zedong and his Chinese Communist Party rose to power in 1949.

Kirby rattled off nearly a dozen examples — from Peking Union Medical College, usurped by the Communist Party in 1951, to Tsinghua University, its iconic gate toppled by the Red Army during the Cultural Revolution. The entire system was “Sovietized,” as Kirby put it, or retooled to train workers according to state priorities.

As the event wound down, one attendee raised the lack of hopeful examples. “We haven’t had a story of a successful rebuttal,” agreed Daniel Ziblatt, Eaton Professor of the Science of Government and director of the CES.

In response, Kirby steered the conversation in a surprising direction.

Today, he suggested, China’s research universities are skirting government control to reclaim some of the academic excellence of an earlier era. And institutions like Tsinghua University, in Beijing, have surpassed Princeton and Yale in at least one global ranking.

Tsinghua leaders officially tout “an education with ‘Chinese characteristics’ — whatever the hell that is,’” Kirby noted to laughs. “No one knows what it is. In fact, it’s just to appease the leadership.”


Earlier warning on pediatric cancer recurrence

AI tool does a better job predicting relapse risk than traditional methods in Harvard study


Health

Earlier warning on pediatric cancer recurrence

Radiologist looks at child's brain scans.
4 min read

AI tool does a better job predicting relapse risk than traditional methods in Harvard study

An AI tool trained to analyze multiple brain scans over time predicted risk of relapse in pediatric cancer patients with far greater accuracy than traditional approaches, according to a new study. Researchers hope the results lead to improved care for children with brain tumors called gliomas, which are typically treatable but vary in risk of recurrence.

“Many pediatric gliomas are curable with surgery alone, but when relapses occur, they can be devastating,” said corresponding author Benjamin Kann of the Artificial Intelligence in Medicine Program at Mass General Brigham and the Department of Radiation Oncology at Brigham and Women’s Hospital. “It is very difficult to predict who may be at risk of recurrence, so patients undergo frequent follow-up with magnetic resonance imaging for many years, a process that can be stressful and burdensome for children and families. We need better tools to identify early which patients are at the highest risk of recurrence.” Kann is also Assistant Professor of Radiation Oncology at Harvard Medical School.

The results of the study by investigators from Mass General Brigham and collaborators at Boston Children’s Hospital and Dana-Farber/Boston Children’s Cancer and Blood Disorders Center were published in The New England Journal of Medicine AI.

The research, which was funded in part by the National Institutes of Health, leveraged institutional partnerships across the country to collect nearly 4,000 MR scans from 715 pediatric patients. To maximize what AI could “learn” from a patient’s brain scans — and more accurately predict recurrence — the researchers employed a technique called temporal learning, which trains the model to synthesize findings from multiple brain scans taken over the course of several months post-surgery. 

“Many pediatric gliomas are curable with surgery alone, but when relapses occur, they can be devastating.”

Benjamin Kann

Typically, AI models for medical imaging are trained to draw conclusions from single scans; with temporal learning, which has not been used previously for medical imaging AI research, images acquired over time inform the algorithm’s prediction of cancer recurrence. To develop the temporal learning model, the researchers first trained the model to sequence a patient’s post-surgery MR scans in chronological order so the model could learn to recognize subtle changes. From there, the researchers fine-tuned the model to correctly associate changes with subsequent cancer recurrence, where appropriate.

Ultimately, the researchers found that the temporal learning model predicted recurrence of either low- or high-grade glioma by one year post-treatment, with an accuracy of 75-89 percent — substantially better than the accuracy associated with predictions based on single images, which they found to be roughly 50 percent (no better than chance). Providing the AI with images from more timepoints post-treatment increased the model’s prediction accuracy, but only four to six images were required before this improvement plateaued.

The researchers caution that further validation across additional settings is necessary prior to clinical application. Ultimately, they hope to launch clinical trials to see if AI-informed risk predictions can result in improvements to care — whether by reducing imaging frequency for the lowest-risk patients or by pre-emptively treating high-risk patients with targeted adjuvant therapies.

“We have shown that AI is capable of effectively analyzing and making predictions from multiple images, not just single scans,” said first author Divyanshu Tak of the AIM Program at Mass General Brigham and the Department of Radiation Oncology at the Brigham. “This technique may be applied in many settings where patients get serial, longitudinal imaging, and we’re excited to see what this project will inspire.”


This study was supported in part by the National Institutes of Health/the National Cancer Institute.


Funding today, entrepreneurship tomorrow. Or not.

Threat to research is a threat to U.S. innovation and growth, HBS analyst says


Work & Economy

Funding today, entrepreneurship tomorrow. Or not.

Researcher working in a lab.
5 min read

Threat to research is a threat to U.S. innovation and growth, HBS analyst says

After Harvard rejected Trump administration demands related to hiring, governance, and the viewpoints of faculty and students, the government froze more than $2 billion in grants for research in science, medicine, and technology at the University. In all, the administration has targeted more than $9 billion in Harvard funding for review. The University responded with a lawsuit late last month.

The disruptive effects of cuts to research funding at Harvard and other institutions of higher ed have already been seen across the U.S. economy. Even if the total funding cuts end up being one-quarter of what has been threatened, gross domestic product will shrink by 3.8 percent (adjusted for inflation) over the coming years, a rate comparable to the 2008-2009 Great Recession, according to new research from economists at American University. Their analysis followed a March report by the nonprofit United for Medical Research that detailed $2.56 in U.S. economic activity for every dollar put into federal biomedical research in 2024.

Less immediately visible are the potential effects the funding freeze could have on a key engine of U.S. economic growth, the startups that help bring scientific innovation and breakthroughs to market.

In this edited conversation, Jeffrey J. Bussgang, senior lecturer in entrepreneurial management at Harvard Business School, discusses the role research universities play in the startup world and how disruptions to funding for science and medicine could reshape the future of entrepreneurship. Bussgang teaches the M.B.A. course “Launching Technology Ventures” and is co-founder and general partner of Flybridge Capital Partners, an early stage venture capital firm.

Jeff Bussgang.

Jeffrey J. Bussgang.

Photo by Nabil Kapasi


How do research universities figure into the startup and venture capital ecosystem?

There are two critical pathways to bridge the university system and the startup ecosystem. One is through the faculty and the second is through the students.

On the faculty side, often we see commercialization pathways coming out of research in the labs. That can occur both in the computer science departments as well as in the biomedical arenas. And, of course, Harvard has many, many labs and many diverse vehicles, whether it’s the Wyss Institute or the Broad Institute, which operates in conjunction with MIT, as well as the electrical engineering, mechanical engineering, and computer science departments. Robotics, as well. Those tend to be very rich environments for startups.

Second, students benefit from an incredibly rich entrepreneurship curriculum. It’s the most popular field of study at Harvard Business School and the largest faculty unit at Harvard Business School. We consistently have dozens and dozens of startups that come out of our students’ work. As does SEAS — both graduate students and undergraduates. 

Research universities seem to play an incubation role in that model. Why has it evolved that way — is it because of risk?

It’s less about risk and more about an intentional curriculum and launching pad for academics and for students. The school is engineered to help faculty through the technology licensing office and various entrepreneurs in residence and venture capitalists that surround the school. We have a very explicit objective of helping our students become company creators and entrepreneurs. So it’s not about risk; it’s more about opportunity and intentionality.

Historically, why is the federal funding of scientific research and development so critical to tech and biomedical startups and entrepreneurs? How does it foster U.S. economic growth?

The more heavily resourced the labs are, the more performative they can be in terms of generating novel ideas that can eventually become massively successful commercial companies. I would also say, the more of a magnet the school is for the best and the brightest internationally, the more likely it is to attract brilliant, aspiring entrepreneurs. And if their work is inspired not by necessarily the labs, but just because of the nature of the work and the quality of the educational system and the quality of the faculty, then that’s also an important magnetic force.

What impact has the federal funding freeze on NIH research and the halting of previously approved grant payments had so far?

We’re just seeing the beginning. There are hiring freezes. There have been initiatives canceled and there have been grants canceled. The pipeline for company creation takes time. The companies that are being created now and launching in 2025 were incubated over the last three years, so we won’t see a short-term effect. It’s going to be more of a medium- and long-term effect in the coming years. We’ll just see fewer promising startups come out of the system.

How long until we start to see the full effects of this situation, and could the damage be reversed?

It could be reversed, but I think it’s going to be a one-to-three-year ripple effect because of how long it takes for these ideas in the lab to come out and to become commercially viable companies.


Making universal connection through the intensely personal

Woodberry Poetry Room workshop project on tradition of elegy inspired by loneliness, grief of pandemic


Writers Maria Lisella, Julia Lisella, Josh Kurtz, and Kenny Likis circle a table in Harvard's Woodberry Poetry Room.

Maria and Julia Lisella (from left), Josh Kurtz, and Kenny Likis collaborate and reflect on their writing during a workshop in Harvard’s Woodberry Poetry Room.

Photos by Grace DuVal

Arts & Culture

Making universal connection through the intensely personal

5 min read

Woodberry Poetry Room workshop project on tradition of elegy inspired by loneliness, grief of pandemic

Elegy, a form of poetry traditionally meant to honor the dead and lament the loss, is often composed in solitude. On a warm recent Tuesday afternoon in Lamont Library, a small group — some poets, most not — gathered to write, read, and workshop elegies of their own.

The workshop, led by Karen Elizabeth Bishop and David Sherman in partnership with the Woodberry Poetry Room, is part of the duo’s ongoing “Elegy Project.” The event late last month was paired with a reading that evening in Houghton Library’s Edison Newman Room by poet Peter Gizzi, author of the T.S. Eliot Prize-winning collection “Fierce Elegy.” 

“The Elegy Project is a public poetry initiative,” Sherman said. “We put poem cards in public places for strangers … Our intention is to make grief less lonely.”

Peter Gizzi reads poetry at Houghton Library.
Poet Peter Gizzi reads in a companion event.

The Elegy Project was the recipient of the Poetry Room’s 2023 Community Megaphone grant. Using funds provided by poet Tom Healy ’83, the Poetry Room began offering stipends to individuals and nonprofits in the Boston area to support their work and creative contributions to the community.

“Elegy is perhaps the most primal and human of poetic impulses — the need to mourn, to praise, and to console all springing from the inescapable human predicament: to be alive is to experience loss,” said Mary Walker Graham, associate curator of the Woodberry Poetry Room. “Elegy not only makes this loss more bearable, it enlarges our capacity to experience the full spectrum of human emotion.”

Started in spring of 2022, Bishop and Sherman said they were inspired to create the Elegy Project when they noticed the loneliness and grief caused by the pandemic and thought there must be a way to show people that they weren’t alone.

“During the pandemic we wanted to do an anthology of elegy. But the publishing world works at glacial speed,” Bishop said. “Everybody was in their houses. And so we thought to do a deconstructed anthology that would be immediately free and accessible, and ‘aggressively randomly accessible,’ as Dave says.”  

Writers look through bookshelves and sit around tables in the Woodberry Poetry Room.

Both Bishop and Sherman distribute poetry cards wherever they go.

“I walk around with thumbtacks in my pocket and the cards, and I put them on wooden utility poles, or leave them in the post office, on the train, or the bus, or maybe a bench, and it’s aggressively contingent and random,” Sherman said. “It’s unsystematic. It’s aggressively embracing randomness.”

Both Bishop and Sherman say they use elegy in their professional work as well. Bishop is an associate professor of Spanish and Comparative Literature at Rutgers University, where she researches and teaches modern poetry and narrative. Sherman is an associate professor of English at Brandeis University, where he researches elegy and the politics of commemoration.

“I think that elegy performs this beautiful kind of stretching toward something that’s gone or something that’s gone missing,” Bishop said. “Isn’t that the nature of death? That you want to reach out, you want to kind of make that movement forward.”

This most recent workshop was the second between the Elegy Project and the Poetry Room. Last spring they did poetry workshops with invited guests. This time around, there was an open call for anyone interested in crafting a poem.

“I think these are people who probably use poetry privately and maybe share with a few friends, and want to expand that experience by a significant step,” Sherman said. “These were people who are busy with life, busy with real experiences where poetry is useful for processing, and they just want to write in community.”

The group assembled ranged from doctoral candidates in physics to retired painters. They were asked to use the Poetry Room’s collection and prompts by Sherman and Bishop for inspiration.

“Elegy is perhaps the most primal and human of poetic impulses — the need to mourn, to praise, and to console all springing from the inescapable human predicament: to be alive is to experience loss.” 

Mary Walker Graham

“The thought behind the steps was to create a dynamic conversation between people and books, between people and people, between lines and other lines, so that something unexpected would emerge,” Sherman said. “It was exploring openly, exploring new books on the shelves, and then feeling the desire to say something back of your own.”

Bishop added that using prompts and exploring texts can help get the creative juices flowing, too.

“It takes a little bit of the pressure off sitting around waiting for a line to appear or waiting for your brain to come up with something,” she said. “I think that that kind of scaffolding is really useful for people to get into to writing a poem or just engage poetry in some way.”

Graham, the Poetry Room’s associate curator and co-organizer of the event, said workshops like the Elegy Project’s are important to engage the community and bring poetry out from the stacks.

“Poetry belongs to everyone, not just to the authors of published books,” she said. “We all have an equal right to access it, not only to receive it but to create it. Workshops like this one nurture the poets in us all.”


How hot is too hot?

Teaming up with grassroots organizers in India, Harvard researchers are collecting data to help workers adapt to dangerous spikes in heat


Nation & World

How hot is too hot?

A man wheels bricks from a kiln under intense heat in India.

A worker labors in the heat of Uttar Pradesh, India, hauling bricks from a kiln.

Photos by David Trilling

8 min read

Teaming up with grassroots organizers in India, Harvard researchers are collecting data to help workers adapt to dangerous spikes in heat

When it gets hot in Ahmedabad, bats pass out and fall from the trees.

Climate change is forcing temperatures into the upper limits of what many mammals, including humans, can bear. Heatwaves are more frequent and last longer. People in the world’s hottest places — like Ahmedabad, a 15th-century city of about 8 million in western India — now routinely struggle for months at a time. Air conditioning there is rare.

While extreme daytime temperatures grab headlines, “being indoors, at home, during the rest hours can be just as dangerous and deadly,” said Satchit Balsari, associate professor in emergency medicine at Harvard Medical School.

Adapting to this new reality is a matter of life or death. But to test adaptation strategies — say, how much does a white roof cool the room below? — urban planners need basic data. For example, how hot is it really in the places where people live and work? Ahmedabad’s official temperature is measured at an airport weather station standing out in the open, not in the dense urban microclimates where homes and livelihoods are concentrated. And how does the body respond to prolonged high temperatures? Or, as Balsari put it: “How do you define how hot is too hot?”

Harvard researchers are working with community leaders in India to build one of the largest datasets ever recorded on extreme heat and human well-being.

Cities and states across India are developing heat action plans to mitigate the impacts on their populations, though they often overlook informal workers.

The data will let civil society groups lobby on behalf of policy solutions, because there are no precise statistics in India on how heat affects work.

To answer these questions, Harvard researchers are collaborating with community leaders in Ahmedabad to build one of the largest datasets ever recorded on extreme heat and human well-being — data that could help millions of others facing rising temperatures around the world. The research team is placing thumb-size heat and humidity sensors in the workplaces and homes of hundreds of local women — in urban dwellings, on streets, and on farms — and monitoring their health with Fitbits and regular checkups over a year.

“This study was born out of an attempt to quantify the lived experience, the temperatures people are experiencing day after day in their homes, and what that means for their health, their heart rate, kidney function, their sleep,” said Caroline Buckee, professor of epidemiology at Harvard T.H. Chan School of Public Health.

Policies meant to offset extreme heat often focus on the risk of heat stroke, “but there’s a range of other health impacts that injure and kill people more slowly,” she added.

A woman harvests wheat at twilight in India.
A woman harvests wheat at twilight, after the worst of the afternoon heat, in Uttar Pradesh.
A man puts up canopies at a mosque in Delhi.
A man erects shade to protect worshippers ahead of Friday prayers at a mosque in Delhi.

Balsari and Buckee lead a research cluster — funded by the Salata Institute for Climate and Sustainability and supported by the Lakshmi Mittal and Family South Asia Institute — studying the impact of warming microenvironments on the lives and livelihoods of the Indian working poor.

“During our pilot study, in certain homes we found temperatures up to 10 degrees hotter than the airport weather station data,” said Balsari. “We realized that a lot of global modeling efforts were dependent on data at a temporal and spatial resolution that may not reflect the lived reality of the millions of people most at risk in South Asia.”

Inside one home their team recorded a heat index of 137 degrees Fahrenheit — a measure that combines temperature and humidity to reflect how hot it feels. “That’s extreme, but the fact that the numbers cross 120 F routinely is terrifying. These thresholds, in many contexts, are unlivable,” Balsari said.

Building resilience with data

Study participants are tenant farmers and piece-rate workers. Data collectors are local social workers who visit participants every two weeks in their homes and workplaces to download data onto a customized smartphone app.

Cities and states across India are developing heat action plans to mitigate the impacts on their populations, though they often overlook informal workers.

The data will let civil society groups lobby on behalf of durable policy solutions, like heat action plans that take their members into account, because there are no precise statistics in India on how heat affects work.

Already these groups offer a growing menu of novel responses to heat: affordable finance to paint roofs a heat-reflecting white, buy umbrellas to shade market stalls, and install vents that let heat escape concrete-block homes. Another innovation is parametric heat insurance: Members buy a policy that will pay a day’s wage when the temperature exceeds a preset threshold, to allow them to stay home during the most brutal heatwaves and not have to choose between feeding their families and protecting their health.

A busy street in Ahmedabad.
Air conditioning is rare in the 15th-century city of Ahmedabad.

These insurance policies are designed to cover the kind of losses suffered last year by Ramila Patini, who sells okra and tomatoes, bottle gourds, and fresh fenugreek from a cart she has pushed around Ahmedabad for 28 years.

Summers have gotten hotter and longer, she said, especially in the last few years. “But I still have to run my business.”

Last May, on one of the many days the mercury topped 110 F, Patini, 47, passed out and hit her head on the ground. A bystander called an ambulance, which took her to a hospital. “That day my vegetables spoiled, so that was a loss. Plus, I incurred hospital costs — a double loss,” she recalled.

This year 250,000 women bought a policy ahead of the heat season, which peaks in May.

No escape

After a deadly 2010 heatwave, Ahmedabad adopted a heat action plan, the first in South Asia. It encourages public awareness of the dangers, trains doctors to spot heat stroke, and expands supplies of drinking water.

Still, argued one of its authors, Dileep Mavalankar of the Indian Institute of Public Health, “there is gross underreporting of heatwave-related deaths” across India, which might be recorded as heart attacks or other emergencies. “The combination of very high daytime temperature and warm nights kills the most. It is so hot that bats are falling unconscious and dropping out of the trees.”

Researchers are placing heat and humidity sensors in the workplaces and homes of hundreds of local women and monitoring their health with Fitbits and regular checkups.

Data collectors visit participants every two weeks to download data onto a smartphone app.

Initial data from the project is validating concerns about the home environments, which remain hot and humid well into monsoon season.

Initial data from the project — known as “Community Heat Adaptation and Treatment Strategies” — is validating concerns about the home environments, which remain hot and humid well into monsoon season.

“The way homes are designed, they absorb and store a lot of heat,” said Robert Meade, a postdoctoral research fellow with the Salata cluster. “Imagine a street vendor. They go to work in the hottest period of the day. Then they return to overheated homes where they must recover, take care of family, clean — all in an environment that is actually hotter than outdoors and doesn’t get that same nighttime drop in temperatures measured out at the airport weather station.”

An adaptation model

Down a lane wide enough only for pedestrians and mopeds, Karunisha Sheik, 55, works as a seamstress in her one-room home in Ahmedabad.

On the cornflower-blue wall, a white sensor records the humidity and temperature, 24 hours per day, year-round. A thermometer reads 93 F on a March afternoon.

“My neighbors gossip. They say the sensor is a camera, that I am being spied upon. But I know the data is being collected to help us,” says Sheik, describing how it “gets hotter every year, so hot I get too weak to work.”

Without local trust in civil society, the Harvard researchers would not be able to reach so many vulnerable women in India’s poorest neighborhoods, said Buckee, the principal investigator.

“It is extremely difficult to implement this kind of study. You have hundreds of participants, sensors that need to be checked, private data. You have to do lab tests regularly. This level of coordination is simply not possible in most places. It’s possible here because our partners are doing the work and they care about finding the answers,” said Buckee.

The research cluster is now scaling up — expanding to other parts of India, distributing Fitbits and sensors in time for peak heat this year. As they collect empirical observations to inform a ground-up picture of the health risks from climate change, they are pioneering a new type of adaptation model by and for workers.

“We see this as a research platform that our partners themselves can use to test their own adaptations, to decide which work best for them,” Buckee said.


How AI sees war photos

Shorenstein fellow wants to deploy tech to preserve the visual record. An image from the front lines in Iraq provides a test.


Arts & Culture

How AI sees war photos

American soldiers at a raid of a residence in Baghdad, Iraq in 2003.

The 3rd Infantry Division in Baghdad, Iraq, on April 6, 2003.

Photograph by Christopher Morris/VII

6 min read

Shorenstein fellow wants to deploy tech to preserve the visual record. An image from the front lines in Iraq provides a test.

Artificial intelligence is posing threats to photojournalists on issues from copyright to misinformation. But Emmy award-winning visual storyteller Kira Pollack sees potential for the technology to actually help photographers preserve their legacy and create a record of how the world looked before AI. 

Pollack, the Walter Shorenstein Media & Democracy Fellow at the Shorenstein Center on Media, Politics and Public Policy, spoke with the Gazette in this edited conversation. 


You were the creative director at Vanity Fair as AI first entered the mainstream. What were your initial thoughts about AI’s potential to impact photography as a craft and an industry? 

My immediate reaction was that we were entering an entirely new era of image-making — one that posed an existential threat to photography as we know it. On one hand, the sophistication of fabricated images was terrifying; on the other, it promised an explosion of creativity. At Vanity Fair, I was commissioning highly produced fashion images of public figures and gritty journalistic pictures from the front lines. As generative AI tools and large language models began to rapidly evolve, and fake images started circulating widely, alarm bells were sounding across the photojournalism community. In my experience, every time a new technology disrupts photography, the most important thing is to understand it — learn how it works, how it might be harnessed for good, and how to protect against its potential harms.

Your fellowship at the Shorenstein Center is focused on addressing a very specific challenge for photojournalists, so tell me about the problem you identified. 

One of the greatest challenges facing photojournalism today is the fate of its archives. When people hear the word “archive,” they often picture dusty boxes — and their eyes glaze over. But to me, archives are living, breathing bodies of work that tell the visual history of our world. Having been on the front lines of assigning that work — as director of photography at Time, deputy photo editor at The New York Times Magazine, and most recently at Vanity Fair — I know the extraordinary material these archives contain. Over the course of their careers, photojournalists amass hundreds of thousands of images, and I’d estimate that 95 percent have never been seen or published. A finite number of professionals documented the defining events of our time, and their images are often the only visual record we have. Many of the world’s greatest photojournalists are still alive and able to contextualize their life’s work — yet we’re at real risk of losing it.

At a moment when we urgently need to preserve these photographs before the era of AI further distorts our sense of visual truth, we also need to explore how AI itself might help. Can these tools help us catalog, organize, and contextualize this vital work to make it discoverable? Can we do it ethically, without exposing these images to unauthorized training or misuse? What are AI’s shortcomings? That’s the core of my research: how to use AI to help us see — at scale — without compromising the integrity of what we see.

“I want to understand where this technology is headed, where it falls short, and whether it can serve the core values of photography: truth, authorship, and memory.”

How have you started experimenting with this so far? 

Working with photojournalist Christopher Morris and engineer Gregor Hochmuth, we’ve conducted nearly a dozen case studies using images from Morris’ archive. In one study, we selected a range of stories — including the U.S. invasion of Iraq, Jan. 6, and the Yugoslav wars — and asked AI to evaluate the images. While AI can easily identify simple visuals — a cat, a car, a person — the real test is whether it can interpret the layered complexity of conflict photography. In one striking example, the AI analyzed a photo from the U.S. invasion of Iraq and correctly identified the action as a house raid, the setting as a residential building, the make of the soldiers’ guns, and the emotions on the civilians’ faces — using nuanced language like “appears nervous” or “appears apprehensive.” It even assessed the composition, lighting, and symbolism. We were stunned that it could extract such specific and accurate insights with so little context.

We’re also exploring questions of authorship and legacy. Archives should be more immersive and dynamic — there’s a depth of narrative and intent from the photographer that goes far beyond captions or keywords. We’re experimenting with how AI might help bring that storytelling to the surface.

Kira Pollak.

Kira Pollack.

Photo by Peter Hapak

You see a potential for AI to help photographers preserve their vast archives of work. How do you square that use of AI with this other side of the conversation, where there are real concerns about the erosion of trust in what’s real? 

I see these as two distinct conversations with some overlap — like a Venn diagram. One part of the conversation focuses on generative AI’s ability to create photorealistic images without a camera or lens. In today’s relentless breaking news environment, where images spread rapidly on social media without gatekeepers, this can be a dangerous mix that erodes public trust. Another concern is copyright — specifically, the risk of photographers’ work being scraped and used to train AI models without consent. This raises urgent questions about ownership, authorship, and protection.

The work I’m doing exists in a third circle of that Venn diagram. It’s about using AI not to generate or exploit images, but to preserve, organize, and surface real photojournalism. These archives are vast, often inaccessible, and under threat — both physically and digitally. I’m exploring whether AI can help responsibly unlock this material at scale, while safeguarding the photographer’s intent, rights, and legacy. It’s about using the technology to reinforce visual truth — not replace it.

What are your hopes for the Shorenstein Fellowship?

My hope is to use this time not just to examine the technology itself, but to engage deeply with the larger questions it raises for photography and journalism. What makes the Shorenstein Center so unique is the opportunity to be in dialogue with people across disciplines — technologists, ethicists, journalists, policymakers — who are thinking critically about the future and the values we carry forward.

I’m not coming to this work as a technologist. I come from journalism, having worked closely with photojournalists around the world and led teams that helped shape how the public sees history as it unfolds. Rather than getting swept up in the momentum of the tech world, I want to understand where this technology is headed, where it falls short, and whether it can serve the core values of photography: truth, authorship, and memory. Ultimately, I hope to bring these insights back to the photojournalism community — to help ensure we’re not just reacting to change but helping to shape it.


Worth the grind

Hard work of securing a federal grant pays off for researchers: ‘It means you can do something to try to help people.’


Health

Worth the grind

Karen Emmons and Jorge Chavarro.

Karen Emmons studies strategies to reduce cancer risk and Jorge Chavarro conducts research on nutrition and human reproduction.

Photos by Veasey Conway/Harvard Staff Photographer and via AP; photo illustration by Liz Zonarich/Harvard Staff

5 min read

Hard work of securing a federal grant pays off for researchers: ‘It means you can do something to try to help people.’

For public health researchers, getting a federal grant is a big deal. 

More than 30 years later, Karen Emmons hasn’t forgotten her first one. She was an assistant professor in Brown University’s Department of Psychiatry when the letter came in the mail on green carbon-copy paper that was so smudged she could barely read it. Now a professor of social and behavioral sciences at the Harvard T.H. Chan School of Public Health, she still has that faded piece of green paper.

“You go into science because you want to make a difference, and when you get a grant, it means you can do something to try to help people,” Emmons said. “It just has so much meaning.” 

Those meaningful moments are now under threat. The Trump administration has frozen more than $2.2 billion in research grants to Harvard, halting studies with implications for neurogenerative disease, tuberculosis, and other conditions. The government’s move came after Harvard rejected White House demands for viewpoint “audits” of students and faculty, hiring changes, and other measures. Last week, the University filed suit against the administration.

The halt to funding disrupts a process that researchers say is appropriately competitive considering the stakes of their primary goal: advances in science and human health.

Jorge Chavarro, a professor of nutrition and epidemiology at the Chan School, understands the challenges from both sides. He applies for grants for his research on nutrition and human reproduction, and he’s served for about a decade on a scientific review group, also called a study section, evaluating other investigators’ proposals. 

“The NIH really does everything it can to ensure there is an absolutely fair review process for every single application,” he said. 

“You can’t just say, ‘I have this idea, please give me grant money.’”

For Emmons, who studies strategies to reduce cancer risk in under-resourced communities, the work begins long before the application is written. It includes building relationships with community partners, staying up to date on what’s been published in her field, and networking with other researchers to gain a sense of what’s coming next.

“You don’t want to do things that somebody’s already doing,” she said. “You want to take things in a new direction.”

Then you have to test the idea. The NIH requires evidence that the research is not just innovative but grounded in evidence.

“You can’t just say, ‘I have this idea, please give me grant money,’” Emmons said. 

It could take another six months to write the application, which begins with a one-page statement, known in NIH lingo as specific aims, explaining how the study fills existing gaps, the impact it could have, and the methods investigators will use. After the aims page comes the full application, which can stretch to more than 100 pages once you add in the 12 pages of detailed science and all the required administrative documentation, Chavarro said. It includes dense summaries of previous work, results from preliminary research, detailed descriptions of methodology, and a biosketch, a kind of academic CV. For Emmons, who works with human participants, there are also lengthy requirements for ensuring the ethical treatment of her subjects. And of course, there’s the budget. 

The cost of doing innovative research has grown faster than the average size of a typical grant, Chavarro said, effectively requiring scientists to be more innovative with the same amount of money. So every line in the budget must be justified. “Why is it important to buy a new piece of equipment that you don’t have?” he said. “Why do you need money for tubes or pipettes, liquid nitrogen?” 

Once submitted, applications are assigned to Scientific Review Groups made up of volunteer scientists who can judge the research on its merits. Study sections score proposals against one another for their innovation, significance, and approach. Then, advisory councils for each institute perform a second-level review to determine whether the studies fit with the missions of their organizations. The two reviews are aligned, and only the top projects receive funding. 

Success varies by institute, but at the National Cancer Institute, where Emmons submits most of her applications, there was a 14.6 percent success rate for the most common type of grant, the R01, in 2023, the most recent data available. That means for all the months or years of preparation, the pilot studies, the partnership-building, the haggling over budget lines, only one in six proposals will be funded. Researchers whose proposals aren’t funded have a chance to incorporate feedback and resubmit.

Both Chavarro and Emmons accept that the process can be frustratingly slow. The meticulousness of the approach, they say, is part of what makes it exceptional. Emmons pointed to the decadeslong public-private partnership between universities and the government as a shared commitment to science as a public good. 

“Early on, the government realized it benefits society and it benefits the government: It keeps people healthier, it gives people access to lifesaving treatments, and it reduces the cost of taking care of people when they’re ill,” she said. “It’s just what the government should be doing: It should be helping people.”


Rick Scott argues tariffs will level playing field, help U.S. workers

Republican senator also views China as nation’s most concerning competitor


Work & Economy

Rick Scott argues tariffs will level playing field, help U.S. workers

Jason Furman (left) and Rick Scott.

Jason Furman (left) and Sen. Rick Scott at the JFK Jr. Forum.

Niles Singer/Harvard Staff Photographer

3 min read

Republican senator also views China as nation’s most concerning competitor

Republican Senator Rick Scott defended the Trump administration’s tariff strategy as a way to press other nations to drop their own levies on American products during a recent conversation with Jason Furman, Aetna Professor of the Practice of Economic Policy.

“What [President] Trump is saying is that the American worker is not going to be disadvantaged any longer,” said Scott. “My approach would be I want the American worker to sell more stuff. So, lower your tariffs, lower your barriers, get rid of all of it.”

The government announced a sweeping series of tariffs on most of the nations in the world in early April as part of an attempt to reshape decades of U.S. trade policy. The move has triggered volatility in global stock markets and is being blamed, in part, for a sharp contraction in first quarter gross domestic product.

At the April 13 event hosted by the JFK Jr. Forum at the Institute of Politics, Furman asked Scott whether he thought the White House could have pursued negotiations with trading partners instead of imposing tariffs unilaterally. It could have prevented fears of an economic downturn that wiped $6 trillion off the stock market, said Furman.

Scott said American workers ultimately will benefit from Trump’s tariffs.

“I want American workers to sell their stuff. Don’t put any barrier on us, we won’t put any barriers on your country’s workers … I don’t know if it’s better to do a big deal like that or individual deals, but I would make it as simple as that,” said Scott, a longtime Trump ally who was governor of Florida from 2011 to 2019.

“My belief is that we should do no trade with China. The only way we don’t go to war with China is if their economy is demolished.”

Sen. Rick Scott

Trump has said tariffs could help close trade deficits and help U.S. manufacturers and workers, but many economists disagree. In a New York Times column, Furman said that Trump’s tariffs would hurt the U.S. economy.

The conversation touched on a wide range of topics, from tariffs to China to debt and executive power. Scott saved his most pointed criticism for China, a country whose economic and political power is more concerning to him than that of Russia.

“My belief is that we should do no trade with China,” said Scott. “The only way we don’t go to war with China is if their economy is demolished.”

The government levied a 10 percent tariff rate on most nations with the exception of China, which now faces a rate of 145 percent. In retaliation, China imposed a 125 percent tariff on U.S. imports.

When asked about the national debt, which the nonpartisan Congressional Budget Office projects will be about $20 trillion over the next decade, Scott suggested that a balanced budget and reduced spending are necessary to help improve the nation’s fiscal outlook.

As for his view on whether tariffs will lead to inflation, Scott said he is not sure.

“I don’t know what the tariffs will do to inflation,” he said. “I think inflation will only get under control if we balance the budget. We’ll see what the tariffs do.”


‘Devastating’ global health void, Gawande says

Surgeon-author speaks from his experience as a leader at USAID before it was gutted


Health

‘Devastating’ global health void, Gawande says

Surgeon-author speaks from his experience as a leader at USAID before it was gutted

4 min read
Atul Gawande speaking with Marcia Castro.

Atul Gawande with Marcia Castro.

Niles Singer/Harvard Staff Photographer

Surgeon and best-selling author Atul Gawande on Monday provided a close-up account of the damage inflicted by the Trump administration’s dismantling of the U.S. Agency for International Development, but with a note of encouragement to students and faculty to stay committed to science and medicine.

Gawande, a surgeon at Brigham and Women’s Hospital and faculty member at the Harvard T.H. Chan School of Public Health and the Medical School, took leave from the University in 2021 after President Joe Biden nominated him to head USAID’s Bureau for Global Health, a post he called “the best job in medicine that you’ve likely never heard of.” He stepped down at the end of Biden’s term.

“USAID cannot be restored to what it was, but it is not too late to save our health and science infrastructure and our talent.”

Atul Gawande

The firing of nearly all USAID staff and the termination of more than 85 percent of its programs have caused “devastating” damage to millions of people and to the U.S. as a global health leader, he said.

“What I know now, three months from when I departed my role at USAID, is USAID cannot be restored to what it was, but it is not too late to save our health and science infrastructure and our talent,” he said during a conversation with Marcia de Castro, Andelot Professor of Demography at the Chan School. “And it’s not too late to stop the destruction.”

Referencing recent government actions halting Harvard research funding, he added: “I’ve returned to this community as it’s come under attack.”

Under threat, he noted, are federal programs supporting health and science, including at the National Institutes of Health and Centers for Disease Control, and partnerships with universities and medical centers. The funding freeze has hit Ariadne Labs, a Harvard- and Brigham and Women’s-affiliated research center Gawande founded in 2012, endangering research and testing related to surgery, childbirth, and primary care, he said.

Recalling his time with USAID, Gawande said that the agency, working with half the budget of a typical Boston hospital, built a 50-country network to surveil deadly diseases like Ebola and bird flu faster than ever before, cutting emergency response time to global outbreaks from more than two weeks to less than 48 hours. Programs to prevent maternal and childhood deaths, which reached 93 million women and children under 5, added six years to their life spans, he said, while support for programs to prevent and treat HIV, tuberculosis, and malaria dramatically improved outcomes for tens of millions of people. Before he stepped down, USAID was preparing to scale up a novel and inexpensive treatment package to reduce severe hemorrhaging after childbirth, the leading cause of maternal deaths.

Most countries USAID was assisting still have six- to nine-month stocks of medications; it’s the immediate cuts to staffing and services that will now affect health outcomes most acutely, said Gawande, who is this year’s Harvard Alumni Day speaker.

“It’s not just having a solution; it’s the follow-through,” he said. “So much of the power of what USAID does, that I see [the World Health Organization] doing as well, is the technical assistance that gets you from 60 percent vaccination to 80 percent and then to 90 percent vaccination.”

Gawande, who in addition to his work in a medicine is a New Yorker staff writer and the author of several books, maintained that he’s “hopeful” about global health in the long run. Still, he said, “As an American, one of the things I’m quite uncertain about is whether America is going to be part of leading and part of the solution any time soon.”

But if the U.S. is no longer going to take a leading role in global health, he said, other countries and individuals will almost certainly emerge to take the reins — along with leaders in Massachusetts and other states.

Whatever happens in the near term, the work of global health remains vital, he told students.

“You and your expertise will be needed no matter what,” he said.


More proof that money isn’t everything

Major global study of flourishing ranks wealthy, lower-income nations, reinforces concerns over well-being among youth


Health

More proof that money isn’t everything

Tyler VanderWeele.

“It raises important questions with regard to whether we are investing enough in our youth,” said Tyler VanderWeele about findings from a new study he led on global well-being.

File photo by Niles Singer/Harvard Staff Photographer

6 min read

Major global study of flourishing ranks wealthy, lower-income nations, reinforces concerns over well-being among youth

A major global study of human flourishing reinforces prior warnings about the lack of well-being among youth, particularly in the U.S., and highlights the adage that money isn’t everything, with middle-income — not wealthy — countries topping a ranking of 22 nations.

“It raises important questions with regard to whether we are investing enough in our youth,” said Tyler VanderWeele, the John L. Loeb and Frances Lehman Loeb Professor of Epidemiology at the Harvard T.H. Chan School of Public Health and one of the study’s lead authors. “Patterns around the world are complex, but in many countries — especially Western countries — this pattern is real.”

The results stem from a huge trove of data gathered by The Global Flourishing Study, a major investigation into individual well-being within specific communities and environments. The survey enrolled about 203,000 people speaking 40 languages and spanning an array of nations, cultures, histories, and economic circumstances. Launched in 2021, the study was conducted on all six inhabited continents and represents about 64 percent of the world’s population, organizers said during a media briefing Monday.

The study’s data allow for comparison across and within nations. Respondents were asked questions about seven variables that together define “flourishing” — health, happiness, meaning, character, relationships, financial security, and spiritual well-being.

It also gathered demographic data such as age, sex, marital and employment status, education, health, religious service attendance, and information about personal history, specifically childhood, including family financial circumstances and exposure to abuse.

VanderWeele called the findings on youth flourishing “troubling.” He said they bear out other recent findings that point to change.

Formerly, a typical life pattern of flourishing looked like a U-shaped curve, with satisfaction highest early and late in life. The lowest point came during the middle years when the pressures of raising children, meeting work expectations, and caring for aging parents come to bear.

It has now shifted to something like a J-shape, with measures of flourishing turning nearly flat from the late teens into the 20s before rising later in life. That pattern was seen in several nations, VanderWeele said, but the U.S. had one of the steepest gradients between flourishing levels of its youth and older adults.

“It’s pretty striking,” said VanderWeele, who is also director of the Human Flourishing Program at Harvard’s Institute for Quantitative Social Science. “It’s real cause for concern.”

The study, published in the journal Nature Mental Health and sponsored by eight private foundations, was led by researchers at Harvard and Baylor universities and included colleagues from 21 institutions, including universities in the U.S., Germany, Poland, Spain, Canada, and the U.K., as well as the Gallup polling firm.

VanderWeele said the national ranking data was the study’s biggest surprise, offering strong evidence that financial circumstances alone don’t guarantee flourishing. The study surveyed 22 countries and one territory (Hong Kong) that organizers said span an array of cultures, races, economic circumstances, and living conditions.

A ranking without financial indicators put Indonesia at the top, followed by Mexico, the Philippines, Israel, and Nigeria. The U.S. was 15th on that list. Adding financial indicators reordered the list slightly, with Israel and Mexico switching places, and Poland moving into the top 5, bumping Nigeria down. The U.S. moved up to 12th in that ranking. Last on both lists, however, was Japan.

Brendan Case, associate director for research at the Human Flourishing Program and a paper author, said the national rankings call into question prevailing models of economic development that raise as examples nations such as Japan — whose rapid post-World War II modernization made it a global industrial power. That contrasts with Indonesia, a nation often cited as an example of the “middle-income trap” where developing nations’ initial economic progress turns to long-term stagnation.

While Japan is wealthier and its people live longer, respondents there were the least likely to answer “yes” to a question asking whether they had an intimate friend, Case said. Indonesia, meanwhile, ranked higher in measures of relationships and pro-social character traits, which foster social connections and community.

“We’re not here to say those outcomes [wealth, longer lifespans] don’t matter a lot, or that we shouldn’t care about democracy, we shouldn’t care about economic growth, we shouldn’t care about public health,” Case said, “but it’s interesting to consider that the Global Flourishing Study raises some important questions about the potential tradeoffs involved in that process.”

While many of the survey’s broader trends masked significant variability, there were a few findings that were nearly universal. Having good maternal and paternal relationships as a child and excellent childhood health were universally associated with higher adult flourishing.

Weekly or more frequent attendance at religious services also was nearly universally associated with adult flourishing. Authors said the salutary effect of religious participation tracks with previous studies in the West and now has been documented globally.

“The results also raise important questions for the future progress of society,” the authors wrote. “Are we sufficiently investing in the future given the notable flourishing-age gradient with the youngest groups often faring the most poorly? Can we carry out economic development in ways that do not compromise meaning and purpose and relationships and character, given that many economically developed nations are not faring as well on these measures? With economic development and secularization, have we sometimes been neglecting, or even suppressing, powerful spiritual pathways to flourishing?”

Researchers said the dataset is enormous — it’s the result of what are essentially 23 separate national or territorial longitudinal studies — and contains many interesting patterns, more of which will emerge with additional analysis. It also extends globally the investigation into human flourishing, which has been mainly focused on populations in the West.

“Each country is a unique place, and we’re keen to study and understand that,” said Tim Lomas, a research scientist in epidemiology at the Harvard Chan School and at the Human Flourishing Program and a paper author.

Some of the questions raised by the survey may be answered as additional data is collected, Case said. The study, which resulted from a Harvard conference six years ago, is longitudinal, so researchers will resurvey respondents annually, with additional analyses planned to be released over the next five years.

“If society is to ultimately flourish,” the authors wrote, “these questions of age, and of development, and of spiritual dynamics need to be taken into consideration.”  


Fighting Alzheimer’s one discovery at a time

‘I was just following the science.’


Beth Stevens.

Photo by Michael Goderre/Boston Children’s Hospital

Health

Protecting the brain requires persistence

Beth Stevens, NIH-supported investigator of Alzheimer’s and other disorders, explains how one discovery can lead to another

3 min read

In efforts to fight Alzheimer’s disease, neuroscientist Beth Stevens has driven a transformation in thinking about microglial cells, which serve as an immune system for the brain.

Microglia patrol the brain for signs of illness or injury, helping clear out dead or damaged cells and selectively pruning synapses, which transmit information among neurons. Sometimes the process takes a dangerous wrong turn.

The Stevens Lab, based at Boston Children’s Hospital and the Broad Institute of MIT and Harvard, has demonstrated that aberrant pruning can contribute to Alzheimer’s disease, Huntington’s disease, and other disorders.

The work has created a foundation for new biomarkers and medicines to detect and treat neurodegenerative disease. It has the potential to affect care for the estimated 7 million Americans living with Alzheimer’s, which is incurable.

“We would never have been able to move forward without the basic science and curiosity-driven science from the beginning.” 

When she was starting out, in the early 2000s, Stevens, now an associate professor of neurology at Harvard Medical School, had no idea where her curiosity would take her.

“I was just following the science,” she said. “It was this interesting new area where the brain’s immune system was helping to sculpt synapses and circuits under normal development.”

She had a hunch about synaptic pruning — and she was right. Vital support from federal agencies helped her follow through.

“The foundation of our research, from the time I was a postdoc to the first decade of my lab, was almost entirely driven by the National Institutes of Health and other federal funding,” she said.

That foundational research doesn’t always have a clear outcome, noted Stevens, who was named a MacArthur “genius” for her work on microglia in 2015. “Someone that doesn’t think about disease implications might say, ‘Oh, Stevens Lab is studying the visual system of a mouse. They’re trying to understand how a mouse’s visual system wires up.’ It can seem like that’s so far from ever translating into anything. Who cares how a mouse might see?”

But these studies allow scientists to explore questions they couldn’t in humans, she noted — which leads to new discoveries, which lead to new understandings of disease, which lead to treatments that improve human lives. 

“Our microglial research,” Stevens said, “is a great example of an immune-related pathway and cell type that we would never have been able to move forward without the basic science and curiosity-driven science from the beginning.” 


Four awarded Harvard Medal for exceptional service

To be honored on June 6 marking Alumni Day


Campus & Community

Four awarded Harvard Medal for exceptional service

A veritas shield hangs above the entrance to Memorial Church in Harvard Yard.

A veritas shield hangs above the entrance to Memorial Church in Harvard Yard.

File photo by Stephanie Mitchell/Harvard Staff Photographer

7 min read

To be honored on June 6 marking Alumni Day

A collection of stories covering Harvard University’s 374th Commencement.

The Harvard Alumni Association (HAA) has announced that Kathy Delaney-Smith, Paul J. Finnegan ’75, M.B.A. ’82, Carolyn Hughes ’54, and David Johnston ’63 will receive the 2025 Harvard Medal.

First awarded in 1981, the Harvard Medal recognizes extraordinary service to the University in areas that include leadership, fundraising, teaching, innovation, administration, and volunteerism. Alumni, former faculty and staff, and members of organizations affiliated with the University are eligible for consideration. The medals will be presented to recipients on Harvard Alumni Day on June 6.

Kathy Delaney-Smith
Photo by Cheryl Clegg

Kathy Delaney-Smith

The all-time winningest coach of any sport — men’s or women’s — in Ivy League history and a trailblazer for gender equity, Kathy Delaney-Smith put Harvard basketball on the map and expanded its profile both nationally and internationally.

With 630 career victories, Delaney-Smith led Harvard Women’s Basketball to 11 Ivy League titles and 16 postseason appearances during her 40 seasons with the Crimson — the second-longest coaching tenure among NCAA Division 1 coaches. In honor of her illustrious career, the women’s coaching position was renamed the Kathy Delaney-Smith Head Coach for Harvard Women’s Basketball upon her retirement.

The first woman named to the Massachusetts Basketball Coaches Hall of Fame, Delaney-Smith has been honored for both her coaching abilities and her advocacy for gender equity in sports. 

Her strong but caring coaching style was defined by her “act as if” mantra, which encouraged team members to carry themselves with the confidence of already having achieved their goals. She employed visualization, mindfulness, and sports psychology decades before they became commonplace, and throughout her long career has guided players through difficult experiences off the court. At the request of basketball alumnae, she wrote the book “Grit and Wit: Empowering Lives and Leaders,” published earlier this year.  

Delaney-Smith came to Harvard in 1982 after compiling a 204–31 record at Westwood (Massachusetts) High School, with six undefeated regular seasons and one state title. During her tenure at Westwood, she worked to ensure that the girls’ team had sufficient resources. She also coached USA Women’s Basketball three times, including the team that won gold at the World University Games in Turkey in 2005.

A cancer survivor, Delaney-Smith has dedicated much of her time to helping the American Cancer Society and spreading the word of early detection, for which she received the Gilda Radner Award. 


Paul J. Finnegan.

Paul J. Finnegan

Paul Finnegan has been a devoted and dynamic champion of Harvard for over 40 years, lending his expertise and steady voice to top leadership roles, including Harvard Corporation member, University treasurer, Harvard Overseer, chair of the Harvard Management Company, and HAA president. Guided by his passion for education and love for his alma mater, Finnegan has worked tirelessly to strengthen the University’s financial health, governance, and educational mission.

Finnegan was a member of the Harvard Corporation, the University’s senior governing board, for 12 years. From 2014 to 2023, he served as University treasurer, where his financial acumen and deep institutional knowledge informed the work of the University’s financial administration and guided major changes at Harvard Management Company, which he chaired from 2015 to 2024. 

Finnegan was also a driving force behind The Harvard Campaign, planning and leading fundraising efforts as executive committee co-chair to raise a remarkable $9.6 billion — making it the most successful fundraising campaign in the history of higher education when it concluded in 2017.

A collegial leader admired for his down-to-earth nature and ability to see opportunities within challenges, Finnegan served from 2008 to 2012 as an elected member of the Harvard Board of Overseers, where he chaired the committee on finance, administration, and management. As HAA president from 2006 to 2007, he enhanced alumni communications systems and expanded global outreach.

Through the decades Finnegan has been closely involved with several Harvard Schools, serving on Harvard Business School’s Board of Dean’s Advisors, Harvard T.H. Chan School of Public Health’s Leadership Council, as honorary co-chair of the Harvard Graduate School of Education’s campaign, and the Faculty of Arts and Sciences’ Dean’s Council, where he spurred meaningful improvements to the undergraduate experience.

A member of the Committee on University Resources, Finnegan was chair of the HBS Fund and of the College Class of 1975 reunion committee. He is a longtime supporter of Teach for America.


Carolyn Hughes.
Rocco Chilelli/Camelot Photography Studios LLC

Carolyn Hughes

Motivated by a passion for education and a commitment to helping future generations of talented students attend Harvard, Carolyn Hughes has been a loyal and celebrated Harvard volunteer and ambassador for nearly 50 years, interviewing countless high school students and engaging alumni through her leadership of the Harvard Club of Long Island.

Hughes grew up in Boston’s Allston neighborhood, the daughter of a prison guard and a homemaker. Though she had not planned to attend college, an eighth-grade teacher insisted she take the academic program and be prepared. Four years later she was admitted to Radcliffe and given partial funding through her high school. Research work on the melting icebergs in the Arctic Ocean paid for the rest. After Radcliffe, she moved to New York and taught herself computer science and systems design, joining the first cohort of women in the field.

Never forgetting the tremendous opportunities Radcliffe provided, Hughes began volunteering in the late 1960s, interviewing college applicants as a member of the Radcliffe Club of Long Island — before it eventually merged with Harvard — and personally visiting 120 of the area’s high schools. In the five decades since, Hughes has served as an HAA director for Clubs and SIGs, an elected director of the HAA, and chair of the National Schools and Scholarship Committee within the Harvard College Admissions Office.

With unwavering dedication, she has held nearly every leadership position in the Harvard Club of Long Island, including president, helping to develop robust programming and outreach. As chair of the Long Island Schools Committee, her role expanded to training Harvard interviewers and organizing guidance counselor programs. She now serves as co-chair emerita of the Club’s Schools and Scholarship Committee.

Hughes has received numerous commendations, including the HAA Award in 1990, the Hiram S. Hunn Award in 2002, and the HAA Clubs Award in 2020.


David Johnston.
Credit: Sgt. Ronald Duchesne, Rideau Hall, OSGG

David Johnston

The 28th governor general of Canada, a former university president, and a professor of law for more than four decades, David Johnston has dedicated his life in service to his country, to academia, and to Harvard — where he brought his strength as a consensus-builder and commitment to excellence to a variety of roles, including president of the University’s Board of Overseers.

Growing up in a mining town outside Sudbury, Ontario, Johnston quickly learned that an education could open many doors. He was first approached by Harvard at age 14 on the advice of an alumnus who had heard he was a promising scholar-athlete. Johnston enrolled in the College in 1959 on a scholarship, excelling in his studies while also becoming a two-time All-American ice hockey player. He graduated magna cum laude and was later named to the Harvard Varsity Club Hall of Fame.

Dedicated to ensuring talented students from all backgrounds have access to the same opportunities that Harvard afforded him, Johnston has been a steadfast volunteer, serving on his class reunion and gift committees for decades, as an HAA elected director, and on several Overseers visiting committees — including athletics; arts and humanities; finance, administration, and management; and information technology.

Elected to the Board of Overseers in 1992, Johnston was named chair in 1997 — the first non-U.S. citizen to hold the position. In recognition of his service to the University, the Harvard Club of Ottawa established the David Johnston Financial Aid Fund for Harvard, which supports students from Canada. 

Johnston was Canada’s governor general from 2010 to 2017. He also served as dean of the faculty of law at the University of Western Ontario, principal and vice-chancellor of McGill University, and president of the University of Waterloo.

Married 61 years, Johnston and wife, Sharon, have five daughters, all in public service, and 14 grandchildren.


Garber announces new initiatives to fight antisemitism, anti-Israeli bias

Actions come as task force releases full report


Campus & Community

Garber announces new initiatives to fight antisemitism, anti-Israeli bias

Jared Ellias and Derek Penslar.

Co-chairs for the Task Force on Combating Antisemitism and Anti-Israeli Bias Jared Ellias (left) and Derek Penslar.

Photos by Niles Singer/Harvard Staff Photographer

long read

Actions come as task force releases full report

Harvard University will build upon its previous work, as well as launch new initiatives and actions, to combat antisemitism and anti-Israeli bias, President Alan M. Garber announced on Tuesday. The actions laid out by Garber come in conjunction with the release of the final report and recommendations from the Presidential Task Force on Combating Antisemitism and Anti-Israeli Bias.

In his community message, Garber thanked the members of the task force “for pursuing their work with a spirit of openness, empathy, and compassion during a period of unrest within our community,” noting that their report is “the product of strenuous, prolonged efforts by some of the most generous and dedicated citizens of our University.”

The actions announced by Garber focus on three main areas: nurturing a widespread sense of belonging and promoting respectful dialogue; revising and implementing policies, procedures, and training; and strengthening academic and residential life. Building upon work the University has done over the last 15 months, the new actions include launching a major initiative to promote viewpoint diversity; dedicating resources to the creation of a research project focused on antisemitism; further review of disciplinary policies and procedures to assess their effectiveness and efficiency; and the expansion of resources to directly support students who experience antisemitism and other forms of discrimination.

Harvard’s Schools are actively reviewing task force recommendations concerning admissions, appointments, curriculum, and orientation and training programs, including those organized by recognized student groups. Deans will work to strengthen existing academic review processes for courses and curricula to ensure that they uphold the highest standards of academic excellence and intellectual rigor. Action plans designed for the College, the Graduate School of Arts and Sciences, and each professional School will be shared with the president’s office by the end of the spring term.

“The scope of recommendations made by both task forces underscores the breadth of the challenges we face. They must be addressed with determination at every level of the University by effectively tackling issues that arise where our students congregate or live; ensuring that expectations for both students and teachers in the classroom are clearly communicated and met; nurturing vibrant debate and open speech in ways that encourage everyone to express their ideas freely; preserving the right to protest and dissent while avoiding disruption, harassment, and threats; and, when our policies are violated, ensuring that our disciplinary processes are fair, consistent, and effective. If we intend to make significant and durable change across Harvard, it is critical that we act decisively in each of these areas,” Garber wrote in his message.

The release of the task force’s report and recommendations caps off an effort that began in spring 2024 to document the experiences of Jewish and Israeli students, faculty, and staff on campus.

Through a series of listening sessions, as well as an online survey last spring and summer, the task force gathered extensive feedback from students, faculty, staff, and alumni. Members were not charged with investigating the reports they heard, though participants were advised of University policies under which they could file formal complaints. Stories are described in the report as they were heard. The task force also completed a comprehensive historical analysis of the Jewish experience at Harvard from the 1920s to present. 

The report includes findings and a set of recommendations designed to address antisemitism and anti-Israeli bias across the University. By reviewing concerns about select courses, events, and programs, the report also identifies specific areas where the task force feels the University can improve its approach to teaching about Israel and Palestine and to ensuring that all students feel free to express their opinions without fear or reservation.

Research and findings

The task force, whose members were appointed in late February 2024, began their work by hosting in March and April 2024 a series of listening sessions with students, staff, and faculty. Nearly 50 sessions were held with about 500 participants. Following the listening sessions, the Task Force on Combating Antisemitism and Anti-Israeli Bias joined with the Task Force on Combating Anti-Muslim, Anti-Arab, and Anti-Palestinian Bias in jointly issuing a University-wide survey.

From those who attended the listening sessions, several themes emerged related to the Jewish and Israeli experience on campus. Most notable was the deterioration of the campus climate after the terrorist attack on Oct. 7, 2023. Jewish students in general, and those who identify as Zionist in particular, felt that the climate had become less welcoming, even leading some to conceal their religious identity. Feelings of rejection and marginalization were common among Israeli students.

“The listening sessions provided a window into the real-time experience of Jewish students on campus, both inside the classroom and within the larger campus community,” said Jared Ellias, task force co-chair and the Scott C. Collins Professor of Law at Harvard Law School. “While specific incidents of antisemitism are of significant concern, there is also this larger issue of Jewish students feeling less of a sense of belonging at Harvard and less comfortable expressing their true selves and true identities.

The task force further explored programs, events, and courses at specific Schools that were perceived to be unbalanced in their approach to Israel and Palestine. In the report, task force members signal concern about these offerings and whether they are consistent with Harvard’s standards for excellence and academic integrity. The authors also argue that perceived bias in academic settings directly impacts the sense of belonging Jewish and Israeli students feel on campus. 

The online survey of the Harvard community indicated that, across nearly every category, Jewish student respondents reported greater levels of discomfort and alienation than their Christian or atheist/agnostic peers. Though the number of individuals responding to the survey was not as high as similar University-wide surveys, the data allowed for a meaningful examination of the differences in responses by subgroup. Of the 2,295 respondents, 477 identified as Jewish. Jewish student respondents reported higher levels of concern about their physical and mental safety. They were also more likely to feel uncomfortable expressing their opinions and, in particular, their political opinions.

“Harvard makes a point of recruiting amazing students, staff, and faculty from all over the country and the world, and our work suggests that at some point in the recent past we stopped looking for ways to connect with one another as Harvard community members and started focusing on the issues that divide us,” Ellias said. “All the faculty on the task force were very surprised at how much student life had changed since we were college students.” 

Many student respondents expressed concern about the University’s response to incidents of bias and were critical of both policies and the timeliness of responses. These concerns and experiences were exacerbated by what they saw from their classmates and, in some cases, teachers, on social media, which often served to amplify hostility and hateful rhetoric.

In addition to the qualitative and quantitative findings, the Task Force on Combating Antisemitism and Anti-Israeli Bias conducted a historical analysis of the Jewish experience at Harvard. This experience, the authors say, has been shaped by both the number of Jewish students on campus and the influence of world events on dialogue, discussion, and activism. The report finds the decline of respectful engagement regarding Israel and Palestine to be deeply troublesome and a significant contributing factor to the current campus climate. 

“The historical analysis provided us with a unique lens into how the Jewish experience at Harvard has changed over time,” said Derek Penslar, co-chair of the task force and the William Lee Frost Professor of Jewish History in the Faculty of Arts and Sciences. “It is clear that world events have often influenced campus events and activities. However, it also became clear that civil discourse on the issue of Israel and Palestine has declined over time, signaling to the faculty that we must help our students learn to engage with each other in respectful ways even when we disagree.” 

Final recommendations

In June 2024, the task force issued a set of preliminary recommendations that identified near-term opportunities to address areas of concern prior to the 2024-25 academic year. Those recommendations asked leadership to clarify University values; act against discrimination, bullying, harassment, and hate; improve student disciplinary processes; implement antisemitism and anti-Israeli bias education and training; foster constructive dialogue; and support Jewish life on campus.

The University rolled out a series of changes, including new campus and protest rules; centralized fact-finding in discipline cases across Schools; new training opportunities for faculty, staff, and students on identifying and preventing antisemitism; and new initiatives in the Schools for constructive dialogue and disagreement across differences.

In the final report, the task force has expanded upon these preliminary recommendations. The final recommendations fall into the following categories: 

Admissions and early student experiences: The task force recommends a focus on attracting and admitting students who are eager to contribute to a learning community that is grounded in open inquiry and mutual respect. The report adds that once on campus, the University should ensure that these values and aspirations are emphasized in early student experiences.

Academics and academic offerings: The task force calls for the University to strive to ensure a classroom experience that is free from antisemitism, anti-Israeli bias, and all forms of discrimination. Moreover, the report recommends that the University’s academic offerings should include significantly more plentiful and diverse opportunities for the study of Jewish civilization, antisemitism and the Holocaust, Israel, and the Israeli-Palestinian conflict. 

Co-curricular activities and residential life and pluralism: The task force recommends providing student organizations with support and guidance to ensure that their activities do not have antisemitic or anti-Israeli impacts, so that their activities enhance the Harvard learning community. According to the task force, this recommendation goes hand in hand with building a pluralistic community in which students can express diverse opinions and viewpoints. 

Religious life: The task force recommends steps to strengthen religious life on campus, better supporting Jewish students and students of all faiths.

Administrative infrastructure and complaint mechanisms: The task force recommends a robust administrative infrastructure to support and coordinate efforts. This recommendation includes efforts to strengthen complaint mechanisms and to develop equitable disciplinary procedures across Schools.

Oversight: The task force calls for changes related to governance issues to strengthen ladder faculty oversight of educational programs and instructor training across Schools. 


Read the full report of the Task Force on Combating Antisemitism and Anti-Israeli Bias, as well as President Garber’s message about the new University action plan and more information on the action steps Harvard has taken to respond to the concerns, information, and recommendations shared by the task force. 


Garber announces new steps to combat bias against Arabs, Muslims, and Palestinians

Moves come amid release of final report from Task Force on Combating Anti-Muslim, Anti-Arab, and Anti-Palestinian Bias


Campus & Community

Garber announces new steps to combat bias against Arabs, Muslims, and Palestinians

Wafaie Fawzi, and Asim Ijaz Khwaja.

Co-chairs for the Task Force on Combating Anti-Muslim, Anti-Arab, and Anti-Palestinian Bias Wafaie Fawzi (left) and Asim Ijaz Khwaja.

Photos by Niles Singer/Harvard Staff Photographer

long read

Moves come amid release of final report from task force

President Alan M. Garber announced new actions and initiatives the University is undertaking in conjunction with the release Tuesday of the final report from the Presidential Task Force on Combating Anti-Muslim, Anti-Arab, and Anti-Palestinian Bias.

In his community message, Garber thanked the members of the task force “for pursuing their work with a spirit of openness, empathy, and compassion during a period of unrest within our community,” noting that their report is “the product of strenuous, prolonged efforts by some of the most generous and dedicated citizens of our University.”

The actions Garber announced focus on three main areas: nurturing a widespread sense of belonging and promoting respectful dialogue; revising and implementing policies, procedures, and training; and strengthening academic and residential life. Building upon work the University has done over the last 15 months, the new actions include launching a major initiative to promote viewpoint diversity; undertaking a comprehensive historical overview of Muslims, Arabs, and Palestinians at the University; and further review of disciplinary policies and procedures to assess their effectiveness in ensuring that every member of the community feels supported.

Harvard’s Schools are actively reviewing task force recommendations concerning admissions, appointments, curriculum, and orientation and training programs, including those organized by recognized student groups. Deans will work to strengthen existing academic review processes for courses and curricula to ensure they uphold the highest standards of academic excellence and intellectual rigor. Action plans designed for the College, the Graduate School of Arts and Sciences, and each professional school will be shared with the president’s office by the end of the spring term.

“The scope of recommendations made by both task forces underscores the breadth of the challenges we face. They must be addressed with determination at every level of the University by effectively tackling issues that arise where our students congregate or live; ensuring that expectations for both students and teachers in the classroom are clearly communicated and met; nurturing vibrant debate and open speech in ways that encourage everyone to express their ideas freely; preserving the right to protest and dissent while avoiding disruption, harassment, and threats; and, when our policies are violated, ensuring that our disciplinary processes are fair, consistent, and effective. If we intend to make significant and durable change across Harvard, it is critical that we act decisively in each of these areas,” Garber wrote in his message.

Last spring and summer, the task force gathered feedback from students, faculty, staff, and alumni through a series of listening sessions and a joint task force survey. In addition, the task force explored how salient events at the University over the past year and key world events over the last several decades impacted the campus climate.

The final report includes findings and a set of recommendations designed to address feelings of abandonment and silencing described by many Muslim, Arab, Palestinian, and pro-Palestinian members of the Harvard community, especially following the Oct. 7, 2023, attacks and their aftermath. Through a review of the concerns raised by community members, the report outlines how the University can improve safety and anti-discrimination policies, uphold free expression and open inquiry inside and outside of the classroom, rebuild institutional trust through an emphasis on equal access and transparency, expand faculty and academic offerings that provide a more comprehensive and representative view of the histories, beliefs, and cultures of Muslims, Arabs, and Palestinians, and related topics.

Research and findings

Task force members were appointed in late February 2024 and began their work in early April 2024, hosting a series of listening sessions with students, staff, and faculty. Nearly 50 sessions were held with an estimated 500 participants. Following the sessions, the Task Force on Combating Anti-Muslim, Anti-Arab, and Anti-Palestinian Bias joined with the Task Force on Combating Antisemitism and Anti-Israeli Bias in issuing a University-wide survey that garnered 2,295 responses. The task force was not charged with investigating reports, but participants were advised of University policies under which they could file formal complaints. Stories were described in the report as they were heard.

From those who attended the gatherings, five themes emerged: descriptions of experiences of discrimination and hate against Muslim, Arab, Palestinian, and pro-Palestinian members of the Harvard community; dissatisfaction with institutional response to incidents of bias and hate; growing divisions, self-censorship, and alienation within the community; concerns about educational experience and a desire for a more inclusive curriculum reflecting global complexities; and calls for divestment as a means for Harvard to address ethical concerns regarding the Israeli-Palestinian conflict.

In addition to describing these themes, the report also notes that the history of Muslims, Arabs, and Palestinians at Harvard reflects a complex and evolving narrative. It starts with a limited presence on campus in the 17th and 18th centuries confined mostly to theological studies. It was followed in the 20th and 21st centuries by a period of increasing Muslim, Arab, and Palestinian diversity among students and activism fueled by global events such as the Israeli-Palestinian conflict. Throughout this latter period, and due to events like the 9/11 terrorist attacks, Muslims, Arabs, and Palestinians reported facing marginalization, discrimination, misrepresentation, and silencing. According to the report, these issues continue today and now affect an even wider set of community members.

The survey also highlighted significant disparities in feelings of safety, belonging, and freedom of expression across religious and racial lines. The data included responses from individuals who self-identified as Muslim, Jewish, Christian, and atheist/agnostic/spiritual. Though the number of individuals responding to the survey was not as high as similar University-wide surveys, the data allow for a meaningful examination of the differences in responses by subgroup. Respondents who described themselves as Muslim and Middle Eastern and North African (MENA) reported some of the worst outcomes on various measures of safety and belonging and freedom of expression: 47 percent of Muslims and 35 percent of MENA respondents felt physically unsafe on campus, and 92 percent of Muslims and 83 percent of MENA respondents felt there were academic/professional penalties for expressing political views. In examining contributing factors, respondents indicated that interactions within the Harvard community with faculty and peers were largely positive, whereas interactions with outside influences were generally perceived negatively.

“The listening sessions, combined with the University-wide survey, brought to light so much of the pain, struggle, and fear that those in the community here at Harvard were experiencing,” said Asim Ijaz Khwaja, task force co-chair and Sumitomo-Foundation of Advanced Studies in International Development Professor at Harvard Kennedy School. “It is critical that we document the experiences and biases faced by Arab, Muslim, Palestinian, and pro-Palestinian members of our community through regular and systematic data gathering and analysis. This will enable us to better understand and address their concerns.”

Final recommendations

Following the review of qualitative findings last spring, the task force provided preliminary recommendations to President Garber in June 2024, which identified urgent issues the task force believed should be addressed prior to the start of the next academic year. Those recommendations included actions related to safety and security, recognition and representation, institutional response, freedom of expression, transparency and trust, relationships among affinity groups, and intellectual excellence. The University pursued a series of changes including new campus and protest rules, centralized fact-finding in discipline cases across Schools, new training opportunities for faculty, staff, and students on identifying and preventing anti-Arab, anti-Muslim, and anti-Palestinian biases, and new initiatives at Harvard’s Schools for constructive dialogue and disagreement across differences.

In the final report, the task force expanded upon these preliminary recommendations and proposed additional ones.

“These recommendations align with Harvard’s academic mission by prioritizing the safety and security of our students, faculty, and staff, and aiming to ensure their full participation in the pursuit of knowledge while guaranteeing that all voices are heard and respected,” said Wafaie Fawzi, task force co-chair, Richard Saltonstall Professor of Population Sciences, and professor of Nutrition, Epidemiology, and Global Health at the Harvard T.H. Chan School of Public Health. “The University can support this mission by ensuring the institutional supports are in place — policies, procedures, and protocols — but also by providing opportunities for our community within and across affinity groups to come together and engage with each other.”

A summary of the final recommendations includes:

Safety and security concerns: The task force recommends continuing to address issues in this area expressed by Muslim, Arab, Palestinian, and Pro-Palestinian students, staff, and faculty. This includes both those involving physical and mental health. The recomendations include investing in culturally competent mental health support, offering comprehensive resources and training to combat doxxing, and formally defining instances of Islamophobia, anti-Arab, and anti-Palestinian bias within University policies.

Recognition and representation: The report recommends establishing a standing advisory committee of faculty and specialists well-versed in areas pertinent to Middle Eastern history to guide policy, programming, and University responses. It further calls for providing regular and ongoing in-person training for stakeholders and actively supporting programming on key community issues to enhance civil discourse and intellectual vitality within the University. The task force also recommends undertaking a comprehensive historical overview of Muslims, Arabs, and Palestinians at Harvard to address bias and promote inclusivity on campus.

Institutional response: The task force calls for adopting clearly communicated, user-friendly, and transparent processes for bias incident complaints and anti-discrimination and anti-bullying procedures. The report also suggests establishing support roles to help manage and guide complainants through these protocols.

Freedom of expression: The task force recommends not only adopting policies to protect open academic inquiry, constructive dialogue, and active demonstrations of freedom of expression, but also proactively encouraging and supporting these efforts and providing safe spaces to exercise them. According to the report, clear and transparent policies should exist to manage protest and counterprotest activities, and it should be clearly communicated that the University celebrates community members exercising free speech, provided they respect time, place, and manner restrictions.

Transparency and trust: The task force recommends developing a shared policy framework adaptable by individual Schools, ensuring consistent understanding and flexible application across the University while recognizing the need for School-specific variations. The report suggests a unified communications strategy for these and related policies should be developed. In addition, the task force states that greater transparency and disclosure is needed on issues raised by some community members, such as divestment and greater engagement in the Middle East, including supporting Palestinian and other universities in the region and facilitating exchanges.

Relationships among affinity groups: To strengthen relationships between and within the community at Harvard, the task force recommends creating dedicated permanent spaces and programming that can address the diverse needs of the Muslim, Arab, Palestinian, and pro-Palestinian community. To facilitate community relationships, both task forces call for a central hub for pluralism efforts. In addition, the report proposes a University-wide Office of Religious, Spiritual, and Ethical Life to bolster multifaith work. As envisioned by the task force, these efforts would connect pluralism and multifaith practices across disciplines and enhance programs like interfaith collaborations and cultural events.

Intellectual excellence: As core to the mission of Harvard University, the task force emphasizes the need to enhance the intellectual experience on campus. The report suggests this could include expanding academic offerings by recruiting faculty and increasing courses on Palestinian studies and Arabic language, designing experiential learning programs to address issues like antisemitism and anti-Palestinian biases, and engaging in more University-wide dialogues on crisis issues, alongside existing campus efforts to model respectful dialogue. The task force also calls for leveraging regular surveys, like the Pulse survey, as well as building the capacity to collate and analyze administrative data to monitor community well-being and address key issues on an ongoing basis.


The full report of the Task Force on Combating Anti-Muslim, Anti-Arab, and Anti-Palestinian Bias can be found here, as well President Garber’s message about the new University action plan, and more information on the action steps Harvard has taken to date to respond to the concerns, information, and recommendations shared by the task force.


Can Trump fire Fed chairman?

Law professor and former Fed Board member says it’s possible but likely market reaction should give pause


Work & Economy

Can Trump fire Fed chairman?

Federal Reserve Chairman Jerome Powell

U.S. Federal Reserve Chairman Jerome Powell at a news conference following a Federal Open Market Committee meeting in March.

Photo by Sha Hanting/China News Service/VCG via AP

8 min read

Law professor and former Fed Board member says it’s possible but likely market reaction should give pause

President Trump has had a difficult relationship with Federal Reserve Chair Jerome Powell.

Concerns over Trump’s global tariff plans roiled markets earlier this month. Powell, who was first nominated to the post by Trump in 2017, noted the president’s policies could lead to higher inflation and slower growth.

Trump accused the Fed chair of failing to boost the economy by not being more aggressive about cutting interest rates. (The two also disagreed over rates in Trump’s first term.) He also hinted he was contemplating ousting Powell before his four-year-term expires next year, further unsettling markets.

Many analysts said such a move would gravely harm the Fed’s longstanding independence and is, according to Powell, “not permitted under the law.”Trump later said he had no plans to fire Powell.

In this edited conversation, Daniel Tarullo, Nomura Professor of International Financial Regulatory Practice at Harvard Law School, discusses the potential fallout should the president make good on his threats to fire Powell. Tarullo served on the Federal Reserve Board and the Federal Open Market Committee (FOMC), the body that decides on interest rates, from 2009 to 2017.


The Federal Reserve Act of 1913 allows governors to be removed for cause, but it doesn’t say anything about the FOMC chair. In your view, does a president, as head of the executive branch, have the power to oust Powell?

There are two separate issues. One is a statutory interpretation issue — whether the addition of the amendment to the Federal Reserve Act in the 1970s, which provided for Senate confirmation of the chair for a four-year term, incorporates the “for cause” protection the original Federal Reserve Act afforded to all members of the Board of Governors.

The alternate reading would be that the four-year term for the chair as chair is not protected by the “for cause” provision.

The second issue, of course, is whether — regardless of what the Federal Reserve Act provides — the Supreme Court believes that the Constitution gives the president removal power for anybody at an independent agency who is performing what the court considers to be “executive” functions. Those two issues are related, but in the first instance, they’re actually distinct.

Daniel Tarullo.

Daniel Tarullo.

Manuel Balce Ceneta/AP file photo

Is the Supreme Court likely to support such a move given recent decisions on the scope of executive authority?

I think most observers expect some further erosion of the famous 1935 decision Humphrey’s Executor, which for 85 years was understood as validating “for cause” protection for the principals at independent agencies.

Whether the court will further erode Humphrey’s step by step or will sweep it away in a single case remains to be seen.

The issue, though, would be whether the Fed (and perhaps other agencies) would be treated differently. And I think we’ve seen some hints from three of the conservative justices — Samuel Alito, John Roberts, and Brett Kavanaugh — that they may regard the Federal Reserve differently from other agencies.

They may still hold a broad view of the president’s authority, but favor a carve-out for the Fed?

Yes. None of the three justices has done more than hint at a potential difference, so we don’t have a sense of what their basis for distinction would be.

One that is available is the legacy of the Federal Reserve in the First and Second Banks of the United States. There could be an argument that from the very first Congress, which convened right after the Constitution was ratified, there was an acknowledgement that Congress could create an independent central bank.

Now, the First Bank of the United States was not a central bank as we would think of it today, but in the late 18th century it was pretty close to what was then thought of as a central bank, epitomized by the Bank of England. So that argument would be available. It’s not overwhelmingly compelling, but it’s arguable. Besides, I haven’t thought that the court’s recent decisions on the “for cause” removal protection have themselves been compelling, so there is an opportunity for the court to do some picking and choosing.

Is there a good legal argument for removing Powell before his term ends?

We can go back to the fact that for 85 years “for cause” protection in independent agencies was generally thought to be the prevailing doctrine.

But the Supreme Court gave substantial reason to question that proposition in Seila Law, the 2020 case that found Congress’ grant of “for cause” removal protection to the head of the Consumer Finance Protection Bureau to be unconstitutional.

So, it’s the court which has changed that 85-year-old understanding and left unanswered the question of how broadly it will ultimately rewrite Humphrey’s Executor.

If there were an effort by the president to remove the chair, the market reaction would be very significant — well before any court had an opportunity to pass on the issue. The anticipated market effect is a disincentive to try to remove the chair, no matter how unhappy the administration may be with his policies.

Given Powell’s term as chair now has only a year to run, that’s probably an additional argument for just waiting until the president can name his own person as a successor. And so, at some level, the market is as much a protection for the Board of Governors as the law may end up being.

Why is Wall Street rattled by the prospect of Powell removal?

Sitting administrations will almost always favor a looser monetary policy in order to promote near-term economic growth. The point of having some independence for a central bank is that the central bankers can look at the potential impact on inflation over the medium term and try to keep inflation closer to what today for the Fed is a 2 percent target. It’s a pretty simple rationale, but it’s a powerful one.

What markets fear is that if a president removes the chair or other members of the Board of Governors, it would be with the intent of having a looser monetary policy. At that point, the markets’ trust in the central bank will be substantially undermined, and thus, the central bank’s credibility as an inflation fighter will be undermined. Longer-term interest rates will then rise, probably dramatically.

Thus, there’s the potential for an odd situation in which the Fed central bank is more responsive to the administration’s desire for near-term growth and reduces short-term rates, but markets, thinking that’s going to be inflationary, essentially demand a higher premium for holding longer-term Treasuries and other longer-term debt. It’s for that reason that I believe that any action by any administration to try to remove the chair or other members of the board is ultimately self-defeating.

Secretary of the Treasury Scott Bessent has quite understandably been focused on the 10-year Treasury rate, because that rate is very important for investment decisions throughout the economy. One would presume the administration doesn’t want to drive up that rate because of uncertainty in markets.

How much power does the chair actually have over internal policy deliberations?

There’s still some significant public misperception on just how powerful the chair is within the board and within the FOMC.

For a period when Alan Greenspan was chair, his preferences and decisions apparently more or less drove FOMC decisions. By the time I joined the Board of Governors in early 2009, that was certainly not the case. I think Ben Bernanke, Janet Yellen, and now Jay Powell have all had to do a substantial amount of internal consultation and internal work trying to forge a consensus around monetary policy.

There’s no question that the chair is far and away the most important individual on the FOMC. But it’s not the case that the chair can simply dictate what policy is going to be and the rest of the FOMC will fall into line.

If Powell was replaced by someone with a certain pedigree, would that calm market jitters?

I think if there were an effort to remove him, the identity of the successor wouldn’t be all that consequential because I believe markets would read into the very act of removal an intent to have a significantly more accommodative monetary policy.

If Jay Powell is allowed to serve out his four-year term, then obviously the identity of the individual whom the president nominates to succeed him will be of substantial interest to markets.


Pulse Survey finds strong sense of belonging and respect at Harvard

Gaps identified, particularly related to sharing opinions and forming relationships with people holding different views.


Campus & Community

Pulse Survey finds strong sense of belonging and respect at Harvard

Students in front of WIdener Library.

Widener Library in Harvard Yard.

File photo by Grace DuVal

8 min read

Gaps identified, particularly related to sharing opinions and forming relationships with people holding different views.

Survey results released by Harvard Monday find a strong sense of belonging among community members, but lower levels of comfort sharing opinions and forming relationships across differences. The new data was released as part of a report of the Pulse Survey on Inclusion & Belonging.

First piloted in 2019 following a recommendation of the Task Force on Inclusion & Belonging, the survey seeks to take the “pulse” of the community and gauge the climate around inclusion and belonging of the entire campus community. Administered for the second time in September 2024, the survey asked every member of Harvard — students, faculty, researchers, and staff — to share their personal experience as an individual interacting with peers, and with the institution as a whole. The results will be integrated with other survey data and used to make improvements to programming related to culture and community. 

“The Pulse Survey is a valuable tool for assessing how members of our community experience the University and understand their place in it,” said President Alan M. Garber. “The insights it provides will help guide us as we work toward creating a culture in which each of us feels included, respected, and valued.” 

To understand the results of the survey, including areas of strength and areas for improvement, the Gazette sat down with Sherri Charleston, chief community and campus life officer, and Drew Allen, associate provost for institutional research and analytics. They shared key findings and next steps for improving campus culture related to inclusion and belonging. 


Sherri, I see that you have a different title, and the name of your office has changed. Can you tell me how those changes came about?   

Charleston: Over the past five years, we have evolved to direct a variety of services on campus. I started in 2020 as the chief diversity and inclusion officer, leading the Office for Diversity, Inclusion, & Belonging. Given the high-level outcomes of the last Pulse Survey, President Garber decided to rename the portfolio to Community and Campus Life to align with its current focus — building community and increasing belonging. As we administered the Pulse Survey again last fall and considered the best way to communicate all the services we offer, it seemed like the right time to adjust my title to better reflect what the offices under my direction do for our campus community. 

Sherri Charleston

Sherri Charleston.

Harvard file photo

Tell us more about the Pulse Survey.

Charleston: The Pulse Survey provides a snapshot of how we are faring as a University community relative to inclusion and belonging goals across a variety of metrics. Because it is a “pulse” and not an “MRI,” it is meant to provide us with data that is directional in nature, rather than diagnostic. It can then be supplemented with other survey data to provide a fuller picture of the climate here at Harvard relative to inclusion and belonging.

Allen: It is rare that we have a survey that allows us to hear directly from every member of our community — students, faculty, researchers, and staff. The data are powerful because they point us in the right direction and provide a catalyst for more specific efforts to examine inclusion and belonging at Schools and units across campus. 

What did the survey ask and how many individuals responded? 

Charleston: The survey questions sought to examine the full breadth of human experience levels at Harvard: individual, community, and institutional. The survey looked specifically at four dimensions of inclusion and belonging: sense of value, acceptance and integration, connection across difference, and supportive assets. We wanted to gauge if individuals felt valued, respected, and recognized. We also wanted to know if they were comfortable expressing themselves and forming meaningful relationships with other community members, including those with viewpoints different than their own.

Allen: Importantly, this survey was taken by over 10,000 members of the Harvard Campus community, representing approximately 20 percent of the population. Given the response rate, which is in line with response rates of similar surveys in higher education, we feel confident that the data give us a valuable pulse of the Harvard community and can provide important direction for future initiatives and resource allocation. 

What are the key highlights from the 2024 Pulse Survey data?

Charleston: The survey showed that large majorities of our respondents — students, faculty, researchers, and staff — feel like they belong at Harvard (including 78 percent of students, 81 percent of staff, and 75 percent of faculty and academic personnel). Respondents also generally feel respected (80 percent of students, 79 percent of staff, and 74 percent of faculty/academic). These numbers are very promising, but of course, come with the caveat that there are portions of our community who do not feel like they belong and do not feel respected.

We also found that while most members of our community feel comfortable sharing opinions with others and have been able to form relationships with people who have different viewpoints, it is not as high as we would like it to be. So, this is another area that we will want to explore to consider how we can effectively expand and strengthen efforts like the President’s Building Bridges Fund, which funds student-driven programs to bring community members together across differences. 
 
Allen: As Sherri points out, the survey did show that the majority of students do feel like they can be their authentic selves here at Harvard. In some cases, our data showed an even higher level of positivity than in 2019 when the survey was first administered. The survey provides us with solid data to inform our decisions moving forward. 

Drew Allen.
Drew Allen.

How will the University use the data? 

Charleston: We will use this data to improve the experience of belonging and connection on campus, particularly across differences. The learnings from this survey can be used directionally to help us make decisions around where we need to allocate resources, both in terms of capacity and focus. 
 
Allen: I think the data can also be used to identify areas of further analysis. A survey is just one method by which we can try to understand inclusion and belonging, but there are other methods we can use to try to understand something that is difficult to measure directly. The Pulse Survey data will guide us to develop additional lines of inquiry that our institutional research office can pursue so that we can better understand our community and their needs.

What improvements or changes were made on campus after the Pulse Survey was administered in 2019? 

Charleston: There has been a real focus on strengthening our community and increasing the sense of belonging here on campus. One specific example was the establishment of the Harvard Culture Lab Innovation Fund  (HCLIF). Funded by the President’s Office, HCLIF supports project ideas that foster a culture of belonging on campus. Grants are awarded to teams that aim to have a direct impact on the University community, engage the broadest audience, and align with the University’s goals toward excellence. 

In addition to HCLIF, we have leaned into both building digital communities and building communities in person on campus. Our office newsletter has about 16,000 subscribers and allows us to share information across many different communities. We have also focused on building communities on campus through our now annual forum, providing community spaces to combat isolation and polarization, and working with colleagues to promote opportunities for community support. Recently, we awarded funding through the President’s Building Bridges Fund to student-led projects designed to build connection and community across differences. 

What are your next steps and when can we expect the next Pulse survey? 

Charleston: Our first step will be to convene community members to help us think about what we have learned and how we can use this data moving forward. Another piece is for us to think about how the various surveys that the University has conducted over the past few years fit together and how we can integrate those findings. We can use this opportunity to ground our decision-making in data and ensure we take actions that will support and improve the sense of belonging and community at Harvard. 

Allen: When we consider when to do this survey again, we want to make sure that enough time has passed so that we can measure meaningful progress. Consistency and timing for the next survey will be important so that the data we collect is valuable and informative. 


How halt in funding hurts efforts to ensure safety of patients in medical research

Stop-work order disrupts system that facilitates oversight of studies happening at multiple sites 


Health

How halt in funding hurts efforts to ensure safety of patients in medical research

Doctor and patient.
6 min read

Stop-work order disrupts system that facilitates oversight of studies happening at multiple sites 

The Trump administration’s freeze of more than $2 billion in federal research grants to Harvard has disrupted work in a number of areas, including efforts to ensure the rights and safety of patients who take part in medical studies.

The administration sent the University a stop-work order for the SMART IRB federal funding contract on April 14. The notice came hours after Harvard rejected government demands that included changes to governance and hiring practices and “audits” of viewpoints of students, faculty, and staff, among other measures.

SMART IRB is a national system administered by a Harvard Catalyst team along with other collaborators. It is used by hospitals, universities, and federal agencies to facilitate oversight of medical research taking place at multiple sites.

Barbara Bierer is the principal investigator and program director of SMART IRB and director of the Regulatory Foundations, Law and Ethics Program at Harvard Catalyst, the University’s clinical and translational science center. She is also a professor of medicine at Harvard Medical School.

In this edited conversation, she outlines how the funding cuts will impact patients who take part in research.


How do NIH funds go toward protecting patients?

Generally research, including NIH-funded research involving human participants, must be reviewed, approved, and then overseen by an institutional review board (IRB) to ensure compliance with applicable institutional, local, state, and federal rules, policies, laws, and regulations, as well as to ensure the rights and welfare of research participants.

For most universities and research institutions, IRB review and oversight are included as indirect costs in the research lifecycle. An NIH policy introduced in 2018 and applied more broadly to federally funded research in 2020 has also required multisite, collaborative research to be reviewed by a single IRB (an sIRB), which takes on the responsibility of reviewing and overseeing the research for all sites.

In some of these cases, the costs may be considered direct costs paid for by federal funding.

What role do these IRBs play in protecting patients?

IRBs, which are set up within — or independently work with — hospitals, universities, and other centers that conduct research, play a key role in carefully reviewing research proposals to ensure participants are protected in a number of ways.

These include consideration of the research question and study design, of recruitment plans, the process for obtaining and continuing to ensure informed consent, assessment and mitigation of risks of harm, participant safety, the determination of the relationship of adverse events to the research, data monitoring, etc.

“Every citizen who has benefited from the efforts of clinical research — taking a new drug, using a medical device, or undergoing a diagnostic test — is impacted by the way we conduct and monitor research.”

IRBs and the human research-protections programs also work to train and support investigators, manage interactions with sponsors, and work with federal and state regulators, among other responsibilities.

Think of IRBs as the “checks and balances” system that maintains the ethics and oversight that medical research studies need. Without this dedicated group of professionals and community members, our studies could potentially, and even inadvertently, cause harm to the individuals and communities that participate. Our valued federal laws and regulations were developed and continue to evolve in response to very real examples of such harms.

Across the U.S., thousands of people dedicate their careers to supporting the ethical oversight and conduct of research, working together every day to safeguard those of us who volunteer to take part in a study.

And of course, every citizen who has benefited from the efforts of clinical research — taking a new drug, using a medical device, or undergoing a diagnostic test — is impacted by the way we conduct and monitor research.

Where do we see this work have the biggest impact?

Concern for the safety, well-being, and protection of study participants drives this community of professionals. We make sure that a system exists for potential study participants to understand the research plan, risks, benefits, and burdens, and freely choose whether or not to participate in the research.

The IRB is also a resource to participants should they have questions or concerns about their participation in a study.

IRBs were the result of historical events that highlighted the need to monitor ethical issues that arise with human research. Can you talk about that a bit?

History has proven what’s at stake: the horrors of medical experimentation by German scientists during World War II; the tragic 1932-72 untreated syphilis study at Tuskegee that upended the public’s notion of safety and consent in medical trials and led to the system of oversight we have today in an act signed by Richard Nixon in 1974; the hepatitis studies at the Willowbrook State School for Children where children with developmental disabilities were intentionally infected with hepatitis; and the betrayal of trust and the principle of informed consent in genetic research involving members of the Havasupai Tribe.

Furthermore, our ability as a nation to advance scientific research is at stake. Imagine you have a dozen or more hospitals and universities across the country working on a new therapeutic that could treat Alzheimer’s disease. Before SMART IRB was available, these centers would have spent countless hours and faced numerous hurdles and delays just to collaborate. The process that is now available has reduced many of these blocks to innovation.

How will funding cuts impact this work? 

Broadly, the increasingly expansive cuts to research funding, the cancellation of countless grants and contracts at exceptional research institutions across the country, will have a significant negative impact on research participants as well as on the IRBs and research professionals.

Studies halted midstream risk significant harms to participants and communities and can reinforce public skepticism and mistrust for the research enterprise and inhibit the commitment of researchers and institutions to fully, honestly, and collaboratively work with the communities they serve.

Since SMART IRB received a stop-work order on April 14, ongoing studies cannot add new clinical sites, more than 25 institutions have been prevented from joining, and dozens and dozens of research studies have been delayed.

At present, support from Harvard Medical School is allowing our team to continue the essential work of supporting collaborative research across the nation. It is our intention to continue to do so: The risks are too great, and the health and safety of the American people depend on it.


Discoveries on a musical path

From Benin to Cuba to the Americas, Yosvany Terry sees how tradition safeguards culture and identity


Arts & Culture

Discoveries on a musical path

Yosvany Terry.

Yosvany Terry.

Credit: @stagetimearts

9 min read

From Benin to Cuba to the Americas, Yosvany Terry sees how tradition safeguards culture and identity

During recent travels to the West African nation of Benin and to Cuba, his home country, internationally renowned musician and composer Yosvany Terry began to research the link between the musical traditions of Benin and the Caribbean.

He had the opportunity to visit with, learn from, and perform alongside musicians keeping those traditions alive. Now Terry, a senior lecturer on music and director of the Harvard Jazz Ensembles, intends to bring his findings to the classroom and his own performances, including one on May 1 as a part of ArtsThursdays.

In this edited conversation, the Gazette sat down with Terry, who shared insights into his research, the importance of expanding the arts through cross-departmental collaboration, and what he likes best about working with Harvard students.


Tell us about your most recent research project.

My research in Benin (the former Kingdom of Dahomey) in January, as well as the research I have conducted in Cuba over the years, is meant to better understand the roots of modern jazz and the impact of the African diaspora on musical traditions.

Going to Benin and visiting remote regions was an opportunity to engage with musicians, learn from them, and perform with them. I could sit with people who are steeped in this culture and its traditions. It was in those magic spaces where they shared their cultural treasures with me. These musical and cultural traditions are not often researched. My Cuban heritage and personal connections to this culture allowed me to be able to connect with the practitioners I met in Benin and to have access to the traditions they continue to practice.

West African musical and cultural traditions came to the Americas with the slave trade, and this profoundly influenced the music that grew as a result of contact with these African traditions.

As we know, slavery ended much later in Cuba than elsewhere. Slaves closely guarded their cultural traditions. Safeguarding these traditions became a part of their rebellion and a way of maintaining their cultural identity under pressure to assimilate. This movement of resistance allowed them to keep the music, dance, culinary arts, spirituality, and religious practices of the societies they came from.

What will you do with this research?

My plan is to give my students access to this primary source material. I want them to know how these traditions prevailed and were safeguarded, but also how they influenced the musical traditions of Cuba, Haiti, Brazil, and the development of American jazz. With this information we can explore how this music influences popular culture and more deeply, how it becomes part of the fabric of who we are — our identity. One of my missions as an artist and an educator is to give life to this incredible wealth of information and culture that gets overlooked. It is so much a part of our daily life, but for so many, we don’t know where it comes from.

“One of my missions as an artist and an educator is to give life to this incredible wealth of information and culture that gets overlooked.”

What impact will it have on you as a musician and composer?

As an artist, this research allows me to create a new body of work that is in conversation with these traditions. I may base new compositions on this research, or I may be inspired to create a new avenue of exploration and inquiry.

I am now working on writing an opera, which is based upon the life of the first free person of color who organized the first rebellion against the Spanish colonial system in 19th-century Cuba. It is relevant today because the core of this work is unearthing a history that has been overlooked or forgotten.

While I was in Benin, I also traveled with a friend, Davey Frankel, a great filmmaker who was filming and documenting our conversations with historians, musicians, and the people of Benin who still practice these music and cultural traditions. The hope is to create a documentary that would connect the dots between the old Kingdom of Dahomey and today’s jazz music.

As director of the Harvard Jazz Orchestra, what is your vision for students who participate in that group?

I was fortunate to inherit a program that Tom Everett founded in 1972. It became an important jumping-off point for jazz at Harvard because it created space for jazz masters to visit the University. With support from the Office for the Arts at Harvard, it grew into something that the University really embraced, naming more than 120 jazz masters.

Part of what I have done to advance the jazz program is to support the engagement of artists of Afro Latin American descent and to make this a fixture of the band. By inviting jazz masters from all different musical backgrounds, including Chucho Valdés, Angélique Kidjo, Gonzalo Rubalcaba, and collaborating with other departments, we have expanded the scope and learning of students who participate. When we bring in artists of this caliber, we get feedback that this experience “changes students’ lives” Whether they decide to become professional musicians or simply to become lifelong supporters of the arts, we have planted the seed that stays with them.

The other piece I have emphasized with the jazz program is to learn from travel. We have visited Cuba and Dominican Republic, which are countries that students may not have otherwise chosen to visit on their own. These educational trips are not centered on tourist attractions, but rather on real learning from educators and other students in these countries. Our students hear lectures from masters of these musical traditions, including jazz band directors and professors. They engage with other music students in concerts and in jam sessions. These educational trips provide unique experiences that students tell us will stay with them for a very long time.

You have participated as a performer in ArtsThursdays a few different times. How has this programming raised the profile of the arts at Harvard and in the larger community?

ArtsThursdays, an initiative of the Harvard University Committee on the Arts (HUCA), has been vitally important to raising the visibility of art-making at Harvard, not only within Harvard but beyond Harvard into our surrounding communities. It has exposed these communities to the incredible work that is done by Harvard faculty who are active artists and performers, by inviting them to free concerts. Not only does it provide unique opportunities for faculty to engage with other artists, but it inspires students to imagine new possibilities. Importantly, it encourages art creators, students and faculty, to reach out across disciplines within the University, but also to bring artists in from other communities.

I am performing at ArtsThursdays again on May 1. At that performance, you will see a direct connection to the research that I did in Benin and Cuba. It reveals the way in which an artist moves from idea to performance — you can see the full circle — artist research, art-making and creation, and then finally, performance.

In conjunction with the May 1 performance, we are planning a dance workshop to engage dance students with these musical traditions. This is an example of the way in which ArtsThursdays inspires collaboration between departments that are not always in conversation. It’s a collaboration that could grow and might show up in our curriculum or classroom teaching in the future.

What is your favorite thing about teaching at Harvard?

Harvard students are, of course, very smart students who really want to learn. They have an enormous sense of curiosity. But many come to our department without knowing very much about the music or genre they are studying. Over the semester, it is so rewarding to see them grow and at the end, it’s possible to see how these courses have transformed their understanding of jazz and its history. They have this new wealth of information that they will take with them, and they become advocates for the information they have learned.

For me as an educator and composer, I love the collaboration with my colleagues across the different departments. I imagine the things you can do with collaboration in unusual departments. For example, I am working with my colleague Demba Ba, the Gordon McKay Professor of Electrical Engineering, on how we can use AI on creative aspects of composition. We are asking the question about how we can train new models to better learn and use aspects of certain musical traditions that AI has not been able to because of the death of data — traditions from West Africa, for example. Basically, how can we teach the system elasticity? This collaboration is exciting and important.

You have been at Harvard for 10 years. What is your hope for the arts in the next 10 years?

Since 2015 I have seen a lot of changes and growth, particularly in our music department. Those changes can be seen in what was offered before and what is offered now. We have been intentional about expanding our offerings to include different musical traditions. By doing so, we are now seeing a broader group of students coming through our department.

Of course, we cannot be complacent. We must continue with initiatives like HUCA, as well as inviting visiting artists and professors and hosting jazz masters in residence. We need to bring the brightest artistic minds to Harvard to spend time here in order to create new spaces for arts understanding. We need to push for new ways to reimagine arts at the University so that we have a healthy, robust, and diverse arts presence on our campus.


Yosvany Terry and Afro-Cuban Roots: Ye-dé-gbé ensemble will perform Imaginary Dialogues: Dahomey May 1 at 7:30 p.m. in Lowell Lecture Hall. This event is part of ArtsThursdays, a University-wide initiative supported by the Harvard University Committee on the Arts, in collaboration with Arts Fest and with additional support from the Hutchins Center for African & African American Research.


Weighing cure for sick kids against troubling ethical questions

Science Center talk outlines potential and risks of gene editing


Neal Baer.

Photos by Niles Singer/Harvard Staff Photographer

Health

Weighing cure for sick kids against troubling ethical questions

Science Center talk outlines potential and risks of gene editing

4 min read

If our differences are part of what make us human, do we have the right — or the responsibility — to change them? That question was at the crux of “The Promise and Peril of CRISPR,” a talk given by Neal Baer, Ed.M. ’79, M.D. ’96, co-director of Harvard Medical School’s master’s degree program in Media, Medicine, and Health. At the Science Center presentation co-sponsored by the FAS’ Division of Science and Harvard Library, Baer discussed the ethical issues surrounding the gene-editing technology with Rebecca Weintraub Brendel, director of the Medical School’s Center for Bioethics.

Introducing the subject — and the book he has edited with the same title — Baer recalled his “horrible” early experience treating children with sickle cell anemia at Children’s Hospital in Los Angeles. “They were suffering. They had strokes,” he recalled. “And there was very little we could do.

“Now,” thanks to CRISPR, “we can cure sickle cell,” he said.

But should we? That remains the central issue for Baer, who also works as a screenwriter, dramatizing medical issues for TV shows such as “Designated Survivor” and “Law and Order: SVU.” (“I am Olivia Benson,” he told the audience, referring to the “Law and Order” protagonist).

With CRISPR technology, scientists can now edit both somatic genes (from the body) and germline genes (from gametes, the sex cells that form embryos), literally clipping out and replacing parts of them. In the case of sickle cell, manipulation of somatic cells can and has removed the genes underlying the disease in individuals. If such changes were made in germline cells, the resulting embryo would never develop the disease at all.

But while curing this painful disease may seem like an unalloyed positive, the questions around gene editing raise many troubling ethical questions. “Should we be using CRISPR for diseases or syndromes that are compatible with life, like Down syndrome?” asked Baer. “Who is going to make those decisions?”

The cost of gene manipulation is another factor. The sickle cell “cure,” for example, comes at a cost of roughly $2.2 million. Noting that approximately 100,000 people in the U.S. suffer from sickle cell, he asked, “Who is going to pay for it?” The domestic population, he continued, is only a fraction of the global sufferers, which raises issues of fairness and health equity.

Neal Baer and Rebecca Brendel.
Neal Baer (left) and Rebecca Brendel speaking during the event.

Citing this “cautionary tale,” Brendel became pragmatic. “The reality is that when we have innovation it makes those who have, have more, and those who don’t have, have less,” she said. “We can’t just innovate without thinking of the ethics. We have to think about the health justice implications as well.”

Even if curing sickle cell is considered a good, Baer argued, the changes made possible by this technology are troubling. For example, what if two deaf parents want their child genetically modified to be able to hear? “Should parents make that decision for their child? Is it up to parents to decide what attributes their children should have?”

In one of the book’s chapters, contributor Ethan J. Weiss divulged that had he and his wife known of their daughter’s albinism, “We would have aborted. But now that we have her, we can’t think of the world without her.”

Baer went on to quote Carol Padden, dean of social sciences at the University of California, San Diego, who was born deaf. “I don’t have a pathology,” she has said. “I have something called human variation. I don’t need to be ‘fixed.’”

Another concern is oversight. “Yes, it is illegal to clone. Yes, it’s illegal to do germline editing. But who is monitoring in Russia?” Baer asked. “Or China?” As if taking a page from a TV drama script, he discussed the possibilities of soldiers genetically altered to feel less pain, fear, or fatigue.

Additionally, Baer pointed out, gene editing may have unintended consequences. He cited a recent advance by the doctor and pharmaceutical company executive Sekar Kathiresan that allowed him to edit the gene controlling LDL cholesterol. While permanently lowering “bad” cholesterol, which is implicated in heart disease and strokes, sounds like a “win,” said Baer, the science isn’t that simple. “This gene evolved over 3 billion years and is involved in dozens and dozens of other” reactions, he said, including those involving insulin and other factors.

“Genes don’t just pop out,” he said. “They evolve and interact and do many different things.”


Turns out, bonobos ‘talk’ a lot like humans

Researchers compile dictionary of vocalizations suggesting the animals use equivalent of word compounds, phrasings to communicate complex social situations


Bonobo vocalizing.

Mia, a young bonobo female, vocalizes in response to distant group members

Martin Surbeck/Kokolopori Bonobo Research Project

Science & Tech

Turns out, bonobos ‘talk’ a lot like humans

Researchers compile dictionary of vocalizations suggesting the animals use equivalent of word compounds, phrasings to communicate complex social situations

4 min read

How old is language? A new study from researchers at the University of Zurich and Harvard University reveals that bonobos, our closest living relatives alongside chimpanzees, use the equivalent of word compounds and phrasings, suggesting that the roots of language predate humans.

Communication has always been about more than just words, say the researchers, Assistant Professor Martin Surbeck of Harvard’s Department of Human Evolutionary Biology, and Professor Simon William Townsend and postdoc Melissa Berthet, both at the University of Zurich. The way we pair words to make phrases and sentences and then link these parts into phrases and sentences defines language, and our ability to communicate with each other.

This capability — known as “compositionality” — lets us create new words and phrases. For example, a “bad dancer” is not necessarily “bad” in any absolute sense. That modifier links with “dancer” to create an easily understandable neologism. Such phrasings can help communicate complex social situations.

“There’s been a long-held evolutionary relationship between vocal complexity and social complexity,” said Townsend. Humans are proof of that. “Arguably humans have the most complex social organization, and we also have the most complex communication system with the most complex forms of ‘combinator’ reality.”


A bonobo whistling in the forest, to coordinate group movements over larger distances.
A bonobo emits a subtle peep before the whistle, to denote tensed social situations.

The study details the researchers’ observations of the vocal behavior of wild bonobos, a key species for reconstructing human evolution, in the Kokolopori reserve in the Democratic Republic of Congo. Using novel methods borrowed from human linguistics, the team demonstrated for the first time that bonobo vocal communication also relies extensively on compositionality.

Like humans, bonobos have complex social bonds. For example, their social group sometimes breaks off into smaller groups before coming together again. “The social organization is perhaps possible because of this more sophisticated communication,” said Berthet, lead author of the study.

The data collection, done over eight months, was painstaking. Researchers began with a list of roughly 300 contextual features to check off when a bonobo made a sound classified as a peep, yelp, or whistle, and “what they were doing or what was happening.” These assumed that a call could give an order — such as, “Run!” — announce an upcoming action (“I will travel”), express an interior state (“I am afraid”), or refer to an external event (“There is a predator”). The team recorded what happened for two minutes after each vocalization to see how that vocalization influenced the group.

Not only did various vocalizations link to various acts or occurrences, but strings of vocalizations revealed their own meanings, allowing the team to create “a dictionary of sorts,” said Berthet. This dictionary revealed how many of the call combinations had the compositionality recognized from human languages. “This dictionary represents an important step in understanding animal communication, as it is the first time researchers have systematically determined the meaning of all the calls of an animal,” Berthet wrote.

Olive, a first time bonobo mother, vocalizing toward distant group members.

Lukas Bierhoff/Kokolopori Bonobo Research Project

“The beauty of this approach is that all of a sudden we have something that allows us to quantify these aspects of the vocal repertoire in all different types of species,” said Surbeck. “It opens a new understanding into animal communication.”

Such structured language is not unique to humans and bonobos: Similar combinations have been observed in chimpanzees. However, that research has tended to focus on single-call combinations, while this new study looked at an entire vocal repertoire.

“It does seem to be the case that at least in chimpanzees and now bonobos, these species that are characterized by this quite complex social system and long-term social bonds between individuals, that you do start to see levels of combinatorial complexity that you might not see in species with less complex social systems,” said Townsend. This suggests that species “evolve a complex communication system so that you can keep the social bonds and the social relationships going at a distance.”

Because humans and bonobos share a common ancestor from approximately 7 million to 13 million years ago, said Surbeck, they share many traits by descent. “It appears that compositionality is likely one of them.”


He got the stop-work order. Then the scrambling began.

Wyss’ Don Ingber details rush to hold onto consequential projects, talented researchers — and system that has driven American innovation 


Science & Tech

He got the stop-work order. Then the scrambling began.

Don Ingber in his lab.

Niles Singer/Harvard Staff Photographer

5 min read

Wyss’ Don Ingber details rush to hold onto consequential projects, talented researchers — and system that has driven American innovation 

It was just hours after Harvard rejected the Trump administration’s demands that the stop-work order arrived in Don Ingber’s inbox.

Ingber, the Wyss Institute for Biologically Inspired Engineering’s founding director, said the April 14 order targeted two of his organ-on-a-chip projects, which together had more than $19 million in multiyear contracts with a unit of the U.S. Department of Health and Human Services.

Ingber, who is also a professor at Harvard Medical School and the Harvard John A. Paulson School of Engineering and Applied Sciences, was among many University researchers who received such orders after the government froze some $2.2 billion in research funding to the University.

The move came in response to Harvard’s rejection of demands that included changes in governance, hiring and admissions, and audits of student, faculty, and staff opinions. A week later, Harvard filed a lawsuit, calling the demands an illegal and unconstitutional overreach and asking for funding to be restored.

After Ingber received the order, work halted but the scrambling — and uncertainty — began for everyone with a direct stake in the projects, including researchers, students, and postdoctoral fellows, he said.

With Harvard and the federal government at odds, with lawsuits filed, and after watching the Trump administration take dramatic steps in other areas only to walk them back, Ingber said he is reluctant to do anything permanent like layoffs.

“This is a stop-work order that could end next week, especially with the lawsuit going,” he said. “We’re going to take care of the people first. The projects need to stop in terms of expending funds, but if there’s spaces on other grants, we’re shifting people to them. We’ll try to find internal funds to keep them going at least until we figure out what’s going on.”

But decisions needed to be made quickly about how to wind down projects. Experiments halted midstream would likely be lost, as would the progress of students and postdoctoral fellows working on theses or papers based on those projects. There has also been a scramble to protect people, Ingber said, by finding places for them in other projects.

The research itself is also of consequence.

Ingber’s primary project uses organ-on-a-chip technology developed at the Wyss to investigate radiation damage to human lung, intestine, bone marrow, and lymph node, providing a tool to both model damage to tissues lining the chip’s tiny channels and identify new drugs that might ameliorate damaging effects.

Ingber said the research is particularly important given the administration’s plans to ramp up nuclear power production to support the energy-intensive artificial intelligence industry.

But even without AI, the project would be useful in modeling radiation damage to human organs in the event of an accident at a nuclear reactor, for cancer patients who undergo radiation therapy, and — in a worst-case scenario — a nuclear bomb explosion.

“What has driven the economy over the past 50 years is America’s innovation engine that fosters sciences which fuel technology development, driven by the pact between the government and academia.” 

The second project uses organ-on-a-chip technology to model the effects of microgravity and radiation exposure on astronauts in spaceflight. Scheduled to be aboard the Artemis II mission to the moon, the specialized chips incorporate the astronauts’ own cells to investigate the impact of spaceflight on bone marrow — where blood cells arise.

“Once you get past the Earth’s atmosphere, solar flares generate incredibly high energy radiation that can be lethal,” Ingber said. “Astronauts will undoubtedly be exposed on a long flight to Mars and you can’t just put them up in a capsule made of lead, which is what some people might suggest, because weight is critical to getting out of the atmosphere. Unless we solve that problem, we’re not going to get to Mars with humans. Maybe robots, but not humans.”

The uncertainty is forcing hard decisions. Ingber said he’s already been approached by one scientist on his team who had immigrated to the U.S. and has decided to leave the Wyss to pursue work in Europe. Ingber agreed to give her a recommendation and help her find a suitable position.

“She’s only been here for six or eight months, but she’s terrified. They’re all terrified,” Ingber said. “It’s hard to know what to tell them, other than we’re going to protect them as much as we can.”

It has also affected the decisions of scientists to come to Boston. A European postdoctoral scientist who had accepted a position at the Wyss recently withdrew his acceptance, saying he had been warned by family and friends it’s not safe to be a foreigner in the U.S.

“We’ve been the magnet for the best and brightest around the world. It’s a positive-feedback loop. They really do attract others, build new industries, and become tax-paying Americans,” Ingber said. “Now, no one from America is going to go into science with its lack of stability, and we already have people in Europe turning down job offers.”

Ingber is baffled at what positive outcome the administration hopes to achieve. He spent 90 percent of his time over the last week managing the crisis: meeting with his leadership team, researchers, and staff; consulting with University administrators; and figuring out where funding can be found to meet rapidly shifting priorities.

He’s also writing op-eds about cuts at the NIH, FDA, and CDC and talking to the media in an attempt to make the broader point that academic research is the foundation of America’s innovation economy and underlies many of the things we accept as part of everyday life, from computers to optical cables to iPhones.

“What has driven the economy over the past 50 years is America’s innovation engine that fosters sciences which fuel technology development, driven by the pact between the government and academia,” he said. “This seems to be coming to an end.” 


Stantcheva awarded Clark Medal

Honored as a leading under-40 economist for pioneering insights on tax policy, innovation, behavior


Work & Economy

Stantcheva awarded Clark Medal

Lawrence Katz wiht Stefanie Stantcheva. .

Lawrence Katz, Elisabeth Allison Professor of Economics (left), during a celebration honoring Stefanie Stantcheva, winner of John Bates Clark Medal.

Photos by Niles Singer/Harvard Staff Photographer

2 min read

Honored as a leading under-40 economist for pioneering insights on tax policy, innovation, behavior

Harvard’s Stefanie Stantcheva has been awarded the American Economic Association’s 2025 John Bates Clark Medal, an annual prize recognizing an under-40 economist for significant contributions to the field.

“I’m incredibly honored, truly humbled, and very grateful for this award,” Stantcheva, the Nathaniel Ropes Professor of Political Economy, said Tuesday during a department celebration with colleagues and students.

In announcing the award, the association praised Stantcheva for exploring questions in public finance and producing new insights on tax policy and its impact on economic behavior. 

Stefanie Stantcheva (left) and Hopi Hoekstra,
Stefanie Stantcheva (left) and FAS Dean Hopi Hoekstra.

“The tax system is something so powerful that can essentially make or break an economy,” Stantcheva said. “It can either encourage things like innovation — if it’s properly designed — or really discourage economic activity.”

In their 2022 paper, “Taxation and Innovation in the 20th Century,” Stantcheva and her co-authors found that innovation responds to changes in tax policy with high elasticity. The study also revealed that higher taxes have a negative effect on the quantity of innovation but not the quality of inventions.

“Stefanie’s important contributions to the field make her so deserving of this award,” said Hopi Hoekstra, Edgerley Family Dean of the Faculty of Arts and Sciences. “It’s wonderful to celebrate her alongside her colleagues, including several past winners, which speaks to the continued strength of this department.”

“We’ve been extremely lucky this year, but not surprised at all that Stefanie got it,” said Elie Tamer, Louis Berkman Professor of Economics and chair of the Economics Department. “She has done stellar work and we’re very proud. It’s a happy day for Harvard and Harvard economics in particular.”

Stantcheva founded the Social Economics Lab in 2018. Her recent work has tackled issues in trade, immigration, climate change, and social mobility.

“I am excited to continue the work at the Social Economics Lab to better understand how people think about economic issues and policies,” Stantcheva said. “We are currently exploring new topics — such as the interplay between emotions and policy — and key mindsets, such as zero-sum thinking.”


Bile imbalance linked to liver cancer

Key molecular switch identified, sheds new light on treatment interventions


Health

Bile imbalance linked to liver cancer

Key molecular switch sheds new light on treatment interventions
3 min read

Key molecular switch identified, sheds new light on treatment interventions

A new study reveals how a critical imbalance in bile acids — the substances made by the liver that help digest fats — can trigger liver diseases, including hepatocellular carcinoma (HCC), the most common form of liver cancer. By identifying a key molecular switch that regulates bile, the study sheds new light on potential liver cancer treatment.

The findings were published this month in Nature Communications.

A unique function of the liver is to produce bile, which in turn acts as a natural detergent, breaking down fats into smaller droplets which are more readily absorbed by the cells in the lining of the small intestine. Beyond acting as a detergent, bile acids — a major component of the bile — also play a hormone-like function that governs a number of metabolic processes. Corresponding author of the study, Yingzi Yang, professor of developmental biology at the Harvard School of Dental Medicine, looked at the delicate control of how bile acids are produced and how disruption of the tight regulation leads to liver injury, inflammation, and eventually HCC.

Yang and her team at HSDM have spent years studying cell signaling. One of the pathways they focus on is the Hippo/YAP pathway — a signaling pathway crucial for regulating cell growth related to cancer.

Yingzi Yang.

Yingzi Yang.

Photo by Tony Rinaldo

“In this study we discovered that YAP promotes tumor formation with a surprising role in regulating bile acid metabolism. Instead of encouraging cell growth as expected, YAP acts as a repressor, interfering with the function of a vital bile acid sensor called FXR,” she said. 

YAP activation paralyzes FXR (Farnesoid X receptor), a nuclear receptor essential to bile acid homeostasis. This causes an overproduction of bile acids that build up in the liver, leading to fibrosis and inflammation, ultimately leading to liver cancer.

Blocking YAP’s repressor activity — either by enhancing FXR function or promoting bile acid excretion — could stop this damaging cycle, according to researchers. In experimental models, activating FXR, inhibiting HDAC1 that enables YAP repressor function, or increasing the expression of a bile acid export protein (BSEP), all helped reduce liver damage and cancer progression.

“With this finding, it could lead us to pharmacological solutions that stimulate FXR, which is very exciting” Yang said.

According to Yang, the findings have additional implications as more is discovered about how YAP influences metabolic control by regulating nutrient sensing. Yang’s interest in studying this function came from her longtime work in cell signaling in liver biology and cancer. She is also a member of the Dana-Farber/Harvard Cancer Center.

The Yang Laboratory uses molecular, cellular, genetic, and genomic approaches to investigate the critical roles of cell signaling in embryonic morphogenesis and adult physiology. Their research focuses on the mammalian skeleton and liver to explore human biology and address the underlying pathophysiological mechanisms of diseases, including cancer.


This work was supported in part by the National Institutes of Health and the National Cancer Institute.


FDA-approved smoking cessation pill helps break vaping habit

Clinical trial shows teens and young adults had three times more success quitting than their placebo counterparts


Health

FDA-approved smoking cessation pill helps break vaping habit

Clinical trial shows teens and young adults had three times more success quitting than their placebo counterparts

3 min read
Young woman vaping.

Teens and young adults who took varenicline — an FDA-approved, twice-daily smoking cessation pill for adults — are more than three times as likely to successfully quit vaping compared to those who received only behavioral counseling, according to a new study from Harvard-affiliated Mass General Brigham. Results are published in JAMA.

“Vaping is extremely popular among kids, and we know that this early nicotine exposure can make drugs like cocaine more addictive down the line, yet ours is the first treatment study to look at this vulnerable population,” said lead author A. Eden Evins, director of the Center for Addiction Medicine at Massachusetts General Hospital and the William Cox Family Professor of Psychiatry in the Field of Addiction Medicine at Harvard Medical School. “We wanted to help teens and young adults quit, and we found that prescribing varenicline is the best way to do that.”

According to investigators, about a quarter of 18-to-25-year-olds vaped in 2023, and roughly 8 percent of high schoolers vaped in 2024. Vapes have become a popular alternative to cigarettes with the added challenge of being easy to conceal and easy to use in public places. Yet they contain many of the same familiar health threats, like nicotine addiction, carcinogen and heavy metal exposure, and pulmonary inflammation. Exploring treatment plans is crucial to provide teens and young adults with safe, effective avenues to quit. 

Because varenicline is already approved for smoking cessation in adults, it can be prescribed for anyone aged 16 to 25 wanting to quit nicotine vaping.

To identify such a treatment avenue, the Mass General Brigham team recruited 261 participants aged 16 to 25 into a randomized clinical trial. Participants were sorted into three treatment groups. The first was varenicline, weekly behavioral counseling, and access to a free text support service called “This is Quitting.” The second was placebo pills, weekly behavioral counseling, and the text service. The third was the text service alone. Each group was treated for 12 weeks, then checked on monthly for another 12 weeks post-treatment.

Each week, participants reported whether they had successfully quit vaping, and their responses were verified with cotinine saliva tests. At the end of 12 weeks of treatment and at three-month follow-up, the varenicline group had the highest quitting success rate. At 12 weeks, 51 percent of varenicline users had stopped vaping, compared to 14 percent of placebo users and 6 percent of text-only users. At 24 weeks, 28 percent of varenicline users had stopped vaping, compared to 7 percent of placebo users and 4 percent of text-only users.

These findings demonstrate the importance of medication to help young people who are addicted to nicotine quit vaping, since the varenicline group had three times more success quitting vaping than their placebo counterparts — despite both engaging in behavioral therapy. Further research is needed to explore the potential impact of other therapeutic approaches, as well as to look at even younger people who use nicotine vapes.

Because varenicline is already approved for smoking cessation in adults, it can be prescribed for anyone aged 16 to 25 wanting to quit nicotine vaping.

“Not only was varenicline effective in this age group — it was safe. Crucially, we didn’t see any participants that quit vaping turn to cigarettes,” said Randi Schuster, founding director of the Center for School Behavioral Health at MGH and associate professor of psychology in the Department of Psychiatry, HMS. “Our findings illustrate the effectiveness and safety of this therapy to address the urgent public health concern of adolescents addicted to nicotine because of vapes.”


This study was funded by the National Institutes of Health.


New, bigger humanitarian crisis in Darfur. But this time, no global outcry.

Regional specialists sound alarm, say displacement, starvation affect many more than two decades ago.


Zoe Marks (from left), Mai Hassan, Alex de Waal, and David Miliband on stage during the event.

Zoe Marks (from left), Mai Hassan, Alex de Waal, and David Miliband.

Niles Singer/Harvard Staff Photographer

Nation & World

New, bigger humanitarian crisis in Darfur. But this time, no global outcry.

Regional specialists sound alarm, say displacement, starvation affect many more than two decades ago.

5 min read

Between 2003 and 2005, Sudan’s Darfur region captured the world’s attention as the government, amid a civil conflict, carried out a campaign of mass killing against an estimated tens of thousands of ethnic Darfuri.

Nearly 20 years later, the country has plunged into another civil war that has led to the world’s largest humanitarian crisis, with around 25 million people, half of Sudan’s population, experiencing acute hunger and 12 million displaced from their homes, according to the U.N.’s World Food Program.

But this time, the international community is not paying attention, decried experts on Sudan during a panel on April 15, “Sudan in Crisis: A Civil War, Humanitarian Emergency, and the Consequences for a Nation and Region,” hosted by the JFK Jr. Forum’s Institute of Politics. The event was moderated by Zoe Marks, Oppenheimer Faculty Director of the Center for African Studies at Harvard.

“This is an awful crisis, and just not enough light has been shed on it,” said Mai Hassan, faculty director of MIT-Africa. “It’s an understatement to say Sudan is in crisis or that Sudan is under fire. Over 150,000 people have died in this conflict. More than 10 million have been displaced, and more than 10 million are facing dire levels of hunger or starvation.”

“It’s an understatement to say Sudan is in crisis or that Sudan is under fire.”

Mai Hassan,  MIT-Africa

The two-year ongoing conflict between the Sudanese Armed Forces (SAF) and the paramilitary Rapid Support Forces (RSF) has claimed the lives of 150,000 people and shows no signs of winding down. Hamid El-Bashir, a development expert originally from Sudan who participated remotely from Washington, D.C., lamented the international community’s apathy and indifference.

“When you look at the international response to the crisis in Sudan, there is no response,” said El-Bashir. “I attended the General Assembly a few months ago, and I came out with this conclusion: Sudan is going to collapse … There is no attention to this country.”

Twenty years ago, the global advocacy movement “Save Darfur” mobilized a worldwide response to condemn the atrocities and spearhead peace efforts in the region. In 2004, the U.S. government accused the government of Sudan and pro-government Arab militias before the U.N. Security Council of committing genocide.

Alex de Waal, executive director of the World Peace Foundation, recalled a visit he made then to Harvard to talk about the Darfur genocide, which became the first genocide of the 21st century.

“I remember being in this forum 20 years ago,” said de Waal. “There was a really vibrant movement on this campus, and other campuses, saying, ‘Save Darfur’ and ‘Never Again’ to genocide. What has happened to that passion, that commitment? And the celebrities who were so active then. They’re all silent now.”

Located in northeast Africa, Sudan is among the continent’s largest countries and boasts a strategic location bordering Egypt to the north and the Red Sea to the east. Sudan’s civil war has spilled over the region, with thousands of refugees having fled to South Sudan, Chad, and Egypt. The conflict is being fueled by regional powers supporting Sudan’s warring factions, which could further destabilize the region, said David Miliband, president and CEO of the International Rescue Committee.

“It’s not as simple as a unified SAF and a unified SAF force, both of which came out of the Sudanese armed forces,” said Miliband. “There is a constellation of forces supporting each side. The United Arab Emirates, the kingdom of Saudi Arabia, Turkey, Russia, Iran, Egypt are all in there supporting different sides, and they’re supporting them sufficiently that both sides think that they can win, and that there’s no reason to stop.”

One student asked for suggestions on how to rally international support to stop the civil war. The panelists highlighted the need to support humanitarian aid, start a widespread movement to demand a ceasefire, and begin a peace process that involves civilians, the United Nations, and Middle Eastern powers.

There needs to be pressure on the regional powers that are fueling the conflict, too, said Miliband, but the first step is to provide humanitarian aid. A community-led initiative formed in Sudan in 2019, the Emergency Response Rooms has sprung into action since the conflict started.

“First of all, you’ve got to stop things getting worse,” said Miliband. “Stopping the slide is very important. I always say humanitarian aid is the first step on the road to development. Unless you can stop things from getting worse, unless you stop the bleeding, we’re going to lose more people, and every bloodshed leads to further danger.”

For MIT-Africa’s Hassan, the situation is dire and requires international action. She remains hopeful that Sudanese civil society will rise up again despite the challenges.

“What’s awful about the situation, not only the actual empirics of it, but that it comes on the heels of a euphoric popular revolution that overthrew a despised Islamist regime,” said Hassan, referring to the 2019 military coup, which took place after a year of massive protests that deposed dictator Omar al-Bashir, who was in power for 30 years.

“I’m hopeful that civil society will be mobilized again in some fashion to help bring some kind of legitimacy to whatever new state emerges or when a peaceful resolution comes about,” said Hassan. “It’s going to involve a popular mobilization. I think civil society can be mobilized again.”


Future doesn’t have to be dystopian, says Ruha Benjamin

In Tanner Lectures, Princeton sociologist talks AI, social justice


Arts & Culture

Future doesn’t have to be dystopian, says Ruha Benjamin

Ruha Benjamin.

Veasey Conway/Harvard Staff Photographer

3 min read

In Tanner Lectures, Princeton sociologist talks AI, social justice

The average citizen shouldn’t be afraid to imagine a radically different future for humanity, Ruha Benjamin argues. After all, the billionaire CEOs of tech companies are doing it.

The professor of African American Studies at Princeton University, who delivered the Tanner Lectures on Human Values hosted by the Mahindra Humanities Center last week, argued that proponents of AI-powered futures often frame their visions as altruistic despite actually being driven by self-interest.

“There’s absolutely no reason to trust that tech elites have any wisdom to offer when it comes to alleviating human suffering,” Benjamin told the audience who packed Paine Hall. “Billionaires building bunkers to survive AI apocalypse, attempting to disrupt death through cryopreservation, scouting the planet for pop-up cities and network states, are not reliable stewards of the collective good.”

Too often AI technologies marketed as “efficient” and “progressive” only create more oppression, Benjamin said, citing examples such as facial recognition software leading to false arrests and automated triage systems deciding who receives healthcare.

Benjamin said AI is often touted as a moral (or, at least, morally neutral) decision-making technology because it operates on math rather than emotion. But making decisions for society based on math and algorithms hurts the same marginalized groups harmed by the 20th-century eugenics movement, she said.

“One of the buzzwords that goes around is that these systems are so special because they’re engaged in ‘deep learning,’ by which people mean computational depth,” Benjamin said. “But what I suggest is that computational depth without social and historical depth ain’t that deep.”

Benjamin said it’s hypocritical to see superintelligence, Mars colonies, and underground apocalypse bunkers as bold innovations while viewing public goods such as free public transportation and affordable housing as impractical.

“This is an invitation to think about the different types of knowledges that we need around the table,” Benjamin said. “We can’t leave it simply to those who have technical know-how. Many of the problems we’re enduring right now are because those people who are creating tech solutions for society don’t know anything about society.”

Benjamin called for a renewed focus on creativity and imagination, urging universities to prioritize inquiry through arts and humanities.

“This is an invitation not only to be critical, but to be creative. To ask ourselves, ‘Now what?’” she said. “Instead of trying to make the world a little less harmful and make these systems a little less harmful, what if we were to completely reimagine them, envisioning a world beyond borders, beyond policing, beyond surveillance and supremacy? In the process, I think we’ll have to work on dismantling the walls in our own minds, those mental barriers that tell us to ‘get real’ when we attempt to imagine otherwise.”


U.S. pregnancy-related deaths continuing to rise

Study researcher says nation, which leads high-income peers in maternal mortality, needs better prenatal, extended postpartum care


person holdiing baby hand
Health

U.S. pregnancy-related deaths continuing to rise

Study researcher says nation, which leads high-income peers in maternal mortality, needs better prenatal, extended postpartum care

7 min read

In the U.S., more than 80 percent of pregnancy-related deaths are preventable. Yet for many years, the nation has had the highest maternal mortality rate among high-income countries. And that rate continued to rise between 2018 and 2022, with large disparities by state, race, and ethnicity, a new study reports.

A team of researchers at the National Institutes of Health, in collaboration with Associate Professor Rose Molina of Harvard Medical School, used data from the Centers for Disease Control and Prevention to study pregnancy-related deaths in that four-year period.

The sharpest rate increase occurred in 2021, likely reflecting the onset of the COVID-19 pandemic in 2020. While the rates then lowered, they were still higher in 2022 (32.6 deaths per 100,00 live births) than they were in 2018 (25.3 deaths per 100,000 live births).

The results were consistent with past research that has demonstrated significant disparities across racial groups. American Indian and Alaska Native women had the highest mortality rate (106.3 deaths per 100,000 live births), nearly four times higher than the rate among white women (27.6 deaths per 100,000 live births), followed by non-Hispanic Black women (76.9 deaths per 100,00 live births).

State rates also varied greatly, ranging from 18.5 to 59.7 deaths per 100,000 live births.

In this edited conversation, Molina, an obstetrician-gynecologist, discusses the findings and what needs to happen next.


Why is pregnancy-related death much higher in the U.S. than other high-income countries?

“There are many reasons: our patchwork healthcare system, inequitable policies, maternity care deserts, as well as persistent systems of bias and discrimination across racial and ethnic groups.”

There are many reasons: our patchwork healthcare system, inequitable policies, maternity care deserts, as well as persistent systems of bias and discrimination across racial and ethnic groups. It’s the way in which the healthcare system is designed. There are also signals that reproductive-age individuals are experiencing more chronic medical conditions, including cardiovascular disease, at younger ages than before.

The results showed some significant racial disparities in maternal mortality rates. Was that surprising?

While I am saddened that the racial inequities have persisted, the reality is that this has been demonstrated over and over again in the literature. There have been some innovations aimed at reducing inequities between racial groups in health systems. But at a population level, as a country, we’re not seeing meaningful improvement yet.

Our study points to different policy levers that need to be addressed, because there shouldn’t be as much state-level variation as there is. One of our biggest findings is that we could have avoided 2,679 pregnancy-related deaths during this time period if the national rate were that of California. If California can do it, then how can we get other states to perform as well?

The overall leading cause of death in your study was cardiovascular disease, which accounted for just over 20 percent of deaths. Has that always been the case?

Over the decades in the U.S., we’ve seen a transition from hemorrhage to cardiovascular disease as the leading cause of pregnancy-related death. Cardiovascular disease encompasses a range of disorders: hypertension, pre-eclampsia, eclampsia, and peripartum cardiomyopathy, cardiac arrest, and stroke.

One reason for the shift may be that more and more people have chronic hypertension. We saw that the highest increased rate of pregnancy-related death was actually in the middle-age group (those 25 to 39), not the highest-age group. Therefore, one of the potential concerns is that chronic diseases like hypertension are affecting younger people. It’s been much more common to have hypertension if you’re 40 or older. But we’re beginning to see more hypertension at an earlier age.

“We saw that the highest increased rate of pregnancy-related death was actually in the middle-age group (those 25 to 39), not the highest-age group. Therefore, one of the potential concerns is that chronic diseases like hypertension are affecting younger people.”

In fact, pregnancy-related death increased for all age groups between 2018 and 2022. How significant is that rise?

It’s only four years, and the studied time period spanned the initial part of the COVID pandemic. But there’s still enough evidence that we should be paying more attention to this increase. Even in 2022, the rates were higher than in 2018. And the rates were already rising in 2019, before the pandemic started.

You also found that “late maternal deaths” — those that occur between 42 days and 1 year after pregnancy — accounted for nearly a third of the total. Yet the World Health Organization does not include late maternal death in its definition of pregnancy-related mortality. Why is it important to consider this time period?

Internationally, any death during pregnancy and up to 42 days after birth is considered a maternal mortality. In the U.S., we’re moving toward being inclusive of the full year after birth, because the 42 days postpartum is somewhat arbitrary.

There’s a growing recognition that the postpartum period doesn’t just end on a cliff at six weeks, even though that’s how many of our healthcare systems are designed, but rather postpartum recovery should be treated as a continuum. The high number of late maternal deaths points to why we need to design better systems of healthcare in those later months, as opposed to only focusing on the first six to 12 weeks.

Rose Molina.

Rose Molina.

Veasey Conway/Harvard Staff Photographer

This study offers a fuller picture of the problem than past tallies. Can you talk a bit about that?

One of the biggest challenges in tracking maternal deaths in the United States is that we didn’t actually have a national system for tracking these deaths consistently until 2018, because that’s when the full implementation of the pregnancy checkbox on death certificates went into full effect across the 50 states.

What that means is that when someone dies, the death certificate now has a pregnancy check box, so there can be some indication as to whether the person who passed away was pregnant at the time. However, it took a long time for all states to fully implement that. That’s why our data is so interesting, because we looked at the data starting in 2018, when that process was fully implemented across the 50 states.

“The biggest take-home message is that we need to continue to invest in public health infrastructure. It’s very clear that we’re not getting better, and if anything, the rates of pregnancy-related deaths are getting worse.”

Now that everything is laid out, how can these numbers be improved? What needs to happen next?

The biggest take-home message is that we need to continue to invest in public health infrastructure. It’s very clear that we’re not getting better, and if anything, the rates of pregnancy-related deaths are getting worse. So we need to change something about how we are addressing this.

In particular, we need to increase investment in innovative solutions to address quality of care during pregnancy and the extended postpartum period. At the state level, we really need to be addressing policy differences and trying to understand why certain states fare so much worse than other states.

It’s a concerning moment because the public health infrastructure to track these deaths is at risk. Research dollars are being cut dramatically. Pregnancy is being deprioritized. These actions and cuts threaten any work trying to improve maternal health outcomes, which can help inform policy at the state level and advocacy to enhance access to quality full-spectrum pregnancy care.


Rewriting genetic destiny

David Liu, Breakthrough Prize recipient, retraces path to an 'incredibly exciting' disease fighter: ‘This is the essence of basic science.’


David Liu.

Veasey Conway/Harvard Staff Photographer

Health

Rewriting genetic destiny

David Liu, Breakthrough Prize recipient, retraces path to an ‘incredibly exciting’ disease fighter: ‘This is the essence of basic science.’

5 min read

In 2022, Alyssa Tapley was 13, suffering from T-cell leukemia, and facing a grim prognosis after existing treatments failed to improve her condition. Then, a clinical trial using a novel gene-editing technology called base editing cleared her cancer. It was a breakthrough for science — Tapley’s therapy was the first enabled by base editing — and a lifeline for the patient.

“Now, 2½ years later, I’m 16, preparing for exams, spending time with my family, arguing with my brother, and doing all the things I thought I’d never be able to do,” Tapley told the audience at the 2025 Breakthrough Prize ceremony on April 5. The prizes, whose recipients this year included several Harvard researchers, honor achievements in physics, life sciences, and mathematics.

The scientist behind the technology that saved Tapley’s life is David Liu, the Dudley Cabot Professor of the Natural Sciences and vice chair of the faculty at the Broad Institute of MIT and Harvard. 

“It’s incredibly exciting, and also comes with a heavy sense of responsibility, to make sure that — to the extent humanly possible — we have done everything we can to make these agents as safe and effective as possible for use in patients,” Liu said. 

Hundreds of millions of people worldwide suffer from genetic diseases. To help them, Liu, with support from the NIH, DARPA, and other federal agencies, has built on and looked beyond CRISPR-Cas9, the transformative gene-editing protein found in bacteria that cuts through DNA like scissors. 

“That approach of cutting the DNA double helix is very useful for gene disruption or deletion,” he said. “But if your goal is to correct a mutation that causes a genetic disease, it’s not easy to use scissors to achieve gene correction.” 

The limits of the “scissors” approach led Liu and his team, including former postdocs Alexis Komor and Nicole Gaudelli, to develop two new approaches to gene editing: base editing and prime editing. Base editing works on the four nucleotide bases of a DNA strand — A, C, G, and T — rather than on the entire double helix.

“You can change a C to a T, a T to a C, an A to a G, or a G to an A,” Liu said. “And those happen to be four of the most common kinds of mutations that cause genetic diseases.” 

But what about genetic diseases caused by other kinds of single-letter swaps, or by unwanted extra letters, or by missing DNA letters? For those cases, Liu’s team, including former postdoc Andrew Anzalone, developed prime editors. Liu likened the tool to a word processor, able to search out a flawed piece of DNA and replace it with a synthesized DNA flap that is specified by the user. 

“There was no knowledge of what CRISPR did, or whether it was going to be useful. But it was interesting enough for curious people to study.” 

As of today, there are at least 18 clinical trials using base editing or prime editing to treat a range of diseases, with dozens of patients already treated, Liu said.

Liu connects his research to basic science — research that seeks to understand something new about the world without a clear application in mind — that began at Japan’s Osaka University in 1987. There, a team of researchers noticed something unusual in DNA from E. coli bacteria: highly repetitive DNA sequences that were interspersed with non-repetitive sequences, but with the exact same spacing. The phenomenon became known as Clustered Regularly Interspaced Short Palindromic Repeats, or CRISPR.

“There was no knowledge of what CRISPR did, or whether it was going to be useful,” Liu said. “But it was interesting enough for curious people to study. This is the essence of basic science.” 

Over the course of decades, researchers learned that CRISPR was a kind of immune system that bacteria use to protect themselves from viruses. When a virus enters a bacterial cell, the bacterium incorporates some of the virus’s DNA as a kind of genetic memory, allowing it to identify and destroy the virus if it encounters it again. 

“You can imagine a critic saying, ‘Why do I care about a bacteria’s ability to kill a virus?’” Liu said. “The answer is that it turned out to lead to all the CRISPR nuclease clinical trials, and eventually led to base editing and prime editing, and now we can make just about any kind of change in the DNA of living systems, including correcting the vast majority of mutations that lead to genetic disease. And it all came from the basic science of geneticists who first looked at these clustered regularly interspaced short palindromic repeats and wondered what they were doing.” 

Liu is loath to call his technologies a cure: “Scientists are reluctant to use that word until there’s evidence of years without any apparent symptoms of the disease,” he said. But, he added, “The writing’s already on the wall: In some of these clinical trials, the patients are no longer on any medication and don’t have any symptoms of the disease.”

Looking to the future of research and innovation, Liu says he’s deeply worried about the current threat to the partnership between higher ed and the federal government, especially as it relates to young scientists.

“There’s a lot of fear and chaos now that is preventing young scientists from entering the phase of their careers where they can contribute to society in a direct way,” he said. “And that’s a very real tragedy.”


Long trail from 1992 discovery to 2024 Nobel

Gary Ruvkun recounts years of research, which gradually drew interest, mostly fueled by NIH grants


Gary Ruvkun, circa 2000, next to a computer screen showing the roundworm C. elegans.

Gary Ruvkun in the 1990s.

Harvard file photo

Science & Tech

Long trail from 1992 discovery to 2024 Nobel

Gary Ruvkun recounts years of research, which gradually drew interest, mostly fueled by NIH grants

4 min read

Gary Ruvkun and Victor Ambros were not known as superstars in their field back in 1992 when they discovered microRNA, a feat that would earn them the 2024 Nobel Prize in physiology or medicine.

“We were fine. We weren’t terrible,” said Ruvkun, a professor of genetics at Harvard Medical School. “But there was nothing about it that made it seem like, ‘Oh, these guys are walking on water!’”

Even after the former Harvard collaborators published their findings in the journal Cell in 1993, revealing a new level of gene regulation in the C. elegans roundworm, the evolutionary biology community was not overly impressed. It wasn’t clear that the genes Ruvkun and Ambros, now a professor at the University of Massachusetts Chan Medical School, discovered mattered to other species, including humans.

Instead, their work, mostly funded by the National Institutes of Health, drew interest from a smaller group of RNA researchers and what Ruvkun calls the “worm community” — those interested in the same model organism.

Gary Ruvkun.

Ruvkun speaks at the Medical School after winning the 2024 Nobel Prize in physiology or medicine for his role in the discovery of microRNA.

Harvard file photo

But the interest in the RNA field kept growing. Meetings that formerly would have drawn 100 attendees doubled in size within a few years. It became clear that the same tiny RNAs had the same role in plants and in worms, and scientists in all different fields were interested in the same questions.

Ruvkun started to realize, “This was some revolutionary stuff, and we were the only people thinking about tiny RNAs in the world.”

Decades of federally funded breakthroughs later, microRNAs are considered fundamental to how organisms develop, mature, and function — playing a key role in translating genes into proteins.

Studies have discovered that the human genome contains about 1,000 microRNAs that control most human protein-producing genes. Therapies based on microRNAs to treat heart disease, cancer, Crohn’s Disease, Alzheimer’s, and several other diseases are in clinical trials.

Ruvkun says about three-quarters of his lab research has been funded by the federal government for the past 40 years, at about $150,000 a year. The money provides enough support for about four people. “It’s not like I had a lab of 50,” he said.

He expresses puzzlement at calls to cut federal funding, emphasizing that spending on scientific work is far from wasteful. “The average pay of the people in my lab has always been about three times the minimum wage,” he said. “These are scientists, and they’re super educated. They have Ph.D.s or are getting Ph.D.s, but they’re paid a little better than working at Dunkin’ Donuts.”

Ruvkun is proud that basic research from his field has led to major pharmaceutical companies like Alnylam, which focuses on the discovery, development, and commercialization of RNA interference therapeutics for genetic diseases.

“It’s one of the 10 biggest companies in Massachusetts,” he said, “and it didn’t even exist 20 years ago.” He’s also glad that his research had enough of an impact that he can continue doing basic science while others worry about the business implications.

Of the top 500 companies in the country, Ruvkun emphasizes, well over half are driven by technology — much of the foundational research behind them driven by federal grants. He credits federal funding with turning the U.S. into a scientific and economic superpower during and after World War II.

He worries that a lack of investment could push members of his laboratory away from science research.

“I have all of these people who are 25, 30 years old, and they’re like, ‘What career do I have? What am I going to do?’” The answer, he said, might be the reverse of the post-war trend: They’ll leave the U.S. for more stable positions in Europe.


Kareem Abdul-Jabbar named Class Day speaker

NBA icon, award-winning author, and humanitarian chosen for ‘his lasting efforts to build a more just and compassionate world’


Campus & Community

Kareem Abdul-Jabbar named Class Day speaker

Abdul Jabbar.

Kareem Abdul-Jabbar

Photo by Dan Winters

4 min read

NBA icon, award-winning author, and humanitarian chosen for ‘his lasting efforts to build a more just and compassionate world’

A collection of stories covering Harvard University’s 374th Commencement.

Legendary basketball player, writer, and activist Kareem Abdul-Jabbar will address the Harvard College Class of 2025 during the annual Class Day celebration on May 28, the day before Harvard’s 374th Commencement.

“We are so excited to welcome Kareem Abdul-Jabbar as the featured Class Day speaker,” said Uzma Issa ’25, first marshal of the 2025 Class Committee. “He’s a champion in every sense of the word — celebrated both for his extraordinary achievements on the court and his lasting efforts to build a more just and compassionate world. He has shown that true leadership is measured by the difference we make in people’s lives.”

“It’s a privilege to share this moment with the Class of 2025 and to celebrate all that lies ahead,” said Abdul-Jabbar. “The world needs their ideas, their energy, and their heart. I hope my words will encourage them to keep learning, keep growing, and keep showing up — for themselves and for others.”

Widely regarded as one of the greatest basketball players of all time, Abdul-Jabbar is also an award-winning author, cultural icon, and tireless advocate for social justice. In 2016, he received the Presidential Medal of Freedom — the nation’s highest civilian honor — in recognition of his contributions on and off the court.

The 7-foot-2 basketball Hall of Famer dominated the NBA for two decades with his trademark skyhook, becoming the league’s all-time leading scorer — a title he held for 39 years. A 19-time NBA All-Star and six-time NBA champion, he remains the only player in NBA history to win six Most Valuable Player awards. Time magazine once dubbed him “History’s Greatest Player.”

Since retiring in 1989, Abdul-Jabbar has continued to use his platform to challenge public thinking on a wide range of issues. An influential columnist, he has written for major media outlets worldwide and now publishes regularly on his Substack newsletter. A nine-time Southern California Journalism Awards Columnist of the Year, he is known for incisive commentary on sports, politics, and popular culture. Today, he remains one of the most outspoken and respected voices confronting racism and inequality in America.

A New York Times bestselling author of 20 books, Abdul-Jabbar’s forthcoming book,We All Want to Change the World: My Journey Through Social Justice Movements From the 1960s to Today,” offers a sweeping account of the protest movements that reshaped America and will be released in May.

Abdul-Jabbar traces his activism back to his high school years in Harlem, when he had the chance to ask Martin Luther King Jr. a question at a news conference. The brief exchange sparked a lifelong commitment to fighting injustice like systemic racism and inequality in education, health, and employment.

Appointed in 2012 as a U.S. Cultural Ambassador by the State Department, he was tasked with promoting education, racial tolerance, and cross-cultural understanding among young people around the world. In 2021, the NBA established the Kareem Abdul-Jabbar Social Justice Champion Award to honor the next generation of athletes working to lift up their communities. His public service efforts have earned him numerous honors, including Harvard’s W.E.B. Du Bois Medal in 2022.

Abdul-Jabbar is the founder and chair of The Skyhook Foundation, which brings science, technology, engineering, and mathematics education to underserved communities in Los Angeles.

An award-winning documentary producer and two-time Emmy-nominated narrator, Abdul-Jabbar is the subject one of HBO’s most-watched sports documentary of all time, “Kareem: Minority of One.” His on-screen appearances span hundreds of iconic film and television roles.

“Kareem Abdul-Jabbar has spent a lifetime speaking out against injustice and using his platform to educate and inspire,” said Srija Vem ’25, second marshal of the 2025 Class Committee. “As we prepare to take our next steps in life, his legacy reminds us that we all have the opportunity — and the responsibility — to use our voices, our intellect, and our talents in service of something greater.”


In addition to Abdul-Jabbar’s address, Class Day includes award presentations and student orations. The event will begin at 2 p.m. on May 28 in Tercentenary Theatre and will be livestreamed.


Harvard files lawsuit against Trump administration

Filing argues freeze of research funding violates First Amendment, laws, procedures


Campus & Community

Harvard files lawsuit against Trump administration

Harvard's Widener Library.

Photo by Grace DuVal

5 min read

Filing argues freeze of research funding violates First Amendment, laws, procedures

Harvard filed a lawsuit Monday against the Trump administration, arguing its freeze on research funding is unconstitutional and “flatly unlawful” and calling on the court to restore more than $2.2 billion in research dollars.

The filing, in U.S. District Court in Boston, requests that the court vacate and set aside the funding freeze to allow previously approved funding to flow and halt administration efforts to freeze current or deny future funding without engaging in procedures contained in federal law.

In a message to the community Monday, President Alan Garber said the suit was prompted by steps the government took over the last week, after the University rejected administration demands for changes to Harvard’s governance, hiring, and admissions policies, and to ensure “viewpoint diversity” in part through audits of viewpoints of students, faculty, and staff.  

Garber described those changes — contained in an April 11 letter from the government — as intrusive and said they’d impose “unprecedented and improper control over the University.”

Garber noted some Trump administration representatives have said since April 11 that the letter was sent by mistake. But he said other statements and the administration’s actions since don’t bear that out.

Within hours of Harvard’s rejection of White House demands, the administration doubled down by announcing a freeze of $2.2 billion in funding and has since said it is considering revoking Harvard’s tax-exempt status and threatening the education of international students. In addition, Garber said, the administration is considering freezing an additional $1 billion in funding.

“Moments ago, we filed a lawsuit to halt the funding freeze because it is unlawful and beyond the government’s authority,” Garber said. “Before taking punitive action, the law requires that the federal government engage with us about the ways we are fighting and will continue to fight antisemitism. Instead, the government’s April 11 demands seek to control whom we hire and what we teach.”

Harvard’s complaint says the First Amendment protects free speech against government interference intended to enforce ideological balance and bars the government from using legal sanctions or other coercion to suppress speech it doesn’t like.

The complaint also describes the government’s freeze-first strategy as violating laws that lay out procedures for research fund recipients suspected of civil rights violations. Prescribed steps progress from voluntary negotiations to an official hearing followed by findings. Then, only 30 days after the findings are released can funding be terminated.

“These fatal procedural shortcomings are compounded by the arbitrary and capricious nature of Defendants’ abrupt and indiscriminate decision,” the lawsuit said.

The filing describes a rapid escalation on the part of the government. After initial inquiries in February from the administration’s multi-agency Task Force to Combat Antisemitism, administration and University officials scheduled an official visit to campus in late April.

In late March, however, Harvard received a letter announcing a review of research grants totaling $8.7 billion to the University and its hospital affiliates. On April 3, Harvard received a list of conditions under which it might ensure continued funding and, finally, on April 11, a letter fleshed out those conditions.

Those details, which included overreaching and broad-ranging demands, prompted the University’s rejection and Garber’s statement that Harvard would not negotiate over either its independence or its constitutional rights.

Garber said the administration’s actions have jeopardized critical research being conducted on cancer, infectious disease, and battlefield injuries.

With funding in flux, the lawsuit says, hard decisions about things like living cell lines being used to investigate disease and the jobs of researchers whose positions are tied to federal grants will have to be made. Unless funding is restored, Harvard’s research programs will be considerably curtailed.

“The consequences of the government’s overreach will be severe and long-lasting,” Garber said. “Indiscriminately slashing medical, scientific, and technological research undermines the nation’s ability to save American lives, foster American success, and maintain America’s position as a global leader in innovation.”

Garber acknowledged that work to fight antisemitism remains to be done on campus. “We need to ensure that the University lives up to its ideals,” he said.

Though Harvard has already taken several steps in that direction, Garber said the Task Force on Combating Antisemitism and Anti-Israeli Bias and the Task Force on Combating Anti-Muslim, Anti-Arab, and Anti-Palestinian Bias will soon release full reports.

He described them as “hard-hitting and painful” and said they include recommendations that have concrete plans for implementation.

“As a Jew and an American, I know very well that there are valid concerns about rising antisemitism. To address it effectively requires understanding, intention, and vigilance,” Garber said. “Harvard takes that work seriously. We will continue to fight hate with the urgency it demands as we fully comply with our obligations under the law. That is not only our legal responsibility, it is our moral imperative.”


Freezing funding halts medical, engineering, and scientific research

Projects focus on issues from TB and chemotherapy to prolonged space travel, pandemic preparedness


Nation & World

Freezing funding halts medical, engineering, and scientific research

Empty test tubes
7 min read

Projects focus on issues from TB and chemotherapy to prolonged space travel, pandemic preparedness

The Trump administration’s decision to freeze more than $2 billion in long-term research grants to Harvard has put a halt to work across a wide range of medical, engineering, and scientific fields. The action came in response to the rejection of White House demands for changes that the University argues infringes on its independence and constitutional rights and exceeds the administration’s lawful authority.

The NIH had earlier halted an estimated $110 million in grants to Harvard and its associated hospitals since late February.

We interviewed some of the researchers whose projects have been halted or face an uncertain future.


Sarah Fortune

John LaPorte Given Professor of Immunology and Infectious Diseases, and chair of the Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health

Research interrupted: A $60 million seven-year, multi-institutional consortium to study how the immune system controls tuberculosis.

“About a third of the world is thought to be infected with TB and carry TB, and most of those people will not get sick. But every year, 10 million people get sick, and 1 million people die, which makes TB the world’s leading infectious cause of death. We’re trying to understand the difference between protective and failed immunity to TB to better identify people with TB and then prevent TB, ideally with an effective vaccine.

“This consortium was conceived of at the National Institutes of Health as their moonshot effort to move the needle on TB. The goal was to bring together the very best researchers from around the country and around the world to bring the very best cutting-edge technology, the very best science to understand TB immunity. And if it stops, the whole thing is gone.

“I’ve been building this consortium since about 2014. For me, this is over a decade of work. Scientific knowledge, scientific expertise is a craft. And if you blow it up, you can’t just rehire people and recreate it and then start again. It’s gone.”

[Open Philanthropy, a California-based philanthropic group, has authorized a $500,000 grant to allow researchers at the University of Pittsburgh School of Medicine to complete an ongoing tuberculosis vaccine study, The Boston Globe reported Monday. That study is a single piece of the broader project Fortune is working on as a principal investigator.]


Donald E. Ingber

Founding director of the Wyss Institute for Biologically Inspired Engineering at Harvard, Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, and Hansjörg Wyss Professor of Bioinspired Engineering, Harvard John A. Paulson School of Engineering and Applied Sciences

Research interrupted: Two contracts worth under $20 million: one to test and develop drugs to treat long-term radiation exposure, including chemotherapy, and the other to study the effects of microgravity and radiation in space on human cells to help astronauts travel to Mars.

“Both projects were contracts administered by the Biomedical Advanced Research and Development Authority (BARDA), which is responsible for developing countermeasures for biological, radiation, and chemical threats for the U.S.

“The larger BARDA contract focuses on development of human organ-on-a-chip microfluidic culture models of human lung, intestine, bone marrow, and lymph to model the human response to exposure to gamma radiation, and to identify potent radiation countermeasure drugs. We have made great progress on this project.

“The BARDA project supported by NASA is to use human organ-on-a-chip technology to create living ‘avatars’ of astronauts by lining the chips with cells from astronauts and then flying the chips alongside them on space missions. The goal is to use these to understand the effects of microgravity and radiation (which currently makes it impossible for man to go on long space flights, to Mars, for example) and again, develop countermeasures. This initial project is to demonstrate the feasibility of this approach.

“Radiation countermeasure drugs we are developing would be valuable for cancer patients, many of whom receive radiation therapy and experience side effects (higher and more effective therapeutic doses could be administered with less toxicity) as well as be stockpiled to protect against a nuclear disaster or attack; and they could enable long term spaceflight, and hence, exploration of Mars, which is not possible now.

“As for what the repercussions are, it means that this type of work would stop but more importantly that the salaries of almost 20 students, fellows, and staff are at risk if this stop order is not reversed soon.”


Duane Wesemann

Associate professor of medicine, Harvard Medical School

Research in peril: A $10 million project grant to fund a large consortium of laboratories to study the immune system and its ability to respond to different coronaviruses as preparation for future possible pandemics. That grant was halted before the most recent freezes and later temporarily reinstated by a court order pending appeal.

“What we learn from coronaviruses is relevant to other infections because we’re trying to understand how the immune system operates.

“We were finishing up our third year of a five-year plan. The termination was a surprise.

“There are multiple levels of loss. On one level, these grants from the NIH are vetted very heavily by independent scientific review, and there’s only a small percentage of grants that end up getting funded because of the review process. Grants like this and others that are terminated, which have been vetted, scored, and deemed important, rigorous, and worthy to happen, represent a loss of all the effort that went into the process.

“For our lab, it is a huge loss of opportunity. We have been collecting longitudinal blood samples from several individuals over many years to try to understand the long-term effects of immunity to the virus, infection, as well as vaccination, to study how long-lasting things are, and what regulates the longevity of the immune response.

“We may have to cancel collecting blood from this cohort. To see this happen to our lab and to see it happen to other labs across the country is devastating.”


Subhash Kulkarni

Assistant professor of medicine, Harvard Medical School

Research facing uncertainty: A $3.5 million neuroscience research project that studies how the neurons in the gut change with aging and conditions such as Parkinson’s and Alzheimer’s diseases.

 “My research project has not been stopped yet. Whether it will be stopped or not is something that I don’t know.

“My project is based at my research lab, which is a neuroscience lab that studies the gut. We study the neurons that reside in the gut and regulate the human functions related to eating, digesting, and defecation.

“It is important to understand how these neurons change with aging or with conditions such as Parkinson disease, Alzheimer’s disease, or irritable bowel syndrome. What our lab does is try to understand how the neurons in our gut age, and what can we do to make them young again.

“This is an ongoing project. Our ability to keep on going depends upon our ability to keep putting in grants and getting in the money because we are at the end of our grant cycle. If our grants don’t get funded, all that research stops, and the years of work will go wasted. We are in the last year of a five-year grant. If the grant is curtailed even before the time ends, then the work will stop immediately.

“One of the main things to remember is that when we get funding, part of that goes toward salaries, but a significant part goes towards buying reagents and chemicals from American manufacturers and buying mice from American companies. Every single dollar of federal funding is spent toward people’s salaries and reagent materials that are here in the U.S.

“Our ability to train undergraduates, who are American, all stops immediately if our funding gets stopped.”

“There is uncertainty right now. We don’t know how it’s going to go.

“We hope that crucial research is not stopped because every research that we do at HMS and elsewhere is a result of a highly competitive process. This is not funding that we get because of the largess of the federal government. We have to compete with every single lab around the entire country and it’s a function of that competitive process that we get grants to do the work that we do.”


What really scares Katie Kitamura

Ahead of Harvard visit, author talks performance, privacy, and horror inspiration for latest novel


Katie Kitamura.

Photo by Clayton Cubitt

Arts & Culture

What really scares Katie Kitamura

Ahead of Harvard visit, author talks performance, privacy, and horror inspiration for latest novel

7 min read

On Tuesday, the Mahindra Humanities Center will host the novelist Katie Kitamura, in conversation with Claire Messud, the Joseph Y. Bae and Janice Lee Senior Lecturer on Fiction in Harvard’s English department.

Kitamura published her fifth novel, “Audition,” earlier this month. Like several of her past books, including 2021’s acclaimed “Intimacies,” it’s taut, engrossing, and occasionally eerie — this time revealing the uncanny underside to life in middle age, inside and out of a family’s New York City apartment.

Kitamura was recently named a 2025 Guggenheim Fellow in fiction. She lives in Brooklyn with her husband, the novelist Hari Kunzru. The following interview was edited for length and clarity.


This latest book takes place under a cloud of uncertainty. In midlife, the central character may be very successful, or headed for a fall. She may be a mother, or not. She may be keeping secrets; her husband may be, too. It’s unsettling — is there any chance you’re becoming a horror novelist?

I love this question. With my last three novels, I’ve always thought of a genre as I was writing them. I wrote a novel called “A Separation,” and I thought of it as a missing-persons novel, a kind of mystery. And then I wrote a book called “Intimacies,” which is set in a war-crimes tribunal; I thought of that as a courtroom drama.

With this one, when I started writing it, I thought I’d like to be in conversation with horror, as a genre. The book that I had front of mind was “Rosemary’s Baby,” by Ira Levin — another book about troubled motherhood and New York real estate. These characters, this family: They’re trapped inside this apartment, and things grow increasingly frenetic.

There are also these uncanny moments — is this really my son? Is my husband all that he appears?

I think the really frightening moments in horror are when you look at something that you believe you understand, and you see something that is strange. In Shirley Jackson’s “The Haunting of Hill House,” one of the characters looks out the window and sees a part of the house she shouldn’t be able to see. Something about the entire geography and architecture of this home has changed.

I wanted to try to create that kind of feeling here: The central character is looking at people she believes she knows, and they seem like strangers to her. That, to me, is a very horror-adjacent feeling.

“The central character is looking at people she believes she knows, and they seem like strangers to her. That, to me, is a very horror-adjacent feeling.”

Book cover for Auditions.

It’s been remarked that this novel has a pandemic feel to it. Was that conscious on your part?

Well, there’s not a single mask, or vaccine, or virus in the book. But it was written during the pandemic, and it was only really in the last couple of weeks that I realized in some ways it is very much a pandemic novel: a small apartment with family members coming home, not having enough space and really driving each other up the wall, on some level.

That was not my intention at all. But my feeling is that as a writer, you can’t help but breathe the air you breathe; all of it, everything in the sociopolitical atmosphere, it ends up on the page in some way.

The title is “Audition.” Your central character is an actor — very attuned to other people’s performances, altogether off-stage. And performance has been a theme of yours for a while — the essential malleability, or adaptability, of who we are, how we are with each other.

Yes. And I think people might read my work and think I’m writing a critique of that — that I’m pointing to those performances to say that they’re artificial in some way.

But it’s almost really the opposite: I think we learn how to be through performance, in a fundamental way. When I look at my children, I know they’re learning what it means to exist in the world in part by mimicking things they’ve seen around them. That’s very natural: to play different parts in different situations.

I just think as a novelist, I’m interested in those moments when the crack between parts starts to show, or the script wears thin. And for a brief moment you see something that is not as contained or controlled — and that can be frightening.

We might live with a spouse, a child, a parent for years and years — and never see some whole parts of them. It feels like you ask here how well we can really know each other.

To me, a successful relationship is one that allows the other person a certain degree of privacy.

I think this idea of full disclosure between two people is a kind of myth, and I’m not sure it’s a particularly healthy one. There are parts of myself that I want to have only to myself, that I don’t feel a profound need to share with my partner. And similarly, I believe there are parts of himself he should be able to keep for himself.

Your novels tend to reveal a real love of language and performance, of literature and visual art. And not only are you writing, but you teach writing at New York University. In the AI moment, in a time of ecological crisis, why does it seem so important to you?

The day after the election, my students came into my workshop and they said, “What is the point of writing fiction in times like this?” And I thought, there’s never been a moment when it feels more crucial to me to write fiction.

The way I put it to them is if books were not powerful, then why would they be being banned all across the country? If they don’t pose some kind of threat to power, why would they be continually under attack? To use language with precision and care, to have control of language, that’s going to be tremendously important over the coming years.

One purpose of fiction is, of course, to observe reality as it exists and as we see it. But part of it is also to imagine a different kind of reality. And if we can’t imagine a different kind of reality, there’s no way that we can bring it into being.

So you’d stick up for the English major.

I would! I was an English major, and I felt like I was able to go lots of different places with that. But also, when I think about my day, I think, the most optimistic thing I do every single day is to read a book.

When you read a book, you open up your mind to another person, and that’s actually quite profound. We are easier to subjugate when we’re divided, when we’re atomized. And books are actually a tremendous force of connection. If you are one of the people who is tending the fire, keeping that connection alive, that is really not nothing at all.


Endowment offers Harvard flexibility but also risks

Economist speaks of balancing act between immediate needs and long-term planning


Campus & Community

Endowment offers Harvard flexibility but also risks

An "H" design embellishes a gate of Harvard Yard.

Harvard University.

Stephanie Mitchell/Harvard Staff Photographer

6 min read

Economist speaks of balancing act between immediate needs and long-term planning

After years of careful stewardship, the University began this fiscal year with its endowment worth a record-setting $53 billion. 

But that overall number can conceal several important details. Most of the endowment is not only restricted by donors and held in separate funds, but the majority of those funds belong to one of the University’s 12 Schools. Less than 5 percent of the overall value is unrestricted and directly under the discretion of University leadership.

After the conflict that erupted last week between the University and the White House, the Trump administration moved to freeze billions in long-term research grants, with many more “under review.” The president has also argued that Harvard should lose its status as a tax-exempt institution. 

To some degree, endowments can be used to allay financial uncertainty and cover unexpected costs. But those decisions come with costs of their own. 

In this edited conversation, John Y. Campbell, who has served as the Morton L. and Carole S. Olshan Professor of Economics at Harvard since 1994, talked about how the endowment actually works.

Campbell’s research focuses on long-term investing, asset pricing, and personal finance. He served on the board of the Harvard Management Company, which oversees the endowment, from 2004 to 2011. And in 2021, he was a member of a working group that helped reimagine endowment management for Harvard’s Faculty of Arts and Sciences, or FAS. 


In 2024, you co-wrote a paper on endowment management, using Harvard’s Faculty of Arts and Sciences as a kind of case study. What generally did you find?  

That paper sought to give a framework for helping the FAS think about its long-run budget situation. I, along with my co-authors Jeremy Stein and Alex Wu, were motivated by a frustration with the usual accounting approach, which is all about managing this year’s cash flows so things add up.

So, for example, if you’re short of money and you can spend a little more from the endowment, that fixes the problem this year. But of course, it takes away resources that you would otherwise have in the future. It doesn’t help you in the long run.

This is an economist’s perspective on what can seem like a very large amount of money. You found that — in the case of FAS — the endowment is already being used to cover what would otherwise be a large budget deficit. 

That’s right: When people in the Harvard community or the public at large look at the endowment, they look at those billions of dollars, and they think that that’s money that can just be spent on anything that the University wishes at any time.

There are two separate problems with that. Yes, much of the endowment is restricted — there are severe limitations on what the money can be spent on. But there’s another problem we identify: That in a certain sense, the endowment revenues have already been spent — to fund the ongoing existing operations of the University. 

Those operations funded out of the endowment vary widely: professorships, research, construction among them. And then about a fifth of the annual distribution allows Harvard to offer really generous financial aid, just increased once more this spring. 

Absolutely — and I’m all for that policy. But it does reduce the revenue that the School could otherwise collect, and thus it puts more burden on the endowment to cover expenses each year. 

Then there are the exogenous shocks: financial crisis, recession, the COVID-19 pandemic. In those cases, a university can — and Harvard has — stepped up distributions to cover shortfalls elsewhere. 

That’s right. You can do it in different ways. You can do a “decap” — using endowment funds for current expenses; you can adjust the payout rate; you can borrow against the endowment.

In a short-term emergency, like the pandemic or what may develop in today’s political environment, it may be entirely appropriate to do so. But the thing you need to be aware of is that, when you do that, you are easing your budget problems this year in return for a tighter budget in future.

Harvard’s approach to endowment management, like many others’, relies on targets and projections: It assumes 8 percent returns on investments, 3 percent inflation, and a payout of roughly 5 percent each year. But if the last 20 years have taught us anything, it’s that reality can be a great deal more volatile than that.

That’s right. Our way of looking at volatility — long adopted by Harvard financial administrators — is, in any one year, to find ways to smooth out its effects.

If the endowment does super-well one year — goes up by 25 percent — now you have a lot of new resources. But you don’t need to spend them all at once; in fact, it would be very imprudent to do so. Instead, you smooth it out, gradually increasing your spending in a cautious, well-planned way. 

Meanwhile, there are also downside risks, too: In the wake of the financial crisis, in 2009, the endowment lost 27 percent of its value. And as of this week billions of federal dollars may be at risk of being frozen or revoked. What are the options now? 

University leaders now need to sit down with the sort of spreadsheet framework that’s in our paper, and they need to do a scenario analysis: “How bad could this get?” 

If there’s an endowment tax, if we lose “x” million dollars in sponsored research funding. You could even look at what might happen if Harvard lost its tax-exempt status.

What they are going to see is — if this a prolonged or permanent change — it’s going to have very meaningful implications for Harvard’s long-term future. And you’ll have to do some radical things: There will have to be a major change in spending or a major change in revenue — where you find it somewhere else. 

You don’t have to do everything at once. That would be foolish. The luxury that Harvard’s endowment gives us is time — you have time to make change in an orderly fashion. But our framework says that if circumstances change so that you have less money coming in on a permanent basis, you are eventually going to have to fully adjust.


Why bother?

What makes someone run 26.2 miles? Boston Marathon’s lead psychologist has heard it all.


Health

Why bother?

Runners cross the finish line of the 2024 Boston Marathon.

Omar Rawlings/Getty Images

5 min read

What makes someone run 26.2 miles? Boston Marathon’s lead psychologist has heard it all.

Some runners cross the Boston Marathon’s finish line with hands held high, a look of elation on their faces. Others find themselves slumped in a medical tent with Jeff Brown, lead psychologist for the Boston Marathon medical team.

“We’re not talking about, ‘Oh, I need ice for an ankle,’” Brown said about these finishers. “Someone is significantly overheated or underheated. They’re having terrible cramps. They’re disoriented. They might not know exactly where they are.” Laid out on cots are people with extremely low levels of salt in the blood, and others who are sad, fearful, and agitated for reasons they can’t explain. Brown’s role, along with his team of mental health clinicians, is to help perform psychological evaluations and recognize symptoms of a wide range of medical conditions.

Seeing these high levels of acute distress mere meters from the finish line, some might ask, “Why bother?” There are other ways to stay in shape or raise money that don’t require an extreme feat of cardiovascular and muscular endurance over multiple hours in unpredictable weather conditions.

It’s a question that Brown, a Harvard Medical School lecturer, McLean Hospital psychologist, and author of “The Runner’s Brain,” ponders each year as thousands of runners funnel past him. It will no doubt be on his mind Monday during the 129th edition of the Boston Marathon.

The reasons, Brown said, are inexhaustible, but what they have in common is that they’re “very, very personal, and really it is that personal energy and commitment that keeps people going, regardless of where they are in their lives.”

Jeff Brown.
“In our world that’s rather cluttered with a lot of criticism, it’s a really nice way of getting affirmations in a healthy way,” psychologist Jeff Brown says about running the Boston Marathon.

Over the years, he’s met hundreds of people who are running for a recently deceased loved one, contending with a cancer diagnosis, and fundraising for a beloved charity. He’s met women who — monitored by medical staff — finished the marathon while far along in their pregnancies and other athletes who explicitly ignored their doctors’ instructions and ran with cracked femurs, torn muscles, recent sprains, and diabetic complications. “Perhaps it’s not a surprise,” said Brown, “that they meet us in the medical tent at some point.”

A marathon channels people’s energy into a methodical, focused pursuit, and, especially at Boston, one that provides some bragging rights. “It allows people to come to terms with themselves,” Brown said. “When it comes to self-concept and belief about one’s capabilities, we always do better when we have some sort of objective measure.”

That objective nature is crucial, Brown says. Not only do you complete a race, but when you finish, you get a medal placed around your neck. “I think of that as kind of this transformational moment,” he said, “because it’s something that was a hope that is now realized as a wish fulfilled. It’s the mind-body thing happening.”

He loves seeing people he’s treated gather enough mental and physical strength to leave the medical tent and finally collect their medals. “It’s almost like they had a chance to review their whole experience one more time,” he said, “and it might mean a little more to them.” He’s seen huge smiles, tears, and quiet reflection. “I think that’s just a reflection of the vast continuum of emotion and purpose and goals that people bring to running the Boston Marathon.”

“For a while there after you complete a marathon, you’re kind of a hero.”

Marathon runners invest enormously varying amounts of time and energy preparing for the race. Some are young, single people who sacrificed late nights out and lazy weekend mornings to set a personal record. Others are older, first-time runners who might be taking time away from their kids and spouses to complete a bucket-list item. A few are looking to advance professional running careers, and others show up having done barely any training at all.

A medal — and some bragging rights — are far from the only reward that motivates some people to invest thousands of hours into race-specific training and for others to ignore the sound medical advice of their doctors.

“In our world that’s rather cluttered with a lot of criticism, it’s a really nice way of getting affirmations in a healthy way,” Brown said. “And people, in our heart of hearts, we just want to be treated civilly.”

Running is also an opportunity to change your own conception of yourself and, at least for a few hours, how others view you. “For a while there after you complete a marathon, you’re kind of a hero,” Brown said. “You’ve done something that a lot of other people would never set out to do or think about doing, which is pretty darn cool.”

The mental side of running still fascinates Brown and has kept him on the Boston Marathon’s medical staff for more than 20 years.

“That one day, with 30,000 runners, there are 30,000 different ways of completing that marathon,” Brown said. “Imagine all the thinking and psychological experiences and reflections and motivations and negative thoughts and positive thoughts that went all those 30,000 different ways.”


‘If you’re boring, you’re not going to educate.’

Randall Kennedy has blazed a path as an open-minded, nuanced, and independent thinker


Randall Kennedy in his office.

Photos by Stephanie Mitchell/Harvard Staff Photographer

Nation & World

‘If you’re boring, you’re not going to educate.’

long read

Randall Kennedy has blazed a path as an open-minded, nuanced, and independent thinker

Scholars at Harvard tell their stories in the Experience series.

Lawyer and legal scholar Randall Kennedy can fairly be described as something of an iconoclast.

As a public intellectual, he is known for his openness to different points of view and his nuanced and sometimes provocative opinions about issues such as affirmative action (there are costs along with benefits), racial profiling (not completely nonsensical but ultimately discriminatory), Diversity, Equity, and Inclusion statements (abandon them), and some other issues typically associated with the left.

Kennedy, the Michael R. Klein Professor of Law, has also been unafraid to engage with the right. In 2020, the conservative Manhattan Institute invited Kennedy, a longtime questioner of critical race theory, to participate in a discussion on the topic. He eventually took other CRT critics on the panel to task for being too categorically dismissive.

“The great thing about his work is that you can never predict where he will end up — on racial justice, he sometimes seems conservative, sometimes liberal,” said then-Law School Dean Martha Minow in a 2013 profile of Kennedy. “In his field of race and the law, he is unique in the legal academy. I don’t know anyone else who has his commitment to pursuing the truth about controversial issues to wherever it goes.”

Kennedy, 70, was born in Columbia, South Carolina, and raised in Washington, D.C. His family’s move north from the Jim Crow South, along with his father’s pessimism about prospects for lasting racial justice in the U.S., left a deep imprint on Kennedy’s intellectual life.

The son of a postal worker and a schoolteacher, Kennedy attended the prestigious St. Albans School, did his undergraduate studies at Princeton, and was a Rhodes Scholar. He attended Yale Law School and has taught at Harvard since 1984. The author of seven books, Kennedy recently spoke with the Gazette about his life, career, and views on racial equality in the U.S. The interview has been edited for clarity and length.


Why did your father decide to move the family from Columbia to D.C.?

My parents were refugees from the Jim Crow South. My father was from Louisiana. My mother was from South Carolina. My father was a postal clerk and my mother a schoolteacher. They met at Fort Jackson, South Carolina, during World War II.

In the mid-’50s, soon after my birth, they left. An incident precipitated their move. It involved my father. He carried a gun as part of his employment driving a truck with the postal service. In some little town in South Carolina a white policeman stopped him. The policeman said, “We don’t allow negroes to have guns. Surrender yours.”

My father refused, and they had a standoff. My father got out of there fast, made it to Washington, D.C., got on the telephone, and said to my mother, “We’re moving.” Years later, I asked my father why he had left inasmuch as he and my mother had just built a house outside of Columbia. He said to me the following: “I thought that if we did not move, I was going to kill a white man, or a white man was going to kill me.”

Randall Kennedy in his Harvard Law School office alongside a portrait of his father Henry.
Kennedy in his Harvard Law School office alongside a portrait of his father, Henry.

Did you experience discrimination while you were growing up?

Yes. The most memorable episodes transpired during trips from D.C. to South Carolina for holidays. Even as a kid, I sensed how the atmosphere changed as soon as we went over the 14th Street Bridge from D.C. into Virginia.

I remember a couple of times when my father was stopped by the police as we were driving in Jim Crow territory. The scenario was the same. A policeman would pull our car over. My father would ask, “Is there a problem, officer?” and the officer would say, “No, there’s no problem. I pulled you over because I noticed you have Washington, D.C., license plates, and I wanted you to know that we do things differently down here.”

The policeman was testing my father, and my father played along. He did what the police officer wanted, and what the cop wanted was for my father to call him “sir,” and be deferential, show that my father knew to stay in his place.

My father performed as required, and we went on our way. God bless my father for that! He put as his highest priority the well-being of his family. If he had to swallow his pride to accomplish that aim, so be it. What commitment. What poise. What discipline. What love. Yes, God bless my father for that.

How did your parents’ views on race influence you?

They influenced me greatly in all sorts of ways, some of which undoubtedly are beyond my conscious awareness. One was my father’s bone-deep pessimism about the possibility for lasting racial justice in America. He believed that the United States of America was created to be a white man’s country and would always be a white man’s country, and he never forgave the United States for its mistreatment of African Americans.

At his burial, because he was a veteran, a representative of the U.S. military was on hand to deliver an American flag, nicely folded, to my mother. I remember looking at my brother and smiling amidst the tears. We both knew that our father would have found this scene uproariously funny because my dad was not a patriot. He was an anti-patriot. The effort to understand the sense of aggrievement that he felt has been a big part of my intellectual life.

Framed photograph of Henry and Rachel Kennedy, Randall Kennedy's parents.
Soon after Kennedy’s birth in the mid-1950s, his parents, Henry and Rachel (pictured right), moved the family from South Carolina to Washington, D.C.

What memories do you have of your childhood?

I had a wonderful childhood! I spent several summers in Columbia, South Carolina, where I would stay with my Aunt Lillian. I had a great time even though during some of those summers no public parks were open. Why? Because South Carolina preferred to close the public parks rather than see them desegregated. But I had lots of friends, and we had lots of fun.

I also recall my childhood in D.C. with fondness. My parents bought a house two blocks from the Takoma public park. It was at that park that I learned to play football, baseball, and, most importantly, tennis. The tennis courts at Takoma public park are named after my father, Henry Kennedy Sr. He was known as “Mr. Tennis.”

To support his tennis-playing children, he learned everything that he could about the game and became quite proficient as a teacher and organizer of tennis tournaments. When he passed away, people in the neighborhood successfully petitioned the city government to name the tennis courts in his honor.  

Is it true that you were a very good tennis player in your teens and that you played against Robert McNamara, who was then secretary of defense under President Lyndon Johnson?

I was a very good junior tournament player, as was my brother. He and I took care of the tennis courts at the St. Albans Tennis Club in Washington, D.C., on the grounds of the National Cathedral.

On Sunday mornings we were supposed to close the courts down during the Cathedral service. Usually, we did. But occasionally Defense Department Secretary Robert McNamara and National Security Adviser Walt Rostow would show up and beseech us to allow them to play. We even played doubles with them from time to time.

On one occasion, a chauffeur came to the courts and announced that the president was on the phone and wanted to speak with McNamara right away. The secretary left for a few minutes, returned, and play continued.

McNamara and Rostow were both quite competitive, but Rostow was the better of the two.

I read that tennis allowed you to attend the prestigious St. Albans School.

When my brother began taking care of the tennis courts at St. Albans, I would help him. When courts were open, and few people were around, I would practice with him.

The head pro at the club, who was also the tennis coach at the St. Albans School, saw me play and contacted my parents about applying to the school. They told him right off that we didn’t have St. Albans-level money. He told them that he could get me a scholarship if I could gain admission.

I ended up applying, gaining admission, and playing No. 1 on the school varsity from the eighth grade to the 12th.

I’ve gone to very fine schools, but the most transformative was St. Albans, where I fell under the sway of my favorite teacher, John F. McCune, known to generation of boys as Gentleman Jack McCune. He was my American history teacher and introduced me to the work of Richard Hofstadter at Columbia University and C. Vann Woodward at Yale University.

Reading their books changed my life. It was Mr. McCune who got me interested in the politics of historiography. He was a thoroughly inspirational figure. We shared a birthday and became close friends. I was with him the day before he died and was honored to speak at his memorial service at the National Cathedral.

“I have been surrounded for nearly 40 years by wonderful colleagues and students. Working here has been a blessing.”

How did you become interested in law?

Lawyering as an idea was an active presence in my household. My father spoke often about the time that he saw Thurgood Marshall argue the South Carolina whites-only primary case, Rice v. Elmore, in 1947.

The plaintiff was a Black business owner by the name of George A. Elmore, who challenged the exclusion of Black voters from the South Carolina Democratic primary. The judge ruled that the Democratic Party of South Carolina could no longer exclude qualified negroes from participating in primary elections.

And my parents were very proud of their friendship with the leading Civil Rights attorney in South Carolina, Matthew J. Perry. Most influential, however, was the example set by my brother, a 1973 graduate of HLS, who became a prosecutor, a Washington, D.C., judge, and then a judge on the United States District Court in the District of Columbia. (When he retired, he was replaced by Ketanji Brown Jackson, who now sits on the Supreme Court.) 

You seem to have great admiration for your brother Henry.

Yes. He was a conscientious jurist and is a remarkably encouraging and loving big brother. He has been a wonderful cheerleader for me and our younger sister, Angela, who is also an attorney. He has been especially important to me since my wife passed away.

Randall Kennedy with oldest son Henry and wife Yvedt Matory.
Kennedy with his oldest son, Henry, and late wife, Yvedt L. Matory.

Could you tell me how you met your wife?

My romance with Yvedt L. Matory began when I was a first-year student at Yale Law School, and she was a second-year student at Yale Medical School. We had met previously when she attended Sidwell Friends School, which was a 15-minute walk from St. Albans.

We married in June 1985 and had three children. She was a surgical oncologist at the Brigham and Women’s Hospital. She died of melanoma when she was only 48 years old. She passed away two months shy of what would have been our 20th wedding anniversary. I have lived a charmed life. The great tragedy that befell it was the death of my wife of blessed memory.

You served as a clerk to Justice Thurgood Marshall in 1983-1984. Can you talk about that experience?

It was thrilling to be able to work with and for “Mr. Civil Rights.” (Two of my co-clerks, by the way, are esteemed colleagues here: Terry Fisher and Howell Jackson.)

A strong argument can be made that Marshall was the greatest lawyer in American history. Think about the variety of posts he held — counsel for the NAACP, court of appeals judge, solicitor general, and Supreme Court justice — and the difficulties he had to overcome to make such positive contributions to American life and law!

I learned a lot working in the Marshall chambers. Seeing him up close was an inspiration that has deepened over time as I’ve gained a better sense of what he was up against and the patience, tenacity, poise, and grit that he displayed over a long period of time.

Did your father get a chance to meet Marshall?

My father met Justice Marshall on the next to last day of my clerkship. My father told “Mr. Civil Rights” how inspiring it had been to see him in that courthouse fighting for Black folks’ rights in a fashion that elicited grudging respect even from racist enemies. 

Randall Kennedy and Thurgood Marshall.
Kennedy keeps this portrait of himself with Supreme Court Justice Thurgood Marshall in his office.

How did you come to Harvard Law School?

When I left Yale Law School, I was all set to go work for the NAACP Legal Defense Fund after my clerkships with Judge J. Skelly Wright and Justice Marshall.

But near the end of my third year of law school, I got a telephone call from HLS Dean James Vorenberg, who invited me to the Law School to talk with him and other members of the faculty about a career in legal academia. I shall always be grateful for his solicitude.

When I talk about my fondness for HLS, some friends tease me, calling me a Pollyanna. Too bad! It’s hard for me to imagine a better setting for a professor than Harvard Law School. I have been surrounded for nearly 40 years by wonderful colleagues and students. Working here has been a blessing.

What role does teaching play in your career compared to research and writing?

I thoroughly enjoy research and teaching and am engaged in writing all the time. The course that I’ve taught the most is contracts. For a long time, I felt considerable anxiety before every class. Over the past decade, though, that anxiety has steadily dissipated. Now teaching contracts is wholly fun. One of my upcoming books will be about contracts in the context of intimate associations — friendship, dating, marriage, surrogacy, adoption, etc.

Much of my teaching and almost all of my writing thus far has been about the regulation of race relations. I am about to complete a book on which I have been working for nearly a decade. It responds to the following question: How did protests over racial injustice in the mid-20th century change American law? I seek to answer that question in 800-plus pages.

“I am deeply alarmed by the effective mobilization of racial resentment that has gripped American politics.”

You wrote a book that examines the historical, cultural, and social significance of one of the most offensive words in the English language. Can you talk about it?

It is my only best-seller and has generated considerable controversy. It provoked an attempted assault at a bookstore reading and has triggered walkouts. It has also prompted lawyers to seek my assistance as an expert witness in employment discrimination suits, union grievance actions, and prosecutions for murders and assaults in which I have testified for the defense in some cases and for the state in others. By the way, the full title of my book is “Nigger: The Strange Career of a Troublesome Word.”

There were many people who said, “Well, you could have titled your book something else,” and there were people who would say, “You’re just trying to be sensationalistic.” My main goal was to educate, but how do you educate? If you’re boring, you’re not going to educate. You have to do something to get people’s attention and keep people’s attention. Do I try to do that? Sure, I try to do that. But I don’t view it as a bad thing.

Some in the media have, at times, labeled you a conservative. How do you respond to that?

Anybody who labels me conservative has not paid attention to what I have written over the course of my life. I believe that the United States is afflicted by unjustifiable hierarchies and inequalities that generate avoidable social misery. I think that it is scandalous that in a country this wealthy, there are so many people who are insecure regarding nutrition, shelter, healthcare, employment, and personal security due to crime and poor policing. I am in favor of reforms that aggressively address these problems.

The intellectual and ideological communities I find most attractive find voice in magazines such as The American Prospect, Dissent, The Nation, and The London Review of Books. If that makes me conservative, so be it.

I think that some observers have erroneously pegged me as conservative because I savor the company of intelligent conservatives such as my recently departed friend and colleague Charles Fried, because I participate enthusiastically in programming sponsored by conservative organizations such as the Federalist Society, because I strongly criticize certain policies such as mandatory Diversity, Equity, and Inclusion statements for university hiring and promotion, and because I indulge in certain rhetorical gestures that raise eyebrows — such as my use of the word “negro,” a term that I began using in 1984 at the insistence of my boss Thurgood Marshall and continue to use in homage to him and A. Philip Randolph, Martin Luther King Jr., Medgar Evers, W.E.B. Du Bois, my grandmother Lillian Spann, “Big Momma,” and countless other admirable souls.  

Randall Kennedy's grandmother Lillian Spann.
Kennedy credits his grandmother Lillian Spann as a major influence.

You said that your father was pessimistic about the possibility of achieving lasting racial justice in America. What is your view?

Yes, my father was a pessimist on the race question. He did not believe that we shall overcome. The tradition he voiced is a strong tradition that includes the likes of Thomas Jefferson, Alexis de Tocqueville, Abraham Lincoln, Marcus Garvey, Malcolm X, and Derrick Bell. Tragically, there is much to which proponents of this tradition can point to substantiate their view that racial justice in America is doomed.

I place myself, however, in a different tradition, the tradition expounded by Frederick Douglass and Martin Luther King Jr., the tradition that embraces the possibility, indeed the likelihood, that racial decency will become an increasingly large and influential feature of American life.

I am deeply alarmed by the effective mobilization of racial resentment that has gripped American politics. But I take solace ironically in recognizing that a substantial part of that menacing reaction stems from remarkable successes in racial reform. 

When I was born on Sept. 10, 1954, my home state of South Carolina explicitly subjected African Americans to a degraded, stigmatized status. It was not alone. Pigmentocracy was pervasive. 

Yet, within a lifetime, by dint of remarkable struggles undertaken by Americans of all complexions, things changed sufficiently to enable a Black man to be president of the United States — a Harvard Law School alumnus who comported himself with consummate intelligence, grace, and honor.   

Finally, what advice do you have for young lawyers?

Keep the fun quotient high by finding work that you love.


Stopping the bleeding

Terence Blue has spent his life managing hemophilia. A new gene therapy offers relief from constant worry and daily needles — ‘I am actually healing faster than I ever have.’


Health

Stopping the bleeding

Terence Blue has spent his life managing hemophilia. A new gene therapy offers relief from constant worry and daily needles — ‘I am actually healing faster than I ever have.’

long read
Terence Blue receives gene therapy for hemophilia B at Brigham and Women's Hospital.

In early February, Terence Blue became the first patient in New England to receive a new gene therapy for hemophilia B, at Harvard-affiliated Brigham and Women’s Hospital.

The first time Terence Blue understood he was different was during a kindergarten kickball game.

The other team fielded his kick and threw the big rubber ball at him to get him out. Blue tripped over the ball and hit his head on the ground, which didn’t rattle him much. What did was the reaction of the adults watching, who gasped and rushed over. Luckily, the 5-year-old had recently received clotting factor as part of his regular treatment for hemophilia. The factor did its job, stopping any bleeding from the tumble’s cuts and scrapes.

“I’d seen other kids take falls and remember thinking, ‘What’s all the fuss?’ Then I realized I really do need to be extremely careful about those things,” Blue said. “I realized then that I had to pay attention.”

For the next 27 years, Blue paid attention. Diagnosed at just months old, for years he visited the hospital two to three times a week for shots of the clotting factor missing from his blood. Eventually his mother learned to give him the shots and, when he was 8, a nurse taught him to do the task himself.

Over time, medical technology made living with hemophilia easier. Synthetic factors eliminated the risk of HIV, hepatitis C, and other pathogens that might lurk in donated blood. New factors last longer, allowing Blue to stretch the interval between shots to two weeks. Still, the idea he might go two months without a shot was more dream than reality.

“I remember being told ‘Within your lifetime, there may be a cure,’” Blue said. “It always seemed like a magic bullet or wishful thinking, a genie-in-a-bottle situation. But it’s starting to prove true. This is one step closer. So science, let’s keep making it happen.”

“I remember being told ‘Within your lifetime, there may be a cure.’ It always seemed like a magic bullet or wishful thinking.”

Terence Blue

In early February, Blue was the first patient in New England to receive a relatively new gene therapy for hemophilia B, at Harvard-affiliated Brigham and Women’s Hospital. Called Hemgenix, it was developed by drug maker CSL Behring and granted FDA approval in November 2022. It is part of surge of gene and cell therapies finally emerging from the long discovery pipeline that leads from the lab to patients’ hospital rooms.

Market reality vs. scientist and patient dreams

While that surge promises an expanding menu of gene and cell therapies — which are targeting more common conditions, have improved safety profiles, and improved vectors to carry them into the body — it also means the new treatments must face another force: the market. An implacable attention to balance sheets can negate both scientists’ long labors and patients’ fervent dreams.

“We’re seeing many more gene therapies coming into the clinic but the field is adjusting to the fact that not only does it matter that you can bring the gene therapies to the clinic and get them approved by the FDA, but there are market pressures and patient acceptance that has to be put into the equation,” said Roger Hajjar, head of Mass General Brigham’s Gene and Cell Therapy Institute. “So if the pricing is too high and too few patients actually benefit from the therapies, certain approved drugs in gene therapy are actually being withdrawn because there’s not enough payers to pay for them and not enough patients to benefit.”

Part of gene therapies’ difficulty is that they offer fewer opportunities to recoup research and development costs. Unlike medications for chronic diseases like diabetes, high cholesterol, and high blood pressure, which are taken regularly over a lifetime, gene therapies are typically given in a single dose that aims to correct disease-causing mutations and provide long-lasting benefits. That means eye-watering prices. Blue’s treatment, for example, lists for $3.5 million, though insurance companies typically negotiate lower rates, said his physician, Nathan Connell, associate director of the Boston Bleeding Disorders Center and vice chair of the Department of Medicine at Brigham and Women’s Hospital.

Nathan Connell.

Blue’s doctor Nathan Connell.

Veasey Conway/Harvard Staff Photographer

That can mean little room for a market to grow and mature as patients and physicians learn about a treatment, according to Nathan Yozwiak, head of research for Mass General Brigham’s Gene and Cell Therapy Institute. The learning curve is often gradual, he said, and patients sometimes aren’t as enthusiastic as expected. Drugmaker Pfizer is already pulling its own hemophilia B gene therapy, Beqvez, from the market less than a year after its FDA approval, citing limited interest among patients and their doctors. In 2021, Bluebird Bio withdrew its beta thalassemia therapy Zynteglo from the market after a dispute with German regulators over its $1.8 million price. Even a groundbreaking treatment like Glybera, a treatment for a rare dysfunction in fat digestion and the world’s first gene therapy, was withdrawn in 2017 after treating just a single patient in five years.

But enthusiasm for gene therapy’s potential to transform patients’ lives, perhaps permanently, ensures that work continues. Today, the field is gathering additional steam as new treatments emerge from the pipeline connecting basic research to the hospital clinic, according to Hajjar, a pioneer in cardiac gene therapy for heart failure. An FDA tally of gene and cell therapies — in which healthy cells or those altered in the lab are given to the patient — shows 44 therapies have been approved in the U.S. Two were approved in 2022, five in 2023, and 18 in 2024 for conditions including multiple myeloma, invasive bladder cancer, sickle cell disease — which employed CRISPR gene editing technology for the first time — and cartilage defects in the knee, among others.

“Within the research side of things, there’s enormous, enormous optimism that’s reflected in the fact that the catalog of diseases for which researchers are pursuing a gene or cell therapy is growing every year,” Yozwiak said. “At the end of the day, I think we’re going to have a number of therapies that are actually very effective. Aligning that with the economic realities can be frustrating for researchers sometimes.”

‘I’m tired of needles’

Blue began talking about gene therapy with Connell two years ago after Hemgenix was approved by the Food and Drug Administration. Blue said it took several months to examine study data on his own, get used to the idea of introducing foreign genes into his body, and decide to move ahead. The idea that he might be able to unhitch his life from the needles that have been a daily reality, that he might be able to travel without needing an emergency supply of factor IX — just in case — and that he might escape the very real social pressures that have cost him friends grew on him.

“I’m tired of needles. They’ve been a part of my life forever,” Blue said. “It’s a small thing but it gets to you.” 

After he decided to move forward, it took months more for the hospital to develop its own scientific review, internal approvals, and protocols before, finally, ordering the drug and administering the treatment.

The therapy takes advantage of viruses’ natural ability to home in on a particular organ and insert viral DNA into cells’ genetic code. In this case, bioengineers picked a virus that targets the liver — where the body makes clotting factor — and replaced the virus’ DNA with a corrected copy of the mutated gene that causes hemophilia B. Once in the liver, the virus inserts its payload into liver cells, jump-starting production of clotting factor IX, which is deficient or missing in hemophilia B, the rarer of hemophilia’s two forms and affecting about 15 percent of patients.

“You basically have a bit of a Trojan horse,” Connell said. “You want to get it into the liver and you use this mechanism to get it there. Patients come into the infusion center and it’s all done as an outpatient.”


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Because the genes causing hemophilia reside on the X chromosome, the condition is more common among men than women. Women have two copies of the X chromosome and even one normal gene usually allows their blood to clot normally. Men, with XY chromosomes, have only one chance: If their single X chromosome contains the mutation, they develop hemophilia. The U.S. Centers for Disease Control and Prevention says exact figures for those living with hemophilia are unknown, but a recent survey showed about 33,000 American males living with the condition.

Hemophilia care has come a long way, greatly aided by recent decades’ standardization of prophylactic injection of clotting factor for severe cases like Blue’s. Life expectancy was under 30 before the advent of modern hemophilia care but today approaches that of the average male population, according to a recent study by Canadian researchers.

“I called him and I think he was in a meeting at work. He didn’t know what to expect. I was really excited to tell him that it’s working.”

Nathan Connell

Though better, care remains imperfect, Connell said. Spontaneous bleeds are part of life, can be difficult to predict or control, and are often internal, affecting different parts of the body, including the brain. It’s not unusual for patients to experience spontaneous bleeds and wake up with a stiff elbow, knee, or other joint, a sign that blood has pooled within. The situation can be managed with an extra dose of clotting factor, but over time the bleeds damage the joints’ smooth, slippery cartilage, causing pain as well as making them prone to additional bleeding. Blue, today 33, has an ankle with an arthritis-like condition called hemophilic arthropathy because of trauma that began with an injury when he was young.

“Before we used prophylaxis, many people with severe hemophilia wound up in wheelchairs or using crutches because they would have frequent bleeds and then lose their ability to walk,” Connell said.

After decades managing the condition, Blue said the physical aspects of living with hemophilia have become routine, though never far from his consciousness. The social aspects are still difficult, however, and can be disheartening. He regularly must explain to companions why he can’t do certain activities and says that revealing his condition has cost him friends. Today, unless he’s engaged in an activity for which he believes companions need to know, he keeps silent.

Even with its limitations, Blue’s been able to live an active life. He got his black belt in tae kwon do when he was 14 — wearing extra pads when sparring — and outside of his work as an IT security engineer, enjoys bachata, a type of Latin social dancing, several times a week.

For something so cutting-edge and potentially impactful, receiving the therapy was fairly routine, if not dull. Blue’s infusion occurred on Feb. 6 and took about two hours. Watched closely by Connell and other members of his care team, Blue reported few side effects. After another four hours of observation, he was able to go home after reporting nothing amiss. In the weeks that followed, he began steroid treatment after enzymes in his liver became elevated. On. Feb. 20, he received his last injection of clotting factor IX, and as of mid-March, was tapering off steroids as liver function improved. By then, his factor IX levels, which had been less than 1 percent, had risen to 32 percent, in the mild hemophilia to low normal range.

“We hope it works. We have data that it works, but until you see it start to do something, you always have a little fear that maybe it’s not going to work out right,” Connell said. “I called him and I think he was in a meeting at work and he stepped out when he saw the number. He didn’t know what to expect. I said, ‘It’s working.’ And I was really excited to tell him that it’s working.”

Though physicians are hesitant to describe these therapies as “cures,” there is the prospect of yearslong or decadeslong effects. Ninety-four percent — 51 of 54 — of those treated with Hemgenix during the clinical trial still do not require factor IX prophylaxis three years later, according to the drugmaker’s website. Blue, who got a painful cut under his thumbnail in March, is still getting used to the healing journey he’s embarked on.

“I’ve had this happen many times before, so after I freaked out for a moment, I went to treat it,” Blue said. “My wife was sitting there looking at me, watching, and within seconds I realized that it was starting to resolve. This is abnormal for me. I’m ‘severe’ and am used to seeing bleeding happen for longer. In that moment I thought, ‘Wow, this is real. This is working. I haven’t had factor in ages, but here I am actually healing faster than I ever have in my life.’”


Immune-system strategy used to treat cancer may help with Alzheimer’s

Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice


Vijay Kuchroo.

Vijay Kuchroo.

Veasey Conway/Harvard Staff Photographer

Health

Immune-system strategy used to treat cancer may help with Alzheimer’s

Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice

7 min read

A new study raises the odds that a strategy already successful against some cancers may be deployed against Alzheimer’s. The research, which highlights the role of an immune system “checkpoint” molecule, showed improved cognition in tests with mice. It was published earlier this month in Nature.

In this edited conversation, the Gazette spoke with Vijay Kuchroo, the Samuel L. Wasserstrom Professor of Neurology at Harvard Medical School and Brigham and Women’s Hospital, and director of the Gene Lay Institute of Immunology and Inflammation of Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School.

Kuchroo, who was a senior author on the paper, outlined work that deleted the expression of a molecule called TIM-3, which blocks brain immune cells called microglia from attacking Alzheimer’s plaques, freeing the cells to clear plaques and restoring memory.


Your work was done in a model of late-onset Alzheimer’s disease. What proportion of cases is it?

Most cases of Alzheimer’s disease (AD), 90 percent to 95 percent, are late-onset. The molecule that we studied, called TIM-3, was linked by a genome-wide association study to late-onset Alzheimer’s and was found to be a genetic risk factor for the disease. There’s a polymorphism in the TIM-3 gene, HAVCR2, in patients with AD. TIM-3 is an inhibitory molecule utilized by the immune system to turn off the immune cells once activated. TIM-3 belongs to a group of inhibitory molecules called checkpoint molecules, which have been exploited for treatment of cancer.

Checkpoint molecules stop the body from attacking itself?

That’s one way to put it. If your immune system gets activated, the checkpoint molecules restrain the immune system from getting out of hand.

The best example is that every time you get an infection like the common cold, your lymph nodes get swollen because you make millions and millions of T cells to fight the virus. Once the infection goes away, checkpoint molecules come in to reduce the number of T cells to a normal level.

Cancers have exploited these checkpoint molecules for their own survival, and every time a T cell goes to attack a tumor cell, the tumor cell induces expression of checkpoint molecules so the T cells don’t attack the tumor cells. The T cells become dysfunctional or exhausted, and the tumor survives.

The new twist is that in Alzheimer’s disease, there is the accumulation of plaque in the brain that doesn’t get cleared by macrophage-like cells called microglia. The microglia show an increased expression of the checkpoint molecule TIM-3.

They’re basically the immune cells of the brain?

Microglia are the immune cells of the brain and have other important functions. During development, synapses are being formed, and synapses are how memory is stored. The problem is that even transient experiences make memories, so you want to get rid of some memories that are not being used again. So, the major job of microglia cells during development is to prune synapses that have not been used often enough in order to sharpen and sustain your memory.

After you’re born and have developed memories, you don’t want to lose them, so at about 28 to 40 days after birth in the mouse and a few months to few years in a human, there is a developmental mechanism by which microglia stop pruning to keep the memories that are made.

To stop the microglia from pruning, they increase expression of the checkpoint molecule TIM-3, and these microglia cells become homeostatic, they do not phagocytose anymore.

That’s good because you don’t want to prune your own memory, but it’s bad as you get older and accumulate gunk in the brain, which can’t be cleared. Who’s going to clean it up? Microglia cells have become homeostatic, and TIM-3 keeps them from engulfing the accumulated gunk, which results in the formation of plaques.

What’s the difference in TIM-3 in an older person who has Alzheimer’s disease, versus not?

There’s a polymorphism in the gene, and in Alzheimer’s patients with the polymorphism, TIM-3 is highly expressed on microglia, significantly more than those that don’t have the disease.

So that all that TIM-3 keeps the microglial cells at homeostasis and not attacking amyloid beta plaques even though they’re harming the brain?

Yes, microglia cells should be clearing amyloid plaque, but they don’t. We discovered this molecule on T cells in the immune system, but it is 100 times — in some cases 1,000 times — more expressed on microglia when they get activated.

So, the same molecule that’s shrinking the T cell population to normal size after infection is being used by microglia cells to stop them from excess pruning. But it’s also a liability, because it inhibits them from attacking plaques that accumulate in Alzheimer’s disease.

You tested this with lab mice who have the HAVCR2 gene — which makes TIM-3 — deleted?

Yes, these mice were made to test the role of TIM-3 in immune system autoimmunity and cancer.

We used the same mice. We genetically deleted the gene, and in these mice the microglia don’t express TIM-3 when the microglia get activated. That enhances clearance of the plaques and changes plaque behavior.

Toxic plaque has fingerlike projections that enter into the brain, but with the microglia nibbling on them, the plaques become compact. So, the deletion of TIM-3 in microglia not only reduces the number of plaques, it also changes the quality of the plaque. These mice actually get the cognition back. Not completely, but the cognitive behavior of these mice improves.

And when we talk about measuring cognitive behavior for mice, we’re talking about their ability to remember and navigate mazes?

That’s correct. When they have plaque burden in their brains, they don’t remember as much. They also have less fear. If you put them in an open space, normal mice will go to a corner, so they don’t wind up as prey. But if they have plaques, they sit there in the center of the maze and don’t hide. When you get rid of the plaques, memory comes back, and that response comes back, because an appropriate level of fear is important for survival.

What would a TIM-3 therapy for Alzheimer’s disease in humans look like?

Therapy would use an anti-TIM-3 antibody or a small molecule that can block the inhibitory function of TIM-3.

What’s the potential of this to make a difference against Alzheimer’s disease? After several failures of major drug trials, recently there have been some successes, though those showed just minor improvement.

Because amyloid beta is also in the endothelium in the blood vessels, a lot of antibody doesn’t go to the brain, it attacks the blood vessels, leading to strokes due to vascular damage, limiting the use of anti-amyloid antibodies in AD. Since TIM-3 has selective expression, existing anti-TIM-3 antibodies can be repurposed for treatment of AD.

How long did this work take?

Five years; each experiment takes about eight, nine months. I want to emphasize that this was in collaboration with a colleague here, Oleg Butovsky at the Ann Romney Center for Neurological Disease. There were about six people, three from my lab and three from his lab, who worked tirelessly to do these experiments.

What happens next?

We are trying to see whether human anti-TIM-3 can halt development of plaques in the brains of Alzheimer’s disease mouse models. We have a mouse model in which the human TIM-3 gene has been inserted, which will be very suitable for testing various candidate antibodies for human disease.


This research was funded in part by the National Institutes of Health.


Slave trade database moving to Harvard

Publicly accessible digital tool compiles four decades of scholarship on more than 30,000 voyages and 200,000 people.


Campus & Community

Slave trade database moving to Harvard

Henry Louis Gates, Jr.

Henry Louis Gates Jr. (left) talks with David Eltis.

Photos by Veasey Conway/Harvard Staff Photographer

4 min read

Publicly accessible digital tool compiles four decades of scholarship on more than 30,000 voyages and 200,000 people

SlaveVoyages, a groundbreaking tool for data on history’s largest slave trades, is getting a new home.

Word of the project’s upcoming move was shared recently by Henry Louis Gates Jr., the Alphonse Fletcher University Professor and director of the Hutchins Center for African & African American Research. “I’m pleased to tell you today that the SlaveVoyages site, with all of its databases, will live in perpetuity here at Harvard University,” Gates announced at a conference dedicated to celebrating the open-access resource.

SlaveVoyages was the result of nearly four decades of scholarly contributions, with researchers from multiple institutions working painstakingly to digitize handwritten records from archives worldwide.

Today, its multisource dataset, currently housed at Rice University, features information on more than 30,000 slaving vessels that traversed the Atlantic between the 16th and 19th centuries. Also documented are details on nearly 221,000 individuals involved with the trans-Atlantic slave trade, including ship captains and the humans they trafficked.

The project’s website, launched in 2008 at Emory University, brings data to life with rich visualizations. A time-lapse animation tracks each of the individual voyages on a map of the trans-Atlantic slave trade. A pair of 18th-century French slaving ships, both bound for present-day Haiti, have been recreated in 3D video based on surviving drawings.

As SlaveVoyages expanded, the Hutchins Center provided key funding along with the National Endowment for the Humanities, the Andrew W. Mellon Foundation, and Emory University. Stepping up to help support the project in its new home is the Harvard & the Legacy of Slavery Initiative (H&LS).

“Education is central to the mission of the initiative.”

Sara Bleich

“Education is central to the mission of the initiative,” said Sara Bleich, vice provost for special projects and the leader of H&LS. “SlaveVoyages’ databases build on the curiosity of Harvard students who catalyzed the University’s ongoing reckoning with its ties to slavery. By cofunding the project with the Hutchins Center, the initiative can help amplify knowledge-sharing and visibility, empower scholars and students worldwide, while also reaffirming our commitment to truth.”

The April 3-5 conference, hosted by the Hutchins Center, attracted researchers associated with the project as well as those it has inspired.

“This conference brings together generations of scholars who dedicated their lives to unearthing centuries of data to help us understand in detail and with nuance the contours of the slave trade — a quantifiably brutal trade in human beings that spanned oceans and continents while devastating millions of lives,” said Gates, who is also a member of the initiative’s Advisory Council.

Over three days, sessions covered a wide range of topics suggesting the global scope of the slave trade. The conference kicked off with a panel on the genetic impacts of the slave trade featuring David Reich of Harvard Medical School, Kasia Bryc of the Broad Institute, as well as scholars from Johns Hopkins University and the National Center of Medical Genetics of Cuba.

Rice University associate professor of history Daniel B. Domingues da Silva, who currently serves as host of the SlaveVoyages project, unpacked his findings on Brazil’s 19th-century slave trade. Jorge Felipe-Gonzalez, an assistant professor of history at University of Texas at San Antonio, discussed the potential integration of AI into the database. Jane Hooper, a professor of history at George Mason University, explored shipboard uprisings on Indian Ocean voyages.

A final panel addressed the South West Pacific trade, with Francis Bobongie-Harris, Queensland University of Technology educator and researcher emphasizing the human cost.

David Eltis
David Eltis is awarded the W.E.B. Du Bois Medal.

Gates opened one of the afternoon sessions with a surprise for SlaveVoyages originator David Eltis, an emeritus professor of history at Emory University and the University of British Columbia, bestowing on him the W.E.B. Du Bois Medal “in recognition of his unyielding vision that brought to life a resource that has transformed our understanding of one of the most cataclysmic and consequential economic, social, and cultural forces unleashed in the history of humanity.”

The medal is “especially fitting” for Eltis, Gates added, given the fact that Du Bois, the first Black American to earn a Ph.D. from Harvard University, wrote his 1895 dissertation on efforts to suppress the trade of enslaved Africans in the U.S.


What we still need to learn from pandemic

School closures, shutdowns caused lasting damage, and debate was shut down in favor of groupthink, public policy experts say


Nation & World

What we still need to learn from pandemic

Frances Lee with Stephen Macedo.

Princeton University professors Frances Lee (left) and Stephen Macedo share their findings.

Veasey Conway/Harvard Staff Photographer

6 min read

School closures, shutdowns caused lasting damage, and debate was shut down in favor of groupthink, public policy experts say

Social distancing, school closures, and stay-at-home orders became hotly disputed during the 2020 COVID-19 crisis. How should these protocols be viewed today?

The new book “In Covid’s Wake: How Our Politics Failed Us” by a pair of Princeton University professors finds no evidence these “non-pharmaceutical interventions” actually reduced mortality rates. What the co-authors do find is that the measures did significant damage to U.S. society — with many mainstream scientists, journalists, and scholars reluctant to make a frank appraisal.

“We argue that, in the pandemic, disagreement was moralized prematurely, and dissent was treated intolerantly,” said co-author Stephen Macedo, the Laurance S. Rockefeller Professor of Politics at the University Center for Human Values. “We see these as failures of educated elites to live up to some of our own deepest values of being open to criticism and divergent points of view.”

In a talk last week hosted by the Department of Government, Macedo and co-author Frances Lee, a professor of politics and public affairs, outlined the book’s thesis and took tough audience questions.

Macedo kicked things off with a survey of pandemic planning documents that predate COVID-19. Reading John M. Barry’s “The Great Influenza” (2004) had piqued the interest of former President George W. Bush. His administration advanced a strategy of containment, influenced by mathematical modelers who said children would likely be primary carriers.

A National Strategy for Pandemic Influenza Implementation Plan, released by the Centers for Disease Control in 2006, emphasized the promise of school closures. “They predicted that school closures, by themselves, could secure a 50 percent reduction in peak death rates,” Macedo said.

Over the next 13 years, several experts cautioned against what the American Civil Liberties Union characterized as “aggressive, coercive actions” in its own 2008 pandemic preparedness report. Frequently emphasized was the danger of disproportionately harming vulnerable populations, including kids from low-income families.

“But the policy flipped on a dime in March 2020,” Macedo said, citing a February 2020 World Health Organization-China report from Wuhan. “The joint mission report unequivocally urged every country in the world to embrace what was, in effect, a zero-COVID policy by the severe implementation of lockdown policies.”

There was some pushback from infectious disease experts in the early days of the pandemic. But, the authors say, the marketplace of ideas was experiencing its own lockdown by the October 2020 release of the Great Barrington Declaration, with its urgent call to relax restrictions for those at minimal risk. The statement, written by three epidemiologists with distinguished credentials, drew thousands of signatories. But it was quickly branded by critics in public health and government as “dangerous” and “fringe.”

“Part of it was that people settled on a wartime framing,” Macedo offered, citing the titles of two early pandemic memoirs — Deborah Birx’s “Silent Invasion” and Sanjay Gupta’s “World War C.”  

Co-author Lee picked up the thread by examining pandemic outcomes across 50 states. At first, blue and red states implemented similar measures, she recalled. But the policymaking appeared deeply polarized by Labor Day.

“Across the South, the Plains, and the Mountain West, schools reopened in the fall of 2020,” Lee said. “But nearly half of public schools around the country were still closed in March 2021.”

By January 2023, states led by Republicans had suffered mortality rates nearly 30 percent higher than their Democratic-led counterparts, according to the co-authors’ assessment of CDC data. But they found no evidence that blue states benefited from longer school closures and stay-at-home orders.

“If you examine COVID mortality across the period before vaccines became available,” Lee said, “there’s not a statistically significant difference.” This was true even when controlling for the percentage of elderly, uninsured, or obese residents. A separate analysis, published in the Lancet in 2023, surfaced similar conclusions.

Yet these non-pharmaceutical measures came at a steep cost, with Lee quickly rattling off more than a dozen examples — from a spike in alcohol-related deaths to emptied downtown business districts and learning losses for schoolchildren.

The injury was also fiscal. Congress authorized more than $5 trillion in COVID relief spending, aimed mostly at helping Americans stay financially afloat during the shutdowns.

“In the first quarter of 2020, total debt held by the public leapt from 80 percent of gross GDP to more than 100 percent,” Lee explained. “This higher plateau persists post-pandemic — and that higher level of indebtedness also entails a higher cost for debt service that puts constraints on our ability to respond to the next economic crisis or address other priorities.”

Are educated elites, largely aligned with the Democratic Party, finally ready for an honest reckoning with the COVID era’s groupthink? Macedo has his doubts. He pointed to an August 2023 JAMA Network Open article outlining varieties of misinformation shared by physicians on social media, with the aim of helping governments and professional societies censor bad actors.

Included were the Wuhan lab leak theory, concerns about the harms of masking children, and suggestions that natural infection can contribute to herd immunity. “All of these matters, as of August 2023, were either true or at least arguable,” Macedo said.

In a lightning-round review of the book’s lessons, Macedo emphasized the need for open debate and viewpoint diversity in navigating future crises.

“We also need greater honesty on the part of public officials — especially in public health,” he concluded, noting the resulting hit to the field’s credibility. “There’s too much of a tendency to not tell the whole truth, because they see their role partly as messaging and trying to nudge people’s behavior. But I think we are owed honesty about the limits of their knowledge.”

During the Q&A session, one attendee pushed back on the authors’ call for prioritizing honesty in a public health emergency. Given the pandemic’s devastating loss of life, the comparison to wartime governments protecting national security was made.

In response, Macedo referred to previous scholarship on the Vietnam War, including Barbara W. Tuchman’s “The March of Folly” (1984). “We think this is another case where people are engaging in wishful thinking — trying to get the public to go along and not being transparent about the cost of these measures and the likelihood of success,” he said.


Hunting a basic building block of universe

Researchers find way to confirm existence of axions, which make up dark matter


Jian-Xiang Qiu (left) and Professor Suyang Xu adjust the lasers inside the Axion Quasiparticle

Jian-Xiang Qiu (left) and Suyang Xu adjust the lasers

Photo by Dylan Goodman

Science & Tech

Hunting a basic building block of the universe

Researchers find way to confirm existence of axions, a leading dark matter candidate

5 min read

No one has ever seen axions. But scientists have theorized their existence as a way to explain some of the biggest questions in particle physics, including the nature of dark matter, the mysterious substance that constitutes most the mass of the cosmos. Confirming the existence of axions could lead to insights into the history and composition of the universe itself.

Now, in a groundbreaking experiment, a team of scientists led by Harvard and King’s College London have made a significant step toward using quasiparticles to hunt for axions, which are hypothesized to actually make up dark matter. The findings, recently published in Nature, open new realms for harnessing quasiparticles to search for dark matter and develop new quantum technologies.

“Axion quasiparticles are simulations of axion particles, which can be further used as a detector of actual particles,” said senior co-author Suyang Xu, assistant professor of chemistry. “If a dark matter axion hits our material, it excites the quasiparticle, and, by detecting this reaction, we can confirm the presence of the dark matter axion.”

Frank Wilczek, the Nobel Prize-winning physicist who first proposed axions, credits these findings as a major breakthrough in the study of these particles.

“The jury is still out on the existence of axions as fundamental particles that beautify the basic equations of physics and provide the cosmological dark matter,” Wilczek said. “But now, thanks to these ingenious new experiments, we know for sure that the Nature makes use of the underlying ideas. Axions now join holes, phonons, plasmons, and a handful of other ‘quasiparticles’ we find emerging as ingredients of matter, available for new scientific and technological creations.”

The experimental work was led by Jian-Xiang Qiu, a Harvard Griffin Graduate School of Arts and Sciences student in the Xu lab. Researchers who assisted in the study include Yu-Fei Liu, Anyuan Gao, Christian Tzschaschel, Houchen Li, Damien Berube, Thao Dinh, Tianye Huang, as well as an international team of researchers from King’s College, UC Berkeley, Northeastern University, and several other institutions.

The researchers utilized manganese bismuth telluride, a material renowned for its unique electronic and magnetic properties. By crafting this material into a 2D crystal structure, they established a platform ideal for nurturing axion quasiparticles. This process involved precision nano-fabrication engineering, in which the material was meticulously layered to enhance its quantum characteristics.

“Our lab has been working on this kind of interesting material for almost five to six years, and it is both a very rich material platform and also it is very difficult to work with,” said first author Qiu. “Because it’s air-sensitive, we needed to exfoliate down to a few atomic layers to be able to tune its property properly.”

Operating in a highly controlled environment, the team coaxed the axion quasiparticles into revealing their dynamic nature in manganese bismuth telluride. To accomplish this delicate feat, the team utilized a series of sophisticated techniques including ultrafast laser optics. Innovative measurement tools allowed them to capture movements of axion quasiparticles with precision, turning an abstract theory into a clearly visible phenomenon.

By demonstrating the coherent behavior and intricate dynamics of axion quasiparticles, the researchers not only affirmed long-held theoretical ideas in the field of condensed-matter physics but also laid the groundwork for future technological developments. For example, the axion polariton is a new form of light-matter interaction that could lead to novel optical applications.

In the field of particle physics and cosmology, this new observation of the axion quasiparticle can be used as a dark-matter detector, which the researchers have described as a “cosmic car radio” that could become the most accurate dark-matter detector yet.

Dark matter remains one of the most profound mysteries in physics, constituting about 85 percent of the universe’s mass without detection. By tuning into specific radio frequencies emitted by axion particles, the team aims to capture dark-matter signals that have eluded previous technology. The researchers believe it could help discover dark matter in 15 years.

“This is a really exciting time to be a dark-matter researcher. There are as many papers being published now about axions as there were about the Higgs-Boson a year before it was found,” said senior co-author David Marsh, a lecturer at King’s College London. “Experiments proposed that axions emitted a frequency in 1983, and we now know we can tune in to it — we’re closing in on the axion and fast.”

Xu is confident that the team’s multifaceted approach enabled their pioneering success.

“Our work is made possible by a highly interdisciplinary approach involving condensed-matter physics, material chemistry, as well as high-energy physics,” Xu said. “It showcased the potential of quantum materials in the realm of particle physics and cosmology.”

Moving forward, the researchers plan to deepen their exploration of axion quasiparticles’ properties, while refining experimental conditions for greater precision.

“The goal for the future is obviously to have an experiment that probes axion dark matter, which would definitely be super beneficial for the whole-particle physics community that is interested in axions,” said senior co-author Jan Schütte Engel, a physicist at UC Berkeley.


This research was partially funded by the U.S. Department of Energy, the Air Force Office of Scientific Research, and the National Science Foundation.


‘This is weakening the United States.’

Scholars react to Trump administration actions against Harvard and other institutions


Campus & Community

‘This is weakening the United States.’

Amberly Xie, Andrew Tyrie, and Joshua Cherniss.

Photos by Veasey Conway/Harvard Staff Photographer; photo illustration by Liz Zonarich/Harvard Staff

4 min read

Scholars react to Trump administration actions against Harvard and other institutions


Harvard on Monday rejected demands by the Trump administration that link $9 billion in federal funding to compliance with changes to University governance and hiring practices, viewpoint “audits” of academic departments, students, and faculty, and other measures.

The funding, more than $2 billion of which was frozen hours after Harvard responded to the demands, supports research that “has led to groundbreaking innovations across a wide range of medical, engineering, and scientific fields,” according to a message President Alan Garber sent to the Harvard community Monday afternoon.

The government has cited concerns about campus antisemitism in explaining its decision to halt funding at Harvard and several other institutions of higher education.

On Tuesday, we sought reactions to the funding cuts in conversations across campus.


Amberly Xie.

Amberly Xie

Third-year Ph.D. student in applied physics

“I feel like at some core level, it violates our rights as people and researchers and scientists — and as a university as well,” said Xie, whose research focuses in part on quantum computing.

Like many students and scholars, she worries that major funding cuts at institutions such as Harvard will slow or in some cases halt scientific progress.

“Universities play a major role because it’s where a lot of research takes place,” she said. “There are companies and startups that do this kind of work, but I feel like it’s truly in universities where a lot of the fundamental work is done, and a lot of the pioneering work in terms of allowing us to not only better understand the platforms like the ones I work with, but also help put them into real-world applications.”


Andrew Tyrie.

Andrew Tyrie

Senior fellow at the Mossavar-Rahmani Center for Business and Government at Harvard Kennedy School; former member of the House of Commons in the British Parliament; current member of the House of Lords

“I think there’s a much bigger job to be done, and that is for all those who disagree with the dramatic and, in my view, dangerous decisions being taken by the new administration to speak up,” said Tyrie, who is studying regulatory reforms in advanced Western economies in his time at the Kennedy School. 

Everyone engaged in academia and politics should be outraged by the Trump administration’s stance, he said.

“And of course, as a non-U.S. citizen, I am concerned about the wider effects on the world — both the prospects for growth and prosperity, but also for its security and stability,” he said. “What I’m not asking is for people to speak up in the interests of the world, but to speak up in the interests of the United States of America. This is weakening the United States and imperiling the prosperity and the security of millions of Americans.”


Joshua Cherniss.

Joshua Cherniss

Visiting fellow at the Edmond and Lily Safra Center for Ethics; associate professor of government at Georgetown University

“I study, to some extent, authoritarian regimes, and I think that some of what we’re seeing — while it’s not equivalent to fully formed authoritarianism — is starting to approach it in terms of trying to have the government dictate the ideas that are taught, that can be expressed and that can’t be expressed,” said Cherniss. “I think that it’s important that Harvard and other universities not buckle under what I think is pretty clearly an assault on academic freedom and university self-governance.”

Cherniss studies political theory, particularly defenses and critiques of liberalism. He said he worries about the impact of funding freezes on fellow scholars inside and outside his field.

“We may have to cut a lot of the most socially useful work that we do in medical sciences and technology — things that have really benefited America and benefit the world in very practical ways,” he said.


The food was good. The conversation was better.

‘Our Harvard’ brings students together to tackle tough issues


Campus & Community

The food was good. The conversation was better.

Professor Michael Sandel

Professor Michael Sandel (right) led a conversation for the “Food For Thought” event.

Photos by Grace DuVal

5 min read

‘Our Harvard’ brings students together to tackle tough issues

First they met for coffee. This month they came together for a full meal.

Spurred by the Gaza conflict, Nim Ravid ’25, an economics concentrator from Israel, wanted to find new ways to connect students across the College. Last summer, he co-founded “Our Harvard” with five of his peers, and one of their first efforts was pairing students for coffee chats meant to encourage conversations across differences.

On April 1 at Smith Campus Center, the group hosted a larger gathering: “Food For Thought: Our Harvard College,” an evening of conversation during which students offered their perspectives on a range of issues.

Students gather in the lobby of the Smith Campus Center to share food.
Following the event, students gathered in the lobby of the Smith Campus Center to share a meal.

Ravid was heartened by the results.

“It was the most vulnerable and honest I’ve ever heard Harvard students communicating with each other, which I think reflects our efforts to bring students from across campus together to this event and create an environment where students assume best intentions and say what they actually think,” he said.

The conversation, which was followed by a meal provided by Harvard University Dining Services, was moderated by Michael Sandel, Anne T. and Robert M. Bass Professor of Government.   

“There’s a risk with conversations like this, that everyone will think it’s much safer to just celebrate diversity, eat some food, and go home, but that would miss the learning and the struggling and the wrestling with the questions out of which friendships and genuine dialogue can be forged,” Sandel told the crowd.  

One by one, members of Our Harvard and those in the audience spoke about feeling ostracized for their identity, national origin, or beliefs, and finding it difficult to establish friendships across differences. Frederico Araujo ’25, an Our Harvard founder from Portugal, discussed his struggles connecting with students from Brazil.

“Sometimes when I came to Annenberg and I initiated a conversation that I hoped would be about our shared language, our shared food, our shared music, and our many shared traditions between Brazilian and Portuguese culture, I would actually get the cold shoulder,” he said. “I don’t need to give a history lesson about the historical background between Portugal and Brazil, but I wasn’t aware that those historical ties would be sufficient for someone to ignore my friendship.” 

In response, Sandel said, “Sometimes seeming similarities can be startling for their distance.”

The conversation covered the Israel-Palestine conflict, with Ravid and others expressing their fears about sharing personal experiences. Several participants with no direct connections to the war said they have found themselves uncomfortably in the middle of friends with different views.

Angie Gabeau ’25, another founding member of Our Harvard and a sociology concentrator, acknowledged being apprehensive when the conversation turned to the Middle East, but said that it was beneficial in the end.

“I’m actually glad that it was brought up,” she said. “If you are talking about the hottest topic on the market right now and are still able to make yourself vulnerable to discussing with people who might not agree with you, then other cases will be a lot less daunting.”

Angie Gabeau ’25.
Angie Gabeau ’25 is a founding member of Our Harvard.

Gabeau, a Boston native, told the audience that she arrived at Harvard hoping to connect with other Black students after coming from a predominantly white high school. The Winthrop House resident joined the Black Students Association, the Kuumba Singers, and Omo Naija x The Wahala Boys, an African dance troupe.

“I was so happy to be able to find a community here,” she said. While emphasizing the importance of these groups, Gabeau also said that she believes it’s important to build relationships across differences. “This conversation wasn’t to shadow the importance of affinity organizations but seeing how we can both share our cultures, ideas, values, and morals with each other, while being able to feel safe here at Harvard,” she said after the event.

Harvard College Dean of Students Tom Dunne found it meaningful “that the core group of students who are organizing this are seniors in their last weeks on campus.”

Ravid expressed his hope that Food for Thought will help spark similar movements at Harvard. “I also hope this event will encourage others to not treat other students differently based on their identity, but rather for who they are,” he said. “I hope students will really take time to get to know each other before they judge.”

Gabeau noted that Our Harvard has set goals that do not ask too much of students.

“I don’t want this to come off as, ‘We can all be friends and everything’s going to be perfect,’ because that’s not really what we’re trying to do,” she said. “There’ll be people who have disagreements that won’t foster friendship. I wouldn’t want people walking around campus pretending to be friends.”

She continued: “It’s not supposed to be creating a perfect utopian universe but rather pushing people to go the extra mile in terms of seizing all the opportunity in the different pockets of joy and growth that there is on campus.”


When making positive change, sometimes you ‘break things’

Key is to avoid hurting people in process, Gina Raimondo says


Gina Raimondo.

Gina Raimondo.

Photo by Martha Stewart

Work & Economy

When making positive change, sometimes you ‘break things’

Key is to avoid hurting people in process, Gina Raimondo says

5 min read

If you want to make things better, says Gina Raimondo, that means things are going to have to change — and sometimes that means you “break things.”

For example, the former U.S. Commerce secretary and Rhode Island governor said that when she was leading the Ocean State, she cut taxes every year, raised the state minimum wage, and made community college tuition free. She also cut 30 percent of the state’s regulations.

“I don’t think we should just accept things because they’re the way things have been done,” Raimondo ’93 said last week during an Institute of Politics forum on “The Future of U.S. Competitiveness.”

This willingness to make changes, she acknowledged, may sound similar to the tactics of Elon Musk’s DOGE. The difference? “Execution matters,” she said. “You can’t hurt people in the process.”

That focus on ensuring fairness and opportunity for regular Americans came early and has remained with her throughout her political career.

The granddaughter of immigrants who stressed hard work, Raimondo, who was instrumental in shaping the Biden administration’s Infrastructure Investment and Jobs Act, credited her large Italian family with getting her into politics. When Ronald Reagan was elected president, she recalled, “My dad kept saying ‘What about the little guy who gets up in the morning and goes to work? Who’s sticking up for us?’

“As I got older and I saw that American Dream being out of reach,” she said. “It motivated me to get involved in politics.”

The IOP discussion with Jeff Liebman, director of the Taubman Center for State and Local Government and Robert W. Scrivner Professor of Social Policy, turned to Raimondo’s tenure as Commerce secretary. The two first focused on the early days when supply chains slowed as COVID raged. “The first thing we had to do was understand the complexity of supply chains,” she said.

In response to endless calls about various essentials that were suddenly not available, “We built spreadsheets for critical supply chains, like pharmaceuticals — and then, under President Biden’s leadership, we got to work making friends with other countries,” she said.

Citing Biden’s belief, she said, “America can’t and shouldn’t go it alone. America is best when we make friends; he sent us to Southeast Asia to build relationships with Indonesia, with the Philippines,” and beyond.

In addition to forging or strengthening those relationships, the Biden administration responded with the CHIPs and Science Act, aimed at making scientific essentials domestically. Liebman asked her how that played out.

“Most semiconductors are a commodity, and many of them are made overseas — a lot in China,” Raimondo responded. “It wouldn’t be a national security disaster if there was a backlog of iPhones. But artificial intelligence — all AI — runs on leading-edge chips. So much of our intelligence-gathering capacity depends on leading-edge chips. That directly affects our national security, and we make zero” of the chips in question.

 “By 2030, we’ll be making a quarter of those chips. That’s a success,” she said.

She also defended the legislation’s fiscal responsibility. “We insisted that for every dollar we put out there, $10 of private-sector dollars come in,” she said. “When we left, we had about 13 private-sector dollars for every dollar that we put in.”

Such self-reliance is essential, she said. Citing China’s BYD electric cars, which are heavily subsidized by the Chinese government and then sold inexpensively around the world, she said, “Free trade is great if everyone plays by the rules. China does not play by the rules. I think having more reciprocity is reasonable.”

Looking back on her time with the Biden administration, she acknowledged mistakes, including — perhaps — too many compromises.

“Politics is not perfect,” she acknowledged. “We did get a lot done, though. People who make those critiques may not know how hard it is to get things done in a 50-50 Senate and a tiny margin in the House.”

Raimondo also defended Biden’s stimulus act, which some blame for inflation. “I was the governor of Rhode Island during COVID,” she said. “In the couple of months after COVID broke out, in a state of about a million people, I had 110,000 file for unemployment insurance.”

Recalling the “pit in my stomach,” she worried, “How am I going to get these people back to work?

“It was really scary,” she said. “It’s easy to say the stimulus shouldn’t have been so big it led to inflation. But nobody says if it wasn’t big enough that unemployment would have continued.”

She also defending tacking so-called social programs onto economic ones. “Companies that wanted our money needed to find workers,” she said. “They’re not going to have enough workers without women, and they’re not going to get women without a childcare plan.

“They weren’t social programs. They were labor market programs designed to be a steward of taxpayer money.”


New experiences at their fingertips

Course on tactile reading shows students ‘Why Braille Matters’


Students feel the braille writing on an example sheet provided.

At the Perkins School for the Blind in Watertown, students try their hand at Boston Line Type, developed in 1835. Braille didn’t make its way to the U.S. until almost 20 years later.

Photos by Niles Singer/Harvard Staff Photographer

Campus & Community

New experiences at their fingertips

Course on tactile reading shows students ‘Why Braille Matters’

6 min read

In his “Literature and Disability” course taught last spring, Professor Marc Shell noticed Katie Sevier ’25 taking notes on her HIMS QBraille XL display, a device that connects to her laptop and allows her to type in braille.

A discussion between Shell and Sevier on the importance of the history, theory, and practice of tactile writing systems used by the visually impaired led the pair to create a course not seen at peer institutions. Now the professor and the student are both the teachers. Their class is called “Why Braille Matters.”

“For me, braille is a sign of access, of freedom, of independence,” Sevier said. “Having this course come to life means so much. It is a course affirming a component of the blind experience — braille — which is so integral to many blind people’s experiences.”

On Thursday afternoons, Sevier can be found preparing for a class as fellow students and two trained guide dogs fill a small room at Dana Palmer House on Harvard’s campus. Throughout the semester, Sevier and Shell have prioritized highlighting different experiences by inviting guest speakers from the blind community or those who work with the blind community.  

“This is and is not a course about disability,” Shell said. “It is really a course about reading and writing systems, and that is the main linkage with Comparative Literature.

Katie Sevier '25 (left) and Marc Shell (far right) in conversation during the trip.
Katie Sevier ’25 (left) and Marc Shell brought students to Perkins School for the Blind as part of their class, “Why Braille Matters.”

“The history of reading and writing goes back thousands of years to tactile forms. These forms might be called ‘pre-braille.’ As our research is now revealing, blind people had many methods of reading and writing,” he added.

Sevier and Shell take an integrative dual approach to teaching “Why Braille Matters.” She instructs students on braille code and blindness education, while he leads discussions on the literary, philosophical, and neurological aspects of the raised-dots writing system. For Sevier, the course is deeply personal. The 23-year-old lost her vision at 6 years old due to intracranial hypertension and began learning braille the summer after kindergarten.

During a recent class, students — who come from across the University — discussed the 1980 film “To Race the Wind,” the story of blind lawyer, activist, and author Harold Krents ’67, J.D. ’70. The film documents Krents’ experience navigating Harvard’s complex campus as an undergraduate. Sevier and other visually impaired students also shared their own stories about learning to move through the Yard.

  • Amy Ojeaburu '25 examines a giant tactile globe.
  • A student examines a braille bingo card.
  • A Perkins Brailler from 1951.

“What was really validating and empowering to see was the way Katie had written out the directions that she used to teach another blind student how to navigate a specific route to the Yard,” said Emma Vrabel ’25, a former white-cane user who now has a guide dog. From this, she said, sighted students were better able to understand “how exhausting” it can be to have to memorize various routes across campus.

“Harvard is a hard place to navigate,” said Vrabel, who is still able to see faces, gestures, and large print. “At the beginning of every semester, I teach my guide dog, Holly, how to find our different class buildings and landmarks. Holly has been super helpful in making that a faster, more efficient process, but it’s still a lot of labor.”

Following class discussion, students break into small groups to attempt to decode different film and literature titles in braille.

“The course started out with tactile sensitivity training, where you’re building up your ability to tactilely distinguish between small differences,” said Sevier, who went on to explain that braille characters include six dots placed in two columns of three dots. Letters of the alphabet, known as “Grade One Braille,” are determined by the number and arrangement of dots. “Grade Two Braille,” or contractions, are characters that stand for parts of words or even whole words.

Alex Waysand ’27, an international student from France with an interest in languages, noted the challenge of learning to read braille.

“This is a commonly shared experience among students in the class, but I was struck to discover how insensitive the tips of my fingers were and how hard it was to decipher braille characters,” he said.

Beyond animated, philosophical classroom examination on the writing system and Sevier’s lessons on reading braille, students visited Perkins School for the Blind in Watertown. There they were given a tour of the library and museum and had the opportunity to use a giant tactile globe that was favored by Helen Keller, Radcliffe College Class of 1904. The globe, which was built in 1837 and stands 13 feet in circumference, was the first thing that Keller touched when she arrived at Perkins as a student at the age of 8.

Vrabel, who is writing her thesis on Perkins’ outreach program and lived there last summer, was glad her Harvard classmates had the chance to acquaint themselves with  the extraordinary world at Perkins. “It was really cool to come back with the class and experience all the exhibits and see people who probably would not have been in the space otherwise,” she said.

Now, more than halfway through the semester, Sevier said she’s happy with how the course has manifested. “I am very impressed with everyone’s ability to put themselves out of their comfort zones to learn more about the braille code,” she said, adding that she hopes students will take with them “the pride and joy blind people have within their community … and that students will be able to see this in other spaces.”

Shell and Sevier plan to teach another iteration of this course next academic year.


Harvard won’t comply with demands from Trump administration

Changes pushed by government ‘unmoored from the law,’ Garber says. ‘The University will not surrender its independence or relinquish its constitutional rights.’


Campus & Community

Harvard won’t comply with demands from Trump administration

Campus of Harvard University.

Harvard University.

Photo by Grace DuVal

5 min read

Changes pushed by government ‘unmoored from the law,’ Garber says. ‘The University will not surrender its independence or relinquish its constitutional rights.’

Harvard on Monday rejected demands from the Trump administration that threaten $9 billion in research funding, arguing that the changes pushed by the government exceed its lawful authority and infringe on both the University’s independence and its constitutional rights.

“The University will not surrender its independence or relinquish its constitutional rights,” Harvard President Alan Garber wrote in a message to the community. He added: “No government — regardless of which party is in power — should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue.”

Garber’s message was a response to a letter sent late Friday by the Trump administration outlining demands that Harvard would have to satisfy to maintain its funding relationship with the federal government. These demands include “audits” of academic programs and departments, along with the viewpoints of students, faculty, and staff, and changes to the University’s governance structure and hiring practices.

The $9 billion under review by the government includes $256 million in research support for Harvard plus $8.7 billion in future commitments to the University and several renowned hospitals, among them Mass General, the Dana-Farber Cancer Institute, and Boston Children’s. Late Monday, the Trump administration announced that it was moving to freeze $2.2 billion in grants and $60 million in contracts to Harvard.

The Trump administration has been critical of Harvard’s handling of student protests related to the Gaza war. It has accused the University of failing to adequately protect Jewish students on campus from antisemitic discrimination and harassment, in violation of Title VI of the Civil Rights Act of 1964.

Garber emphasized that Harvard remains committed to fighting antisemitism, including through a series of campus measures implemented over the past 15 months. In addition, he said, the University has complied with the Supreme Court decision that ended race-conscious admissions and has worked to broaden intellectual and viewpoint diversity at Harvard.

The University’s objectives in fighting antisemitism will “not be achieved by assertions of power, unmoored from the law, to control teaching and learning at Harvard and to dictate how we operate,” Garber said. “The work of addressing our shortcomings, fulfilling our commitments, and embodying our values is ours to define and undertake as a community.”

Harvard is just one of dozens of schools targeted by the Trump administration in recent weeks. Last month, the Department of Education sent letters to 60 universities, including Columbia, Northwestern, the University of Michigan, and Tufts, threatening enforcement actions for noncompliance with anti-discrimination provisions in the Civil Rights Act of 1964. The administration has taken the additional step of freezing research funding at several institutions.

Robust research and innovation partnerships among universities, the federal government, and private industry date to World War II. Government-backed research conducted at schools across the nation has led to countless discoveries, devices, treatments, and other advances that have helped shape the modern world. Computers, robotics, artificial intelligence, vaccines, and treatments for devastating diseases have all stemmed from government-financed research that crosses from labs and libraries into industry, creating new products, companies, and jobs.

In March, a report from the nonprofit United for Medical Research showed that every dollar of research funded by the National Institutes of Health — the nation’s largest funder of biomedical research — generates $2.56 in economic activity. In 2024 alone, the NIH awarded $36.9 billion in research grants, generating $94.5 billion in economic activity and supporting 408,000 jobs, according to the report.

In an interview on Monday, Daniel P. Gross, an associate professor of business administration at Duke University and co-author of a recent NBER working paper on the decades-long partnership between the U.S. government and higher ed, said the withdrawal of research funding from universities would be “catastrophic” to American innovation.

“Universities are such an integral part of the modern U.S. innovation system that it wouldn’t stand without them,” said Gross, who taught at Harvard Business School before moving to Duke.

George Q. Daley, dean of Harvard Medical School, said that biomedicine has long depended on a strong partnership with the federal government, one that has paid off for Americans in life-saving advances. Just this month, he noted, the Medical School’s Joel Habener was recognized with a Breakthrough Prize for his work on GLP-1, which has led to diabetes and anti-obesity drugs. Daley also cited transformative work in cardiovascular health, cancer immunotherapy, and a host of other conditions.

“As we look back over the 70 years of that partnership, it has returned brilliantly on the investments the government has made,” he said. “The fact that we have Harvard, MIT, and all these extraordinary hospitals, that has been a magnet for venture capital investment and now we have the pharmaceutical research infrastructure being brought into our community. All of this is a jewel in the crown of American bioscience.”

The threat to that science is an even bigger issue in an era of stepped-up competition with China, he added.

“It seems self-defeating and injurious to the economy and to U.S. leadership in biotechnology and pharmaceuticals,” Daley said. “It feels like the hammer has come down in a way that threatens something that is intrinsic to U.S. leadership and ultimately to our economic competitiveness with places like China, which are investing very, very heavily in biotechnology.”

In his message to the community, Garber stressed the contributions of university research to scientific and medical progress while underlining the importance of independent thought and scholarship.

“Freedom of thought and inquiry, along with the government’s longstanding commitment to respect and protect it, has enabled universities to contribute in vital ways to a free society and to healthier, more prosperous lives for people everywhere,” he said. “All of us share a stake in safeguarding that freedom.”


Becky G gets real at Cultural Rhythms

Artist of the Year applauds student performers for ‘leaning into authenticity’


Arts & Culture

Becky G gets real at Cultural Rhythms

RAZA Ballet Folklórico performs at Sanders Theatre.

RAZA Ballet Folklórico performs at Sanders Theatre.

Photos by Veasey Conway/Harvard Staff Photographer

4 min read

Artist of the Year applauds student performers for ‘leaning into authenticity’

Dance dominated the 39th annual Cultural Rhythms festival as students showcased impressive footwork from around the world.

“It just feels right to be surrounded by so many young individuals who are dedicating themselves to representation and to leaning into authenticity,” said five-time Latin Grammy nominee Becky G, honored as Artist of the Year at the April 5 production.

Since 1986, Cultural Rhythms has united the Harvard community for a celebration of the cultural and ethnic diversity of its student body. The tradition has grown into a weeklong series, including a fashion show and food fair. The grand finale, hosted by the Harvard Foundation, is a student-led performing arts showcase and Artist of the Year ceremony at Sanders Theatre.

Becky G, the 39th annual Cultural Rhythms’ Artist of the Year,

Becky G acknowledges the audience after receiving her award.

Harvard University

The award’s past recipients include musical performers Lady Gaga and Rubén Blades as well as actors Courtney B. Vance, Angela Bassett, Eva Longoria, and Viola Davis.

“It’s a heavy-hitting list of incredible individuals who’ve accomplished so many things,” Becky G, 28, told the Gazette. “I feel like I’m just getting started.”

This year’s around-the-world tour featured Harvard Dankira Dance Troupe, with its Ethiopian- and Eritrean-inspired folk dances, and Bhangra, which pumped up the crowd with electric Punjabi moves. Audience members were pulled to their feet by Omo Naija x The Wahala Boys, who put on a Vegas-worthy dance skit. Becky G was seen cheering from her seat as Bryant Valenzuela ’25 and Mariachi Veritas x RAZA Ballet Folklórico performed Mexico’s varied movement and musical traditions.

The 2½-hour program, titled “Global Encounters,” included musical performances by 10 student groups. A highlight came when the Kuumba Singers of Harvard College offered their powerful rendition of “Can’t Give Up Now” by the duo Mary Mary. The song includes an adapted chorus from the Black gospel classic “I Don’t Feel Noways Tired.”

Habiba Braimah, senior director of the Harvard Foundation for Intercultural and Race Relations, offered her thoughts on the impact of these sets. “We are reminded that art is powerful,” she told the audience. “Dance, storytelling and music is healing, and culture — all cultures, your culture — matters in a world that makes you feel divided, where our identities might be misunderstood or even challenged.”

Becky G was honored for artistic excellence and other positive contributions. At the end of the evening, the singer, songwriter, actress, and activist took the stage with festival co-directors Anapaula Barba ’25 and Hayat Hassan ’25 for a conversation covering everything from career to mental health and philanthropy.

Becky G, whose real name is Rebecca Marie Gomez, has been open in the past about her anxiety. At Sanders, she encouraged those in the midst of mental health struggles to ask for help, no matter what cultural taboos they face.

“I realized as I got older that my responsibility isn’t necessarily to be a role model but to be a real model,” Becky G said in an interview. “That means speaking to the fact that I am imperfect and that I make mistakes.”

With more than 28 billion career streams and high-profile roles in the films “Power Rangers” (2017) and DC’s “Blue Beetle” (2023), along with her hit songs “Shower” and “Mayores,” performed with Bad Bunny, Becky G uses her position to raise awareness for vulnerable communities.

“One thing that comes to mind is that there’s no lack of talent and there’s no lack of passionate individuals who are willing to do what it takes to do the work, but there is a lack of opportunity,” she said.

She is active with Altadena Girls, an organization supporting girls who lost their homes in this year’s Eaton Canyon fire.

A big fan of the late Selena Quintanilla — aka the Queen of Tejano Music — as well as contemporary reggaeton artists, she celebrated the fact that Latinx artists no longer need to “cross over.” Breaking into the U.S. market may have required performing in English for past generations. But Spanish-speaking singers today can stick to their roots.

“When we open the door for ourselves, we’re holding it open for the next generations and we’re making things better brick by brick,” said Becky G, the first Latina to receive Artist of the Year in a decade.


Helping the U.S. fight addiction, cancer, other afflictions

A snapshot of research backed by partnership between government agencies and higher ed


Campus & Community

Helping the U.S. fight addiction, cancer, other afflictions

Detail of microscope in lab.
4 min read

A snapshot of research backed by partnership between government agencies and higher ed

Examples of how Harvard scholars are tackling real-world problems — through critical research supported by federal funding — appear daily in the Gazette. The following is a snapshot of recent coverage.


Preventing opioid deaths

The fentanyl crisis hits close to home for Harvard-trained researcher Travis Donahoe, whose research probes the forces driving opioid deaths and the best ways to intervene. “Ending this epidemic is one of the most important changes we can make to improve the health — and dignity — of all Americans.”

Repairing eye damage once thought untreatable

A stem cell therapy developed at Mass Eye and Ear safely restored the cornea’s surface for 14 patients in a clinical trial. When a person suffers a cornea injury, it can deplete the limbal epithelial cells, which can never regenerate. People with these injuries often experience persistent pain and visual difficulties.

Creating at-home test to catch Alzheimer’s early

Researchers from Harvard-affiliated Mass General Brigham developed olfactory tests — in which participants sniff odor labels that have been placed on a card — to assess people’s ability to discriminate, identify, and remember odors.

Identifying 296 genetic disorders that can be treated before birth

“We saw a critical gap in prenatal care and an opportunity to define the genetic disorders that are treatable during this time,” said the study’s senior author. “These conditions are actionable — meaning that, empowered with diagnostic information, we can intervene early and improve outcomes.”

Exploring a cheaper way to make RX drugs

Chemist and Ph.D. candidate Brandon Campbell sees in silver an opportunity to lower the cost of medicine in the U.S., where consumers pay nearly three times more than 33 other nations in the Organization for Economic Cooperation and Development.

Anticipating surge in demand for AC

A Harvard startup has developed a “third way” of pulling moisture from the air that works like a coffee filter. It uses much less energy than traditional air conditioners and dehumidifiers and is more stable than desiccant systems.

Tracking dark energy, future of universe

The fate of the universe hinges on the balance between matter and dark energy, which is the force thought to be driving the universe’s accelerating expansion. New research suggesting that dark energy, widely thought to be a “cosmological constant,” might be weakening suggests the standard model of how the universe works may need an update.

Uncovering potential new therapies for autism, anxiety

New insights on how inflammation sparked by the body’s immune response alters mood and behavior could lead to alternatives to traditional psychiatric drugs that act directly on the brain. These treatments would work indirectly by altering immune chemicals outside the brain.

“Studies have previously investigated dietary patterns in the context of specific diseases or how long people live,” said one of the researchers. “Ours takes a multifaceted view, asking, how does diet impact people’s ability to live independently and enjoy a good quality of life as they age?”

Building a lens now found in millions of electronic devices

Over the course of his Harvard doctoral studies, Rob Devlin must have made 100 of a new kind of mini-lens, experimenting with materials and prototyping new designs to bend light like a traditional camera only using a series of tiny pillars on a millimeter-thin wafer.

Advancing progress toward treating rare, fatal condition

“Milestone” in nine-year quest to find a treatment for prion disease is personal for patient-scientist and her husband.

Calculating longevity benefits of simple dietary swap

A study finds that replacing butter with plant-based oils cuts the risk of premature death by up to 17 percent.

Solving confounding medical mysteries

With key contributions from Harvard researchers, the Undiagnosed Diseases Network identifies the rarest of illnesses and discovers new ones.

Opening new fronts against A-fib

Researchers double the number of genetic factors associated with a condition that affects more than 5 million Americans.

Making leap in quantum computing

For the first time, scientists succeeded in trapping molecules to perform quantum operations. The technology promises speeds exponentially faster than classical computers, which could enable game-changing advances in fields including medicine, science, and finance.

Finding powerful tool for colon cancer survival

Patients who exercise regularly after treatment live longer, according to research from the Dana-Farber Cancer Institute research.

Taking big step toward targeted molecular therapies for cancer

Researchers developed innovative approaches to understand, target, and disrupt uncontrollable growth of disease.

Discovering citrus might be a mood protector

A physician-researcher outlined gut-brain clues behind an “orange a day” depression finding.

Unlocking possible key to diseases linked to X chromosome

A Jell-O-like substance could be key to treating Fragile X and Rett syndromes, researchers found.


Leveraging social capital to defend worthy causes, people in need of representation

Legal scholar and Law School grad returns for student panel


Nation & World

Leveraging social capital to defend worthy causes, people in need of representation

Legal scholar and Law School grad returns for student panel

3 min read
Margaret Montoya.

Margaret Montoya, J.D. ’78.

Veasey Conway/Harvard Staff Photographer

Law school provides job security with high earning potential, legal scholar Margaret Montoya, J.D. ’78, said during a March 27 student panel at Harvard Law School. But it also gives students cross-functional skills, social capital, and the chance to work for the greater good.

Montoya, the first Latina to be accepted to Harvard Law School, urged the students to give back by engaging with communities in need of legal representation, finding worthy causes to defend, and advocating for democracy.

“I was asked a question just a moment ago, ‘Why would you return to Harvard?’” said Montoya. “I return for you … I would hope that you go out and change the world. You can use the social capital offered by a Harvard degree … It is a certificate that’s worth a lot. Use it. Come back here. And help others.”

“You can use the social capital offered by a Harvard degree … It is a certificate that’s worth a lot. Use it. Come back here. And help others.”

Margaret Montoya, J.D. ’78,

A native New Mexican, Montoya, now professor emerita, has been at the University of New Mexico Law School since 1992. She has taught courses in constitutional rights, torts, contracts, clinical law, and employment law, and has written about race, ethnicity, gender, culture, and language.

After graduating from HLS, Montoya was awarded Harvard University’s Frederick Sheldon Traveling Fellowship, which allowed her to travel through Europe and Asia. Over the years, she has often returned to campus to meet and talk with students about how to make the most of their legal educations.

During her talk, Montoya compared her experience as a law student in the 1970s, when she was the only Latina student in the HLS classrooms, to that of students today.

“When I look at you, the demography, the social geography is very different,” said Montoya. “I arrived as a child from a low-income family … This is a place that teaches you about power. That is something that is worth experiencing because in order to change the society we have to understand power.”

Montoya asked student panelists what they felt were the biggest gaps in their legal education. Many responded that their courses sometimes lacked perspective on how the law affects the lives of average Americans, skipping over issues of race, social class, politics, and history.

“There’s a lot missing in the education of law students. First and foremost, it’s how the law impacts real people,” said Liz Ross, J.D. ’21 and a Ph.D. candidate in history. “That was probably the biggest gap that I saw when I was here … I think empathy is missing in legal education.”

When asked by Montoya how they enhanced their legal education, panelists underscored the importance of working with like-minded people by forming study or reading groups, getting involved with student organizations, and bringing new voices and perspectives to classrooms.

Montoya asked students to use their law degrees to help vulnerable communities, defend social and racial progress, and protect democracy when it’s threatened by authoritarian forces. A law degree offers tools to become guardians of democracy, she said.

“Harvard transfers social capital to those of us who are here and who graduate,” Montoya said during an interview after her talk. “We can turn that social capital to become stewards of democracy. We can name ourselves as being on the side of justice. Harvard Law School gives us the social capital to be able use different tools to change the status quo.”